IS4041A - Hydroxamicsýruafleiður, aðferð til framleiðslu þeirra og notkunar sem lyfja - Google Patents

Hydroxamicsýruafleiður, aðferð til framleiðslu þeirra og notkunar sem lyfja

Info

Publication number: IS4041A
Authority: IS; Iceland
Prior art keywords: alkyl; atom; amino acid; carbamoyl; oxo
Prior art date: 1992-06-25

Application number

IS4041A

Other languages

English (en)

Inventor

John Broadhurst Michael

Anthony Brown Paul

Henry Johnson William

Lawton Geoffrey

Original Assignee

F. Hoffmann-La Roche Ag

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1992-06-25

Filing date

1993-06-24

Publication date

1993-12-26

1992-06-25 Priority claimed from GB929213473A external-priority patent/GB9213473D0/en

1993-06-24 Application filed by F. Hoffmann-La Roche Ag filed Critical F. Hoffmann-La Roche Ag

1993-12-26 Publication of IS4041A publication Critical patent/IS4041A/is

Links

NEAQRZUHTPSBBM-UHFFFAOYSA-N 2-hydroxy-3,3-dimethyl-7-nitro-4h-isoquinolin-1-one Chemical compound C1=C([N+]([O-])=O)C=C2C(=O)N(O)C(C)(C)CC2=C1 NEAQRZUHTPSBBM-UHFFFAOYSA-N 0.000 title abstract 2
239000002253 acid Substances 0.000 title abstract 2
238000000034 method Methods 0.000 title abstract 2
239000003814 drug Substances 0.000 title 1
238000004519 manufacturing process Methods 0.000 title 1
125000000217 alkyl group Chemical group 0.000 abstract 6
229910052739 hydrogen Inorganic materials 0.000 abstract 4
239000001257 hydrogen Substances 0.000 abstract 4
125000004433 nitrogen atom Chemical group N* 0.000 abstract 4
UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 3
150000001371 alpha-amino acids Chemical class 0.000 abstract 2
235000008206 alpha-amino acids Nutrition 0.000 abstract 2
125000003917 carbamoyl group Chemical group [H]N([H])C(*)=O 0.000 abstract 2
125000004432 carbon atom Chemical group C* 0.000 abstract 2
125000000524 functional group Chemical group 0.000 abstract 2
201000008482 osteoarthritis Diseases 0.000 abstract 2
201000001320 Atherosclerosis Diseases 0.000 abstract 1
206010028980 Neoplasm Diseases 0.000 abstract 1
125000003545 alkoxy group Chemical group 0.000 abstract 1
235000001014 amino acid Nutrition 0.000 abstract 1
150000001413 amino acids Chemical class 0.000 abstract 1
-1 benzyloxyamino compound Chemical class 0.000 abstract 1
125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 1
125000005842 heteroatom Chemical group 0.000 abstract 1
150000002431 hydrogen Chemical class 0.000 abstract 1
239000003771 matrix metalloproteinase inhibitor Substances 0.000 abstract 1
229940121386 matrix metalloproteinase inhibitor Drugs 0.000 abstract 1
201000006417 multiple sclerosis Diseases 0.000 abstract 1
230000002265 prevention Effects 0.000 abstract 1
206010039073 rheumatoid arthritis Diseases 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/44—Iso-indoles; Hydrogenated iso-indoles
- C07D209/48—Iso-indoles; Hydrogenated iso-indoles with oxygen atoms in positions 1 and 3, e.g. phthalimide
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C259/00—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups
- C07C259/04—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups without replacement of the other oxygen atom of the carboxyl group, e.g. hydroxamic acids
- C07C259/06—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups without replacement of the other oxygen atom of the carboxyl group, e.g. hydroxamic acids having carbon atoms of hydroxamic groups bound to hydrogen atoms or to acyclic carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D233/72—Two oxygen atoms, e.g. hydantoin
- C07D233/74—Two oxygen atoms, e.g. hydantoin with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to other ring members
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06008—Dipeptides with the first amino acid being neutral
- C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
- C07K5/06026—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atom, i.e. Gly or Ala
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06008—Dipeptides with the first amino acid being neutral
- C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
- C07K5/06034—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 2 to 4 carbon atoms
- C07K5/06043—Leu-amino acid
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06008—Dipeptides with the first amino acid being neutral
- C07K5/06078—Dipeptides with the first amino acid being neutral and aromatic or cycloaliphatic
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06086—Dipeptides with the first amino acid being basic

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Biochemistry (AREA)
Chemical Kinetics & Catalysis (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Animal Behavior & Ethology (AREA)
General Chemical & Material Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Pharmacology & Pharmacy (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Molecular Biology (AREA)
Genetics & Genomics (AREA)
Biophysics (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Pain & Pain Management (AREA)
Rheumatology (AREA)
Heart & Thoracic Surgery (AREA)
Cardiology (AREA)
Vascular Medicine (AREA)
Urology & Nephrology (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Peptides Or Proteins (AREA)

