IS2884B - Kínasólínafleiður - Google Patents

Kínasólínafleiður

Info

Publication number
IS2884B
IS2884B IS8714A IS8714A IS2884B IS 2884 B IS2884 B IS 2884B IS 8714 A IS8714 A IS 8714A IS 8714 A IS8714 A IS 8714A IS 2884 B IS2884 B IS 2884B
Authority
IS
Iceland
Prior art keywords
kínasólínafleiður
Prior art date
Application number
IS8714A
Other languages
English (en)
Other versions
IS8714A (is
Inventor
Nicola Murdoch Heron
Andrew Austen Mortlock
Frederic Henri Jung
Georges Rene Pasquet
Original Assignee
Astrazeneca Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Astrazeneca Ab filed Critical Astrazeneca Ab
Publication of IS8714A publication Critical patent/IS8714A/is
Publication of IS2884B publication Critical patent/IS2884B/is

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/645—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having two nitrogen atoms as the only ring hetero atoms
    • C07F9/6509—Six-membered rings
    • C07F9/6512—Six-membered rings having the nitrogen atoms in positions 1 and 3
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6558—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system
    • C07F9/65583—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system each of the hetero rings containing nitrogen as ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • A61K31/661—Phosphorus acids or esters thereof not having P—C bonds, e.g. fosfosal, dichlorvos, malathion or mevinphos
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6558—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Oncology (AREA)
  • Hematology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
IS8714A 2002-12-24 2008-02-13 Kínasólínafleiður IS2884B (is)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP02293238 2002-12-24
EP03291315 2003-06-02

Publications (2)

Publication Number Publication Date
IS8714A IS8714A (is) 2008-02-13
IS2884B true IS2884B (is) 2014-06-15

Family

ID=32683824

Family Applications (2)

Application Number Title Priority Date Filing Date
IS7948A IS2504B (is) 2002-12-24 2005-07-20 Fosfónóoxýkínasólínafleiður og lyfjafræileg notkun þeirra
IS8714A IS2884B (is) 2002-12-24 2008-02-13 Kínasólínafleiður

Family Applications Before (1)

Application Number Title Priority Date Filing Date
IS7948A IS2504B (is) 2002-12-24 2005-07-20 Fosfónóoxýkínasólínafleiður og lyfjafræileg notkun þeirra

Country Status (29)

Country Link
US (4) US7528121B2 (is)
EP (2) EP1578755B1 (is)
JP (3) JP4422102B2 (is)
KR (1) KR101010299B1 (is)
AR (2) AR042668A1 (is)
AT (2) ATE438644T1 (is)
AU (1) AU2003290313B2 (is)
BR (1) BRPI0317717B8 (is)
CA (1) CA2511613C (is)
CL (1) CL2003002731A1 (is)
CY (2) CY1107775T1 (is)
DE (2) DE60328735D1 (is)
DK (2) DK1578755T3 (is)
ES (2) ES2290529T3 (is)
IL (2) IL169112A (is)
IS (2) IS2504B (is)
MX (1) MXPA05006918A (is)
MY (2) MY147761A (is)
NO (2) NO335193B1 (is)
NZ (1) NZ540698A (is)
PL (2) PL223998B1 (is)
PT (2) PT1847539E (is)
RU (3) RU2350611C1 (is)
SA (1) SA04240504B1 (is)
SI (2) SI1847539T1 (is)
TW (2) TWI336327B (is)
UA (1) UA83814C2 (is)
UY (1) UY28149A1 (is)
WO (1) WO2004058781A1 (is)

