IS2986B - Nýr tilbúinn fjölræsivaki til að nota við meðferð á manneskjum - Google Patents

Nýr tilbúinn fjölræsivaki til að nota við meðferð á manneskjum

Info

Publication number
IS2986B
IS2986B IS7083A IS7083A IS2986B IS 2986 B IS2986 B IS 2986B IS 7083 A IS7083 A IS 7083A IS 7083 A IS7083 A IS 7083A IS 2986 B IS2986 B IS 2986B
Authority
IS
Iceland
Prior art keywords
human therapy
new synthetic
synthetic multilayer
multilayer agent
agent
Prior art date
Application number
IS7083A
Other languages
English (en)
Other versions
IS7083A (is
Inventor
Forsberg Göran
Erlandsson Eva
Antonsson Per
Walse Björn
Original Assignee
Active Biotech Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Active Biotech Ab filed Critical Active Biotech Ab
Publication of IS7083A publication Critical patent/IS7083A/is
Publication of IS2986B publication Critical patent/IS2986B/is

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K19/00—Hybrid peptides, i.e. peptides covalently bound to nucleic acids, or non-covalently bound protein-protein complexes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/305—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Micrococcaceae (F)
    • C07K14/31—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Micrococcaceae (F) from Staphylococcus (G)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
    • A61K47/6835—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site
    • A61K47/6851—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site the antibody targeting a determinant of a tumour cell
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/315—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Streptococcus (G), e.g. Enterococci
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
    • H—ELECTRICITY
    • H04—ELECTRIC COMMUNICATION TECHNIQUE
    • H04L—TRANSMISSION OF DIGITAL INFORMATION, e.g. TELEGRAPHIC COMMUNICATION
    • H04L51/00—User-to-user messaging in packet-switching networks, transmitted according to store-and-forward or real-time protocols, e.g. e-mail
    • H04L51/06—Message adaptation to terminal or network requirements
    • H04L51/063—Content adaptation, e.g. replacement of unsuitable content
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • H—ELECTRICITY
    • H04—ELECTRIC COMMUNICATION TECHNIQUE
    • H04L—TRANSMISSION OF DIGITAL INFORMATION, e.g. TELEGRAPHIC COMMUNICATION
    • H04L51/00—User-to-user messaging in packet-switching networks, transmitted according to store-and-forward or real-time protocols, e.g. e-mail
    • H04L51/58—Message adaptation for wireless communication

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Immunology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Engineering & Computer Science (AREA)
  • Cell Biology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Computer Networks & Wireless Communication (AREA)
  • Signal Processing (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
IS7083A 2001-06-28 2003-12-18 Nýr tilbúinn fjölræsivaki til að nota við meðferð á manneskjum IS2986B (is)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
SE0102327A SE0102327D0 (sv) 2001-06-28 2001-06-28 A novel engineered superantigen for human therapy
PCT/SE2002/001188 WO2003002143A1 (en) 2001-06-28 2002-06-19 A novel engineered superantigen for human therapy

Publications (2)

Publication Number Publication Date
IS7083A IS7083A (is) 2003-12-18
IS2986B true IS2986B (is) 2017-09-15

Family

ID=20284677

Family Applications (1)

Application Number Title Priority Date Filing Date
IS7083A IS2986B (is) 2001-06-28 2003-12-18 Nýr tilbúinn fjölræsivaki til að nota við meðferð á manneskjum

Country Status (27)

Country Link
US (3) US7125554B2 (is)
EP (1) EP1406657B1 (is)
JP (1) JP4523773B2 (is)
KR (1) KR100961054B1 (is)
CN (1) CN1522156B (is)
BG (1) BG66321B1 (is)
BR (1) BRPI0210568B8 (is)
CA (1) CA2451847C (is)
CZ (1) CZ307180B6 (is)
DK (1) DK1406657T3 (is)
EE (1) EE05475B1 (is)
ES (1) ES2564041T3 (is)
HR (1) HRP20031054B1 (is)
HU (1) HUP0400313A3 (is)
IL (2) IL159562A0 (is)
IS (1) IS2986B (is)
MX (1) MXPA03011761A (is)
NO (1) NO333676B1 (is)
NZ (1) NZ529827A (is)
PL (1) PL216516B1 (is)
RS (1) RS52581B (is)
RU (1) RU2307837C2 (is)
SE (1) SE0102327D0 (is)
SK (1) SK16112003A3 (is)
UA (1) UA85993C2 (is)
WO (1) WO2003002143A1 (is)
ZA (1) ZA200309150B (is)

