IN2014CN02806A - - Google Patents
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- Publication number
- IN2014CN02806A IN2014CN02806A IN2806CHN2014A IN2014CN02806A IN 2014CN02806 A IN2014CN02806 A IN 2014CN02806A IN 2806CHN2014 A IN2806CHN2014 A IN 2806CHN2014A IN 2014CN02806 A IN2014CN02806 A IN 2014CN02806A
- Authority
- IN
- India
- Prior art keywords
- compounds
- medicaments
- variables
- inhibitors
- formula
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 abstract 2
- 108010080805 Factor XIa Proteins 0.000 abstract 1
- 102000003827 Plasma Kallikrein Human genes 0.000 abstract 1
- 108090000113 Plasma Kallikrein Proteins 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 239000003112 inhibitor Substances 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing aromatic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/22—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring
- C07D217/26—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Other In-Based Heterocyclic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161547305P | 2011-10-14 | 2011-10-14 | |
| PCT/US2012/059859 WO2013055984A1 (fr) | 2011-10-14 | 2012-10-12 | Composés tétrahydroisoquinolines substitués en tant qu'inhibiteurs du facteur xia |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| IN2014CN02806A true IN2014CN02806A (fr) | 2015-07-03 |
Family
ID=47080862
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IN2806CHN2014 IN2014CN02806A (fr) | 2011-10-14 | 2012-10-12 |
Country Status (7)
| Country | Link |
|---|---|
| US (5) | US9108951B2 (fr) |
| EP (2) | EP2766345B1 (fr) |
| JP (1) | JP6033317B2 (fr) |
| CN (1) | CN103987697B (fr) |
| ES (2) | ES2572908T3 (fr) |
| IN (1) | IN2014CN02806A (fr) |
| WO (1) | WO2013055984A1 (fr) |
Families Citing this family (54)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2674745T3 (es) | 2010-02-11 | 2018-07-03 | Bristol-Myers Squibb Company | Macrociclos como inhibidores del factor XIa |
| TW201311689A (zh) | 2011-08-05 | 2013-03-16 | 必治妥美雅史谷比公司 | 作為因子ｘｉａ抑制劑之新穎巨環化合物 |
| TW201319068A (zh) | 2011-08-05 | 2013-05-16 | 必治妥美雅史谷比公司 | 作為ｘｉａ因子抑制劑之環狀ｐ１接合劑 |
| KR101937514B1 (ko) | 2011-10-14 | 2019-01-10 | 브리스톨-마이어스 스큅 컴퍼니 | 인자 xia 억제제로서의 치환된 테트라히드로이소퀴놀린 화합물 |
| ES2579832T3 (es) | 2011-10-14 | 2016-08-17 | Bristol-Myers Squibb Company | Compuestos de tetrahidroisoquinolina sustituida como inhibidores del factor XIa |
| EP2766345B1 (fr) | 2011-10-14 | 2016-03-16 | Bristol-Myers Squibb Company | Composés tétrahydroisoquinolines substitués en tant qu'inhibiteurs du facteur xia |
| KR20150038369A (ko) | 2012-08-03 | 2015-04-08 | 브리스톨-마이어스 스큅 컴퍼니 | 인자 XIa 억제제로서의 디히드로피리돈 P1 |
| MX361759B (es) | 2012-08-03 | 2018-12-17 | Bristol Myers Squibb Co | Compuestos macrocíclicos de dihidropiridona como inhibidores del factor xia y el uso de los mismos en el tratamiento de un trastorno tromboembólico. |
| WO2014059214A1 (fr) * | 2012-10-12 | 2014-04-17 | Bristol-Myers Squibb Company | Composés de tétrahydroisoquinoléine à substitution guanidine et amine utilisés comme inhibiteurs du facteur xia |
| EP2906552B1 (fr) | 2012-10-12 | 2017-11-22 | Bristol-Myers Squibb Company | Composés de tetrahydroisoquinoline substitués par guanidine en tant qu'inhibiteurs de factor xia |
| TR201807316T4 (tr) | 2012-10-12 | 2018-06-21 | Bristol Myers Squibb Co | Bir faktör XIa inhibitörünün kristalli formları. |
| EP2975031A4 (fr) | 2013-03-14 | 2017-04-19 | Takeda Pharmaceutical Company Limited | Composé hétérocyclique |
| ES2712699T3 (es) | 2013-03-25 | 2019-05-14 | Bristol Myers Squibb Co | Tetrahidroisoquinolinas que contienen azoles sustituidos como inhibidores del factor XIa |
