IN2012CH03778A - - Google Patents

Info

Publication number
IN2012CH03778A
IN2012CH03778A IN3778CH2012A IN2012CH03778A IN 2012CH03778 A IN2012CH03778 A IN 2012CH03778A IN 3778CH2012 A IN3778CH2012 A IN 3778CH2012A IN 2012CH03778 A IN2012CH03778 A IN 2012CH03778A
Authority
IN
India
Prior art keywords
protein
phe309ser
asp519val
haemophilia
mutations
Prior art date
Application number
Other languages
English (en)
Inventor
C Joseph Bilgimol
P K Satheeshkumar
M A Vijayalakshmi
Original Assignee
Ct For Bioseparation Technology Vit
Christian Medical College
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ct For Bioseparation Technology Vit, Christian Medical College filed Critical Ct For Bioseparation Technology Vit
Priority to EP13837157.0A priority Critical patent/EP2897634B1/en
Priority to PCT/IB2013/058490 priority patent/WO2014041500A2/en
Priority to IN3778CH2012 priority patent/IN2012CH03778A/en
Priority to US14/427,936 priority patent/US20150337028A1/en
Publication of IN2012CH03778A publication Critical patent/IN2012CH03778A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/745—Blood coagulation or fibrinolysis factors
    • C07K14/755—Factors VIII, e.g. factor VIII C (AHF), factor VIII Ag (VWF)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6424—Serine endopeptidases (3.4.21)
    • C12N9/647—Blood coagulation factors not provided for in a preceding group or according to more than one of the proceeding groups
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Hematology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Wood Science & Technology (AREA)
  • Biomedical Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Toxicology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biophysics (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Diabetes (AREA)
  • Public Health (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
IN3778CH2012 2012-09-12 2013-09-12 IN2012CH03778A (th)

Priority Applications (4)

Application Number Priority Date Filing Date Title
EP13837157.0A EP2897634B1 (en) 2012-09-12 2013-09-12 Double mutant coagulation factor viii and methods thereof
PCT/IB2013/058490 WO2014041500A2 (en) 2012-09-12 2013-09-12 Double mutant coagulation factor viii and methods thereof
IN3778CH2012 IN2012CH03778A (th) 2012-09-12 2013-09-12
US14/427,936 US20150337028A1 (en) 2012-09-12 2013-09-12 Double Mutant Coagulation Factor VIII and Methods Thereof

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IN3778CH2012 IN2012CH03778A (th) 2012-09-12 2013-09-12

Publications (1)

Publication Number Publication Date
IN2012CH03778A true IN2012CH03778A (th) 2015-04-24

Family

ID=50278793

Family Applications (1)

Application Number Title Priority Date Filing Date
IN3778CH2012 IN2012CH03778A (th) 2012-09-12 2013-09-12

Country Status (4)

Country Link
US (1) US20150337028A1 (th)
EP (1) EP2897634B1 (th)
IN (1) IN2012CH03778A (th)
WO (1) WO2014041500A2 (th)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2014083510A1 (en) * 2012-11-30 2014-06-05 Centre For Bioseparation Technology - Vit Monolith-based pseudo-bioaffinity purification methods for factor viii and applications thereof
CN112119158A (zh) * 2018-04-12 2020-12-22 生物测试股份公司 去免疫化的因子viii分子以及包含其的药物组合物

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PT1754718E (pt) * 1996-04-24 2011-07-13 Univ Michigan Factor viii resistente à inactivação
US8183344B2 (en) * 1996-04-24 2012-05-22 University Of Michigan Inactivation resistant factor VIII
WO1998000542A2 (en) * 1996-07-03 1998-01-08 Chiron Corporation Methods for administration of recombinant gene delivery vehicles for treatment of hemophilia
ES2427627T3 (es) * 2009-04-06 2013-10-31 Novo Nordisk A/S Entrega dirigida de proteínas de Factor VIII a plaquetas
US8637448B2 (en) * 2010-09-14 2014-01-28 University Of Rochester Recombinant factor VIII having enhanced stability following mutation at the A1-C2 domain interface

Also Published As

Publication number Publication date
WO2014041500A2 (en) 2014-03-20
WO2014041500A3 (en) 2014-07-31
EP2897634A4 (en) 2016-05-04
EP2897634A2 (en) 2015-07-29
EP2897634B1 (en) 2018-03-21
US20150337028A1 (en) 2015-11-26

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