IN2014DN02483A - - Google Patents

Info

Publication number
IN2014DN02483A
IN2014DN02483A IN2483DEN2014A IN2014DN02483A IN 2014DN02483 A IN2014DN02483 A IN 2014DN02483A IN 2483DEN2014 A IN2483DEN2014 A IN 2483DEN2014A IN 2014DN02483 A IN2014DN02483 A IN 2014DN02483A
Authority
IN
India
Prior art keywords
protein production
sequences
activity
mar
increasing
Prior art date
Application number
Other languages
English (en)
Inventor
Nicolas Mermod
Pierre Alain Girod
Philipp Bucher
Duc-Quang Nguyen
David Calabrese
Damien Saugy
Stefania Puttini
Original Assignee
Selexis Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Selexis Sa filed Critical Selexis Sa
Publication of IN2014DN02483A publication Critical patent/IN2014DN02483A/en

Links

Classifications

    • GPHYSICS
    • G16INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16BBIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B5/00ICT specially adapted for modelling or simulations in systems biology, e.g. gene-regulatory networks, protein interaction networks or metabolic networks
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12PFERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P21/00Preparation of peptides or proteins
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/10Processes for the isolation, preparation or purification of DNA or RNA
    • C12N15/1034Isolating an individual clone by screening libraries
    • C12N15/1089Design, preparation, screening or analysis of libraries using computer algorithms
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/11DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/63Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • GPHYSICS
    • G16INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16BBIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B15/00ICT specially adapted for analysing two-dimensional [2D] or three-dimensional [3D] molecular structures, e.g. structural or functional relations or structure alignment
    • GPHYSICS
    • G16INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16BBIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B30/00ICT specially adapted for sequence analysis involving nucleotides or amino acids

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • Organic Chemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Physics & Mathematics (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Plant Pathology (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Theoretical Computer Science (AREA)
  • Medical Informatics (AREA)
  • Evolutionary Biology (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Analytical Chemistry (AREA)
  • Physiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
IN2483DEN2014 2003-10-24 2004-10-22 IN2014DN02483A (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US51357403P 2003-10-24 2003-10-24
EP04002722 2004-02-06
PCT/EP2004/011974 WO2005040377A2 (fr) 2003-10-24 2004-10-22 Transfert et expression genique a efficacite elevee dans des cellules de mammiferes au moyen d'une procedure de transfection multiple de sequences mar

Publications (1)

Publication Number Publication Date
IN2014DN02483A true IN2014DN02483A (fr) 2015-05-15

Family

ID=34524793

Family Applications (2)

Application Number Title Priority Date Filing Date
IN2484DEN2014 IN2014DN02484A (fr) 2003-10-24 2004-10-22
IN2483DEN2014 IN2014DN02483A (fr) 2003-10-24 2004-10-22

Family Applications Before (1)

Application Number Title Priority Date Filing Date
IN2484DEN2014 IN2014DN02484A (fr) 2003-10-24 2004-10-22

Country Status (15)

Country Link
US (3) US8252917B2 (fr)
EP (5) EP2298898B1 (fr)
JP (1) JP5396653B2 (fr)
KR (4) KR101269656B1 (fr)
CN (1) CN1863913B (fr)
AT (1) ATE551420T1 (fr)
AU (4) AU2004284220B2 (fr)
CA (1) CA2535836C (fr)
IL (2) IL175142A0 (fr)
IN (2) IN2014DN02484A (fr)
PL (4) PL1959011T3 (fr)
RU (1) RU2375450C2 (fr)
SG (1) SG147468A1 (fr)
WO (1) WO2005040377A2 (fr)
ZA (1) ZA200604032B (fr)

