IN163758B - - Google Patents

Info

Publication number: IN163758B
Authority: IN; India
Prior art keywords: sub; leu; ala; phe; ser
Prior art date: 1985-08-29

Application number

IN593/MAS/86A

Other languages

English (en)

Inventor

Emit Thomas Kaiser

Velicelebi Gonul

Original Assignee

Salk Inst For Biological Studi

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1985-08-29

Filing date

1986-07-24

Publication date

1988-11-05

1986-07-24 Application filed by Salk Inst For Biological Studi filed Critical Salk Inst For Biological Studi

1988-11-05 Publication of IN163758B publication Critical patent/IN163758B/en

Links

241001465754 Metazoa Species 0.000 abstract 3
241000282412 Homo Species 0.000 abstract 2
-1 Phe Chemical compound 0.000 abstract 2
102000004196 processed proteins & peptides Human genes 0.000 abstract 2
108090000765 processed proteins & peptides Proteins 0.000 abstract 2
CKLJMWTZIZZHCS-UHFFFAOYSA-N D-OH-Asp Natural products OC(=O)C(N)CC(O)=O CKLJMWTZIZZHCS-UHFFFAOYSA-N 0.000 abstract 1
QNAYBMKLOCPYGJ-UWTATZPHSA-N D-alanine Chemical compound C[C@@H](N)C(O)=O QNAYBMKLOCPYGJ-UWTATZPHSA-N 0.000 abstract 1
CKLJMWTZIZZHCS-UWTATZPHSA-N D-aspartic acid Chemical compound OC(=O)[C@H](N)CC(O)=O CKLJMWTZIZZHCS-UWTATZPHSA-N 0.000 abstract 1
HNDVDQJCIGZPNO-RXMQYKEDSA-N D-histidine Chemical compound OC(=O)[C@H](N)CC1=CN=CN1 HNDVDQJCIGZPNO-RXMQYKEDSA-N 0.000 abstract 1
COLNVLDHVKWLRT-MRVPVSSYSA-N D-phenylalanine Chemical compound OC(=O)[C@H](N)CC1=CC=CC=C1 COLNVLDHVKWLRT-MRVPVSSYSA-N 0.000 abstract 1
OUYCCCASQSFEME-MRVPVSSYSA-N D-tyrosine Chemical compound OC(=O)[C@H](N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-MRVPVSSYSA-N 0.000 abstract 1
SGCGMORCWLEJNZ-UWVGGRQHSA-N His-His Chemical compound C([C@H]([NH3+])C(=O)N[C@@H](CC=1NC=NC=1)C([O-])=O)C1=CN=CN1 SGCGMORCWLEJNZ-UWVGGRQHSA-N 0.000 abstract 1
DEFJQIDDEAULHB-IMJSIDKUSA-N L-alanyl-L-alanine Chemical compound C[C@H](N)C(=O)N[C@@H](C)C(O)=O DEFJQIDDEAULHB-IMJSIDKUSA-N 0.000 abstract 1
CKLJMWTZIZZHCS-REOHCLBHSA-N L-aspartic acid Chemical compound OC(=O)[C@@H](N)CC(O)=O CKLJMWTZIZZHCS-REOHCLBHSA-N 0.000 abstract 1
125000000393 L-methionino group Chemical group [H]OC(=O)[C@@]([H])(N([H])[*])C([H])([H])C(SC([H])([H])[H])([H])[H] 0.000 abstract 1
150000001413 amino acids Chemical class 0.000 abstract 1
230000002267 hypothalamic effect Effects 0.000 abstract 1
231100000252 nontoxic Toxicity 0.000 abstract 1
230000003000 nontoxic effect Effects 0.000 abstract 1
230000001817 pituitary effect Effects 0.000 abstract 1
230000003389 potentiating effect Effects 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1
241000894007 species Species 0.000 abstract 1
238000006467 substitution reaction Methods 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/60—Growth hormone-releasing factor [GH-RF], i.e. somatoliberin
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S930/00—Peptide or protein sequence
- Y10S930/01—Peptide or protein sequence
- Y10S930/12—Growth hormone, growth factor other than t-cell or b-cell growth factor, and growth hormone releasing factor; related peptides

