IN2013MU03696A - - Google Patents
Download PDFInfo
- Publication number
- IN2013MU03696A IN2013MU03696A IN3696MU2013A IN2013MU03696A IN 2013MU03696 A IN2013MU03696 A IN 2013MU03696A IN 3696MU2013 A IN3696MU2013 A IN 3696MU2013A IN 2013MU03696 A IN2013MU03696 A IN 2013MU03696A
- Authority
- IN
- India
- Prior art keywords
- iii
- diethyl
- acetamido
- malonate
- fingolimod hydrochloride
- Prior art date
Links
- SWZTYAVBMYWFGS-UHFFFAOYSA-N fingolimod hydrochloride Chemical compound Cl.CCCCCCCCC1=CC=C(CCC(N)(CO)CO)C=C1 SWZTYAVBMYWFGS-UHFFFAOYSA-N 0.000 abstract 3
- YURZVKRFVMTWMC-UHFFFAOYSA-N 1-(2-iodoethyl)-4-octylbenzene Chemical compound CCCCCCCCC1=CC=C(CCI)C=C1 YURZVKRFVMTWMC-UHFFFAOYSA-N 0.000 abstract 2
- 229960004967 fingolimod hydrochloride Drugs 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 1
- ISOLMABRZPQKOV-UHFFFAOYSA-N diethyl 2-acetamidopropanedioate Chemical compound CCOC(=O)C(NC(C)=O)C(=O)OCC ISOLMABRZPQKOV-UHFFFAOYSA-N 0.000 abstract 1
- 125000004177 diethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 abstract 1
- UKFXDFUAPNAMPJ-UHFFFAOYSA-N ethylmalonic acid Chemical compound CCC(C(O)=O)C(O)=O UKFXDFUAPNAMPJ-UHFFFAOYSA-N 0.000 abstract 1
- 239000012535 impurity Substances 0.000 abstract 1
- 239000012336 iodinating agent Substances 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 239000003960 organic solvent Substances 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
- 230000001105 regulatory effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C213/00—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton
- C07C213/02—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton by reactions involving the formation of amino groups from compounds containing hydroxy groups or etherified or esterified hydroxy groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C213/00—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C215/00—Compounds containing amino and hydroxy groups bound to the same carbon skeleton
- C07C215/02—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton
- C07C215/22—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being unsaturated
- C07C215/28—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being unsaturated and containing six-membered aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C231/00—Preparation of carboxylic acid amides
- C07C231/12—Preparation of carboxylic acid amides by reactions not involving the formation of carboxamide groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/07—Optical isomers
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Priority Applications (6)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ES14853182T ES2729404T3 (es) | 2013-11-25 | 2014-11-14 | Proceso de hidrocloruro de fingolimod |
| CA2930089A CA2930089C (fr) | 2013-11-25 | 2014-11-14 | Procede de preparation du chlorhydrate de fingolimod |
| PCT/IN2014/000720 WO2015092809A2 (fr) | 2013-11-25 | 2014-11-14 | Procédé de préparation du chlorhydrate de fingolimod |
| IN3696MU2013 IN2013MU03696A (fr) | 2013-11-25 | 2014-11-14 | |
| US15/035,306 US9643914B2 (en) | 2013-11-25 | 2014-11-14 | Fingolimod hydrochloride process |
| EP14853182.5A EP3074374B1 (fr) | 2013-11-25 | 2014-11-14 | Procédé de préparation du chlorhydrate de fingolimod |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IN3696MU2013 IN2013MU03696A (fr) | 2013-11-25 | 2014-11-14 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| IN2013MU03696A true IN2013MU03696A (fr) | 2015-07-31 |
Family
ID=52823744
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IN3696MU2013 IN2013MU03696A (fr) | 2013-11-25 | 2014-11-14 |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US9643914B2 (fr) |
| EP (1) | EP3074374B1 (fr) |
| CA (1) | CA2930089C (fr) |
| ES (1) | ES2729404T3 (fr) |
| IN (1) | IN2013MU03696A (fr) |