Families Citing this family (41)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE354645T1 (de) 2002-12-20 2007-03-15 Chromagenics Bv Mittel und methoden zur produktion eines proteins durch chromatin-öffner, die chromatin zugänglicher für transkriptionsfaktoren machen können
KR101269656B1 (ko) 2003-10-24 2013-05-30 셀렉시스 에스. 에이. Mar 서열의 복합 트랜스펙션 방법에 의한 포유동물 세포에서의 고효율 유전자 전달 및 발현
DE102004043207C5 (de) * 2004-09-03 2010-09-09 Südzucker AG Mannheim/Ochsenfurt Wurzel- und xylemparenchymspezifischer Promotor
US8039230B2 (en) 2004-11-08 2011-10-18 Chromagenics B.V. Selection of host cells expressing protein at high levels
KR101271884B1 (ko) 2004-11-08 2013-06-05 크로마제닉스 비.브이. 고수준으로 단백질을 발현하는 숙주세포의 선택
US8999667B2 (en) 2004-11-08 2015-04-07 Chromagenics B.V. Selection of host cells expressing protein at high levels
US20060195935A1 (en) 2004-11-08 2006-08-31 Chromagenics B.V. Selection of host cells expressing protein at high levels
US7968700B2 (en) 2006-03-20 2011-06-28 Chromagenics B.V. Expression augmenting DNA fragments, use thereof, and methods for finding thereof
RU2469089C2 (ru) * 2006-08-23 2012-12-10 Селексис С.А. Экспрессионная система для повышения уровня экспрессии гена, молекула нуклеиновой кислоты, клетка, трансгенное животное и набор
EP1975228A1 (fr) 2007-03-28 2008-10-01 Fachhochschule Mannheim Polynucléides pour améliorer l'expression d'un polynucléide intéressant
JP5711972B2 (ja) 2007-12-24 2015-05-07 アイディー バイオメディカル コーポレイション オブ ケベック 組換えrsv抗原
CN101580842B (zh) * 2008-05-15 2011-02-09 中国农业科学院生物技术研究所 一种增强基因表达的dna分子及其应用
ES2539045T3 (es) 2009-01-19 2015-06-25 Innate Pharma Anticuerpos anti-KIR3D
EP2445527A2 (fr) 2009-06-24 2012-05-02 ID Biomedical Corporation of Quebec Vaccin
HUE028085T2 (en) 2009-06-24 2016-11-28 Glaxosmithkline Biologicals Sa Recombinant RSV antigens
CA2768186A1 (fr) 2009-07-15 2011-01-20 Novartis Ag Compositions a base de proteine f du vrs et procedes de fabrication associes
CN102575264A (zh) * 2009-09-18 2012-07-11 瑟莱克斯公司 增加的转基因表达和加工的产品和方法
WO2011070405A1 (fr) * 2009-12-07 2011-06-16 Avesthagen Limited Vecteur d'expression portant une/des région(s) s/mar
RU2422512C1 (ru) * 2010-02-16 2011-06-27 Автономная некоммерческая организация "Институт молекулярной диагностики" (АНО "ИнМоДи") ШТАММ Escherichia coli BL21(DE3)/pAFP11D3 - ПРОДУЦЕНТ ФРАГМЕНТА С 404 ПО 609 АМИНОКИСЛОТУ АЛЬФА-ФЕТОПРОТЕИНА ЧЕЛОВЕКА
WO2012019630A1 (fr) 2010-08-13 2012-02-16 Curevac Gmbh Acide nucléique comprenant ou codant pour une tige-boucle d'histone et une séquence poly(a) ou un signal de polyadénylation pour augmenter l'expression d'une protéine codée
WO2012095514A1 (fr) 2011-01-14 2012-07-19 Vivalis Système de production de protéines recombinantes
