IS2123B - Indól-2,3-díon-3-oxíms afleiður - Google Patents

Indól-2,3-díon-3-oxíms afleiður

Info

Publication number: IS2123B
Authority: IS; Iceland
Prior art keywords: dione; het; oxime derivatives; indole; ring
Prior art date: 1996-10-01

Application number

IS4748A

Other languages

English (en)

Icelandic (is)

Other versions

IS4748A (is

Inventor

Wuetjen Frank

Drejer Jorgen

Original Assignee

Neurosearch As

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1996-10-01

Filing date

1998-05-18

Publication date

2006-07-14

1998-05-18 Application filed by Neurosearch As filed Critical Neurosearch As

1998-05-18 Publication of IS4748A publication Critical patent/IS4748A/is

2006-07-14 Publication of IS2123B publication Critical patent/IS2123B/xx

Links

LNMAXZZQNSPQSR-UHFFFAOYSA-N 3-(hydroxyamino)indol-2-one Chemical class C1=CC=CC2=NC(=O)C(NO)=C21 LNMAXZZQNSPQSR-UHFFFAOYSA-N 0.000 title abstract 3
WHUUTDBJXJRKMK-VKHMYHEASA-N L-glutamic acid Chemical compound OC(=O)[C@@H](N)CCC(O)=O WHUUTDBJXJRKMK-VKHMYHEASA-N 0.000 abstract 1
125000005092 alkenyloxycarbonyl group Chemical group 0.000 abstract 1
125000004453 alkoxycarbonyl group Chemical group 0.000 abstract 1
125000000217 alkyl group Chemical group 0.000 abstract 1
125000005225 alkynyloxycarbonyl group Chemical group 0.000 abstract 1
125000005161 aryl oxy carbonyl group Chemical group 0.000 abstract 1
125000004429 atom Chemical group 0.000 abstract 1
125000005605 benzo group Chemical group 0.000 abstract 1
230000000694 effects Effects 0.000 abstract 1
239000003257 excitatory amino acid Substances 0.000 abstract 1
230000002461 excitatory amino acid Effects 0.000 abstract 1
229930195712 glutamate Natural products 0.000 abstract 1
125000000623 heterocyclic group Chemical group 0.000 abstract 1
229910052739 hydrogen Inorganic materials 0.000 abstract 1
239000001257 hydrogen Substances 0.000 abstract 1
125000004435 hydrogen atom Chemical class [H]* 0.000 abstract 1
-1 hydroxy, carboxy Chemical group 0.000 abstract 1
125000002768 hydroxyalkyl group Chemical group 0.000 abstract 1
125000002950 monocyclic group Chemical group 0.000 abstract 1
125000001624 naphthyl group Chemical group 0.000 abstract 1
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
125000004076 pyridyl group Chemical group 0.000 abstract 1
229920006395 saturated elastomer Polymers 0.000 abstract 1
125000001544 thienyl group Chemical group 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems

Landscapes

Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Veterinary Medicine (AREA)
General Health & Medical Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Neurology (AREA)
Public Health (AREA)
Chemical Kinetics & Catalysis (AREA)
Medicinal Chemistry (AREA)
Neurosurgery (AREA)
Biomedical Technology (AREA)
Psychiatry (AREA)
Psychology (AREA)
Pain & Pain Management (AREA)
Heart & Thoracic Surgery (AREA)
Cardiology (AREA)
Hospice & Palliative Care (AREA)
Addiction (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Indole Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Plural Heterocyclic Compounds (AREA)

IS4748A 1996-10-01 1998-05-18 Indól-2,3-díon-3-oxíms afleiður IS2123B (is)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
DK106996		1996-10-01
DK127796		1996-11-13
PCT/DK1997/000418 WO1998014447A1 (en)	1996-10-01	1997-10-01	Novel indole-2,3-dione-3-oxime derivatives

Publications (2)

Publication Number	Publication Date
IS4748A IS4748A (is)	1998-05-18
IS2123B true IS2123B (is)	2006-07-14

Family

ID=26065167

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
IS4748A IS2123B (is)	1996-10-01	1998-05-18	Indól-2,3-díon-3-oxíms afleiður

Country Status (28)

