MA37762A1 - Composés n-aryltriazole utilisés comme antagonistes de lpar - Google Patents
Composés n-aryltriazole utilisés comme antagonistes de lparInfo
- Publication number
- MA37762A1 MA37762A1 MA37762A MA37762A MA37762A1 MA 37762 A1 MA37762 A1 MA 37762A1 MA 37762 A MA37762 A MA 37762A MA 37762 A MA37762 A MA 37762A MA 37762 A1 MA37762 A1 MA 37762A1
- Authority
- MA
- Morocco
- Prior art keywords
- lpar
- antagonists
- compounds used
- aryltriazole
- compounds
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title abstract 3
- 239000005557 antagonist Substances 0.000 title 1
- 208000027866 inflammatory disease Diseases 0.000 abstract 2
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 208000005069 pulmonary fibrosis Diseases 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
- C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D249/04—1,2,3-Triazoles; Hydrogenated 1,2,3-triazoles
- C07D249/06—1,2,3-Triazoles; Hydrogenated 1,2,3-triazoles with aryl radicals directly attached to ring atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
- C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
- C07D249/10—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D249/14—Nitrogen atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Immunology (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Pulmonology (AREA)
- Urology & Nephrology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
L'invention concerne des composés de formule (i) ainsi que des sels pharmaceutiquement acceptables de ceux-ci, les substituants étant ceux qui sont indiqués dans la description. Ces composés, et les compositions pharmaceutiques les contenant, sont utiles pour le traitement de maladies et de troubles inflammatoires tels que le fibrose pulmonaire par exemple.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261661953P | 2012-06-20 | 2012-06-20 | |
| PCT/EP2013/062463 WO2013189865A1 (fr) | 2012-06-20 | 2013-06-17 | Composés n-aryltriazole utilisés comme antagonistes de lpar |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| MA37762A1 true MA37762A1 (fr) | 2017-07-31 |
| MA37762B1 MA37762B1 (fr) | 2018-04-30 |
Family
ID=48628669
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MA37762A MA37762B1 (fr) | 2012-06-20 | 2013-06-17 | Composés n-aryltriazole utilisés comme antagonistes de lpar |
Country Status (22)
| Country | Link |
|---|---|
| US (1) | US20150133512A1 (fr) |
| EP (1) | EP2864301A1 (fr) |
| JP (1) | JP2015520203A (fr) |
| KR (1) | KR20150011389A (fr) |
| CN (1) | CN104395299A (fr) |
| AU (1) | AU2013279513A1 (fr) |
| BR (1) | BR112014030674A2 (fr) |
| CA (1) | CA2869564A1 (fr) |
| CL (1) | CL2014003241A1 (fr) |
| CO (1) | CO7131357A2 (fr) |
| EA (1) | EA201492281A1 (fr) |
| HK (1) | HK1206339A1 (fr) |
| IL (1) | IL236087A0 (fr) |
| IN (1) | IN2014DN09352A (fr) |
| MA (1) | MA37762B1 (fr) |
| MX (1) | MX2014014711A (fr) |
| PE (1) | PE20142305A1 (fr) |
| PH (1) | PH12014502363A1 (fr) |
| SG (1) | SG11201407228PA (fr) |
| UA (1) | UA110310C2 (fr) |
| WO (1) | WO2013189865A1 (fr) |
| ZA (1) | ZA201408167B (fr) |
Families Citing this family (34)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2014525932A (ja) | 2011-08-15 | 2014-10-02 | インターミューン, インコーポレイテッド | リゾホスファチド酸レセプターアンタゴニスト |
| US20140213538A1 (en) * | 2013-01-15 | 2014-07-31 | Intermune, Inc. | Lysophosphatidic acid receptor antagonists |
| WO2014145873A2 (fr) | 2013-03-15 | 2014-09-18 | Epigen Biosciences, Inc. | Composés hétérocycliques utilisés pour le traitement de maladies |