Families Citing this family (40)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE9402430L (sv) * 1994-07-11 1996-01-12 Pharmacia Ab Konjugat mellan modifierat superantigen och en målsökande förening samt användning av konjugaten
TW517061B (en) * 1996-03-29 2003-01-11 Pharmacia & Amp Upjohn Ab Modified/chimeric superantigens and their use
BR9815493A (pt) * 1997-07-21 2000-10-31 Pharmacia & Upjohn Ab Citólise dirigida de células-alvo, agentes e composições que causam citólise, e compostos que podem ser usados para produzir os agentes
US7491402B2 (en) * 1998-12-24 2009-02-17 Auckland Uniservices Limited Superantigens SMEZ-2, SPE-G, SPE-H and SPE-J and uses thereof
US20040214783A1 (en) * 2002-05-08 2004-10-28 Terman David S. Compositions and methods for treatment of neoplastic disease
SE0102327D0 (sv) 2001-06-28 2001-06-28 Active Biotech Ab A novel engineered superantigen for human therapy
GB0126378D0 (en) * 2001-11-02 2002-01-02 Oxford Biomedica Ltd Antigen
MXPA05001933A (es) * 2002-08-19 2005-04-28 Genentech Inc Composiciones y metodos para el diagnostico y tratamiento de tumores.
DE602004026039D1 (de) * 2003-03-28 2010-04-29 Kowa Co Seb-modifikation und diese enthaltendes vorbeugendes mittel/heilmittel gegen krankheiten mit einer immunanomalität
SE0402025D0 (sv) * 2004-08-13 2004-08-13 Active Biotech Ab Treatment of hyperproliferative disease with superantigens in combination with another anticancer agent
EP1812574A2 (en) * 2004-11-18 2007-08-01 Avidex Limited Soluble bifunctional proteins
GB0427585D0 (en) * 2004-12-16 2005-01-19 Avidex Ltd Assay
CN101641010A (zh) * 2007-01-26 2010-02-03 路易斯维尔大学研究基金会公司 用作疫苗的外来体组分的修饰
GB0822836D0 (en) * 2008-12-15 2009-01-21 Oxford Biomedica Ltd Method
WO2012019168A2 (en) 2010-08-06 2012-02-09 Moderna Therapeutics, Inc. Engineered nucleic acids and methods of use thereof
EP2625189B1 (en) 2010-10-01 2018-06-27 ModernaTX, Inc. Engineered nucleic acids and methods of use thereof
AU2012236099A1 (en) 2011-03-31 2013-10-03 Moderna Therapeutics, Inc. Delivery and formulation of engineered nucleic acids
US9464124B2 (en) 2011-09-12 2016-10-11 Moderna Therapeutics, Inc. Engineered nucleic acids and methods of use thereof
CA2846432A1 (en) 2011-09-23 2013-03-28 Amgen Research (Munich) Gmbh Bispecific binding molecules for 5t4 and cd3
DE19216461T1 (de) 2011-10-03 2021-10-07 Modernatx, Inc. Modifizierte nukleoside, nukleotide und nukleinsäuren und verwendungen davon
