IN2012DN01152A - 2-[[[2-[(hydroxyacetyl)amino]-4-pyridinyl]methyl]thio]-n-[4-(trifluoromethoxy)phenyl]-3-pyridinecarboxamide benzenesulfonate crystal of same crystal polymorph thereof and methods for production thereof - Google Patents
2-[[[2-[(hydroxyacetyl)amino]-4-pyridinyl]methyl]thio]-n-[4-(trifluoromethoxy)phenyl]-3-pyridinecarboxamide benzenesulfonate crystal of same crystal polymorph thereof and methods for production thereofInfo
- Publication number
- IN2012DN01152A IN2012DN01152A IN1152DEN2012A IN2012DN01152A IN 2012DN01152 A IN2012DN01152 A IN 2012DN01152A IN 1152DEN2012 A IN1152DEN2012 A IN 1152DEN2012A IN 2012DN01152 A IN2012DN01152 A IN 2012DN01152A
- Authority
- IN
- India
- Prior art keywords
- compound
- hydroxyacetyl
- trifluoromethoxy
- pyridinyl
- thio
- Prior art date
Links
- 239000013078 crystal Substances 0.000 title abstract 3
- 125000000350 glycoloyl group Chemical group O=C([*])C([H])([H])O[H] 0.000 title abstract 2
- 238000000034 method Methods 0.000 title abstract 2
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 title abstract 2
- 229960003966 nicotinamide Drugs 0.000 title abstract 2
- 239000011570 nicotinamide Substances 0.000 title abstract 2
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 title abstract 2
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 title abstract 2
- 125000000446 sulfanediyl group Chemical group *S* 0.000 title abstract 2
- SRSXLGNVWSONIS-UHFFFAOYSA-M benzenesulfonate Chemical compound [O-]S(=O)(=O)C1=CC=CC=C1 SRSXLGNVWSONIS-UHFFFAOYSA-M 0.000 title 1
- 229940077388 benzenesulfonate Drugs 0.000 title 1
- 229940126062 Compound A Drugs 0.000 abstract 5
- NLDMNSXOCDLTTB-UHFFFAOYSA-N Heterophylliin A Natural products O1C2COC(=O)C3=CC(O)=C(O)C(O)=C3C3=C(O)C(O)=C(O)C=C3C(=O)OC2C(OC(=O)C=2C=C(O)C(O)=C(O)C=2)C(O)C1OC(=O)C1=CC(O)=C(O)C(O)=C1 NLDMNSXOCDLTTB-UHFFFAOYSA-N 0.000 abstract 5
- 150000003839 salts Chemical class 0.000 abstract 3
- 238000002425 crystallisation Methods 0.000 abstract 1
- 230000008025 crystallization Effects 0.000 abstract 1
- 230000008021 deposition Effects 0.000 abstract 1
- 229910052500 inorganic mineral Inorganic materials 0.000 abstract 1
- 239000011707 mineral Substances 0.000 abstract 1
- 235000005152 nicotinamide Nutrition 0.000 abstract 1
- DFPAKSUCGFBDDF-UHFFFAOYSA-N nicotinic acid amide Natural products NC(=O)C1=CC=CN=C1 DFPAKSUCGFBDDF-UHFFFAOYSA-N 0.000 abstract 1
- 210000002784 stomach Anatomy 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/455—Nicotinic acids, e.g. niacin; Derivatives thereof, e.g. esters, amides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/10—Antioedematous agents; Diuretics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/14—Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C303/00—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides
- C07C303/32—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides of salts of sulfonic acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C309/00—Sulfonic acids; Halides, esters, or anhydrides thereof
- C07C309/01—Sulfonic acids
- C07C309/28—Sulfonic acids having sulfo groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