IS4041A 1992-06-25 1993-06-24 Hydroxamicsýruafleiður, aðferð til framleiðslu þeirra og notkunar sem lyfja IS4041A (is)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
GB929213473A GB9213473D0 (en)	1992-06-25	1992-06-25	Hydroxamic acid derivatives
GB939307081A GB9307081D0 (en)	1992-06-25	1993-04-05	Hydroxamic acid derivatives

Publications (1)

Publication Number	Publication Date
IS4041A true IS4041A (is)	1993-12-26

Family

ID=26301123

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
IS4041A IS4041A (is)	1992-06-25	1993-06-24	Hydroxamicsýruafleiður, aðferð til framleiðslu þeirra og notkunar sem lyfja

Country Status (19)

Country	Link
EP (1)	EP0575844B1 (is)
JP (1)	JP2594014B2 (is)
CN (1)	CN1054599C (is)
AT (1)	ATE162514T1 (is)
AU (1)	AU666727B2 (is)
BG (1)	BG97895A (is)
CA (1)	CA2098166A1 (is)
CZ (1)	CZ118393A3 (is)
DE (1)	DE69316456T2 (is)
DK (1)	DK0575844T3 (is)
ES (1)	ES2112929T3 (is)
FI (1)	FI932950A7 (is)
GR (1)	GR3026623T3 (is)
HU (1)	HU9301773D0 (is)
IL (1)	IL106059A0 (is)
IS (1)	IS4041A (is)
NO (1)	NO932326L (is)
NZ (1)	NZ247926A (is)
SK (1)	SK64993A3 (is)

Families Citing this family (42)