| UY36060A (es) | 2014-04-02 | 2015-10-30 | Bayer Pharma AG | Compuestos de azol sustituidos con amida |
| RU2689315C2 (ru) | 2014-06-27 | 2019-05-27 | Убе Индастриз, Лтд. | Соль гетероциклического соединения, замещенного галогеном |
| WO2017055313A1 (fr) | 2015-10-01 | 2017-04-06 | Bayer Pharma Aktiengesellschaft | Composés azole amido-substitués |
| WO2017055316A1 (fr) | 2015-10-01 | 2017-04-06 | Bayer Pharma Aktiengesellschaft | Composés azole à substitution amido |
| AR108838A1 (es) | 2016-06-21 | 2018-10-03 | Bristol Myers Squibb Co | Ácidos de carbamoiloximetil triazol ciclohexilo como antagonistas de lpa |
| WO2018078005A1 (fr) | 2016-10-29 | 2018-05-03 | Bayer Pharma Aktiengesellschaft | Dérivés d'azaspiro à substitution amido en tant qu'inhibiteurs de tankyrase |
| WO2018078009A1 (fr) | 2016-10-29 | 2018-05-03 | Bayer Pharma Aktiengesellschaft | Dérivés de cyclohexane à substitution amido |
| WO2018087126A1 (fr) | 2016-11-09 | 2018-05-17 | Bayer Pharma Aktiengesellschaft | Dérivés de cyclohexane à substitution amido en tant qu'inhibiteurs de tankyrase |
| CN107827829A (zh) * | 2017-11-07 | 2018-03-23 | 大连理工大学 | 5‑酰胺基‑1,4,5‑三取代的1,2,3‑三氮唑在水相及生物介质中的制备方法 |
| CN107721984A (zh) * | 2017-11-07 | 2018-02-23 | 大连理工大学 | 一种新型5‑酰胺基‑1,4,5‑三取代的1,2,3‑三氮唑的制备方法 |
| JP7212047B2 (ja) | 2017-12-19 | 2023-01-24 | ブリストル-マイヤーズ スクイブ カンパニー | Lpaアンタゴニストとしてのシクロヘキシル酸ピラゾールアゾール |
| JP7208240B2 (ja) | 2017-12-19 | 2023-01-18 | ブリストル-マイヤーズ スクイブ カンパニー | Lpaアンタゴニストとしてのシクロヘキシル酸トリアゾールアジン |
| EP3728216B1 (fr) | 2017-12-19 | 2023-09-06 | Bristol-Myers Squibb Company | Acides carbamoyle cyclohexyliques à liaison n pyrazole utilisés en tant qu'antagonistes de lpa |
| US11447475B2 (en) | 2017-12-19 | 2022-09-20 | Bristol-Myers Squibb Company | Isoxazole N-linked carbamoyl cyclohexyl acids as LPA antagonists |
| US11261180B2 (en) | 2017-12-19 | 2022-03-01 | Bristol-Myers Squibb Company | Cyclohexyl acid isoxazole azoles as LPA antagonists |
| JP7299892B2 (ja) | 2017-12-19 | 2023-06-28 | ブリストル-マイヤーズ スクイブ カンパニー | Lpaアンタゴニストとしてのシクロヘキシル酸ピラゾールアジン |
| WO2019126084A1 (fr) | 2017-12-19 | 2019-06-27 | Bristol-Myers Squibb Company | Acides carbamoyle cyclohexyliques à liaison o isoxazole utilisés en tant qu'antagonistes de lpa |
| CN111712492B (zh) | 2017-12-19 | 2024-05-31 | 百时美施贵宝公司 | 作为lpa拮抗剂的环己基酸三唑唑类 |
| EP3728209B1 (fr) | 2017-12-19 | 2025-12-24 | Bristol-Myers Squibb Company | Azines isoxazole d'acide de cyclohexyle en tant qu'antagonistes de lpa |
| CN112041302B (zh) | 2017-12-19 | 2024-11-19 | 百时美施贵宝公司 | 作为lpa拮抗剂的吡唑o-连接的氨基甲酰基环己基酸 |
| EP3853232B1 (fr) | 2018-09-18 | 2023-03-01 | Bristol-Myers Squibb Company | Oxabicyclo-acides en tant qu'antagonistes de lpa |
| ES2946657T3 (es) | 2018-09-18 | 2023-07-24 | Bristol Myers Squibb Co | Acidos ciclopentílicos como antagonistas de LPA |
| CN111434653A (zh) * | 2019-01-15 | 2020-07-21 | 武汉朗来科技发展有限公司 | 三氮唑类化合物及其制备方法与用途 |
| EP4058144A1 (fr) | 2019-11-15 | 2022-09-21 | Gilead Sciences, Inc. | Pyridylsulfonamides de carbamate de triazole utilisées en tant qu'antagonistes du récepteur de lpa et leurs utilisations |
| EP4161936A1 (fr) | 2020-06-03 | 2023-04-12 | Gilead Sciences, Inc. | Antagonistes du récepteur lpa et leurs utilisations |
| TWI843503B (zh) | 2020-06-03 | 2024-05-21 | 美商基利科學股份有限公司 | Lpa受體拮抗劑及其用途 |
| WO2022240879A1 (fr) | 2021-05-11 | 2022-11-17 | Gilead Sciences, Inc. | Antagonistes du récepteur lpa et leurs utilisations |
| KR20240007233A (ko) | 2021-05-13 | 2024-01-16 | 길리애드 사이언시즈, 인코포레이티드 | Lpa 수용체 길항제 및 이의 용도 |
| WO2023107938A1 (fr) | 2021-12-08 | 2023-06-15 | Gilead Sciences, Inc. | Antagonistes du récepteur lpa et leurs utilisations |