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Endocrinology (AREA)
Medicinal Chemistry (AREA)
General Health & Medical Sciences (AREA)
Genetics & Genomics (AREA)
Biochemistry (AREA)
Biophysics (AREA)
Gastroenterology & Hepatology (AREA)
Molecular Biology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Toxicology (AREA)
Zoology (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Public Health (AREA)
Animal Behavior & Ethology (AREA)
Pharmacology & Pharmacy (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Diabetes (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Veterinary Medicine (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Peptides Or Proteins (AREA)
Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Surface Acoustic Wave Elements And Circuit Networks Thereof (AREA)
Junction Field-Effect Transistors (AREA)
Lighting Device Outwards From Vehicle And Optical Signal (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Steroid Compounds (AREA)
Diaphragms For Electromechanical Transducers (AREA)
Control Of High-Frequency Heating Circuits (AREA)
Superconductors And Manufacturing Methods Therefor (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

IN593/MAS/86A 1985-08-29 1986-07-24 IN163758B (fr)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US06/770,683 US4689318A (en)	1985-08-29	1985-08-29	GRF analogs

Publications (1)

Publication Number	Publication Date
IN163758B true IN163758B (fr)	1988-11-05

Family

ID=25089358

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
IN593/MAS/86A IN163758B (fr)	1985-08-29	1986-07-24

Country Status (19)

Country	Link
US (1)	US4689318A (fr)
EP (1)	EP0216517B1 (fr)
JP (1)	JPH0762037B2 (fr)
KR (1)	KR910002701B1 (fr)
AT (1)	ATE69821T1 (fr)
AU (1)	AU589674B2 (fr)
CA (1)	CA1299507C (fr)
DE (1)	DE3682641D1 (fr)
DK (1)	DK413986A (fr)
ES (1)	ES2001274A6 (fr)
GR (1)	GR862194B (fr)
HU (1)	HU206126B (fr)
IL (1)	IL79534A0 (fr)
IN (1)	IN163758B (fr)
NO (1)	NO863432L (fr)
NZ (1)	NZ217280A (fr)
PH (1)	PH23188A (fr)
SU (1)	SU1651787A3 (fr)
ZA (1)	ZA865886B (fr)