WO2012139195A1 (fr) 2011-04-13 2012-10-18 National Research Council Of Canada Système d'expression à un élément sar d'ifnα2
CA2835644C (fr) 2011-05-13 2021-06-15 Novartis Ag Antigenes de pre-fusion f du vrs
WO2013120499A1 (fr) 2012-02-15 2013-08-22 Curevac Gmbh Acide nucléique comprenant ou codant pour une tige-boucle d'histone et une séquence poly(a) ou un signal de polyadénylation pour augmenter l'expression d'un antigène pathogène codé
WO2013120500A1 (fr) 2012-02-15 2013-08-22 Curevac Gmbh Acide nucléique comprenant ou codant pour une tige-boucle d'histone et une séquence poly(a) ou un signal de polyadénylation en vue d'augmenter l'expression d'un antigène tumoral codé
WO2013120497A1 (fr) 2012-02-15 2013-08-22 Curevac Gmbh Acide nucléique comprenant ou codant pour une tige-boucle d'histone et une séquence poly(a) ou un signal de polyadénylation pour l'augmentation de l'expression d'une protéine thérapeutique codée
WO2013120498A1 (fr) 2012-02-15 2013-08-22 Curevac Gmbh Acide nucléique comprenant ou codant pour une tige-boucle d'histone et une séquence poly(a) ou un signal de polyadénylation pour augmenter l'expression d'un autoantigène auto-immun ou d'un antigène allergène codé
MX362981B (es) 2012-03-27 2019-02-28 Curevac Ag Moleculas artificiales de acido nucleico para la expresion mejorada de proteina o peptido.
FI3536797T3 (fi) 2013-02-01 2023-03-23 Selexis Sa Siirtogeenin tehostettu ilmentäminen ja prosessointi
CN103667440A (zh) * 2013-09-05 2014-03-26 谢小冬 Gata4基因snp位点的用途
WO2015060935A1 (fr) 2013-10-22 2015-04-30 Lubris, Llc Régulation des propriétés rhéologiques de solutions de hyaluronate/lubricine mélangées
CN109576269B (zh) * 2014-04-01 2020-08-28 三生国健药业(上海)股份有限公司 一种含mar核心片段的动物细胞表达载体
CN104974933B (zh) * 2014-04-04 2017-08-15 上海泰因生物技术有限公司 一种大规模连续多次悬浮瞬转表达重组蛋白的装置和方法
US11518791B2 (en) 2016-05-23 2022-12-06 Luxembourg Institute Of Health (Lih) Multifunctional heteromultimeric constructs
DK3456821T4 (da) * 2017-09-19 2024-04-15 Deutsches Krebsforsch Ikke-integrerende dna-vektorer til genetisk modifikation af celler
US20230193341A1 (en) 2018-10-24 2023-06-22 Selexis Sa Expression systems, recombinant cells and uses thereof
WO2020118169A1 (fr) 2018-12-07 2020-06-11 Celltheon Corporation Régions de fixation de matrice et utilisations dans la promotion de l'expression génique
KR20220145361A (ko) 2020-02-24 2022-10-28 노파르티스 아게 재조합적으로 생성된 폴리펩타이드의 정제
AU2020447192A1 (en) * 2020-05-11 2023-01-19 Samsung Bioepis Co., Ltd. Human genome-derived polynucleotide and method for producing polypeptide of interest using same
AU2021311027A1 (en) * 2020-07-22 2023-03-02 Deutsches Krebsforschungszentrum 5' S/MAR applications
CN121137185B (zh) * 2025-11-20 2026-03-03 中国科学院海洋研究所 一种与贻贝品种相关的分子标记、引物对及其应用

