IN2014DN09352A - - Google Patents

Info

Publication number
IN2014DN09352A
IN2014DN09352A IN9352DEN2014A IN2014DN09352A IN 2014DN09352 A IN2014DN09352 A IN 2014DN09352A IN 9352DEN2014 A IN9352DEN2014 A IN 9352DEN2014A IN 2014DN09352 A IN2014DN09352 A IN 2014DN09352A
Authority
IN
India
Prior art keywords
compounds
disorders
substituents
useful
formula
Prior art date
Application number
Other languages
English (en)
Inventor
Stephen Deems Gabriel
Matthew Michael Hamilton
Yimin Qian
Achyutharao Sidduri
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=48628669&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=IN2014DN09352(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of IN2014DN09352A publication Critical patent/IN2014DN09352A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/04—1,2,3-Triazoles; Hydrogenated 1,2,3-triazoles
    • C07D249/06—1,2,3-Triazoles; Hydrogenated 1,2,3-triazoles with aryl radicals directly attached to ring atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
    • C07D249/10—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D249/14—Nitrogen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Pulmonology (AREA)
  • Urology & Nephrology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
IN9352DEN2014 2012-06-20 2013-06-17 IN2014DN09352A (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201261661953P 2012-06-20 2012-06-20
PCT/EP2013/062463 WO2013189865A1 (fr) 2012-06-20 2013-06-17 Composés n-aryltriazole utilisés comme antagonistes de lpar

Publications (1)

Publication Number Publication Date
IN2014DN09352A true IN2014DN09352A (fr) 2015-07-17

Family

ID=48628669

Family Applications (1)

Application Number Title Priority Date Filing Date
IN9352DEN2014 IN2014DN09352A (fr) 2012-06-20 2013-06-17

Country Status (22)

Country Link
US (1) US20150133512A1 (fr)
EP (1) EP2864301A1 (fr)
JP (1) JP2015520203A (fr)
KR (1) KR20150011389A (fr)
CN (1) CN104395299A (fr)
AU (1) AU2013279513A1 (fr)
BR (1) BR112014030674A2 (fr)
CA (1) CA2869564A1 (fr)
CL (1) CL2014003241A1 (fr)
CO (1) CO7131357A2 (fr)
EA (1) EA201492281A1 (fr)
HK (1) HK1206339A1 (fr)
IL (1) IL236087A0 (fr)
IN (1) IN2014DN09352A (fr)
MA (1) MA37762B1 (fr)
MX (1) MX2014014711A (fr)
PE (1) PE20142305A1 (fr)
PH (1) PH12014502363A1 (fr)
SG (1) SG11201407228PA (fr)
UA (1) UA110310C2 (fr)
WO (1) WO2013189865A1 (fr)
ZA (1) ZA201408167B (fr)

