CU20110244A7 - Sistemas espiroesteroidales con efectos neuroactivos y anti-inflamatorios - Google Patents

Sistemas espiroesteroidales con efectos neuroactivos y anti-inflamatorios

Info

Publication number
CU20110244A7
CU20110244A7 CU2011000244A CU20110244A CU20110244A7 CU 20110244 A7 CU20110244 A7 CU 20110244A7 CU 2011000244 A CU2011000244 A CU 2011000244A CU 20110244 A CU20110244 A CU 20110244A CU 20110244 A7 CU20110244 A7 CU 20110244A7
Authority
CU
Cuba
Prior art keywords
molecular entities
general formula
esteroid
neuroactive
spi
Prior art date
Application number
CU2011000244A
Other languages
English (en)
Inventor
Pupo Laura García
Figueredo Yanier Núñez
Morales Juan Enrique Tacoronte
Reyes Yamila Verdecia
Rodríguez Estael Ochoa
Castro Armando Zaldo
Original Assignee
Ct De Investigación Y Desarrollo De Medicamentos Cidem
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ct De Investigación Y Desarrollo De Medicamentos Cidem filed Critical Ct De Investigación Y Desarrollo De Medicamentos Cidem
Priority to CU2011000244A priority Critical patent/CU20110244A7/es
Priority to JP2014549357A priority patent/JP2015506929A/ja
Priority to CA2861958A priority patent/CA2861958A1/en
Priority to IN1419MUN2014 priority patent/IN2014MN01419A/en
Priority to EP12821233.9A priority patent/EP2801581A1/en
Priority to PCT/CU2012/000008 priority patent/WO2013097835A1/es
Priority to ARP120105012A priority patent/AR089491A1/es
Priority to BR112014016127A priority patent/BR112014016127A2/pt
Priority to US14/368,668 priority patent/US20150140088A1/en
Publication of CU20110244A7 publication Critical patent/CU20110244A7/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
    • C07J71/0005—Oxygen-containing hetero ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J21/00—Normal steroids containing carbon, hydrogen, halogen or oxygen having an oxygen-containing hetero ring spiro-condensed with the cyclopenta(a)hydrophenanthrene skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J33/00—Normal steroids having a sulfur-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton
    • C07J33/005—Normal steroids having a sulfur-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton spiro-condensed
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J43/00—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton
    • C07J43/006—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton spiro-condensed

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Neurosurgery (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Neurology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Hospice & Palliative Care (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Psychiatry (AREA)
  • Steroid Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)

Abstract

La presente invención se relaciona con la química, la farmacéutica y en particular con la obtención de nuevas entidades moleculares, derivados esteroidales, con acción sobre el Sistema Nervioso Central. A partir de la diosgenina, la cual constituye una sapogenina de origen natural, se obtienen derivados esteroidales espirostánicos hexacíclicos de fórmula general I-IV, mediante reacciones con compuestos de tipo oxidantes, epoxidantes, etc., así como posteriores transformaciones a algunos de ellos. Las entidades moleculares de fórmula general I-IV contienen el núcleo ciclopentanoperhidrofenantreno, donde el ciclo A son anillos espirostánicos sustituidos con diferentes átomos electronegativos. Estas entidades moleculares presentan acción anti-glutamatérgica y anti-inflamatoria, utilizables en el tratamiento de las enfermedades inflamatorias crónicas y agudas, neurodegenerativas, neuropsiquiátricas y neurológicas.
CU2011000244A 2011-12-27 2011-12-27 Sistemas espiroesteroidales con efectos neuroactivos y anti-inflamatorios CU20110244A7 (es)

Priority Applications (9)

Application Number Priority Date Filing Date Title
CU2011000244A CU20110244A7 (es) 2011-12-27 2011-12-27 Sistemas espiroesteroidales con efectos neuroactivos y anti-inflamatorios
JP2014549357A JP2015506929A (ja) 2011-12-27 2012-12-27 神経保護剤及び抗炎症剤として作用するスピロステロイド系
CA2861958A CA2861958A1 (en) 2011-12-27 2012-12-27 Spirosteroidal systems having neuroactive, anti-inflammatory effects
IN1419MUN2014 IN2014MN01419A (es) 2011-12-27 2012-12-27
EP12821233.9A EP2801581A1 (en) 2011-12-27 2012-12-27 Spirosteroidal systems having neuroactive, anti-inflammatory effects
PCT/CU2012/000008 WO2013097835A1 (es) 2011-12-27 2012-12-27 Sistemas espiroesteroidales con efectos neuroactivos y anti- inflamatorios
ARP120105012A AR089491A1 (es) 2011-12-27 2012-12-27 Sistemas espiroesteroidales con efectos neuroactivos y anti-inflamatorios
BR112014016127A BR112014016127A2 (pt) 2011-12-27 2012-12-27 sistemas espiroesteroidais com efeitos neuroativos e anti-inflamatórios, e, composição farmacêutica
US14/368,668 US20150140088A1 (en) 2011-12-27 2012-12-27 Spirosteroid systems acting as neuroprotective and anti-inflammatory agents