Families Citing this family (33)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4734399A (en) *	1985-08-06	1988-03-29	Hoffmann-La Roche Inc.	Growth hormone releasing factor analogs
US4828988A (en) *	1986-05-15	1989-05-09	Smith Kline - Rit	Hybrid polypeptides comprising somatocrinine and alpha1 -antitrypsin, method for their production from bacterial clones and use thereof for the production of somatocrinine
US5565606A (en) *	1986-10-21	1996-10-15	Hoechst Aktiengesellschaft	Synthesis of peptide aminoalkylamides and peptide hydrazides by the solid-phase method
DE3742633A1 (de) *	1987-12-16	1989-06-29	Hoechst Ag	Peptide mit beeinflussender wirkung auf die hypophyse von saeugern
US4784987A (en) *	1987-01-13	1988-11-15	The Salk Institute For Biological Studies	GRF analogs VI
IL84758A (en) *	1987-01-13	1992-03-29	Salk Inst For Biological Studi	Peptides stimulating the release of pituitary growth hormone in fish and amphibians,and pharmaceutical compositions containing them
US4843064A (en) *	1987-01-13	1989-06-27	The Salk Institute For Biological Studies	GRF analogs V
IL86102A (en) *	1987-05-11	1994-04-12	Univ Tulane	Alkylated growth hormone-releasing peptides and use thereof
US5112808A (en) *	1987-05-11	1992-05-12	American Cyanamid Company	Alkylated hormone-releasing peptides and method of treatig mammals therewith
US5002931A (en) *	1987-05-22	1991-03-26	The Salk Institute For Biological Studies	GRF analogs VII
US5098995A (en) *	1987-05-22	1992-03-24	The Salk Institute For Biological Studies	GRF Analogs VIIA
US5043322A (en) *	1988-07-22	1991-08-27	The Salk Institute For Biological Studies	Cyclic GRF analogs
US5756458A (en) *	1989-06-16	1998-05-26	Pharmacia & Upjohn Company	Stabilized potent GRF analogs
AU651976B2 (en) *	1990-05-04	1994-08-11	The Administrators Of The Tulane Eductional Fund	Novel synthetic GRF analogs
ZA914983B (en) *	1990-06-29	1992-03-25	Hoffmann La Roche	His-grf-analogs
AU655791B2 (en) *	1990-11-14	1995-01-12	Pharmacia & Upjohn Company	Stabilized, potent GRF analogs
ATE119916T1 (de) *	1990-12-10	1995-04-15	Hoffmann La Roche	Verfahren zur enzymatischen herstellung von grf(1-44)nh2.
EP0525838A3 (fr) *	1991-04-09	1993-02-10	F. Hoffmann-La Roche Ag	Analogues de l'hormone libérant l'hormone de croissance
AU1907292A (en) *	1991-04-24	1992-12-21	Warner-Lambert Company	Alpha-substituted polypeptides having therapeutic activity
US5262519A (en) *	1991-05-15	1993-11-16	The Salk Institute For Biological Studies	GRF analogs XI
US5550212A (en) *	1993-12-17	1996-08-27	The Administrators Of The Tulane Educational Fund	Analogues of hGH-RH(1-29)NH2 having antagonistic activity
JPH07200419A (ja) *	1993-12-28	1995-08-04	Nec Corp	バスインタフェース装置
US5792747A (en) *	1995-01-24	1998-08-11	The Administrators Of The Tulane Educational Fund	Highly potent agonists of growth hormone releasing hormone
JPH11503454A (ja) *	1995-04-14	1999-03-26	ジアドミニストレイターズオブザチューレンエデュケイショナルファンド	成長ホルモン放出因子の類似体
CN1491233A (zh) *	2001-02-02	2004-04-21	康久化学公司	长效生长激素释放因子衍生物
US20060128615A1 (en) *	2002-09-18	2006-06-15	Pierrette Gaudreau	Ghrh analogues
US20090088380A1 (en) *	2007-07-12	2009-04-02	Pierrette Gaudreau	Ghrh analogs and therapeutic uses thereof
WO2009108364A2 (fr) *	2008-02-27	2009-09-03	Ipsen Pharma S.A.S.	Analogues antagonistes de ghrh
WO2011153491A2 (fr)	2010-06-03	2011-12-08	University Of Miami	Agonistes de l'hormone de libération de l'hormone de croissance en tant qu'effecteurs de la survie et de la prolifération d'îlots pancréatiques
US9079974B2 (en)	2011-12-21	2015-07-14	The University Of Miami	GH-RH analogs with potent agonistic effects
US9855312B2 (en)	2012-12-21	2018-01-02	University Of Miami	GHRH agonists for the treatment of ischemic disorders
WO2014100816A2 (fr)	2012-12-21	2014-06-26	University Of Miami	Agonistes de ghrh pour la greffe et fonction de cellules d'îlot et le traitement du diabète
CA3021231A1 (fr)	2016-04-19	2017-10-26	Griffon Pharmaceuticals Inc.	Peptides pegyles bioactifs et utilisations correspondantes

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4595676A (en) *	1983-04-26	1986-06-17	The Salk Institute For Biological Studies	Rat hypothalamic GRF
US4529595A (en) *	1983-01-13	1985-07-16	The Salk Institute For Biological Studies	GRF Analogs
US4500910A (en) *	1982-11-30	1985-02-19	Rca Corporation	Hue control system
US4518586A (en) *	1983-01-13	1985-05-21	The Salk Institute For Biological Studies	GRF Analogs III
IL70530A (en) *	1983-01-13	1986-09-30	Salk Inst For Biological Studi	Synthetic peptides having growth hormone releasing factor activity and compositions containing them
US4514331A (en) *	1983-06-29	1985-04-30	University Patents, Inc.	Peptide hormones with calcitonin-like activity
US4528190A (en) *	1983-10-25	1985-07-09	The Salk Institute For Biological Studies	GRF Analogs IV
US4649131A (en) *	1984-09-24	1987-03-10	Hoffmann-La Roche Inc.	Growth hormone releasing factor analogs