| JP6427491B2 (ja) | 2013-07-03 | 2018-11-21 | 武田薬品工業株式会社 | 複素環化合物 |
| ES2950424T3 (es) | 2013-07-03 | 2023-10-09 | Takeda Pharmaceuticals Co | Compuesto de amida |
| WO2015047973A1 (fr) * | 2013-09-27 | 2015-04-02 | Merck Sharp & Dohme Corp. | Inhibiteurs du facteur xia |
| WO2015054087A1 (fr) | 2013-10-07 | 2015-04-16 | Merck Sharp & Dohme Corp. | Inhibitors du facteur xia |
| NO2760821T3 (fr) | 2014-01-31 | 2018-03-10 | ||
| CN116987080A (zh) | 2014-01-31 | 2023-11-03 | 百时美施贵宝公司 | 作为因子xia抑制剂的具有杂环p2′基团的大环化合物 |
| US9676723B2 (en) | 2014-02-11 | 2017-06-13 | Merck Sharp & Dohme Corp | Factor XIa inhibitors |
| EP3104703B1 (fr) | 2014-02-11 | 2020-11-18 | Merck Sharp & Dohme Corp. | Inhibiteurs du facteur xia |
| WO2015164308A1 (fr) | 2014-04-22 | 2015-10-29 | Merck Sharp & Dohme Corp. | Inhibiteurs du facteur xia |
| WO2015176060A1 (fr) * | 2014-05-16 | 2015-11-19 | Cumberland Pharmaceuticals, Inc. | Compositions et procédés pour traiter la fibrose cardiaque avec ifétroban |
| KR20170016987A (ko) | 2014-07-01 | 2017-02-14 | 다케다 야쿠힌 고교 가부시키가이샤 | 헤테로시클릭 화합물 및 이들의 레티노이드-관련 희귀 수용체 (ｒｏｒ) 감마-ｔ 저해제로서의 용도 |
| EP3180317B1 (fr) | 2014-07-28 | 2021-04-14 | Merck Sharp & Dohme Corp. | Inhibiteurs du facteur xia |
| RU2743074C2 (ru) | 2014-08-01 | 2021-02-15 | Нуэволюшон А/С | Соединения, активные по отношению к бромодоменам |
| CN105461688B (zh) * | 2014-08-26 | 2017-12-29 | 上海医药工业研究院 | 苯并咪唑化合物k的合成方法 |
| CN107074821B (zh) | 2014-09-04 | 2020-05-22 | 百时美施贵宝公司 | 为fxia抑制剂的二酰胺大环化合物 |
| CN106715473B (zh) * | 2014-10-01 | 2021-11-23 | 免疫医疗有限公司 | 替格瑞洛的抗体及其使用方法 |
| US9453018B2 (en) | 2014-10-01 | 2016-09-27 | Bristol-Myers Squibb Company | Pyrimidinones as factor XIa inhibitors |
| WO2016205482A1 (fr) | 2015-06-19 | 2016-12-22 | Bristol-Myers Squibb Company | Macrocycles diamides utilisés en tant qu'inhibiteurs du facteur xia |
| CN114569608A (zh) | 2015-06-30 | 2022-06-03 | 坎伯兰医药品股份有限公司 | Aerd/哮喘中的血栓烷受体拮抗剂 |
| LT3319959T (lt) | 2015-07-06 | 2021-12-27 | Alkermes, Inc. | Histono deacetilazės hetero-halogeno inhibitoriai |
| EP3319968A1 (fr) | 2015-07-06 | 2018-05-16 | Rodin Therapeutics, Inc. | N-aminophényl-amides hétérocycliques en tant qu'inhibiteurs de l'histone désacétylase |
| ES2871111T3 (es) | 2015-07-29 | 2021-10-28 | Bristol Myers Squibb Co | Inhibidores macrocíclicos del factor XIa que contienen un grupo P2' no aromático |
| US10287288B2 (en) | 2015-07-29 | 2019-05-14 | Bristol-Myers Squibb | Factor XIa macrocyclic inhibitors bearing alkyl or cycloalkyl P2' moieties |
| WO2017074833A1 (fr) | 2015-10-29 | 2017-05-04 | Merck Sharp & Dohme Corp. | Dérivé spirocarbamate macrocyclique comme inhibiteurs du facteur xia, compositions pharmaceutiquement acceptables et leur utilisation |
| MX387515B (es) | 2015-10-29 | 2025-03-18 | Merck Sharp & Dohme Llc | Inhibidores de factor xia. |
| US10189841B2 (en) | 2015-11-20 | 2019-01-29 | Forma Therapeutics, Inc. | Purinones as ubiquitin-specific protease 1 inhibitors |
| JP6844890B2 (ja) * | 2016-01-07 | 2021-03-17 | 藤森工業株式会社 | 採血管、試薬及びそれらを利用した血液性状分析方法 |
| CN107540659A (zh) * | 2016-06-29 | 2018-01-05 | 四川科伦博泰生物医药股份有限公司 | 四氢异喹啉类化合物、其制备方法、药物组合物及其用途 |
| EP3500556B1 (fr) | 2016-08-22 | 2023-08-02 | Merck Sharp & Dohme LLC | Dérivés pyridine-1-oxyde et leur utilisation en tant qu'inhbiteurs du facteur xia |
| RS62959B1 (sr) | 2017-01-11 | 2022-03-31 | Alkermes Inc | Biciklični inhibitori histon-deacetilaze |
| US11225475B2 (en) | 2017-08-07 | 2022-01-18 | Alkermes, Inc. | Substituted pyridines as inhibitors of histone deacetylase |