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CU2011000244A CU20110244A7 (es) 2011-12-27 2011-12-27 Sistemas espiroesteroidales con efectos neuroactivos y anti-inflamatorios

Publications (1)

Publication Number Publication Date
CU20110244A7 true CU20110244A7 (es) 2013-08-29

Family

ID=47665756

Family Applications (1)

Application Number Title Priority Date Filing Date
CU2011000244A CU20110244A7 (es) 2011-12-27 2011-12-27 Sistemas espiroesteroidales con efectos neuroactivos y anti-inflamatorios

Country Status (9)

Country Link
US (1) US20150140088A1 (es)
EP (1) EP2801581A1 (es)
JP (1) JP2015506929A (es)
AR (1) AR089491A1 (es)
BR (1) BR112014016127A2 (es)
CA (1) CA2861958A1 (es)
CU (1) CU20110244A7 (es)
IN (1) IN2014MN01419A (es)
WO (1) WO2013097835A1 (es)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104558085B (zh) * 2014-12-16 2016-08-17 吉林农业大学 萘甲酸环戊烷并多氢菲酯b及其提取方法和药物用途
CN109053854B (zh) * 2018-09-29 2021-05-14 深圳清博汇能医药科技有限公司 基于知母菝契皂苷元结构的衍生物、药物组合物及其应用
CN110452283B (zh) * 2019-04-24 2020-09-25 西南民族大学 一种抗肿瘤季铵盐类衍生物及其制备方法及应用

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US3002969A (en) * 1957-05-03 1961-10-03 British Drug Houses Ltd 3beta-hydroxy-6-methyl-delta5-steroids and method of preparation
US3105068A (en) * 1961-03-09 1963-09-24 Sato Yoshio Improved preparation of allopregnenolone and pregnadienolone from tomatidine and solasodine
DE1804331A1 (de) * 1967-10-23 1969-05-22 Erba Carlo Spa Derivate von (25R)-3ss-Amino-5alpha-22alpha-spirostan und Verfahren zu deren Herstellung
US5116829A (en) 1990-04-23 1992-05-26 Kao Corporation Steroid compounds
JPH04230696A (ja) * 1990-12-28 1992-08-19 Sanwa Shiyouyaku Kk 新規なステロイド系化合物および制癌剤
BR9306619A (pt) * 1992-06-26 1998-12-08 Pfizer Glicosídeos esteroidais para o tratamento da hipercolesterolemia
DE4303214A1 (de) * 1993-02-04 1994-08-11 Wolfgang Marks Behandlung von Erkrankungen viraler, viroidaler oder onkogener Genese durch Steroid-Saponine oder deren Aglykone
CA2136803A1 (en) 1993-12-22 1995-06-23 Kazumi Ogata Steroid derivatives
CU22860A1 (es) * 1995-10-12 2003-05-26 Univ La Habana Espirostanonas con funciones oxigenadas en el anillo a. como reguladores del crecimiento vegetal y su procedimiento de obtención
GB9923076D0 (en) * 1999-09-29 1999-12-01 Phytopharm Plc Sapogenin derivatives and their use
GB9923078D0 (en) * 1999-09-29 1999-12-01 Phytopharm Plc Sapogenin derivatives and their use
IT1311922B1 (it) 1999-04-13 2002-03-20 Nicox Sa Composti farmaceutici.
GB9923077D0 (en) * 1999-09-29 1999-12-01 Phytopharm Plc Sapogenin derivatives and their use
GB0003524D0 (en) 2000-02-15 2000-04-05 Btg Int Ltd Cytoprotective steroids (II)
GB2363984A (en) 2000-06-29 2002-01-16 Hunter Fleming Ltd Protection against neuronal damage using 3-hydroxy-7 -hydroxy steroids and 3-oxo-7 -hydroxy steroids
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BR112013001422A2 (pt) * 2010-07-20 2019-09-24 Phytopharm Plc metodo para tratar ou previnir disturbios induzidos por l-dopa, agonista dopamina e/ou acentuador de dopamina em um individuo que necessita dos mesmos, agente, composição, uso de ou mais agentes e metodo para tratar a doença de parkinson

Also Published As

Publication number Publication date
JP2015506929A (ja) 2015-03-05
BR112014016127A2 (pt) 2017-07-04
IN2014MN01419A (es) 2015-04-03
WO2013097835A1 (es) 2013-07-04
CA2861958A1 (en) 2013-07-04
US20150140088A1 (en) 2015-05-21
AR089491A1 (es) 2014-08-27
EP2801581A1 (en) 2014-11-12

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