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Publication number	Priority date	Publication date	Assignee	Title
US5892112A (en) *	1990-11-21	1999-04-06	Glycomed Incorporated	Process for preparing synthetic matrix metalloprotease inhibitors
GB9401129D0 (en) *	1994-01-21	1994-03-16	British Bio Technology	Hydroxamic acid derivatives as metalloproteinase inhibitors
JP3827324B2 (ja) *	1994-01-22	2006-09-27	ブリテッシュバイオテックファーマシューティカルズリミテッド	金属タンパク質分解酵素阻害剤
GB2300188B (en) *	1994-01-22	1998-07-01	British Biotech Pharm	Metalloproteinase inhibitors
US5514716A (en) *	1994-02-25	1996-05-07	Sterling Winthrop, Inc.	Hydroxamic acid and carboxylic acid derivatives, process for their preparation and use thereof
GB9501737D0 (en) *	1994-04-25	1995-03-22	Hoffmann La Roche	Hydroxamic acid derivatives
WO1995032944A1 (en) *	1994-05-28	1995-12-07	British Biotech Pharmaceuticals Limited	Succinyl hydroxamic acid, n-formyl-n-hydroxy amino carboxylic acid and succinic acid amide derivatives as metalloprotease inhibitors
GB9411088D0 (en) *	1994-06-03	1994-07-27	Hoffmann La Roche	Hydroxylamine derivatives
GB9411598D0 (en) *	1994-06-09	1994-08-03	Hoffmann La Roche	Hydroxamic acid derivatives
US5831004A (en)	1994-10-27	1998-11-03	Affymax Technologies N.V.	Inhibitors of metalloproteases, pharmaceutical compositions comprising same and methods of their use
US5840698A (en) *	1994-10-27	1998-11-24	Affymax Technologies N.V.	Inhibitors of collagenase-1 and stormelysin-I metalloproteases, pharmaceutical compositions comprising same and methods of their use
GB9423914D0 (en) *	1994-11-26	1995-01-11	British Biotech Pharm	Polyether derivatives as metalloproteinase inhibitors
US5639746A (en) *	1994-12-29	1997-06-17	The Procter & Gamble Company	Hydroxamic acid-containing inhibitors of matrix metalloproteases
US5672598A (en) *	1995-03-21	1997-09-30	The Procter & Gamble Company	Lactam-containing hydroxamic acids
US5691381A (en) *	1995-04-18	1997-11-25	The Dupont Merck Pharmaceutical Company	Hydroxamic and carbocyclic acids as metalloprotease inhibitors
GB9507799D0 (en) *	1995-04-18	1995-05-31	British Biotech Pharm	Metalloproteinase inhibitors
US5703092A (en) *	1995-04-18	1997-12-30	The Dupont Merck Pharmaceutical Company	Hydroxamic acid compounds as metalloprotease and TNF inhibitors
WO1996033733A1 (en) *	1995-04-25	1996-10-31	Fuji Yakuhin Kogyo Kabushiki Kaisha	Novel remedy for skin deficiencies
DE69632821T2 (de) *	1995-04-25	2005-08-25	Daiichi Fine Chemical Co., Ltd., Takaoka	In wasser hochlöslicher metalloproteinase-inhibitor
AU706064B2 (en) *	1995-05-10	1999-06-10	Darwin Discovery Limited	Peptide compounds which inhibit metalloproteinase and TNF liberation, and their therapeutic use
US5677282A (en) *	1995-06-07	1997-10-14	Proscript, Inc.	Amino acid amides of 1,3,4-thiadiazoles as matrix metalloproteinase
US5917090A (en) *	1995-06-30	1999-06-29	British Biotech Pharmaceuticals Ltd.	Matrix metalloproteinase inhibitors
JP2000500761A (ja)	1995-11-23	2000-01-25	ブリティッシュバイオテックファーマシューティカルズリミテッド	金属タンパク質分解酵素阻害剤
EP0923561B1 (en) *	1996-08-28	2002-10-23	The Procter & Gamble Company	Heterocyclic metalloprotease inhibitors
IL128661A (en) *	1996-08-28	2001-10-31	Procter & Gamble	Teleprotease inhibitors 1, 3 - diethocycles and pharmaceutical preparations containing them
WO1998008850A1 (en) *	1996-08-28	1998-03-05	The Procter & Gamble Company	Spirocyclic metalloprotease inhibitors
WO1998008827A1 (en) *	1996-08-28	1998-03-05	The Procter & Gamble Company	Heterocyclic metalloprotease inhibitors
ATE226590T1 (de) *	1996-08-28	2002-11-15	Procter & Gamble	Phosphinsäureamide als matrix metalloprotease inhibitoren
US6462023B1 (en)	1996-09-10	2002-10-08	British Biotech Pharmaceuticals, Ltd.	Cytostatic agents
NZ333923A (en)	1996-09-10	2000-11-24	British Biotech Pharm	Cytostatic hydroxamic acid derivatives for inhibiting proliferation of tumour cells
US5952320A (en) *	1997-01-07	1999-09-14	Abbott Laboratories	Macrocyclic inhibitors of matrix metalloproteinases and TNFα secretion
ZA9818B (en) *	1997-01-07	1998-07-02	Abbott Lab	C-terminal ketone inhibitors of matrix metalloproteinases and tnf alpha secretion
US5985911A (en) *	1997-01-07	1999-11-16	Abbott Laboratories	C-terminal ketone inhibitors of matrix metalloproteinases and TNFα secretion
JP2001513484A (ja)	1997-07-31	2001-09-04	ザプロクターアンドギャンブルカンパニー	非環式メタロプロテアーゼ阻害剤
US6329418B1 (en)	1998-04-14	2001-12-11	The Procter & Gamble Company	Substituted pyrrolidine hydroxamate metalloprotease inhibitors
US6288261B1 (en)	1998-12-18	2001-09-11	Abbott Laboratories	Inhibitors of matrix metalloproteinases
CN1349498A (zh)	1999-03-03	2002-05-15	宝洁公司	含有链烯基和炔基的金属蛋白酶抑制剂
JP2001055327A (ja) *	1999-06-11	2001-02-27	Fuji Chemical Industries Ltd	新規なヒドロキサム酸誘導体を含む医薬
US6696456B1 (en)	1999-10-14	2004-02-24	The Procter & Gamble Company	Beta disubstituted metalloprotease inhibitors
CA2401728A1 (en)	2000-03-21	2001-09-27	The Procter & Gamble Company	Difluorobutyric acid metalloprotease inhibitors
RU2245876C2 (ru)	2000-03-21	2005-02-10	Дзе Проктер Энд Гэмбл Компани	Производные сульфонамидов и фармацевтическая композиция на их основе
GB0421308D0 (en) *	2004-09-24	2004-10-27	Amersham Plc	Enzyme inhibitor imaging agents

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4743587A (en) *	1985-09-10	1988-05-10	G. D. Searle & Co.	Hydroxamic acid based collagenase inhibitors
US4771038A (en) *	1986-01-21	1988-09-13	Ici Americas Inc.	Hydroxamic acids
GB8601368D0 (en) *	1986-01-21	1986-02-26	Ici America Inc	Hydroxamic acids
DK77487A (da) *	1986-03-11	1987-09-12	Hoffmann La Roche	Hydroxylaminderivater
GB8630721D0 (en) *	1986-12-23	1987-02-04	Unilever Plc	Cosmetic compositions
US5189178A (en) *	1990-11-21	1993-02-23	Galardy Richard E	Matrix metalloprotease inhibitors
CA2073510A1 (en) *	1990-12-03	1992-06-04	Celltech Therapeutics Limited	Peptidyl derivatives