| CN109721539B (zh) * | 2017-10-27 | 2021-07-09 | 天津药物研究院有限公司 | 吡唑酰胺类衍生物及其制备方法和用途 |
| CN109867660A (zh) * | 2017-12-01 | 2019-06-11 | 四川科伦博泰生物医药股份有限公司 | 含季铵离子的四氢异喹啉酰胺化合物及其药物用途 |
| EP3778597B1 (fr) | 2018-03-28 | 2025-05-28 | Sichuan Kelun-Biotech Biopharmaceutical Co., Ltd. | Dérivé de tétrahydro-isoquinoline, son procédé de préparation et ses applications |
| EP3856178B1 (fr) | 2018-09-28 | 2026-03-11 | Janssen Pharmaceutica NV | Modulateurs de la monoacylglycérol lipase |
| WO2020065614A1 (fr) * | 2018-09-28 | 2020-04-02 | Janssen Pharmaceutica Nv | Modulateurs de la monoacylglycérol lipase |
| ES2963613T3 (es) * | 2018-10-22 | 2024-04-01 | C4X Discovery Ltd | Compuestos terapéuticos |
| CN111727186B (zh) * | 2018-11-11 | 2022-11-08 | 上海海雁医药科技有限公司 | 双杂环取代的吡啶-2(1h)-酮衍生物、其制法与医药上的用途 |
| MX2022003819A (es) | 2019-09-30 | 2022-05-11 | Janssen Pharmaceutica Nv | Ligandos de pet de mgl radiomarcados. |
| WO2021121371A1 (fr) * | 2019-12-19 | 2021-06-24 | 贝达药业股份有限公司 | Inhibiteur de kras g12c et son utilisation pharmaceutique |
| CN116133660B (zh) | 2020-07-22 | 2025-05-02 | 詹森药业有限公司 | 可用作因子XIa抑制剂的化合物 |
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| WO2007070816A2 (fr) | 2005-12-14 | 2007-06-21 | Bristol-Myers Squibb Company | Derives de thiophene en tant qu'inhibiteurs du facteur xia |
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| MX361759B (es) | 2012-08-03 | 2018-12-17 | Bristol Myers Squibb Co | Compuestos macrocíclicos de dihidropiridona como inhibidores del factor xia y el uso de los mismos en el tratamiento de un trastorno tromboembólico. |
| KR20150038369A (ko) | 2012-08-03 | 2015-04-08 | 브리스톨-마이어스 스큅 컴퍼니 | 인자 XIa 억제제로서의 디히드로피리돈 P1 |
-
2012
- 2012-10-12 EP EP12778912.1A patent/EP2766345B1/fr not_active Not-in-force
- 2012-10-12 WO PCT/US2012/059859 patent/WO2013055984A1/fr not_active Ceased
- 2012-10-12 JP JP2014535894A patent/JP6033317B2/ja not_active Expired - Fee Related
- 2012-10-12 US US14/350,417 patent/US9108951B2/en active Active
- 2012-10-12 EP EP14195397.6A patent/EP2899183B1/fr not_active Not-in-force
- 2012-10-12 IN IN2806CHN2014 patent/IN2014CN02806A/en unknown
- 2012-10-12 CN CN201280061670.3A patent/CN103987697B/zh not_active Expired - Fee Related
- 2012-10-12 ES ES12778912.1T patent/ES2572908T3/es active Active
- 2012-10-12 ES ES14195397T patent/ES2699226T3/es active Active
-
2015
- 2015-07-15 US US14/799,681 patent/US9394276B2/en active Active
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2016
- 2016-06-15 US US15/183,051 patent/US9725435B2/en active Active
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2017
- 2017-07-07 US US15/643,891 patent/US10000466B2/en active Active
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2018
- 2018-05-17 US US15/982,038 patent/US10906886B2/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| ES2699226T3 (es) | 2019-02-08 |
| US9108951B2 (en) | 2015-08-18 |
| US10000466B2 (en) | 2018-06-19 |
| CN103987697A (zh) | 2014-08-13 |
| US9394276B2 (en) | 2016-07-19 |
| US20170305880A1 (en) | 2017-10-26 |
| US20160289209A1 (en) | 2016-10-06 |
| EP2899183A1 (fr) | 2015-07-29 |
| JP2014528479A (ja) | 2014-10-27 |
| US20140275061A1 (en) | 2014-09-18 |
| US20150315200A1 (en) | 2015-11-05 |
| EP2766345A1 (fr) | 2014-08-20 |
| JP6033317B2 (ja) | 2016-11-30 |
| EP2899183B1 (fr) | 2018-09-19 |
| US20180265494A1 (en) | 2018-09-20 |
| US10906886B2 (en) | 2021-02-02 |
| CN103987697B (zh) | 2017-04-26 |
| US9725435B2 (en) | 2017-08-08 |
| EP2766345B1 (fr) | 2016-03-16 |
| ES2572908T3 (es) | 2016-06-03 |
| WO2013055984A1 (fr) | 2013-04-18 |
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