Country	Link
US (3)	US6124285A (ja)
EP (1)	EP0869958B1 (ja)
JP (1)	JP3319762B2 (ja)
KR (1)	KR100492052B1 (ja)
CN (1)	CN1093859C (ja)
AT (1)	ATE286052T1 (ja)
AU (1)	AU716435B2 (ja)
BG (1)	BG63874B1 (ja)
BR (1)	BR9706765A (ja)
CA (1)	CA2238410C (ja)
CZ (1)	CZ297938B6 (ja)
DE (1)	DE69732090T2 (ja)
DK (1)	DK0869958T3 (ja)
EE (1)	EE9800144A (ja)
ES (1)	ES2235253T3 (ja)
HU (1)	HU225145B1 (ja)
IL (1)	IL124563A (ja)
IS (1)	IS2123B (ja)
NO (1)	NO310722B1 (ja)
NZ (1)	NZ330456A (ja)
PL (1)	PL193041B1 (ja)
PT (1)	PT869958E (ja)
RU (1)	RU2190612C2 (ja)
SI (1)	SI0869958T1 (ja)
SK (1)	SK282729B6 (ja)
TR (1)	TR199800956T1 (ja)
UA (1)	UA54403C2 (ja)
WO (1)	WO1998014447A1 (ja)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
UA54403C2 (uk) *	1996-10-01	2003-03-17	Н'Юросерч А/С	Похідні індол-2,3-діон-3-оксиму, фармацевтична композиція, спосіб лікування розладу чи захворювання ссавців, у тому числі людини та спосіб одержання похідних індол-2,3-діон-3-оксиму
AU751414B2 (en)	1998-03-31	2002-08-15	Neurosearch A/S	Indole-2,3-dione-3-oxime derivatives for therapeutic use
WO2000071102A2 (en) *	1999-05-19	2000-11-30	Neurosearch A/S	Inhibitors of proton-gated cation channels and their use in the treatment of ischaemic disorders
EP1736468A3 (en) *	2000-01-24	2007-01-03	NeuroSearch A/S	Isatin derivatives with neurotrophic activity useful in the treatment of diseases mediated by the nerve growth factor (NGF) activation
IT1318636B1 (it) *	2000-07-21	2003-08-27	Roberto Pellicciari	Derivati dell'acido 2- o 3- tenoico ad attivita' antagonista deirecettori del glutammato.
US20040063742A1 (en) *	2001-02-15	2004-04-01	Dan Peters	Treatment of parkinson's disease by the combined action of a compound with neurotrophic activity and a compound enhancing the dopamine activity
BR0211140A (pt)	2001-07-13	2005-10-25	Upjohn Co	Compostos e composições de indóis de hexaidroazepina (4, 5-g) e indolinas como ligantes de receptores 5-ht
DK1532146T3 (da) *	2002-08-22	2006-07-03	Neurosearch As	Fremgangsmåde til fremstilling af enantiomerer af indol-2,3-dion-3-oximderivater
GB0507298D0 (en)	2005-04-11	2005-05-18	Novartis Ag	Organic compounds
KR20080070749A (ko) *	2005-11-23	2008-07-30	페인셉터 파마 코포레이션	개폐 이온 통로를 조절하기 위한 조성물 및 방법
CA2652307A1 (en) *	2006-04-10	2007-10-18	Painceptor Pharma Corporation	Compositions and methods for modulating gated ion channels
US20080021034A1 (en) *	2006-04-10	2008-01-24	Painceptor Pharma Corporation	Compositions and methods for modulating gated ion channels
US20100041691A1 (en) *	2006-09-12	2010-02-18	Neurosearch A/S	Pharmaceutical compositions comprising combinations of an ampa/kainate antagonistic compound and an inhibitor of a multidrug resistance protein
US20080108622A1 (en) *	2006-10-19	2008-05-08	Eisenach James C	Combination therapy for the treatment of pain
US20080108603A1 (en) *	2006-10-19	2008-05-08	Eisenach James C	Combination therapy for the treatment of pain
WO2010104324A2 (ko) *	2009-03-10	2010-09-16	한국과학기술연구원	베타-아밀로이드 집적체 및 피브릴에 우수한 결합 친화도를 가지는 할로겐화 이소인돌론 화합물, 및 이의 제조 방법 및 용도
CN102653538A (zh) *	2011-03-04	2012-09-05	爱斯医药科技(南京)有限公司	Spd-502的制备方法
BR112017023200A2 (pt) *	2015-04-29	2018-08-07	Janssen Pharmaceutica Nv	compostos de indolona e seu uso como moduladores do receptor de ampa
BR122023023802A2 (pt)	2015-04-29	2023-12-26	Janssen Pharmaceutica Nv	Compostos azabenzimidazóis, seu uso como moduladores do receptor de ampa e composições farmacêuticas que os compreendem
KR20170141767A (ko)	2015-04-29	2017-12-26	얀센 파마슈티카 엔.브이.	벤즈이미다졸론 및 벤조티아졸론 화합물 및 ampa 수용체 조절제로서의 이들의 용도
BR112017023038A2 (pt)	2015-04-29	2018-07-03	Janssen Pharmaceutica Nv	imidazopirazinas e pirazolopirimidinas e seu uso como moduladores do receptor ampa