CN102516392B (zh) * 2011-11-25 2014-05-28 孙嘉琳 一种癌靶向超抗原融合蛋白及制备方法及用途
CA3018046A1 (en) 2011-12-16 2013-06-20 Moderna Therapeutics, Inc. Modified nucleoside, nucleotide, and nucleic acid compositions
WO2013151665A2 (en) 2012-04-02 2013-10-10 modeRNA Therapeutics Modified polynucleotides for the production of proteins associated with human disease
US9254311B2 (en) 2012-04-02 2016-02-09 Moderna Therapeutics, Inc. Modified polynucleotides for the production of proteins
US9283287B2 (en) 2012-04-02 2016-03-15 Moderna Therapeutics, Inc. Modified polynucleotides for the production of nuclear proteins
US9572897B2 (en) 2012-04-02 2017-02-21 Modernatx, Inc. Modified polynucleotides for the production of cytoplasmic and cytoskeletal proteins
PL2922554T3 (pl) 2012-11-26 2022-06-20 Modernatx, Inc. Na zmodyfikowany na końcach
CN103965302B (zh) * 2013-01-29 2019-05-28 军事科学院军事医学研究院微生物流行病研究所 一种重组超抗原seb突变体，其制备方法及应用
US8980864B2 (en) 2013-03-15 2015-03-17 Moderna Therapeutics, Inc. Compositions and methods of altering cholesterol levels
WO2015048744A2 (en) 2013-09-30 2015-04-02 Moderna Therapeutics, Inc. Polynucleotides encoding immune modulating polypeptides
EP3052521A1 (en) 2013-10-03 2016-08-10 Moderna Therapeutics, Inc. Polynucleotides encoding low density lipoprotein receptor
KR20250071286A (ko) 2016-01-10 2025-05-21 네오티엑스 테라퓨틱스 엘티디. 면역강화제에 의해 증진되는 초항원 매개된 암 면역요법
JP7303791B2 (ja) 2017-07-27 2023-07-05 アブヴァク インコーポレイテッド スーパー抗原トキソイドに由来する融合ペプチドを含む免疫原性組成物
US12514914B2 (en) 2019-05-14 2026-01-06 The University Of Chicago Methods and compositions comprising Staphylococcus protein a (SpA) variants
CA3139899A1 (en) 2019-05-15 2020-11-19 Neotx Therapeutics Ltd. Cancer treatment
CN115484978A (zh) 2020-03-05 2022-12-16 尼奥克斯医疗有限公司 使用免疫细胞治疗癌症的方法和组合物
US20230114276A1 (en) * 2020-03-06 2023-04-13 Stichting Het Nederlands Kanker Instituut-Antoni van Leeuwenhoek Ziekenhuis Modulating anti-tumor immunity
IL299950A (en) * 2020-07-20 2023-03-01 Neotx Therapeutics Ltd Superantigen conjugate for use in methods and compositions for the treatment of cancer
WO2022067255A2 (en) * 2020-09-28 2022-03-31 Janssen Pharmaceuticals, Inc. Variant staphylococcus aureus luka and lukb polypeptides and vaccine compositions
CA3258344A1 (en) 2022-06-07 2023-12-14 Actinium Pharmaceuticals, Inc. CHELETARIANS AND BIFUNCTIONAL CONJUGATES