Family Cites Families (92)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1077994A (en) * 1963-04-18 1967-08-02 Kobe Steel Ltd Process for producing cold-forged products from tempered steel wire
DE2605560C3 (de) 1976-02-12 1979-08-30 Siemens Ag, 1000 Berlin Und 8000 Muenchen Aufschlußverfahren für Biomaterialien
DE3376405D1 (en) 1982-12-23 1988-06-01 Britax Weathershields Vehicle sliding roof
DE122007000007I2 (de) 1986-04-09 2010-12-30 Genzyme Corp Genetisch transformierte Tiere, die ein gewünschtes Protein in Milch absondern
US4873316A (en) 1987-06-23 1989-10-10 Biogen, Inc. Isolation of exogenous recombinant proteins from the milk of transgenic mammals
GB8925590D0 (en) 1989-11-13 1990-01-04 Central Blood Lab Authority Monoclonal antibodies
US5733761A (en) 1991-11-05 1998-03-31 Transkaryotic Therapies, Inc. Protein production and protein delivery
US6063630A (en) 1991-11-05 2000-05-16 Transkaryotic Therapies, Inc. Targeted introduction of DNA into primary or secondary cells and their use for gene therapy
AU673859B2 (en) 1992-10-05 1996-11-28 North Carolina State University Method for increasing expression and reducing expression variability of foreign genes in plant cells
US5610053A (en) 1993-04-07 1997-03-11 The United States Of America As Represented By The Department Of Health And Human Services DNA sequence which acts as a chromatin insulator element to protect expressed genes from cis-acting regulatory sequences in mammalian cells
US5464758A (en) 1993-06-14 1995-11-07 Gossen; Manfred Tight control of gene expression in eucaryotic cells by tetracycline-responsive promoters
US5888981A (en) 1993-06-14 1999-03-30 Basf Aktiengesellschaft Methods for regulating gene expression
US5907078A (en) 1994-12-09 1999-05-25 Greenberg; Norman M. Transgenic mouse model for prostate cancer
US5705364A (en) 1995-06-06 1998-01-06 Genentech, Inc. Mammalian cell culture process
DE19541450C2 (de) 1995-11-07 1997-10-02 Gsf Forschungszentrum Umwelt Genkonstrukt und dessen Verwendung
US6596514B2 (en) 1996-01-11 2003-07-22 Immunex Corporation Expression augmenting sequence elements (EASE) for eukaryotic expression systems
US5773695A (en) 1996-01-26 1998-06-30 North Carolina State University Plant nuclear scaffold attachment region and method for increasing gene expression in transgenic cells
AU2064297A (en) 1996-02-29 1997-09-16 Immusol, Inc Hepatitis c virus ribozymes
IL127215A0 (en) 1996-06-06 1999-09-22 Novartis Ag Vectors comprising sar elements
CA2689842A1 (fr) 1996-12-02 1998-06-11 Genaera Corporation Variants de recepteur il-9, utilises pour le traitement et le diagnostic des allergies atopique, y compris l'asthme et les troubles apparentes
US6245974B1 (en) 1997-08-06 2001-06-12 North Carolina State University Matrix attachment regions
US6897066B1 (en) 1997-09-26 2005-05-24 Athersys, Inc. Compositions and methods for non-targeted activation of endogenous genes
CA2308565A1 (fr) 1997-11-05 1999-05-14 Baylor College Of Medicine Sequences pour cibler les cellules metastatiques
US6635806B1 (en) 1998-05-14 2003-10-21 Dekalb Genetics Corporation Methods and compositions for expression of transgenes in plants
US6004284A (en) 1998-06-04 1999-12-21 Alcon Laboratories, Inc. Surgical handpiece
AU771111B2 (en) 1998-07-21 2004-03-11 Emd Millipore Corporation A polynucleotide comprising a ubiquitous chromatin opening element (UCOE)
US6338066B1 (en) 1998-09-25 2002-01-08 International Business Machines Corporation Surfaid predictor: web-based system for predicting surfer behavior
AU1105600A (en) 1998-10-07 2000-04-26 Adobe Systems Incorporated Distributing access to a data item
DE19848017A1 (de) 1998-10-17 2000-04-20 Multigene Biotech Gmbh Episomal replizierender Vektor zur Expression eines Transgens in Säugerzellen
WO2000032800A1 (fr) 1998-12-01 2000-06-08 Dow Agrosciences Llc Region de fixation de matrice artificielle destinee a augmenter l'expression de genes introduits dans des cellules vegetales