1985
- 1985-08-29 US US06/770,683 patent/US4689318A/en not_active Expired - Lifetime
1986
- 1986-07-24 IN IN593/MAS/86A patent/IN163758B/en unknown
- 1986-07-28 IL IL79534A patent/IL79534A0/xx not_active IP Right Cessation
- 1986-07-29 CA CA000514869A patent/CA1299507C/fr not_active Expired - Lifetime
- 1986-07-31 PH PH34087A patent/PH23188A/en unknown
- 1986-08-05 ZA ZA865886A patent/ZA865886B/xx unknown
- 1986-08-20 NZ NZ217280A patent/NZ217280A/xx unknown
- 1986-08-22 SU SU864027997A patent/SU1651787A3/ru active
- 1986-08-22 EP EP86306535A patent/EP0216517B1/fr not_active Expired - Lifetime
- 1986-08-22 DE DE8686306535T patent/DE3682641D1/de not_active Expired - Lifetime
- 1986-08-22 AT AT86306535T patent/ATE69821T1/de not_active IP Right Cessation
- 1986-08-25 GR GR862194A patent/GR862194B/el unknown
- 1986-08-26 AU AU61838/86A patent/AU589674B2/en not_active Ceased
- 1986-08-27 NO NO863432A patent/NO863432L/no unknown
- 1986-08-28 KR KR1019860007174A patent/KR910002701B1/ko not_active Expired
- 1986-08-28 HU HU863722A patent/HU206126B/hu not_active IP Right Cessation
- 1986-08-28 ES ES8601432A patent/ES2001274A6/es not_active Expired
- 1986-08-29 DK DK413986A patent/DK413986A/da not_active Application Discontinuation
- 1986-08-29 JP JP61203579A patent/JPH0762037B2/ja not_active Expired - Fee Related

Also Published As

Publication number	Publication date
DE3682641D1 (de)	1992-01-09
CA1299507C (fr)	1992-04-28
PH23188A (en)	1989-05-29
JPS6251698A (ja)	1987-03-06
DK413986D0 (da)	1986-08-29
ATE69821T1 (de)	1991-12-15
IL79534A0 (en)	1986-10-31
NO863432D0 (no)	1986-08-27
EP0216517B1 (fr)	1991-11-27
HUT41819A (en)	1987-05-28
GR862194B (en)	1986-12-31
HU206126B (en)	1992-08-28
EP0216517A2 (fr)	1987-04-01
AU589674B2 (en)	1989-10-19
NO863432L (no)	1987-03-02
ZA865886B (en)	1987-03-25
KR870002163A (ko)	1987-03-30
KR910002701B1 (ko)	1991-05-03
SU1651787A3 (ru)	1991-05-23
ES2001274A6 (es)	1988-05-01
DK413986A (da)	1987-03-01
AU6183886A (en)	1987-03-05
US4689318A (en)	1987-08-25
NZ217280A (en)	1989-04-26
EP0216517A3 (en)	1988-09-21
JPH0762037B2 (ja)	1995-07-05

Publication	Publication Date	Title
AU589674B2 (en)	1989-10-19	GRF analogs
KR910000379B1 (ko)	1991-01-24	합성 grt 펩티드
IL69897A (en)	1986-12-31	Human pancreatic grf analogs,compositions comprising them and use thereof
ES8600217A1 (es)	1985-10-01	Un procedimiento para producir peptidos que influyen en la funcion de la glandula pituitaria
IL90766A0 (en)	1990-01-18	Cyclic grf analogs and pharmaceutical compositions containing them
PT87529B (pt)	1992-09-30	Processo de preparacao de analogos do factor de libertacao de hormona de crescimento vii (flhc)
FI94356C (fi)	1995-08-25	Menetelmä farmaseuttisesti käyttökelpoisen kasvuhormonia vapauttavan tekijän synteettisen peptidianalogin tai sen ei-myrkyllisen suolan valmistamiseksi
AU593973B2 (en)	1990-02-22	Grf analogs v
CA1304192C (fr)	1992-06-23	Analogues de type ii de la grf
DD234427A5 (de)	1986-04-02	Verfahren zur herstellung von peptiden