- C07C309/29—Sulfonic acids having sulfo groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton of non-condensed six-membered aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/81—Amides; Imides
- C07D213/82—Amides; Imides in position 3
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/13—Crystalline forms, e.g. polymorphs
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Epidemiology (AREA)
- Rheumatology (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Vascular Medicine (AREA)
- Diabetes (AREA)
- Pain & Pain Management (AREA)
- Hematology (AREA)
- Ophthalmology & Optometry (AREA)
- Urology & Nephrology (AREA)
- Immunology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Pyridine Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2009169130 | 2009-07-17 | ||
| PCT/JP2010/062071 WO2011007870A1 (fr) | 2009-07-17 | 2010-07-16 | Benzène-sulfonate de 2-[[[2-[(hydroxyacétyl)amino]-4-pyridinyl]méthyl]thio]-n-[4-(trifluorométhoxy)phényl]-3-pyridinecarboxamide, cristaux de celui-ci, ses polymorphes et ses procédés de fabrication |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| IN2012DN01152A true IN2012DN01152A (en) | 2015-04-10 |
Family
ID=43449480
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IN1152DEN2012 IN2012DN01152A (en) | 2009-07-17 | 2010-07-16 | 2-[[[2-[(hydroxyacetyl)amino]-4-pyridinyl]methyl]thio]-n-[4-(trifluoromethoxy)phenyl]-3-pyridinecarboxamide benzenesulfonate crystal of same crystal polymorph thereof and methods for production thereof |
Country Status (16)
| Country | Link |
|---|---|
| US (4) | US9029398B2 (fr) |
| EP (1) | EP2455368B1 (fr) |
| JP (1) | JP5662719B2 (fr) |
| KR (1) | KR101710740B1 (fr) |
| CN (1) | CN102471273B (fr) |
| AU (1) | AU2010271746B2 (fr) |
| BR (1) | BR112012001159A2 (fr) |
| CA (1) | CA2767992C (fr) |
| EA (1) | EA019689B1 (fr) |
| ES (1) | ES2554360T3 (fr) |
| IN (1) | IN2012DN01152A (fr) |
| MX (1) | MX2012000749A (fr) |
| MY (1) | MY157122A (fr) |
| NZ (1) | NZ597495A (fr) |
| SG (1) | SG177576A1 (fr) |
| WO (1) | WO2011007870A1 (fr) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20150000874A (ko) | 2012-01-31 | 2015-01-05 | 산텐 세이야꾸 가부시키가이샤 | 비수성 액체 조성물 |
| KR20160060656A (ko) | 2013-09-20 | 2016-05-30 | 산텐 세이야꾸 가부시키가이샤 | 폴리에틸렌글리콜 함유 조성물 |
| TW201609145A (zh) | 2013-12-25 | 2016-03-16 | 參天製藥股份有限公司 | 注射劑及形成緩釋（ｄｅｐｏｔ）之方法 |
| CA2979802C (fr) * | 2015-03-17 | 2023-06-27 | Santen Pharmaceutical Co., Ltd. | Composition pharmaceutique comprenant un polypeptide |
| US11090296B2 (en) * | 2015-03-18 | 2021-08-17 | Santen Pharmaceutical Co., Ltd. | Sustained-release pharmaceutical composition |
| TW201639568A (zh) * | 2015-03-18 | 2016-11-16 | 參天製藥股份有限公司 | 醫藥組成物之安定保存 |
| WO2016178900A1 (fr) * | 2015-05-01 | 2016-11-10 | Odin Biotech | Implant oculaire pour l'administration de dérivé pyridine-carboxamide |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP4626353B2 (ja) * | 2004-02-17 | 2011-02-09 | 参天製薬株式会社 | 置換又は無置換アミノ基を導入した４−ピリジルアルキルチオ基を有する新規環式化合物 |