US6225113B1 (en) 1998-12-04 2001-05-01 Genvec, Inc. Use of trans-activation and cis-activation to modulate the persistence of expression of a transgene in an at least E4-deficient adenovirus
US6194636B1 (en) 1999-05-14 2001-02-27 Dekalb Genetics Corp. Maize RS324 promoter and methods for use thereof
US6207879B1 (en) 1999-05-14 2001-03-27 Dekalb Genetics Corporation Maize RS81 promoter and methods for use thereof
US6232526B1 (en) 1999-05-14 2001-05-15 Dekalb Genetics Corp. Maize A3 promoter and methods for use thereof
US6429357B1 (en) 1999-05-14 2002-08-06 Dekalb Genetics Corp. Rice actin 2 promoter and intron and methods for use thereof
AU4940700A (en) 1999-05-28 2000-12-18 Sangamo Biosciences, Inc. Gene switches
US20050129669A1 (en) 1999-06-21 2005-06-16 Transkaryotic Therapies, Inc., A Massachusetts Corporation DNA construct for effecting homologous recombination and uses thereof
US6972349B1 (en) 1999-11-12 2005-12-06 University Of South Carolina Control of post-transcriptional gene silencing in plants
JP3507858B2 (ja) 1999-11-19 2004-03-15 奈良先端科学技術大学院大学長 植物において外来遺伝子の発現を安定化させるdna断片、外来遺伝子を植物において安定に発現させる遺伝子導入方法、外来遺伝子を安定に発現させた形質転換植物
WO2001040488A1 (fr) 1999-11-30 2001-06-07 Novartis Ag Expression transgenique accrue dans des vecteurs retroviraux possedant une region d'attachement sar
US6864085B2 (en) 1999-12-14 2005-03-08 Novartis Ag Bovine immunodeficiency virus (BIV) based vectors
US20020127199A1 (en) 2000-02-03 2002-09-12 Tang Y. Tom Novel nucleic acids and polypeptides
US6821775B1 (en) 2000-02-11 2004-11-23 Genvec, Inc. Viral vector encoding pigment epithelium-derived factor
DE10006886A1 (de) 2000-02-16 2001-08-23 Hepavec Ag Fuer Gentherapie Nichthumaner helferabhängiger Virusvektor
US6569681B1 (en) 2000-03-14 2003-05-27 Transkaryotic Therapies, Inc. Methods of improving homologous recombination
US6747189B1 (en) 2000-03-21 2004-06-08 Dekalb Genetics Corporation Maize glycine rich protein promoter compositions and methods for use thereof
US6730826B2 (en) 2000-03-22 2004-05-04 University Of Kentucky Research Foundation Plant trichome gland specific promoter sequence
US20030157715A1 (en) 2000-06-26 2003-08-21 Ulrich Laemmli Modulation of chromosome function by chromatin remodeling agents
CA2409408A1 (fr) 2000-06-26 2002-01-03 Ulrich Laemmli Modulation de la fonction chromosomique par des agents remodelant la chromatine
US8030537B1 (en) 2000-07-27 2011-10-04 Apogene Gmbh & Co. Kg Somatic cloning gene transfer for the production of recombinant proteins, cells and organs
KR100408844B1 (ko) 2000-07-29 2003-12-06 한국산업기술평가원 동물세포 발현벡터
EP1724355A3 (fr) 2000-08-30 2007-05-23 North Carolina State University Plantes transgéniques contenant des leurres moléculaires qui modifient la teneur en protéines
AU9379801A (en) 2000-09-09 2002-03-22 Basf Plant Science Gmbh Modified tet-inducible system for regulation of gene expression in plants
GB0022995D0 (en) 2000-09-20 2000-11-01 Cobra Therapeutics Ltd Polynucleotide
US6919204B2 (en) 2000-09-29 2005-07-19 Sangamo Biosciences, Inc. Modulation of gene expression using localization domains
US7405276B2 (en) 2000-11-01 2008-07-29 Elusys Therapeutics, Inc. Method of producing bispecific molecules by protein trans-splicing
DE10061150A1 (de) 2000-12-08 2002-06-13 Icon Genetics Ag Verfahren und Vektoren zur Erzeugung von transgenen Pflanzen
WO2002048379A1 (fr) 2000-12-15 2002-06-20 Pangen Biotech Inc. Vecteur d'expression pour cellule animale contenant une region de liaison matricielle nucleique de l'interferon $g(b)
US7151204B2 (en) 2001-01-09 2006-12-19 Monsanto Technology Llc Maize chloroplast aldolase promoter compositions and methods for use thereof
DK1395669T3 (da) 2001-01-26 2009-11-16 Selexis Sa Matriks bindingsregioner og fremgangsmåder til anvendelse af disse
