IN2014MN01419A - - Google Patents
Info
- Publication number
- IN2014MN01419A IN2014MN01419A IN1419MUN2014A IN2014MN01419A IN 2014MN01419 A IN2014MN01419 A IN 2014MN01419A IN 1419MUN2014 A IN1419MUN2014 A IN 1419MUN2014A IN 2014MN01419 A IN2014MN01419 A IN 2014MN01419A
- Authority
- IN
- India
- Prior art keywords
- molecular entities
- spirostanic
- general formula
- steroid derivatives
- epoxidising
- Prior art date
Links
- WQLVFSAGQJTQCK-UHFFFAOYSA-N diosgenin Natural products CC1C(C2(CCC3C4(C)CCC(O)CC4=CCC3C2C2)C)C2OC11CCC(C)CO1 WQLVFSAGQJTQCK-UHFFFAOYSA-N 0.000 abstract 2
- 150000003431 steroids Chemical class 0.000 abstract 2
- 208000012902 Nervous system disease Diseases 0.000 abstract 1
- 208000025966 Neurological disease Diseases 0.000 abstract 1
- DWCSNWXARWMZTG-UHFFFAOYSA-N Trigonegenin A Natural products CC1C(C2(CCC3C4(C)CCC(O)C=C4CCC3C2C2)C)C2OC11CCC(C)CO1 DWCSNWXARWMZTG-UHFFFAOYSA-N 0.000 abstract 1
- 230000001154 acute effect Effects 0.000 abstract 1
- 230000001910 anti-glutamatergic effect Effects 0.000 abstract 1
- 230000003110 anti-inflammatory effect Effects 0.000 abstract 1
- 210000003169 central nervous system Anatomy 0.000 abstract 1
- 230000001684 chronic effect Effects 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- WQLVFSAGQJTQCK-VKROHFNGSA-N diosgenin Chemical compound O([C@@H]1[C@@H]([C@]2(CC[C@@H]3[C@@]4(C)CC[C@H](O)CC4=CC[C@H]3[C@@H]2C1)C)[C@@H]1C)[C@]11CC[C@@H](C)CO1 WQLVFSAGQJTQCK-VKROHFNGSA-N 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 230000002757 inflammatory effect Effects 0.000 abstract 1
- 230000000626 neurodegenerative effect Effects 0.000 abstract 1
- NWMIYTWHUDFRPL-UHFFFAOYSA-N sapogenin Natural products COC(=O)C1(CO)C(O)CCC2(C)C1CCC3(C)C2CC=C4C5C(C)(O)C(C)CCC5(CCC34C)C(=O)O NWMIYTWHUDFRPL-UHFFFAOYSA-N 0.000 abstract 1
- 230000009466 transformation Effects 0.000 abstract 1
- 238000000844 transformation Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
- C07J71/0005—Oxygen-containing hetero ring
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J21/00—Normal steroids containing carbon, hydrogen, halogen or oxygen having an oxygen-containing hetero ring spiro-condensed with the cyclopenta(a)hydrophenanthrene skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J33/00—Normal steroids having a sulfur-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton
- C07J33/005—Normal steroids having a sulfur-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton spiro-condensed
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J43/00—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton
- C07J43/006—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton spiro-condensed
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Neurosurgery (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Neurology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Hospice & Palliative Care (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Psychiatry (AREA)
- Steroid Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CU2011000244A CU20110244A7 (es) | 2011-12-27 | 2011-12-27 | Sistemas espiroesteroidales con efectos neuroactivos y anti-inflamatorios |
| PCT/CU2012/000008 WO2013097835A1 (es) | 2011-12-27 | 2012-12-27 | Sistemas espiroesteroidales con efectos neuroactivos y anti- inflamatorios |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| IN2014MN01419A true IN2014MN01419A (es) | 2015-04-03 |
Family
ID=47665756
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IN1419MUN2014 IN2014MN01419A (es) | 2011-12-27 | 2012-12-27 |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US20150140088A1 (es) |
| EP (1) | EP2801581A1 (es) |
| JP (1) | JP2015506929A (es) |
| AR (1) | AR089491A1 (es) |
| BR (1) | BR112014016127A2 (es) |
| CA (1) | CA2861958A1 (es) |
| CU (1) | CU20110244A7 (es) |
| IN (1) | IN2014MN01419A (es) |
| WO (1) | WO2013097835A1 (es) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104558085B (zh) * | 2014-12-16 | 2016-08-17 | 吉林农业大学 | 萘甲酸环戊烷并多氢菲酯b及其提取方法和药物用途 |
| CN109053854B (zh) * | 2018-09-29 | 2021-05-14 | 深圳清博汇能医药科技有限公司 | 基于知母菝契皂苷元结构的衍生物、药物组合物及其应用 |
| CN110452283B (zh) * | 2019-04-24 | 2020-09-25 | 西南民族大学 | 一种抗肿瘤季铵盐类衍生物及其制备方法及应用 |