| WO (1) | WO2015092809A2 (fr) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2020165672A1 (fr) | 2019-02-15 | 2020-08-20 | Shivalik Rasayan Limited | Procédé de préparation de chlorhydrate de fingolimod pur |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1994008943A1 (fr) | 1992-10-21 | 1994-04-28 | Yoshitomi Pharmaceutical Industries, Ltd. | Compose 2-amino-1,3-propanediol et immunosuppresseur |
| ES2237970T3 (es) | 1998-11-11 | 2005-08-01 | Novartis Ag | Produccion de 2-amino-2-(2-(4-alquil c2-20-fenil)etil)propano-1,3-dioles. |
| US6423871B1 (en) * | 1999-02-26 | 2002-07-23 | University Of South Florida | Efficient synthesis of secondary amines by selective alkylation of primary amines |
| EP2646409A4 (fr) * | 2010-11-25 | 2015-12-16 | Shilpa Medicare Ltd | Polymorphes du fingolimode et leurs procédés |
| EP2702034A4 (fr) * | 2011-04-29 | 2015-03-25 | Reddys Lab Ltd Dr | Préparation du fingolimod et ses sels |
| EP2807143B1 (fr) | 2012-01-25 | 2017-08-30 | Glenmark Generics Limited | Procédé pour la préparation de fingolimod |
-
2014
- 2014-11-14 IN IN3696MU2013 patent/IN2013MU03696A/en unknown
- 2014-11-14 CA CA2930089A patent/CA2930089C/fr active Active
- 2014-11-14 EP EP14853182.5A patent/EP3074374B1/fr active Active
- 2014-11-14 US US15/035,306 patent/US9643914B2/en active Active
- 2014-11-14 WO PCT/IN2014/000720 patent/WO2015092809A2/fr not_active Ceased
- 2014-11-14 ES ES14853182T patent/ES2729404T3/es active Active
Also Published As
| Publication number | Publication date |
|---|---|
| EP3074374A2 (fr) | 2016-10-05 |
| WO2015092809A3 (fr) | 2015-08-13 |
| ES2729404T3 (es) | 2019-11-04 |
| US20160289166A1 (en) | 2016-10-06 |
| CA2930089A1 (fr) | 2015-06-25 |
| EP3074374B1 (fr) | 2019-03-13 |
| US9643914B2 (en) | 2017-05-09 |
| CA2930089C (fr) | 2021-08-03 |
| WO2015092809A2 (fr) | 2015-06-25 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| PH12018501094A1 (en) | Process for the preparation of an apoptosis-inducing agent | |
| MX2017002214A (es) | Proceso para la preparacion de 5-fluoro-1h-pirazoles partiendo de hexafluoropropeno. | |
| EA201591349A1 (ru) | Способ получения вортиоксетина | |
| MY169028A (en) | Process for making hydroxylated cyclopentylpyrimidine compounds | |
| MX2016008909A (es) | Compuestos de isopropil triazolo piridina. | |
| TW201613871A (en) | Process for the preparation of 5-fluoro-1H-pyrazoles starting from hexafluoropropene | |
| MX343959B (es) | Proceso para fabricar benzoxazinonas. | |
| MY160902A (en) | Process for the preparation of the L-arginine salt of perindopril | |
| MY185367A (en) | Improved process for the preparation of osimertinib (azd9291) or a salt thereof, and ?azd9291 aniline? or a salt thereof | |
| MY165487A (en) | Process for preparing a polyol ether | |
| MX386134B (es) | Proceso para la preparación de 5-fluoro-1h-pirazoles. | |
| EP2883870A4 (fr) | Procédé de fabrication d'un composé 1,4-benzoxazine | |
| SA518391413B1 (ar) | عملية تحضير وتبلر لليوزيمينول | |
| GB201107985D0 (en) | Process | |
| AU2011380449A8 (en) | Iodination process for the preparation of 3,5-disubstituted-2,4,6-triiodo aromatic amines compounds | |
| MX337997B (es) | Nuevo procedimiento de sintesis de la ivabradina y de sus sales de adicion a un acido farmaceuticamente aceptable. | |
| EA201300792A1 (ru) | Химические соединения | |
| IN2013MU03696A (fr) | ||
| MY191759A (en) | Processes for the preparation of pyrimidinylcyclopentane compounds | |
| JO3189B1 (ar) | طريقة جديدة لتخليق (e2) -3- (3, 4- داي ميثوكسي فينيل)بروب-2 - يننيتريل واستخدامها لتخليق ايفابرادين والاملاح المضافة منها مع حمض مقبول صيدلانيا | |
| GB2511240A (en) | Nitrofurfuryl substituted phenyl linked piperidino-oxadiazoline conjugates as anti-tubercular agents and process for the preparation thereof | |
| IN2014DN10440A (fr) | ||
| IN2013DE03555A (fr) | ||
| WO2015082592A3 (fr) | Procédé de préparation de composés aminoarylborane ou de dérivés correspondants | |
| IN2013MU01501A (fr) |