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KR20060003351A (ko) * 2003-04-16 2006-01-10 아스트라제네카 아베 화합물
CA2526285A1 (en) * 2003-05-15 2004-12-23 Arqule, Inc. Inhibitors of p38 and methods of using the same
ATE401080T1 (de) * 2003-06-02 2008-08-15 Astrazeneca Ab (3-((chinazolin-4-yl)amino)-1h-pyrazol-1- yl)acetamid derivate und verwandte verbindungen als aurora kinase inhibitoren zur behandlung von proliferativen erkrankungen wie krebs
EP1694686A1 (en) 2003-12-19 2006-08-30 Takeda San Diego, Inc. Kinase inhibitors
WO2006023931A2 (en) 2004-08-18 2006-03-02 Takeda San Diego, Inc. Kinase inhibitors
BRPI0516093A (pt) * 2004-10-12 2008-08-19 Astrazeneca Ab derivado de quinazolina, processo para a preparação do mesmo, composição farmacêutica, uso de um derivado de quinazolina, e, método para tratamento de distúrbios proliferativos celulares em um animal de sanque quente
US20090036474A1 (en) * 2004-10-12 2009-02-05 Patrick Ple Quinazoline derivatives for use against cancer
EP1812439B2 (en) 2004-10-15 2017-12-06 Takeda Pharmaceutical Company Limited Kinase inhibitors
EP2258704A1 (en) * 2004-10-19 2010-12-08 ArQule, Inc. Synthesis of imidazooxazole and imidazothiazole inhibitors of p38 map kinase
US8119655B2 (en) 2005-10-07 2012-02-21 Takeda Pharmaceutical Company Limited Kinase inhibitors
UY30183A1 (es) 2006-03-02 2007-10-31 Astrazeneca Ab Derivados de quinolina
WO2007123892A2 (en) * 2006-04-17 2007-11-01 Arqule Inc. Raf inhibitors and their uses
GB0609621D0 (en) * 2006-05-16 2006-06-21 Astrazeneca Ab Novel co-crystal
GB0609617D0 (en) 2006-05-16 2006-06-21 Astrazeneca Ab Process & intermediate
GB0609619D0 (en) * 2006-05-16 2006-06-21 Astrazeneca Ab Combination
SG158147A1 (en) 2006-10-09 2010-01-29 Takeda Pharmaceutical Kinase inhibitors
WO2009111028A1 (en) * 2008-03-04 2009-09-11 Vitae Pharmaceuticals, Inc. Aurora kinase inhibitors
WO2009114703A2 (en) * 2008-03-12 2009-09-17 Fox Chase Cancer Center Combination therapy for the treatment of cancer
CN102014627B (zh) 2008-04-30 2014-10-29 国家卫生研究院 作为极光激酶抑制剂的稠合双环嘧啶化合物
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EP2361254A1 (en) * 2008-12-05 2011-08-31 ArQule, Inc. Raf inhibitors and their uses
BRPI0923504A2 (pt) 2008-12-11 2020-05-26 Axcentua Pharmaceuticals Ab Formas cristalinas de genisteína.
US7863325B2 (en) 2008-12-11 2011-01-04 Axcentua Pharmaceuticals Ab Crystalline genistein sodium salt dihydrate
RU2535032C2 (ru) 2008-12-22 2014-12-10 Милленниум Фармасьютикалз, Инк. Сочетание ингибиторов аврора киназы и анти-cd 20 антител
US9604963B2 (en) 2011-03-04 2017-03-28 Glaxosmithkline Intellectual Property Development Limited Amino-quinolines as kinase inhibitors
TWI547494B (zh) 2011-08-18 2016-09-01 葛蘭素史克智慧財產發展有限公司 作為激酶抑制劑之胺基喹唑啉類
AR092529A1 (es) 2012-09-13 2015-04-22 Glaxosmithkline Llc Compuesto de aminoquinazolina, composicion farmaceutica que lo comprende y uso de dicho compuesto para la preparacion de un medicamento
TW201425307A (zh) 2012-09-13 2014-07-01 Glaxosmithkline Llc 作為激酶抑制劑之胺基－喹啉類
EP2956138B1 (en) 2013-02-15 2022-06-22 Kala Pharmaceuticals, Inc. Therapeutic compounds and uses thereof
MX368903B (es) 2013-02-20 2019-10-21 Kala Pharmaceuticals Inc Compuestos terapéuticos y sus usos en el tratamiento de enfermedades proliferativas.
US9688688B2 (en) 2013-02-20 2017-06-27 Kala Pharmaceuticals, Inc. Crystalline forms of 4-((4-((4-fluoro-2-methyl-1H-indol-5-yl)oxy)-6-methoxyquinazolin-7-yl)oxy)-1-(2-oxa-7-azaspiro[3.5]nonan-7-yl)butan-1-one and uses thereof
CA2902132C (en) 2013-02-21 2020-09-22 Glaxosmithkline Intellectual Property Development Limited Quinazolines as kinase inhibitors
RS60093B1 (sr) * 2013-09-16 2020-05-29 Astrazeneca Ab Terapeutske polimerne nanočestice i postupci njihove pripreme i primene
US9458169B2 (en) 2013-11-01 2016-10-04 Kala Pharmaceuticals, Inc. Crystalline forms of therapeutic compounds and uses thereof
US9890173B2 (en) 2013-11-01 2018-02-13 Kala Pharmaceuticals, Inc. Crystalline forms of therapeutic compounds and uses thereof
EP3076963A4 (en) 2013-12-06 2017-09-13 Millennium Pharmaceuticals, Inc. Combination of aurora kinase inhibitors and anti-cd30 antibodies
WO2017015316A1 (en) 2015-07-21 2017-01-26 Millennium Pharmaceuticals, Inc. Administration of aurora kinase inhibitor and chemotherapeutic agents
AU2017324713B2 (en) 2016-09-08 2020-08-13 KALA BIO, Inc. Crystalline forms of therapeutic compounds and uses thereof
US10336767B2 (en) 2016-09-08 2019-07-02 Kala Pharmaceuticals, Inc. Crystalline forms of therapeutic compounds and uses thereof
EP3509423A4 (en) 2016-09-08 2020-05-13 Kala Pharmaceuticals, Inc. CRYSTALLINE FORMS OF THERAPEUTIC COMPOUNDS AND USES THEREOF
KR20240151869A (ko) 2017-09-08 2024-10-18 더 보드 어브 트러스티스 어브 더 리랜드 스탠포드 주니어 유니버시티 Enpp1 저해제 및 암의 치료용의 이의 용도
WO2019195658A1 (en) 2018-04-05 2019-10-10 Dana-Farber Cancer Institute, Inc. Sting levels as a biomarker for cancer immunotherapy
WO2020049208A1 (es) 2018-09-09 2020-03-12 Fundacio Privada Institut De Recerca De La Sida - Caixa Aurora cinasa como diana para tratar, prevenir o curar una infección por vih o sida
US20220305048A1 (en) 2019-08-26 2022-09-29 Dana-Farber Cancer Institute, Inc. Use of heparin to promote type 1 interferon signaling
WO2021094379A1 (en) 2019-11-12 2021-05-20 Astrazeneca Ab Epidermal growth factor receptor tyrosine kinase inhibitors for the treatment of cancer
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WO2021260582A1 (en) 2020-06-24 2021-12-30 Astrazeneca Uk Limited Combination of antibody-drug conjugate and aurora b inhibitor
WO2022192139A1 (en) 2021-03-10 2022-09-15 Astrazeneca Ab Aurora kinase b inhibitors for use for treating cancer

