ES2139750T3 - 2-aminoindanos como ligandos selectivos d3 de la dopamina. - Google Patents

2-aminoindanos como ligandos selectivos d3 de la dopamina.

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Publication number
ES2139750T3
ES2139750T3 ES94925094T ES94925094T ES2139750T3 ES 2139750 T3 ES2139750 T3 ES 2139750T3 ES 94925094 T ES94925094 T ES 94925094T ES 94925094 T ES94925094 T ES 94925094T ES 2139750 T3 ES2139750 T3 ES 2139750T3
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Spain
Prior art keywords
alkyl
hydrogen
pct
cycloalkyl
alkenyl
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ES94925094T
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English (en)
Inventor
Susanne R Haadsma-Svensson
Bengt R Andersson
Clas A Sonesson
Chiu-Hong Lin
R Nicholas Waters
Kjell A I Svensson
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Pharmacia and Upjohn Co
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Pharmacia and Upjohn Co
Upjohn Co
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    • C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
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  • Pyrrole Compounds (AREA)

Abstract

SE PRESENTAN COMPUESTOS Y SUS SALES FARMACOLOGICAMENTE ACEPTABLES ADECUADOS PARA EL TRATAMIENTO DE ENFERMEDADES DEL SISTEMA NERVIOSO CENTRAL ASOCIADAS CON LA ACTIVIDAD DEL RECEPTOR DE LA DOPAMINA D3 Y QUE TIENEN LA FORMULA (I), EN DONDE R1 Y R2 SE ESCOGEN INDEPENDIENTEMENTE ENTRE HIDROGENO, ALQUIL C1-8, OCH3, OH, OSO2-CF3, OSO2-CH3, SOR5, CO2-R5, CONH2, CONR5-R6, COR5, CF3, CN, SR5, SO2-NH2, SO2-NR5-R6, SO2-R5, -OCO-ALQUIL C1-6, -NCO-ALQUILO C1-6, -CH2O-ALQUILO C16, -CH2OH, -CO-ARILO, -NHSO2-ARILO, -NHSO2-ALQUILO C1-6, PFTALAMIDO, TIOFENILO, PIRROL, PIRROLINILO, OXAZOL, HALOGENO (BR, CL, F, I), R6 O R1 Y R2 JUNTAS FORMAN O(CH2)M}O- (EN DONDE M ES 1-2) O CH2(CH2-P-CH2- (EN DONDE P ES 1-4); (EXCEPTO QUE SOLAMENTE UNA DE R1 Y R2 PUEDE SER HIDROGENO, OCH3 U OH EN CUALQUIERA DE TALES COMPUESTOS); R3 Y R4 SE ESCOGEN INDEPENDIENTEMENTE ENTRE ALQUENILO C1-4, ALQUINILO C3-8, CICLOALQUILO C3-8, -(CH2-P-TIENILO (EN DONDE P ES 1-4), HIDROGENO (EXCEPTO QUE SOLAMENTE UNA DE R3 U R4 PUEDE SER HIDROGENO ENDICHO COMPUESTO) O ALQUILO C1-8 (EXCEPTO CUANDO R1 O R2 SEN HIDROGENO, OCH3 O OH); R5 ES HIDROGENO, ALQUILO C1-8, ALQUENILO C2-4, CICLOALQUILO C3-8; Y R6 ES ALQUILO C1-8, ALQUENILO C2-4, ALQUINILO C2-8, CICLOALQUILO C3-8, O ARILO.
ES94925094T 1993-08-06 1994-07-21 2-aminoindanos como ligandos selectivos d3 de la dopamina. Expired - Lifetime ES2139750T3 (es)

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WO1995004713A1 (en) 1995-02-16
US5708018A (en) 1998-01-13
GR3032508T3 (en) 2000-05-31
EP0712387A1 (en) 1996-05-22
EP0712387B1 (en) 1999-12-08
DK0712387T3 (da) 2000-05-29
ATE187436T1 (de) 1999-12-15
DE69422044T2 (de) 2000-05-31
DE69422044D1 (de) 2000-01-13
JP3342491B2 (ja) 2002-11-11
LV12630B (en) 2001-08-20
JPH09501429A (ja) 1997-02-10
LV12630A (lv) 2001-03-20

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