DE10109780A1 (de) 2001-02-28 2002-09-05 Cardion Ag Episomale Vektoren enthaltend Matrix-Anheftungsregionen zur zellspezifischen Genexpression
WO2002072138A1 (fr) 2001-03-08 2002-09-19 Hyseq, Inc. Methodes et materiels se rapportant a des polypeptides et a des polynucleotides apparentes a la fibuline
JP4817514B2 (ja) 2001-03-09 2011-11-16 協和発酵キリン株式会社 新規動物細胞用ベクターおよびその使用
AU2002252370A1 (en) 2001-03-12 2002-09-24 Irm, Llc. Genomics-driven high speed cellular assays, development thereof, and collections of cellular reporters
IL157335A0 (en) 2001-03-13 2004-02-19 Novartis Ag Lentiviral packaging constructs
WO2002079447A2 (fr) * 2001-03-30 2002-10-10 Avigenics, Inc. Promoteur de lysozymes aviaires
DE10129010A1 (de) 2001-06-13 2002-12-19 Icon Genetics Ag Verfahren und Vektoren zur Erzeugung von transgenen Pflanzen
US20030032597A1 (en) 2001-07-31 2003-02-13 Sebestyen Magdolna G. Targeting nucleic acids to a cellular nucleus
KR100464962B1 (ko) * 2001-09-14 2005-01-05 삼화강봉주식회사 냉간압조 특성이 우수한 조질 강선
US7122715B2 (en) 2001-09-20 2006-10-17 Monsanto Technology Llc In vitro method to create circular molecules for use in transformation
AU2002341795A1 (en) 2001-09-21 2003-04-01 Avigenics, Inc. Production of transgenic avians using sperm-mediated transfection
US7138278B2 (en) 2001-11-20 2006-11-21 Monsanto Technology, L.L.C. Maize cytoplasmic glutamine synthetase promoter compositions and methods for use thereof
FR2832423B1 (fr) 2001-11-22 2004-10-08 Vivalis Systeme d'expression de proteines exogenes dans un systeme aviaire
US6875588B2 (en) 2001-11-30 2005-04-05 Avigenics, Inc. Ovomucoid promoter and methods of use
CA2427190A1 (fr) 2002-04-30 2003-10-30 Alberta Research Council Inc. Production du facteur de croissance epidermique recombinant dans les plantes
US20030224477A1 (en) 2002-05-31 2003-12-04 Heartlein Michael W. Optimized promoter constructs
EP1513929A4 (fr) 2002-06-18 2006-04-19 Zymogenetics Inc Vecteur hybride comprenant un activateur du cytomegalovirus et un promoteur du virus du sarcome myeloproliferatif
US20040016015A1 (en) 2002-07-17 2004-01-22 Nguyen Thanh-Tuyen T. High efficiency germline transformation system
US6933136B2 (en) 2002-09-20 2005-08-23 Novo Nordisk A/S Method for making recombinant proteins
CN1263860C (zh) 2002-09-30 2006-07-12 华南农业大学 多基因载体的构建方法与应用
WO2004053106A2 (fr) 2002-12-05 2004-06-24 Regulome Corporation Sites regulateurs profiles utiles pour le controle de l'expression genique
AU2003283174A1 (en) 2002-12-11 2004-06-30 Cytos Biotechnology Ag Method for protein production
AU2002953381A0 (en) 2002-12-18 2003-01-09 Diatech Pty Ltd In vivo affinity maturation scheme
EP1445320A1 (fr) 2003-02-05 2004-08-11 ARTEMIS Pharmaceuticals GmbH Gene targeting automatique à l aide de marqueurs détectables non toxiques
EP1623035A4 (fr) 2003-04-15 2006-08-30 Univ Georgia Res Found Transgenese aviaire utilisant une region du gene de l'ovalbumine du poulet
WO2004106375A1 (fr) 2003-05-30 2004-12-09 Merus Biopharmaceuticals B.V. I.O. Banque de fab pour la preparation de fab anti-vegf et antirabique
EP1644508A1 (fr) 2003-07-11 2006-04-12 Cytos Biotechnology AG Systeme d'expression genetique
AU2004269200B8 (en) 2003-08-27 2011-11-24 Orf Liftaekni Hf. Enhancing accumulation of heterologous polypeptides in plant seeds through targeted suppression of endogenous storage proteins
PT1675956E (pt) 2003-10-21 2010-11-04 Merck Serono Sa Sequência mínima de adn que actua como um isolador de cromatina e sua utilização na expressão de proteína
KR101269656B1 (ko) 2003-10-24 2013-05-30 셀렉시스 에스. 에이. Mar 서열의 복합 트랜스펙션 방법에 의한 포유동물 세포에서의 고효율 유전자 전달 및 발현
RU2469089C2 (ru) 2006-08-23 2012-12-10 Селексис С.А. Экспрессионная система для повышения уровня экспрессии гена, молекула нуклеиновой кислоты, клетка, трансгенное животное и набор
WO2008073303A2 (fr) * 2006-12-07 2008-06-19 Switchgear Genomics Éléments de régulation transcriptionnelle de voies biologiques, outils, et procédés