Family Cites Families (64)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4554101A (en) 1981-01-09 1985-11-19 New York Blood Center, Inc. Identification and preparation of epitopes on antigens and allergens on the basis of hydrophilicity
US4596792A (en) 1981-09-04 1986-06-24 The Regents Of The University Of California Safe vaccine for hepatitis containing polymerized serum albumin
JPS5938877A (ja) 1982-08-30 1984-03-02 Musashi Eng Kk 紙葉判別方法
US4599230A (en) 1984-03-09 1986-07-08 Scripps Clinic And Research Foundation Synthetic hepatitis B virus vaccine including both T cell and B cell determinants
US4599231A (en) 1984-03-09 1986-07-08 Scripps Clinic And Research Foundation Synthetic hepatitis B virus vaccine including both T cell and B cell determinants
US5221605A (en) 1984-10-31 1993-06-22 Igen, Inc. Luminescent metal chelate labels and means for detection
US5238808A (en) 1984-10-31 1993-08-24 Igen, Inc. Luminescent metal chelate labels and means for detection
US4608251A (en) 1984-11-09 1986-08-26 Pitman-Moore, Inc. LHRH analogues useful in stimulating anti-LHRH antibodies and vaccines containing such analogues
US4601903A (en) 1985-05-01 1986-07-22 The United States Of America As Represented By The Department Of Health And Human Services Vaccine against Neisseria meningitidis Group B serotype 2 invasive disease
US5284760A (en) 1989-04-03 1994-02-08 Feinstone Stephen M Techniques for producing site-directed mutagenesis of cloned DNA
US6042837A (en) 1989-09-20 2000-03-28 Kalland; Terje Methods of staphylococcal enterotoxin directed cell-mediated cytotoxicity (SDCC)
US6126945A (en) 1989-10-03 2000-10-03 Pharmacia Ab Tumor killing effects of enterotoxins, superantigens, and related compounds
US5728388A (en) 1989-10-03 1998-03-17 Terman; David S. Method of cancer treatment
EP1129717B2 (en) 1990-01-17 2013-03-06 TERMAN, David S. Use of homologues of staphylococcal enterotoxins for cancer treatment
US5220007A (en) 1990-02-15 1993-06-15 The Worcester Foundation For Experimental Biology Method of site-specific alteration of RNA and production of encoded polypeptides
US5149797A (en) 1990-02-15 1992-09-22 The Worcester Foundation For Experimental Biology Method of site-specific alteration of rna and production of encoded polypeptides
CA2079802C (en) 1990-04-05 2001-09-18 Roberto Crea Walk-through mutagenesis
US6197299B1 (en) 1990-07-20 2001-03-06 Pharmacia & Upjohn Ab Antibody conjugates
US5858363A (en) 1990-07-20 1999-01-12 Pharmacia & Upjohn Ab Target specific antibody-superantigen conjugates and their preparation
WO1993024136A1 (en) 1991-01-17 1993-12-09 Terman David S Tumor killing effects of enterotoxins, superantigens, and related compounds
WO1992013878A2 (en) 1991-02-07 1992-08-20 Board Of Trustees Of The University Of Illinois Conformationally restricted mimetics of beta turns and beta bulges and peptides containing the same
US5475085A (en) 1991-02-07 1995-12-12 Molecumetics, Ltd. Conformationally restricted mimetics of beta turns and beta bulges and peptides containing the same
JP3398957B2 (ja) 1991-12-24 2003-04-21 ザ・プレジデント・アンド・フエローズ・オブ・ハーバード・カレツジ Ｄｎａの特定部位の突然変異誘発
US5389514A (en) 1992-08-28 1995-02-14 Fox Chase Cancer Center Method for specifically altering the nucleotide sequence of RNA
US5545716A (en) 1992-09-08 1996-08-13 University Of Florida Superantigen agonist and antagonist peptides
US5446128A (en) 1993-06-18 1995-08-29 The Board Of Trustees Of The University Of Illinois Alpha-helix mimetics and methods relating thereto
US5519114A (en) 1993-10-29 1996-05-21 University Of Florida Research Foundation, Inc. Retroviral superantigens, superantigen peptides, and methods of use
SE9402430L (sv) 1994-07-11 1996-01-12 Pharmacia Ab Konjugat mellan modifierat superantigen och en målsökande förening samt användning av konjugaten
US5935568A (en) 1995-05-18 1999-08-10 National Jewish Medical & Research Center Gene therapy for effector cell regulation
JPH11514844A (ja) 1995-06-07 1999-12-21 リージェンツ オブ ザ ユニバーシティー オブ ミネソタ 連鎖球菌毒素ａの突然変異体および使用方法