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
IE69677B1 (en) *	1989-12-11	1996-10-02	Neurosearch As	Isatine derivatives their preparation and use
CA2076948C (en) *	1991-08-28	2002-04-16	Frank Watjen	Isatineoxime derivatives, their preparation and use
JP3419539B2 (ja) *	1993-02-17	2003-06-23	中外製薬株式会社	インドリン−２−オン誘導体
US5721230A (en)	1993-05-10	1998-02-24	Hoffmann-La Roche Inc.	Substituted pyrroles
NZ267081A (en)	1993-05-13	1997-11-24	Neurosearch As	Hetero-fused indole and quinoxaline compounds and medicaments thereof
DK81593D0 (da) *	1993-07-07	1993-07-07	Neurosearch As	Nye isatinoximderivater, deres fremstilling og anvendelse
JP3164372B2 (ja) *	1994-09-14	2001-05-08	ノイロサーチアクティーゼルスカブ	融合インドール及びキノキサリン誘導体、その製造および使用
AU687255B2 (en) *	1994-09-14	1998-02-19	Neurosearch A/S	Indole-2,3-dione-3-oxime derivatives, their preparation and use
UA54403C2 (uk) *	1996-10-01	2003-03-17	Н'Юросерч А/С	Похідні індол-2,3-діон-3-оксиму, фармацевтична композиція, спосіб лікування розладу чи захворювання ссавців, у тому числі людини та спосіб одержання похідних індол-2,3-діон-3-оксиму

1997
- 1997-01-10 UA UA98052752A patent/UA54403C2/uk unknown
- 1997-10-01 JP JP51615898A patent/JP3319762B2/ja not_active Expired - Fee Related
- 1997-10-01 PL PL327073A patent/PL193041B1/pl not_active IP Right Cessation
- 1997-10-01 KR KR10-1998-0704103A patent/KR100492052B1/ko not_active Expired - Fee Related
- 1997-10-01 BR BR9706765-2A patent/BR9706765A/pt not_active Application Discontinuation
- 1997-10-01 DK DK97941880T patent/DK0869958T3/da active
- 1997-10-01 NZ NZ330456A patent/NZ330456A/en unknown
- 1997-10-01 PT PT97941880T patent/PT869958E/pt unknown
- 1997-10-01 DE DE69732090T patent/DE69732090T2/de not_active Expired - Lifetime
- 1997-10-01 CA CA002238410A patent/CA2238410C/en not_active Expired - Fee Related
- 1997-10-01 HU HU9901630A patent/HU225145B1/hu not_active IP Right Cessation
- 1997-10-01 TR TR1998/00956T patent/TR199800956T1/xx unknown
- 1997-10-01 CN CN97191602A patent/CN1093859C/zh not_active Expired - Fee Related
- 1997-10-01 US US09/077,554 patent/US6124285A/en not_active Expired - Lifetime
- 1997-10-01 CZ CZ0160698A patent/CZ297938B6/cs not_active IP Right Cessation
- 1997-10-01 AT AT97941880T patent/ATE286052T1/de not_active IP Right Cessation
- 1997-10-01 US US09/956,892 patent/USRE38200E1/en not_active Expired - Fee Related
- 1997-10-01 AU AU43768/97A patent/AU716435B2/en not_active Ceased
- 1997-10-01 SI SI9730698T patent/SI0869958T1/xx unknown
- 1997-10-01 WO PCT/DK1997/000418 patent/WO1998014447A1/en not_active Ceased
- 1997-10-01 EE EE9800144A patent/EE9800144A/xx unknown
- 1997-10-01 EP EP97941880A patent/EP0869958B1/en not_active Expired - Lifetime
- 1997-10-01 RU RU98112237/04A patent/RU2190612C2/ru not_active IP Right Cessation
- 1997-10-01 IL IL12456397A patent/IL124563A/xx not_active IP Right Cessation
- 1997-10-01 SK SK676-98A patent/SK282729B6/sk not_active IP Right Cessation
- 1997-10-01 ES ES97941880T patent/ES2235253T3/es not_active Expired - Lifetime
1998
- 1998-05-18 IS IS4748A patent/IS2123B/xx unknown
- 1998-05-26 BG BG102489A patent/BG63874B1/bg unknown
- 1998-05-29 NO NO19982466A patent/NO310722B1/no not_active IP Right Cessation
2000
- 2000-05-31 US US09/584,117 patent/US6693111B1/en not_active Expired - Fee Related