Also Published As

Publication number Publication date
PL1959011T3 (pl) 2012-07-31
IN2014DN02484A (fr) 2015-05-15
ZA200604032B (en) 2008-05-28
PL2287302T3 (pl) 2013-05-31
AU2004284220A1 (en) 2005-05-06
WO2005040377A2 (fr) 2005-05-06
EP2298898B1 (fr) 2012-12-26
US8252917B2 (en) 2012-08-28
EP1959011A3 (fr) 2008-08-27
KR20060100372A (ko) 2006-09-20
EP1959011B1 (fr) 2012-03-28
CA2535836A1 (fr) 2005-05-06
CN1863913A (zh) 2006-11-15
HK1151825A1 (en) 2012-02-10
AU2010236093A1 (en) 2010-12-02
KR101230838B1 (ko) 2013-02-06
IL198863A (en) 2011-09-27
AU2010236072B2 (en) 2011-09-01
AU2010236072A1 (en) 2010-11-18
RU2375450C2 (ru) 2009-12-10
AU2010236091A1 (en) 2010-11-25
KR101269656B1 (ko) 2013-05-30
AU2010236093B2 (en) 2011-10-13
PL2298898T3 (pl) 2013-05-31
JP5396653B2 (ja) 2014-01-22
EP2292754B1 (fr) 2012-12-26
EP2298898A1 (fr) 2011-03-23
EP2287302B1 (fr) 2012-12-26
US20180187229A1 (en) 2018-07-05
EP2292754A1 (fr) 2011-03-09
KR20110112882A (ko) 2011-10-13
SG147468A1 (en) 2008-11-28
EP1675952A2 (fr) 2006-07-05
KR101229989B1 (ko) 2013-02-06
JP2007508831A (ja) 2007-04-12
KR20110112883A (ko) 2011-10-13
US9879297B2 (en) 2018-01-30
HK1120549A1 (en) 2009-04-03
KR20110112884A (ko) 2011-10-13
HK1149777A1 (en) 2011-10-14
HK1151824A1 (en) 2012-02-10
KR101222025B1 (ko) 2013-01-15
AU2010236091B2 (en) 2011-07-07
CA2535836C (fr) 2014-02-04
PL2292754T3 (pl) 2013-06-28
IL175142A0 (en) 2006-09-05
US20070178469A1 (en) 2007-08-02
EP1959011A2 (fr) 2008-08-20
EP2287302A1 (fr) 2011-02-23
US10669562B2 (en) 2020-06-02
RU2006117757A (ru) 2007-11-27
ATE551420T1 (de) 2012-04-15
US20130143264A1 (en) 2013-06-06
CN1863913B (zh) 2011-01-12
AU2004284220B2 (en) 2010-10-14
WO2005040377A3 (fr) 2005-09-15

