IN2015CH02019A - - Google Patents

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Publication number
IN2015CH02019A
IN2015CH02019A IN2019CH2015A IN2015CH02019A IN 2015CH02019 A IN2015CH02019 A IN 2015CH02019A IN 2019CH2015 A IN2019CH2015 A IN 2019CH2015A IN 2015CH02019 A IN2015CH02019 A IN 2015CH02019A
Authority
IN
India
Prior art keywords
aspartyl
phenylalanine
preparation
methyl ester
novelprocess
Prior art date
Application number
Inventor
Krishna Prasad Divi Murali
Aswatha Narayana Rao Mysore
Nowshuddin Shaik
Original Assignee
Divis Lab Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Divis Lab Ltd filed Critical Divis Lab Ltd
Priority to IN2019CH2015 priority Critical patent/IN2015CH02019A/en
Publication of IN2015CH02019A publication Critical patent/IN2015CH02019A/en
Priority to US14/848,533 priority patent/US9512063B2/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C231/00—Preparation of carboxylic acid amides
    • C07C231/12—Preparation of carboxylic acid amides by reactions not involving the formation of carboxamide groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C231/00—Preparation of carboxylic acid amides
    • C07C231/14—Preparation of carboxylic acid amides by formation of carboxamide groups together with reactions not involving the carboxamide groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/45—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by condensation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/45—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by condensation
    • C07C45/455—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by condensation with carboxylic acids or their derivatives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06104—Dipeptides with the first amino acid being acidic
    • C07K5/06113—Asp- or Asn-amino acid
    • C07K5/06121—Asp- or Asn-amino acid the second amino acid being aromatic or cycloaliphatic
    • C07K5/0613—Aspartame

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Peptides Or Proteins (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

Abstract

Process for the Preparation of Advantame : A novelprocess for the preparation of N-[N-[3-(3-hydroxy-4-methoxyphenyl)-propyl]-L-a-aspartyl]-L-phenylalanine-l-methyl ester is described. It comprises, reacting isovanillin or its derivative with vinyl acétate followed by reductive condensation with L-[a-aspartyl]-L-phenylalanine-1-methyl ester.
IN2019CH2015 2015-04-20 2015-04-20 IN2015CH02019A (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
IN2019CH2015 IN2015CH02019A (en) 2015-04-20 2015-04-20
US14/848,533 US9512063B2 (en) 2015-04-20 2015-09-09 Process for the preparation of advantame

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IN2019CH2015 IN2015CH02019A (en) 2015-04-20 2015-04-20

Publications (1)

Publication Number Publication Date
IN2015CH02019A true IN2015CH02019A (en) 2015-06-05

Family

ID=54396326

Family Applications (1)

Application Number Title Priority Date Filing Date
IN2019CH2015 IN2015CH02019A (en) 2015-04-20 2015-04-20

Country Status (2)

Country Link
US (1) US9512063B2 (en)
IN (1) IN2015CH02019A (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN111875666B (en) * 2020-07-07 2022-08-12 辽宁启康生物科技有限公司 Method for synthesizing Edwarden sweet

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2697844B1 (en) * 1992-11-12 1995-01-27 Claude Nofre New compounds derived from dipeptides or dipeptide analogues useful as sweetening agents, process for their preparation.
JP3959964B2 (en) 1998-04-09 2007-08-15 味の素株式会社 Aspartyl dipeptide ester derivatives and sweeteners
SK3682001A3 (en) * 1998-09-18 2001-10-08 Ajinomoto Kk N-alkylaspartyldipeptide ester derivatives and sweeteners
CN1378558A (en) * 1999-10-07 2002-11-06 味之素株式会社 Processes for producing and purifying aspartame derivatives and process for producing intemediates
AU7321900A (en) 1999-10-07 2001-05-10 Ajinomoto Co., Inc. Process for the production of aspartyldipeptide ester derivatives, novel intermediates therefor and process for the production of the intermediates
ES2335193T3 (en) 2000-05-16 2010-03-23 Ajinomoto Co., Inc. PROCESS TO PRODUCE DERIVATIVES OF CINAMALDEHIDO, USE OF THE SAME AND IMILAR.

Also Published As

Publication number Publication date
US9512063B2 (en) 2016-12-06
US20160304439A1 (en) 2016-10-20

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