| CN115745848A (zh) * | 2022-12-07 | 2023-03-07 | 上海优合生物科技有限公司 | 一种氨基胍的加工合成工艺 |
| US20240343695A1 (en) * | 2023-03-06 | 2024-10-17 | Lakehead University | Lysophosphatidic Acid Receptor 1 Antagonists as Migrastatics for Cancer |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2011159550A2 (fr) * | 2010-06-14 | 2011-12-22 | Amidra Pharmaceuticals, Inc. | Antagoniste du récepteur de l'acide lysophosphatidique et ses utilisations |
| WO2011159633A1 (fr) * | 2010-06-15 | 2011-12-22 | Amira Pharmaceuticals, Inc. | Formulations inhalables d'antagonistes de récepteur d'acide lysophosphatidique |
| KR20130126659A (ko) * | 2010-12-07 | 2013-11-20 | 아미라 파마슈티칼스 인코포레이티드 | 리소포스파티드산 수용체 길항제 및 섬유증 치료에서의 그의 용도 |
| WO2012138648A1 (fr) * | 2011-04-06 | 2012-10-11 | Irm Llc | Compositions et procédés pour la modulation de récepteurs au lpa |
| JP2014525932A (ja) * | 2011-08-15 | 2014-10-02 | インターミューン, インコーポレイテッド | リゾホスファチド酸レセプターアンタゴニスト |
| JP2015520202A (ja) * | 2012-06-20 | 2015-07-16 | エフ.ホフマン−ラ ロシュ アーゲーF. Hoffmann−La Roche Aktiengesellschaft | Lpar拮抗薬としてのn−アルキルトリアゾール化合物 |
-
2013
- 2013-06-17 IN IN9352DEN2014 patent/IN2014DN09352A/en unknown
- 2013-06-17 PE PE2014002213A patent/PE20142305A1/es not_active Application Discontinuation
- 2013-06-17 UA UAA201500426A patent/UA110310C2/uk unknown
- 2013-06-17 EP EP13729332.0A patent/EP2864301A1/fr not_active Withdrawn
- 2013-06-17 AU AU2013279513A patent/AU2013279513A1/en not_active Abandoned
- 2013-06-17 CA CA2869564A patent/CA2869564A1/fr not_active Abandoned
- 2013-06-17 MA MA37762A patent/MA37762B1/fr unknown
- 2013-06-17 US US14/403,261 patent/US20150133512A1/en not_active Abandoned
- 2013-06-17 SG SG11201407228PA patent/SG11201407228PA/en unknown
- 2013-06-17 WO PCT/EP2013/062463 patent/WO2013189865A1/fr not_active Ceased
- 2013-06-17 MX MX2014014711A patent/MX2014014711A/es unknown
- 2013-06-17 JP JP2015517705A patent/JP2015520203A/ja active Pending
- 2013-06-17 BR BR112014030674A patent/BR112014030674A2/pt not_active Application Discontinuation
- 2013-06-17 CN CN201380031806.0A patent/CN104395299A/zh active Pending
- 2013-06-17 KR KR1020147035551A patent/KR20150011389A/ko not_active Ceased
- 2013-06-17 EA EA201492281A patent/EA201492281A1/ru unknown
- 2013-06-17 HK HK15106924.1A patent/HK1206339A1/xx unknown
-
2014
- 2014-10-22 PH PH12014502363A patent/PH12014502363A1/en unknown
- 2014-11-07 ZA ZA2014/08167A patent/ZA201408167B/en unknown
- 2014-11-20 CO CO14255124A patent/CO7131357A2/es unknown
- 2014-11-28 CL CL2014003241A patent/CL2014003241A1/es unknown
- 2014-12-04 IL IL236087A patent/IL236087A0/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| KR20150011389A (ko) | 2015-01-30 |
| CA2869564A1 (fr) | 2013-12-27 |
| UA110310C2 (uk) | 2015-12-10 |
| PE20142305A1 (es) | 2015-01-16 |
| IL236087A0 (en) | 2015-02-01 |
| CN104395299A (zh) | 2015-03-04 |
| WO2013189865A1 (fr) | 2013-12-27 |
| AU2013279513A1 (en) | 2014-10-16 |
| HK1206339A1 (en) | 2016-01-08 |
| EP2864301A1 (fr) | 2015-04-29 |
| MX2014014711A (es) | 2015-03-04 |
| SG11201407228PA (en) | 2014-12-30 |
| CL2014003241A1 (es) | 2015-03-20 |
| EA201492281A1 (ru) | 2015-04-30 |
| US20150133512A1 (en) | 2015-05-14 |
| BR112014030674A2 (pt) | 2017-06-27 |
| JP2015520203A (ja) | 2015-07-16 |
| IN2014DN09352A (fr) | 2015-07-17 |
| ZA201408167B (en) | 2015-12-23 |
| CO7131357A2 (es) | 2014-12-01 |
| MA37762B1 (fr) | 2018-04-30 |
| PH12014502363A1 (en) | 2015-01-12 |
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