1993
- 1993-05-31 AU AU39931/93A patent/AU666727B2/en not_active Ceased
- 1993-06-07 CZ CZ931183A patent/CZ118393A3/cs unknown
- 1993-06-10 CA CA002098166A patent/CA2098166A1/en not_active Abandoned
- 1993-06-14 DK DK93109443T patent/DK0575844T3/da active
- 1993-06-14 AT AT93109443T patent/ATE162514T1/de not_active IP Right Cessation
- 1993-06-14 ES ES93109443T patent/ES2112929T3/es not_active Expired - Lifetime
- 1993-06-14 EP EP93109443A patent/EP0575844B1/en not_active Expired - Lifetime
- 1993-06-14 DE DE69316456T patent/DE69316456T2/de not_active Expired - Fee Related
- 1993-06-18 NZ NZ247926A patent/NZ247926A/en unknown
- 1993-06-18 HU HU9301773A patent/HU9301773D0/hu unknown
- 1993-06-18 IL IL106059A patent/IL106059A0/xx unknown
- 1993-06-22 BG BG97895A patent/BG97895A/xx unknown
- 1993-06-22 SK SK649-93A patent/SK64993A3/sk unknown
- 1993-06-23 JP JP5174673A patent/JP2594014B2/ja not_active Expired - Fee Related
- 1993-06-23 CN CN93107609A patent/CN1054599C/zh not_active Expired - Fee Related
- 1993-06-24 IS IS4041A patent/IS4041A/is unknown
- 1993-06-24 FI FI932950A patent/FI932950A7/fi unknown
- 1993-06-24 NO NO932326A patent/NO932326L/no unknown
1998
- 1998-04-10 GR GR980400819T patent/GR3026623T3/el unknown

Also Published As

Publication number	Publication date
EP0575844B1 (en)	1998-01-21
CN1082027A (zh)	1994-02-16
EP0575844A3 (is)	1994-03-09
ATE162514T1 (de)	1998-02-15
ES2112929T3 (es)	1998-04-16
FI932950A0 (fi)	1993-06-24
CN1054599C (zh)	2000-07-19
DE69316456T2 (de)	1998-07-09
HU9301773D0 (en)	1993-09-28
NO932326D0 (no)	1993-06-24
SK64993A3 (en)	1994-01-12
CA2098166A1 (en)	1993-12-26
FI932950A7 (fi)	1993-12-26
DE69316456D1 (de)	1998-02-26
IL106059A0 (en)	1993-10-20
JP2594014B2 (ja)	1997-03-26
NO932326L (no)	1993-12-27
JPH0687813A (ja)	1994-03-29
CZ118393A3 (en)	1994-02-16
NZ247926A (en)	1995-10-26
AU3993193A (en)	1994-01-06
GR3026623T3 (en)	1998-07-31
EP0575844A2 (en)	1993-12-29
AU666727B2 (en)	1996-02-22
BG97895A (en)	1994-06-30
DK0575844T3 (da)	1998-09-14

Publication	Publication Date	Title
NO932326D0 (no)	1993-06-24	Hydroksaminsyrederivater
DK0684240T3 (da)	2000-11-13	Hydroxamsyrederivater med tre ringsubstituenter
MY108798A (en)	1996-11-30	Hydroxamic acid derivatives.
DE69613365D1 (de)	2001-07-19	Ester der 5-aminolevulinsäure als mittel zur photosensibilisierung in der chemotherapie
CA2159450A1 (en)	1994-10-13	1-amidinophenyl-pyrrolidones piperidinones azetinones as platelet aggregation inhibitors
DK0467248T3 (da)	1999-07-05	Pyrazolopyridinforbindelse og fremgangsmåder til fremstilling heraf
DK0715623T3 (da)	1999-02-22	Blodpladeaggregationsinhibitorer
ES8303353A1 (es)	1983-02-16	Un procedimiento para la preparacion de nuevos derivados de caprilolactama.
MY134743A (en)	2007-12-31	Derivatives of hydroxyamino-succinic acid
WO2003070690A3 (fr)	2004-04-08	Nouveaux derives d'acides amines, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
RU93047029A (ru)	1996-10-10	Производные гидроксамовой кислоты
ATE221897T1 (de)	2002-08-15	Inhibitoren der blutplättchen-aggregation, die c- terminale aminosäurereste mit aminergen seitenketten enthalten
TH16326A (th)	1995-08-17	อาริลอัลคิลอะมีนต่าง ๆ ขบวนการในการเตรียมสาร?เหล่านี้ และส่วนผสมทางเภสัชกรรมที่มีสารเหล่านี้
TH17612B (th)	2004-09-08	อาริลอัลคิลอะมีนต่าง ๆ ขบวนการในการเตรียมสาร?เหล่านี้ และส่วนผสมทางเภสัชกรรมที่มีสารเหล่านี้