Families Citing this family (33)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2012296662A1 (en) 2011-08-15 2014-03-27 Intermune, Inc. Lysophosphatidic acid receptor antagonists
US20140213538A1 (en) * 2013-01-15 2014-07-31 Intermune, Inc. Lysophosphatidic acid receptor antagonists
US10000459B2 (en) 2013-03-15 2018-06-19 Epigen Biosciences, Inc. Heterocyclic compounds useful in the treatment of disease
UY36060A (es) 2014-04-02 2015-10-30 Bayer Pharma AG Compuestos de azol sustituidos con amida
AU2015281021B9 (en) 2014-06-27 2019-03-28 Ube Corporation Salt of halogen-substituted heterocyclic compound
WO2017055316A1 (fr) 2015-10-01 2017-04-06 Bayer Pharma Aktiengesellschaft Composés azole à substitution amido
WO2017055313A1 (fr) 2015-10-01 2017-04-06 Bayer Pharma Aktiengesellschaft Composés azole amido-substitués
AR108838A1 (es) 2016-06-21 2018-10-03 Bristol Myers Squibb Co Ácidos de carbamoiloximetil triazol ciclohexilo como antagonistas de lpa
WO2018078005A1 (fr) 2016-10-29 2018-05-03 Bayer Pharma Aktiengesellschaft Dérivés d'azaspiro à substitution amido en tant qu'inhibiteurs de tankyrase
WO2018078009A1 (fr) 2016-10-29 2018-05-03 Bayer Pharma Aktiengesellschaft Dérivés de cyclohexane à substitution amido
WO2018087126A1 (fr) 2016-11-09 2018-05-17 Bayer Pharma Aktiengesellschaft Dérivés de cyclohexane à substitution amido en tant qu'inhibiteurs de tankyrase
CN107827829A (zh) * 2017-11-07 2018-03-23 大连理工大学 5‑酰胺基‑1,4,5‑三取代的1,2,3‑三氮唑在水相及生物介质中的制备方法
CN107721984A (zh) * 2017-11-07 2018-02-23 大连理工大学 一种新型5‑酰胺基‑1,4,5‑三取代的1,2,3‑三氮唑的制备方法
CN112074515B (zh) 2017-12-19 2025-01-10 百时美施贵宝公司 作为lpa拮抗剂的环己基酸异噁唑唑类
TW202017918A (zh) 2017-12-19 2020-05-16 美商必治妥美雅史谷比公司 作為lpa拮抗劑之環己基酸三唑吖
WO2019126103A1 (fr) 2017-12-19 2019-06-27 Bristol-Myers Squibb Company Acides pyrazoles azoles cyclohexyliques utilisés en tant qu'antagonistes de lpa
EP3728210B1 (fr) 2017-12-19 2026-02-11 Bristol-Myers Squibb Company Acides carbamoyle cyclohexyliques à liaison n isoxazole utilisés en tant qu'antagonistes de lpa
KR20200100713A (ko) 2017-12-19 2020-08-26 브리스톨-마이어스 스큅 컴퍼니 Lpa 길항제로서의 시클로헥실 산 트리아졸 아졸
JP7202383B2 (ja) 2017-12-19 2023-01-11 ブリストル－マイヤーズ スクイブ カンパニー Ｌｐａアンタゴニストとしてのピラゾールｏ－架橋カルバモイルシクロヘキシル酸
US11312706B2 (en) 2017-12-19 2022-04-26 Bristol-Myers Squibb Company Cyclohexyl acid pyrazole azines as LPA antagonists
JP7526096B2 (ja) * 2017-12-19 2024-07-31 ブリストル－マイヤーズ スクイブ カンパニー Ｌｐａアンタゴニストとしてのシクロヘキシル酸イソキサゾールアジン
KR102698386B1 (ko) 2017-12-19 2024-08-22 브리스톨-마이어스 스큅 컴퍼니 Lpa 길항제로서의 피라졸 n-연결된 카르바모일 시클로헥실 산
KR102697358B1 (ko) 2017-12-19 2024-08-20 브리스톨-마이어스 스큅 컴퍼니 Lpa 길항제로서의 이속사졸 o-연결된 카르바모일 시클로헥실 산
CN113366000A (zh) 2018-09-18 2021-09-07 百时美施贵宝公司 作为lpa拮抗剂的氧杂双环酸
ES2946657T3 (es) 2018-09-18 2023-07-24 Bristol Myers Squibb Co Acidos ciclopentílicos como antagonistas de LPA
CN111434653A (zh) * 2019-01-15 2020-07-21 武汉朗来科技发展有限公司 三氮唑类化合物及其制备方法与用途
EP4058144A1 (fr) 2019-11-15 2022-09-21 Gilead Sciences, Inc. Pyridylsulfonamides de carbamate de triazole utilisées en tant qu'antagonistes du récepteur de lpa et leurs utilisations
TWI843503B (zh) 2020-06-03 2024-05-21 美商基利科學股份有限公司 Lpa受體拮抗劑及其用途
KR102913125B1 (ko) 2020-06-03 2026-01-20 길리애드 사이언시즈, 인코포레이티드 Lpa 수용체 길항제 및 이의 용도
CA3218917A1 (fr) 2021-05-11 2022-11-17 Gilead Sciences, Inc. Antagonistes du recepteur lpa et leurs utilisations
WO2022241023A1 (fr) 2021-05-13 2022-11-17 Gilead Sciences, Inc. Antagonistes du récepteur lpa et leurs utilisations
KR20240115978A (ko) 2021-12-08 2024-07-26 길리애드 사이언시즈, 인코포레이티드 Lpa 수용체 길항제 및 이의 용도
CN115745848A (zh) * 2022-12-07 2023-03-07 上海优合生物科技有限公司 一种氨基胍的加工合成工艺