Family Cites Families (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE1058988B (de) * | 1957-05-03 | 1959-06-11 | British Drug Houses Ltd | Verfahren zur Herstellung von 3ª‰-Hydroxy-6-methyl-?-steroiden |
| US3002969A (en) * | 1957-05-03 | 1961-10-03 | British Drug Houses Ltd | 3beta-hydroxy-6-methyl-delta5-steroids and method of preparation |
| US3105068A (en) * | 1961-03-09 | 1963-09-24 | Sato Yoshio | Improved preparation of allopregnenolone and pregnadienolone from tomatidine and solasodine |
| DE1804331A1 (de) * | 1967-10-23 | 1969-05-22 | Erba Carlo Spa | Derivate von (25R)-3ss-Amino-5alpha-22alpha-spirostan und Verfahren zu deren Herstellung |
| US5116829A (en) | 1990-04-23 | 1992-05-26 | Kao Corporation | Steroid compounds |
| JPH04230696A (ja) * | 1990-12-28 | 1992-08-19 | Sanwa Shiyouyaku Kk | 新規なステロイド系化合物および制癌剤 |
| BR9306619A (pt) * | 1992-06-26 | 1998-12-08 | Pfizer | Glicosídeos esteroidais para o tratamento da hipercolesterolemia |
| DE4303214A1 (de) * | 1993-02-04 | 1994-08-11 | Wolfgang Marks | Behandlung von Erkrankungen viraler, viroidaler oder onkogener Genese durch Steroid-Saponine oder deren Aglykone |
| CA2136803A1 (en) | 1993-12-22 | 1995-06-23 | Kazumi Ogata | Steroid derivatives |
| CU22860A1 (es) * | 1995-10-12 | 2003-05-26 | Univ La Habana | Espirostanonas con funciones oxigenadas en el anillo a. como reguladores del crecimiento vegetal y su procedimiento de obtención |
| GB9923076D0 (en) * | 1999-09-29 | 1999-12-01 | Phytopharm Plc | Sapogenin derivatives and their use |
| GB9923078D0 (en) * | 1999-09-29 | 1999-12-01 | Phytopharm Plc | Sapogenin derivatives and their use |
| IT1311922B1 (it) | 1999-04-13 | 2002-03-20 | Nicox Sa | Composti farmaceutici. |
| GB9923077D0 (en) * | 1999-09-29 | 1999-12-01 | Phytopharm Plc | Sapogenin derivatives and their use |
| GB0003524D0 (en) | 2000-02-15 | 2000-04-05 | Btg Int Ltd | Cytoprotective steroids (II) |
| GB2363984A (en) | 2000-06-29 | 2002-01-16 | Hunter Fleming Ltd | Protection against neuronal damage using 3-hydroxy-7 -hydroxy steroids and 3-oxo-7 -hydroxy steroids |
| GB0107822D0 (en) * | 2001-03-28 | 2001-05-23 | Phytopharm Plc | Sapogenin derivatives their synthesis and use methods based upon their use |
| CA2479249A1 (en) | 2002-03-15 | 2003-09-25 | Samaritan Pharmaceuticals, Inc. | Neuroprotective spirostenol pharmaceutical compositions |
| BR0308788A (pt) * | 2002-03-27 | 2005-01-11 | Phytopharm Plc | Processos terapêuticos e usos de sapogeninas e seus derivados |
| PL213697B1 (pl) * | 2002-03-27 | 2013-04-30 | Phytopharm Plc | Substancje czynne do stosowania w leczeniu chorób, zwlaszcza chorób neurodegeneracyjnych |
| GB0523550D0 (en) | 2005-11-18 | 2005-12-28 | Hunter Fleming Ltd | Therapeutic uses of steroidal compounds |
| JP2011027429A (ja) * | 2009-07-21 | 2011-02-10 | Kirin Holdings Co Ltd | 液体クロマトグラフィーを用いたグリコアルカロイド類の精製および分析法 |
| BR112013001422A2 (pt) * | 2010-07-20 | 2019-09-24 | Phytopharm Plc | metodo para tratar ou previnir disturbios induzidos por l-dopa, agonista dopamina e/ou acentuador de dopamina em um individuo que necessita dos mesmos, agente, composição, uso de ou mais agentes e metodo para tratar a doença de parkinson |
-
2011
- 2011-12-27 CU CU2011000244A patent/CU20110244A7/es unknown
-
2012
- 2012-12-27 JP JP2014549357A patent/JP2015506929A/ja active Pending
- 2012-12-27 EP EP12821233.9A patent/EP2801581A1/en not_active Withdrawn
- 2012-12-27 WO PCT/CU2012/000008 patent/WO2013097835A1/es not_active Ceased
- 2012-12-27 CA CA2861958A patent/CA2861958A1/en not_active Abandoned
- 2012-12-27 AR ARP120105012A patent/AR089491A1/es unknown
- 2012-12-27 US US14/368,668 patent/US20150140088A1/en not_active Abandoned
- 2012-12-27 BR BR112014016127A patent/BR112014016127A2/pt not_active IP Right Cessation
- 2012-12-27 IN IN1419MUN2014 patent/IN2014MN01419A/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| CU20110244A7 (es) | 2013-08-29 |
| JP2015506929A (ja) | 2015-03-05 |
| BR112014016127A2 (pt) | 2017-07-04 |
| WO2013097835A1 (es) | 2013-07-04 |
| CA2861958A1 (en) | 2013-07-04 |
| US20150140088A1 (en) | 2015-05-21 |
| AR089491A1 (es) | 2014-08-27 |
| EP2801581A1 (en) | 2014-11-12 |
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