Also Published As

Publication number	Publication date
DE69732090T2 (de)	2005-12-29
HK1017682A1 (en)	1999-11-26
HU225145B1 (en)	2006-07-28
WO1998014447A1 (en)	1998-04-09
ATE286052T1 (de)	2005-01-15
HUP9901630A2 (hu)	1999-08-30
EP0869958A1 (en)	1998-10-14
NO982466L (no)	1998-07-31
AU716435B2 (en)	2000-02-24
ES2235253T3 (es)	2005-07-01
NO310722B1 (no)	2001-08-20
PL193041B1 (pl)	2007-01-31
CZ160698A3 (cs)	1998-10-14
HUP9901630A3 (en)	2001-11-28
RU2190612C2 (ru)	2002-10-10
US6124285A (en)	2000-09-26
USRE38200E1 (en)	2003-07-22
EE9800144A (et)	1998-10-15
IL124563A (en)	2005-05-17
CN1207100A (zh)	1999-02-03
JP2000501432A (ja)	2000-02-08
SK67698A3 (en)	1998-11-04
CN1093859C (zh)	2002-11-06
KR19990071823A (ko)	1999-09-27
IL124563A0 (en)	1998-12-06
JP3319762B2 (ja)	2002-09-03
MX9804365A (es)	1998-10-31
US6693111B1 (en)	2004-02-17
CZ297938B6 (cs)	2007-05-02
KR100492052B1 (ko)	2005-09-30
TR199800956T1 (xx)	1998-12-21
CA2238410C (en)	2007-06-12
BG102489A (en)	1999-04-30
PL327073A1 (en)	1998-11-23
PT869958E (pt)	2005-05-31
NZ330456A (en)	1998-11-25
AU4376897A (en)	1998-04-24
DK0869958T3 (da)	2005-04-18
EP0869958B1 (en)	2004-12-29
SK282729B6 (sk)	2002-11-06
DE69732090D1 (de)	2005-02-03
NO982466D0 (no)	1998-05-29
UA54403C2 (uk)	2003-03-17
IS4748A (is)	1998-05-18
BR9706765A (pt)	1999-09-14
SI0869958T1 (en)	2005-06-30
BG63874B1 (bg)	2003-04-30
CA2238410A1 (en)	1998-04-09

Publication	Publication Date	Title
IS4748A (is)	1998-05-18	Indól-2,3-díon-3-oxíms afleiður
EA200100970A1 (ru)	2002-04-25	Аминопроизводные как ингибиторы протеазы
ATE157355T1 (de)	1997-09-15	3-benzyliden-1-carbamoyl-2-pyrrolidon-analoga
TW349098B (en)	1999-01-01	Naphthalene derivatives, process for the preparation thereof, and intermediates therefor
HUP0204418A2 (hu)	2003-04-28	NHE-1 inhibitor hatású N-[(helyettesített öttagú, di- vagy triaza-, kétszeresen telítetlen gyűrű)-karbonil]-guanidin-származékok és alkalmazásuk
ES2189234T3 (es)	2003-07-01	Nuevos derivados de taxano.
UY25679A1 (es)	2000-03-31	Derivados de quinolin-2-ona inhibidores de la farnesil proteína transferasa útiles como agentes contra el cáncer
NL980001I1 (nl)	1998-03-02	Therapeutische heterocyclische verbindingen.
DE69924292D1 (de)	2005-04-21	Pyrazol verbindungen und ihre verwendung
BG94282A (bg)	1993-12-24	2,9-дизаместени-4н-пиридо/1,2,-а/пиримидин-4-они
NO305287B1 (no)	1999-05-03	AMPA antagonister
ATE197305T1 (de)	2000-11-15	Endothelin antagonisten
DE59710816D1 (de)	2003-11-06	Neue thiazol-derivate mit phosphodiesterase inhibierender wirkung
ATE302772T1 (de)	2005-09-15	2-(1h-indol-3-yl)-2-oxo-acetamide mit antitumoraler wirkung
YU75394A (sh)	1997-09-30	Anelirani dihidropiridini i njihova primena za pripremanje farmaceutskih preparata
EA199700205A1 (ru)	1998-02-26	Прокинетические оксадиазолы
DE60310928D1 (de)	2007-02-15	Par-2-aktivierendes peptidderivat und pharmazeutische zusammensetzung, in der dieses verwendet wird
AR019390A1 (es)	2002-02-20	Derivados de acidos sulfonilaminofosfinicos y sulfonilaminofosfonicos, procedimiento para su preparacion, compuestos intermediarios, medicamentos, procedimiento para su preparacion y empleo de dichos derivados para la preparacion de un medicamento.
AR036554A1 (es)	2004-09-15	Coniosulfuros y sus derivados, procedimiento para su preparacion y su utilizacion como medicamentos
ES455436A1 (es)	1978-04-16	Procedimiento de preparacion de acidos tienotienilcarbonife-nilalcanoicos.
ATE120749T1 (de)	1995-04-15	(3h,7h>thiazolo(3,4-a>pyridine mit antiasthmatischer und entzündungshemmender wirkung auf die atmungswege.