| BRPI0507757A (pt) | 2004-02-17 | 2007-07-10 | Santen Pharmaceutical Co Ltd | composto, composição farmacêutica, e agente terapêutico para uma doença na qual a angiogênese ou a hipermeabilidade vascular está envolvida |
| CN1918127B (zh) | 2004-02-17 | 2012-02-15 | 参天制药株式会社 | 具有引入了取代或无取代氨基的4-吡啶基烷硫基的环状化合物 |
| EP1864977B1 (fr) * | 2005-03-31 | 2015-07-29 | Santen Pharmaceutical Co., Ltd. | Nouveaux composes cycliques possedant un groupe pyrimidinylalkylthio |
| JP4834441B2 (ja) | 2005-03-31 | 2011-12-14 | 参天製薬株式会社 | ピリミジニルアルキルチオ基を有する新規環式化合物 |
-
2010
- 2010-07-16 NZ NZ597495A patent/NZ597495A/xx not_active IP Right Cessation
- 2010-07-16 SG SG2012001467A patent/SG177576A1/en unknown
- 2010-07-16 KR KR1020127003670A patent/KR101710740B1/ko not_active Expired - Fee Related
- 2010-07-16 WO PCT/JP2010/062071 patent/WO2011007870A1/fr not_active Ceased
- 2010-07-16 MX MX2012000749A patent/MX2012000749A/es active IP Right Grant
- 2010-07-16 EP EP10799928.6A patent/EP2455368B1/fr not_active Not-in-force
- 2010-07-16 BR BR112012001159A patent/BR112012001159A2/pt not_active IP Right Cessation
- 2010-07-16 JP JP2010161881A patent/JP5662719B2/ja not_active Expired - Fee Related
- 2010-07-16 CN CN201080031652.1A patent/CN102471273B/zh not_active Expired - Fee Related
- 2010-07-16 CA CA2767992A patent/CA2767992C/fr not_active Expired - Fee Related
- 2010-07-16 US US13/384,590 patent/US9029398B2/en not_active Expired - Fee Related
- 2010-07-16 IN IN1152DEN2012 patent/IN2012DN01152A/en unknown
- 2010-07-16 MY MYPI2011006369A patent/MY157122A/en unknown
- 2010-07-16 AU AU2010271746A patent/AU2010271746B2/en not_active Ceased
- 2010-07-16 ES ES10799928.6T patent/ES2554360T3/es active Active
- 2010-07-16 EA EA201200146A patent/EA019689B1/ru not_active IP Right Cessation
-
2015
- 2015-04-14 US US14/686,577 patent/US9359328B2/en not_active Expired - Fee Related
-
2016
- 2016-05-10 US US15/150,901 patent/US9546140B2/en not_active Expired - Fee Related
- 2016-12-02 US US15/368,028 patent/US9902698B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| MY157122A (en) | 2016-05-13 |
| CN102471273A (zh) | 2012-05-23 |
| EA201200146A1 (ru) | 2012-06-29 |
| US20150291560A1 (en) | 2015-10-15 |
| HK1167644A1 (en) | 2012-12-07 |
| HK1167647A1 (en) | 2012-12-07 |
| US9902698B2 (en) | 2018-02-27 |
| US20120116088A1 (en) | 2012-05-10 |
| CA2767992C (fr) | 2017-03-21 |
| JP5662719B2 (ja) | 2015-02-04 |
| EP2455368A1 (fr) | 2012-05-23 |
| AU2010271746B2 (en) | 2014-07-03 |
| NZ597495A (en) | 2013-08-30 |
| JP2011037844A (ja) | 2011-02-24 |
| CA2767992A1 (fr) | 2011-01-20 |
| EA019689B1 (ru) | 2014-05-30 |
| US20160251314A1 (en) | 2016-09-01 |
| KR101710740B1 (ko) | 2017-02-27 |
| CN102471273B (zh) | 2014-07-16 |
| AU2010271746A1 (en) | 2012-02-02 |
| WO2011007870A1 (fr) | 2011-01-20 |
| KR20130025857A (ko) | 2013-03-12 |
| SG177576A1 (en) | 2012-02-28 |
| EP2455368B1 (fr) | 2015-09-16 |
| MX2012000749A (es) | 2012-01-27 |
| US20170081286A1 (en) | 2017-03-23 |
| BR112012001159A2 (pt) | 2016-03-01 |
| US9359328B2 (en) | 2016-06-07 |
| EP2455368A4 (fr) | 2013-01-09 |
| US9029398B2 (en) | 2015-05-12 |
| US9546140B2 (en) | 2017-01-17 |
| ES2554360T3 (es) | 2015-12-18 |
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