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SI1847539T1 (sl) * 2002-12-24 2010-01-29 Astrazeneca Ab Kinazolinski derivati
KR20060003351A (ko) * 2003-04-16 2006-01-10 아스트라제네카 아베 화합물

Also Published As

Publication number Publication date
US20100069412A1 (en) 2010-03-18
EP1847539A1 (en) 2007-10-24
EP1578755A1 (en) 2005-09-28
DE60328735D1 (de) 2009-09-17
PL221490B1 (pl) 2016-04-29
IL185176A0 (en) 2007-12-03
BRPI0317717B8 (pt) 2021-05-25
IL169112A (en) 2010-12-30
IL185176A (en) 2011-10-31
SI1847539T1 (sl) 2010-01-29
EP1847539B1 (en) 2009-08-05
CY1109479T1 (el) 2014-08-13
JP2006512418A (ja) 2006-04-13
UY28149A1 (es) 2004-07-30
ATE438644T1 (de) 2009-08-15
IS7948A (is) 2005-07-20
JP2009046514A (ja) 2009-03-05
DK1578755T3 (da) 2007-11-12
MXPA05006918A (es) 2005-08-18
NO20052855D0 (no) 2005-06-13
NO20052855L (no) 2005-08-03
RU2007121850A (ru) 2008-12-20
JP4422102B2 (ja) 2010-02-24
PL377680A1 (pl) 2006-02-06
IL169112A0 (en) 2009-02-11
UA83814C2 (ru) 2008-08-26
SA04240504B1 (ar) 2008-04-01
MY147761A (en) 2013-01-31
TW201102369A (en) 2011-01-16
DE60315892D1 (de) 2007-10-04
ES2329623T3 (es) 2009-11-27
HK1111417A1 (en) 2008-08-08
CY1107775T1 (el) 2013-06-19
PL223998B1 (pl) 2016-11-30
NZ540698A (en) 2008-05-30
DK1847539T3 (da) 2009-11-09
RU2350611C1 (ru) 2009-03-27
US8268841B2 (en) 2012-09-18
KR101010299B1 (ko) 2011-01-25
CL2003002731A1 (es) 2005-01-07
US7528121B2 (en) 2009-05-05
PT1578755E (pt) 2007-10-19
JP2007326862A (ja) 2007-12-20
JP4906608B2 (ja) 2012-03-28
CA2511613C (en) 2012-10-02
SI1578755T1 (sl) 2007-12-31
PT1847539E (pt) 2009-10-06
AU2003290313A1 (en) 2004-07-22
TWI336327B (en) 2011-01-21
IS8714A (is) 2008-02-13
NO335193B1 (no) 2014-10-20
TWI393710B (zh) 2013-04-21
DE60315892T2 (de) 2008-08-14
MY136174A (en) 2008-08-29
BR0317717A (pt) 2005-11-22
US20140162984A1 (en) 2014-06-12
RU2357971C2 (ru) 2009-06-10
US9567358B2 (en) 2017-02-14
NO20131444L (no) 2005-08-03
SA04240504A (ar) 2005-12-03
TW200510342A (en) 2005-03-16
AU2003290313B2 (en) 2007-05-10
US20150307534A1 (en) 2015-10-29
JP4503090B2 (ja) 2010-07-14
RU2005123485A (ru) 2006-03-10
US20060116357A1 (en) 2006-06-01
HK1080481A1 (en) 2006-04-28
ATE370958T1 (de) 2007-09-15
EP1578755B1 (en) 2007-08-22
PL412704A1 (pl) 2015-10-12
AR042668A1 (es) 2005-06-29
AR057753A2 (es) 2007-12-19
NO335446B1 (no) 2014-12-15
KR20050088333A (ko) 2005-09-05
CA2511613A1 (en) 2004-07-15
WO2004058781A1 (en) 2004-07-15
BRPI0317717B1 (pt) 2017-12-19
IS2504B (is) 2009-04-15
ES2290529T3 (es) 2008-02-16
US9018191B2 (en) 2015-04-28

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