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2011159550A2 (fr) * 2010-06-14 2011-12-22 Amidra Pharmaceuticals, Inc. Antagoniste du récepteur de l'acide lysophosphatidique et ses utilisations
WO2011159633A1 (fr) * 2010-06-15 2011-12-22 Amira Pharmaceuticals, Inc. Formulations inhalables d'antagonistes de récepteur d'acide lysophosphatidique
PH12013501136A1 (en) * 2010-12-07 2013-07-08 Amira Pharmaceuticals Inc Lysophosphatidic acid receptor antagonists and uses thereof
WO2012138648A1 (fr) * 2011-04-06 2012-10-11 Irm Llc Compositions et procédés pour la modulation de récepteurs au lpa
AU2012296662A1 (en) * 2011-08-15 2014-03-27 Intermune, Inc. Lysophosphatidic acid receptor antagonists
EA201492285A1 (ru) * 2012-06-20 2015-04-30 Ф. Хоффманн-Ля Рош Аг Соединения n-алкилтриазола в качестве антагонистов лизофосфатидной кислоты (lpar)

Also Published As

Publication number Publication date
EA201492281A1 (ru) 2015-04-30
MA37762A1 (fr) 2017-07-31
BR112014030674A2 (pt) 2017-06-27
IL236087A0 (en) 2015-02-01
EP2864301A1 (fr) 2015-04-29
UA110310C2 (uk) 2015-12-10
PE20142305A1 (es) 2015-01-16
PH12014502363A1 (en) 2015-01-12
ZA201408167B (en) 2015-12-23
US20150133512A1 (en) 2015-05-14
AU2013279513A1 (en) 2014-10-16
CL2014003241A1 (es) 2015-03-20
KR20150011389A (ko) 2015-01-30
JP2015520203A (ja) 2015-07-16
WO2013189865A1 (fr) 2013-12-27
SG11201407228PA (en) 2014-12-30
CN104395299A (zh) 2015-03-04
MX2014014711A (es) 2015-03-04
CO7131357A2 (es) 2014-12-01
HK1206339A1 (en) 2016-01-08
CA2869564A1 (fr) 2013-12-27
MA37762B1 (fr) 2018-04-30

Similar Documents

Publication Publication Date Title
IN2014DN09352A (fr)
IN2014DN09348A (fr)
IN2014DN09347A (fr)
IN2014MN02598A (fr)
IN2015DN01119A (fr)
WO2014179564A8 (fr) Inhibiteurs du ror-gamma à base de thiazolopyrrolidine
PH12016500024A1 (en) Bromodomain inhibitor
IN2014DN09434A (fr)
MX2014000341A (es) Novedosos derivados de trifluoro-metil-oxadiazol y su uso en el tratamiento de enfermedades.
PH12014501542A1 (en) Substituted pyrrolidine -2- carboxamides
EA201500298A1 (ru) Алкоксипиразолы в качестве активаторов растворимой гуанилатциклазы
PH12014501514A1 (en) New azetidine derivatives, pharmaceutical compositions and uses thereof
PH12013500007A1 (en) Piperidine derivatives and their use for the treatment of metabolic disorders
MX2016002794A (es) Compuestos antiproliferativos.
IN2014DN06869A (fr)
MX340574B (es) Imidazo pirazinas.
EA032271B9 (ru) Вещества, фармацевтическая композиция и методы применения при лечении воспалительных заболеваний
MX2015001657A (es) Compuestos de cianopirazol substituidos con receptores de acido lisofosfatidico (lpar).
MX2017013099A (es) Metodos para el tratamiento de trastornos inflamatorios.
IN2013DN02555A (fr)
MX2014001862A (es) 5-cicloalquil-o 5-heterociclil-nicotinamidas.
WO2014160143A3 (fr) Composés d'isatine, compositions et procédés pour le traitement de maladies et de troubles dégénératifs
WO2015002755A3 (fr) Composés pour le traitement du paludisme
PH12015502717B1 (en) Anti-fibrogenic compounds, methods and uses thereof
MY166057A (en) Carbocyclic nucleosides and their pharmaceutical use and compositions