US5929237A (en) 1995-10-27 1999-07-27 Molecumetics Ltd. Reverse-turn mimetics and methods relating thereto
US5840833A (en) 1995-10-27 1998-11-24 Molecumetics, Ltd Alpha-helix mimetics and methods relating thereto
US5789166A (en) 1995-12-08 1998-08-04 Stratagene Circular site-directed mutagenesis
SE9601245D0 (sv) * 1996-03-29 1996-03-29 Pharmacia Ab Chimeric superantigens and their use
WO1997036032A1 (de) 1996-03-27 1997-10-02 Zellweger Luwa Ag Verfahren und vorrichtung zur qualitätsüberwachung von garnen
WO1997036614A1 (en) 1996-03-29 1997-10-09 Terman David S Polymerized staphylococcal protein a for treatment of diseases
TW517061B (en) 1996-03-29 2003-01-11 Pharmacia & Amp Upjohn Ab Modified/chimeric superantigens and their use
US6774218B2 (en) 1996-12-06 2004-08-10 Regents Of The University Of Minnesota Mutants of streptococcal toxin C and methods of use
CN1211487C (zh) 1996-12-06 2005-07-20 明尼苏达大学董事会 链球菌毒素a突变体及其使用方法
CN1148449C (zh) 1996-12-06 2004-05-05 明尼苏达大学董事会 链球菌毒素c突变体及其使用方法
US6340461B1 (en) 1996-12-17 2002-01-22 David Stephen Terman Superantigen based methods and compositions for treatment of diseases
IL119938A (en) 1996-12-30 2005-08-31 Yissum Res Dev Co Peptides capable of eliciting protective immunity against toxic shock induced by pyrogenic exotoxins or of antagonizing toxin-mediated activation of t cells
US6713284B2 (en) 1997-06-25 2004-03-30 The United States Of America As Represented By The Secretary Of The Army Bacterial superantigen vaccines
US7087235B2 (en) 1997-06-25 2006-08-08 The United States Of America As Represented By The Secretary Of The Army Fusion protein of streptococcal pyrogenic exotoxins
BR9815493A (pt) 1997-07-21 2000-10-31 Pharmacia & Upjohn Ab Citólise dirigida de células-alvo, agentes e composições que causam citólise, e compostos que podem ser usados para produzir os agentes
RU2115429C1 (ru) * 1997-07-22 1998-07-20 Закрытое акционерное общество "Фосфосорб" Рекомбинантный иммунотоксин на основе дифтерийного токсина и интерлейкина-2 (дт 482-il2) и способ его получения
WO1999036433A2 (en) 1998-01-14 1999-07-22 Morphogenesis, Inc. Materials and methods for treating oncological disease
CA2337966A1 (en) 1998-07-10 2000-01-20 U.S. Medical Research Institute Of Infectious Diseases Vaccine against staphylococcus intoxication
US20040214783A1 (en) * 2002-05-08 2004-10-28 Terman David S. Compositions and methods for treatment of neoplastic disease
US20020177551A1 (en) 2000-05-31 2002-11-28 Terman David S. Compositions and methods for treatment of neoplastic disease
US20050112141A1 (en) * 2000-08-30 2005-05-26 Terman David S. Compositions and methods for treatment of neoplastic disease
SE9903895D0 (sv) 1999-10-28 1999-10-28 Active Biotech Ab Novel compounds
JP2003515323A (ja) 1999-11-18 2003-05-07 オックスフォード バイオメディカ（ユーケイ）リミテッド 抗 体
US20030157113A1 (en) 1999-12-28 2003-08-21 Terman David S. Compositions and methods for treatment of neoplastic disease
US20010046501A1 (en) 2000-03-14 2001-11-29 Johnson Howard M. Superantigen enhancement of specific immune responses
JP4283430B2 (ja) 2000-09-26 2009-06-24 株式会社カネカ エンテロトキシンの吸着材、吸着除去方法および吸着器
JP2004515479A (ja) 2000-12-04 2004-05-27 オークランド ユニサーヴィスィズ リミテッド 免疫調節性構築物およびその使用
CN1369550A (zh) 2001-02-16 2002-09-18 沈阳协合集团有限公司 一种金黄色葡萄球菌的培养物及其制备方法
SE0102327D0 (sv) * 2001-06-28 2001-06-28 Active Biotech Ab A novel engineered superantigen for human therapy
US20050240009A1 (en) * 2002-08-21 2005-10-27 Carr Francis J T-cell epitopes in staphylococcal enterotoxin b
WO2006004620A2 (en) * 2004-06-29 2006-01-12 Terman David S Enterotoxin gene cluster (egc) superantigens to treat malignant disease
US20060005711A1 (en) 2004-07-07 2006-01-12 Andrew Olefson Replaceable filter for a vehicle air conditioning system adapted to scent air
SE0402025D0 (sv) 2004-08-13 2004-08-13 Active Biotech Ab Treatment of hyperproliferative disease with superantigens in combination with another anticancer agent
US20070280905A1 (en) * 2006-06-01 2007-12-06 Shulin Li Prognosis and Systemic Therapy for Treating Malignancy