Similar Documents

Publication Publication Date Title
IN2014DN02484A (fr)
ES2375058T8 (es) Axmi-010, un gen de la delta-endotoxina y métodos para su uso.
WO2001047944A3 (fr) Acides nucleiques contenant des polymorphismes mononucleotidiques et procedes d'utilisation correspondants
HUP0402271A2 (hu) Pseudoplectania nigrellá-ból származó antimikrobiális polipeptidek
AU3246300A (en) Polypeptides having galactose oxidase activity and nucleic acids encoding same
ATE300613T1 (de) Menschliche, für zyklische nukleotide spezifische phosphodiesterase
WO2005021585A3 (fr) Axmi-003, un gene de $g(d)-endotoxine, et procede d'utilisation correspondant
MXPA00008459A (es) Nuevas secuencias nucleotidicas codificadoras de gen thre y procedimiento para la preparacion por fermentacion de l-treonina utilizando bacterias corineformes.
MXPA06000092A (es) Transformacion de cloroplasto de la lenteja de agua.
WO1999057282A3 (fr) Toxines pesticides et sequences nucleotidiques codant pour ces toxines
WO2000029623A3 (fr) Acides nucleiques contenant des polymorphismes d'un seul nucleotide et utilisations de ces acides nucleiques
GB0020331D0 (en) Enzyme
IL155878A0 (en) Isolated luciferases and the use thereof
WO2003089617A3 (fr) Methodes pour augmenter la recombinaison homologue d'une sequence d'acide nucleique
ATE533779T1 (de) Isoliertes photoprotein mtclytin, sowie dessen verwendung
WO2001040521A3 (fr) Acides nucleiques contenant des polymorphismes mononucleotidiques et procedes d'utilisation correspondants
WO2001048245A3 (fr) Acides nucleiques contenant des polymorphismes de nucleotides simples, et procedes d'utilisation correspondants
AU2294102A (en) Mutant muscle-specific enhancers
AU2003219134A1 (en) Identification of 3-ketosteroid 9-alfa-hydroxylase genes and microorganisms blocked in 3-ketosteroid 9-alfa-hydroxylase activity
AU2001276385A1 (en) Nucleotide sequences which code for the lysr3 gene
WO2001051670A3 (fr) Acides nucleiques renfermant des polymorphismes de nucleotide simple et procede d'utilisation associe
WO2000029622A3 (fr) Acides nucleiques contenant des polymorphismes d'un nucleotide unique et utilisation de ces acides nucleiques
WO2005049818A3 (fr) Gene
WO2001038586A3 (fr) Acides nucleiques contenant des polymorphismes de nucleotides simples et methodes d'utilisation correspondantes
ATE346920T1 (de) Neues immunoregulatorisches protein lst-1