IN2013CH05455A - - Google Patents

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Publication number
IN2013CH05455A
IN2013CH05455A IN5455CH2013A IN2013CH05455A IN 2013CH05455 A IN2013CH05455 A IN 2013CH05455A IN 5455CH2013 A IN5455CH2013 A IN 5455CH2013A IN 2013CH05455 A IN2013CH05455 A IN 2013CH05455A
Authority
IN
India
Prior art keywords
diastereomer
undesired
racemization
recycle
efficient
Prior art date
Application number
Inventor
Thatipally Suresh
Swamy Udutha Kumara
Bushan Kotala Mani
Lakshmi Narasimha Rao Dammalapati Venkata
Ramanjaneyulu Gorantla Seeta
Chava Satyanarayana
Original Assignee
Laurus Labs Private Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Laurus Labs Private Ltd filed Critical Laurus Labs Private Ltd
Priority to IN5455CH2013 priority Critical patent/IN2013CH05455A/en
Priority to PCT/IN2014/000734 priority patent/WO2015079455A2/en
Publication of IN2013CH05455A publication Critical patent/IN2013CH05455A/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings
    • C07F9/65616—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings containing the ring system having three or more than three double bonds between ring members or between ring members and non-ring members, e.g. purine or analogs

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Pyrrole Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

The present invention relates to an efficient and economical process to recycle the undesired diastereomer of Tenofovir alafenamide to desired diastereomer by racemization of the undesired diastereomer followed by separation of the desired diastereomer from the racemic mixture.
IN5455CH2013 2013-11-27 2014-11-27 IN2013CH05455A (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
IN5455CH2013 IN2013CH05455A (en) 2013-11-27 2014-11-27
PCT/IN2014/000734 WO2015079455A2 (en) 2013-11-27 2014-11-27 A recycling process for preparing tenofovir alafenamide diastereomers

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IN5455CH2013 IN2013CH05455A (en) 2013-11-27 2014-11-27

Publications (1)

Publication Number Publication Date
IN2013CH05455A true IN2013CH05455A (en) 2015-08-07

Family

ID=53199699

Family Applications (1)

Application Number Title Priority Date Filing Date
IN5455CH2013 IN2013CH05455A (en) 2013-11-27 2014-11-27

Country Status (2)

Country Link
IN (1) IN2013CH05455A (en)
WO (1) WO2015079455A2 (en)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN107179355B (en) * 2016-03-11 2021-08-10 广东东阳光药业有限公司 Method for separating and detecting tenofovir alafenamide and related substances thereof
CN107655987B (en) * 2017-09-08 2020-11-03 厦门蔚扬药业有限公司 HPLC detection method for tenofovir alafenamide and isomer thereof
CN111239285B (en) * 2020-02-20 2020-10-09 北京阳光诺和药物研究有限公司 Method for detecting content of genotoxic impurities in Tenofovir alafenamide
CN111189947B (en) * 2020-03-30 2022-06-17 济南新科医药科技有限公司 Analysis method for separating and detecting propane fumarate tenofovir disoproxil isomer
CN113970612B (en) * 2020-07-22 2023-08-01 北京四环制药有限公司 Method for measuring related substances of propiophenone tenofovir by high performance liquid chromatography
CN114137092B (en) * 2020-09-03 2025-02-11 北京四环制药有限公司 A method for determining isomers of tenofovir alafenamide
CN113075307B (en) * 2021-03-08 2025-03-11 瑞阳制药股份有限公司 Detection method of tenofovir alafenamide isomers in fumarate
CN116609445B (en) * 2022-12-01 2025-12-16 上海医药工业研究院有限公司 Acyclic nucleoside phosphonate compound and preparation method, analysis method and application thereof
CN118883741A (en) * 2024-07-05 2024-11-01 福建广生堂药业股份有限公司 A separation and detection method for tenofovir alafenamide fumarate and its enantiomers and its application

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CZ304734B6 (en) * 2000-07-21 2014-09-10 Gilead Sciences, Inc. Process for preparing 9-[2-(phosphonomethoxy)propyl]adenine and 9-[2-(phosphonomethoxy)ethyl]adenine
KR20140119177A (en) * 2012-02-03 2014-10-08 길리애드 사이언시즈, 인코포레이티드 Combination therapy comprising tenofovir alafenamide hemifumarate and cobicistat for use in the treatment of viral infections
SI3333173T1 (en) * 2012-10-03 2019-08-30 Gilead Sciences, Inc. Methods for the preparation of antiviral nucleotide analogues

Also Published As

Publication number Publication date
WO2015079455A3 (en) 2015-08-27
WO2015079455A2 (en) 2015-06-04

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