Also Published As

Publication number Publication date
CN1522156B (zh) 2012-10-10
US20030039655A1 (en) 2003-02-27
RU2004102199A (ru) 2005-05-20
IL159562A (en) 2010-12-30
CA2451847C (en) 2012-10-16
SK16112003A3 (en) 2004-11-03
HK1067980A1 (en) 2005-04-22
KR20040015264A (ko) 2004-02-18
IS7083A (is) 2003-12-18
ES2564041T3 (es) 2016-03-17
EP1406657A1 (en) 2004-04-14
YU101503A (en) 2006-05-25
US20100111978A1 (en) 2010-05-06
HRP20031054A2 (en) 2004-04-30
PL368048A1 (en) 2005-03-21
SE0102327D0 (sv) 2001-06-28
EE05475B1 (et) 2011-10-17
JP2005503362A (ja) 2005-02-03
KR100961054B1 (ko) 2010-06-01
BG108499A (en) 2005-03-31
BR0210568A (pt) 2004-08-03
MXPA03011761A (es) 2004-04-02
BG66321B1 (bg) 2013-05-31
BRPI0210568B8 (pt) 2021-05-25
US20070082001A1 (en) 2007-04-12
WO2003002143A1 (en) 2003-01-09
HRP20031054B1 (hr) 2016-12-30
EP1406657B1 (en) 2015-12-30
CZ307180B6 (cs) 2018-02-28
NO20035773L (no) 2004-02-27
CA2451847A1 (en) 2003-01-09
NO333676B1 (no) 2013-08-05
HUP0400313A3 (en) 2006-02-28
BRPI0210568B1 (pt) 2020-10-13
IL159562A0 (en) 2004-06-01
PL216516B1 (pl) 2014-04-30
HUP0400313A2 (hu) 2004-09-28
CN1522156A (zh) 2004-08-18
US7615225B2 (en) 2009-11-10
DK1406657T3 (en) 2016-03-07
RU2307837C2 (ru) 2007-10-10
RS52581B (sr) 2013-04-30
ZA200309150B (en) 2005-01-26
US7125554B2 (en) 2006-10-24
NZ529827A (en) 2005-06-24
CZ20033559A3 (en) 2004-06-16
UA85993C2 (ru) 2009-03-25
JP4523773B2 (ja) 2010-08-11
EE200400037A (et) 2004-04-15

Similar Documents

Publication Publication Date Title
IS2986B (is) Nýr tilbúinn fjölræsivaki til að nota við meðferð á manneskjum
EE04528B1 (et) Teraapias kasutatavad spirofuropridiinide aralklamiinid
DE60324099D1 (de) Arzneistoffhaltiger tampon
IS8267A (is) [1,8]naftýridín-2-ón og tengd efnasambönd til notkunar við meðferð á geðklofa
EP1494530A4 (en) COMBINATION THERAPY USING TREFLE LEAF PEPTIDES
DK1513836T3 (da) Piperazinylacylpiperidinderivater, fremstilling og terapeutisk anvendelse heraf
IS7444A (is) Morfólínýl-þvagefna afleiður til notkunar við meðhöndlun á bólguvaldandi sjúkdómum
EP1570270A4 (en) THERAPEUTIC BIOKON JUGATE
IS7577A (is) Arómatísk súlfón og læknisfræðileg notkun þeirra
DK1556382T3 (da) 3-Phenylpyridoindolderivater, fremstilling og terapeutisk anvendelse deraf
IS7275A (is) Samsetning fyrir hollegg og notkun á henni
NO20050689L (no) Terapeutisk anvendelse
DE60222664D1 (de) Hautbehandlungsmittel
DK1496918T3 (da) Anvendelse af natriummetaarsenit til behandling af tumorer
DK1660532T3 (da) Fusionspolypeptider, og anvendelse deraf i antivaskulær tumorterapi
IS2487B (is) Asýloxýpýrrólidín afleiður, framleiðsla og meðferðarnotkun þar á
ES1052847Y (es) Dispositivo para ducha e hidromasaje.
EE200300025A (et) CRF2 ligandid kasutamiseks kombineeritud ravis
EP1483407A4 (en) THERAPY AND DIAGNOSTIC PROCEDURES
AU2003215767A8 (en) Devices for use in medicine
IS8391A (is) Notkun á síramesíni við meðhöndlun á krabbameini
FI20012565A0 (fi) Immunosuppressiivisessa terapiassa käytettäviä tuotteita
ES1048917Y (es) Unidad movil perfeccionada para peluqueria y estetica.
SE0201783D0 (sv) Medical use
SE0202256D0 (sv) Novel sequence information and methods for its use in diagnosis and therapy XVI