NO932326L - Hydroksaminsyrederivater - Google Patents

Hydroksaminsyrederivater

Info

Publication number: NO932326L
Authority: NO; Norway
Prior art keywords: alkyl; atom; hydrogen; amino acid; carbamoyl
Prior art date: 1992-06-25

Application number

NO932326A

Other languages

English (en)

Norwegian (no)

Other versions

NO932326D0 (no

Inventor

Michale John Broadhurst

Paul Anthony Brown

Geoffrey Lawton

William Henry Johnson

Original Assignee

Hoffmann La Roche

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1992-06-25

Filing date

1993-06-24

Publication date

1993-12-27

1992-06-25 Priority claimed from GB929213473A external-priority patent/GB9213473D0/en

1993-06-24 Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche

1993-06-24 Publication of NO932326D0 publication Critical patent/NO932326D0/no

1993-12-27 Publication of NO932326L publication Critical patent/NO932326L/no

Links

NEAQRZUHTPSBBM-UHFFFAOYSA-N 2-hydroxy-3,3-dimethyl-7-nitro-4h-isoquinolin-1-one Chemical compound C1=C([N+]([O-])=O)C=C2C(=O)N(O)C(C)(C)CC2=C1 NEAQRZUHTPSBBM-UHFFFAOYSA-N 0.000 title abstract 2
239000002253 acid Substances 0.000 title abstract 2
229910052739 hydrogen Inorganic materials 0.000 abstract 4
239000001257 hydrogen Substances 0.000 abstract 4
125000004433 nitrogen atom Chemical group N* 0.000 abstract 4
UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 2
150000001371 alpha-amino acids Chemical class 0.000 abstract 2
235000008206 alpha-amino acids Nutrition 0.000 abstract 2
125000003917 carbamoyl group Chemical group [H]N([H])C(*)=O 0.000 abstract 2
125000004432 carbon atom Chemical group C* 0.000 abstract 2
125000000524 functional group Chemical group 0.000 abstract 2
201000008482 osteoarthritis Diseases 0.000 abstract 2
201000001320 Atherosclerosis Diseases 0.000 abstract 1
206010028980 Neoplasm Diseases 0.000 abstract 1
125000003545 alkoxy group Chemical group 0.000 abstract 1
125000000217 alkyl group Chemical group 0.000 abstract 1
235000001014 amino acid Nutrition 0.000 abstract 1
150000001413 amino acids Chemical class 0.000 abstract 1
ZXKINMCYCKHYFR-UHFFFAOYSA-N aminooxidanide Chemical compound [O-]N ZXKINMCYCKHYFR-UHFFFAOYSA-N 0.000 abstract 1
-1 benzyloxyamino compound Chemical class 0.000 abstract 1
125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 abstract 1
125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 1
125000005842 heteroatom Chemical group 0.000 abstract 1
150000002431 hydrogen Chemical class 0.000 abstract 1
125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
239000003771 matrix metalloproteinase inhibitor Substances 0.000 abstract 1
229940121386 matrix metalloproteinase inhibitor Drugs 0.000 abstract 1
201000006417 multiple sclerosis Diseases 0.000 abstract 1
230000002265 prevention Effects 0.000 abstract 1
206010039073 rheumatoid arthritis Diseases 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/44—Iso-indoles; Hydrogenated iso-indoles
- C07D209/48—Iso-indoles; Hydrogenated iso-indoles with oxygen atoms in positions 1 and 3, e.g. phthalimide
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C259/00—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups
- C07C259/04—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups without replacement of the other oxygen atom of the carboxyl group, e.g. hydroxamic acids
- C07C259/06—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups without replacement of the other oxygen atom of the carboxyl group, e.g. hydroxamic acids having carbon atoms of hydroxamic groups bound to hydrogen atoms or to acyclic carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D233/72—Two oxygen atoms, e.g. hydantoin
- C07D233/74—Two oxygen atoms, e.g. hydantoin with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to other ring members
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06008—Dipeptides with the first amino acid being neutral
- C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
- C07K5/06026—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atom, i.e. Gly or Ala
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06008—Dipeptides with the first amino acid being neutral
- C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
- C07K5/06034—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 2 to 4 carbon atoms
- C07K5/06043—Leu-amino acid
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06008—Dipeptides with the first amino acid being neutral
- C07K5/06078—Dipeptides with the first amino acid being neutral and aromatic or cycloaliphatic
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06086—Dipeptides with the first amino acid being basic

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
General Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Veterinary Medicine (AREA)
Proteomics, Peptides & Aminoacids (AREA)
General Chemical & Material Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Chemical Kinetics & Catalysis (AREA)
Animal Behavior & Ethology (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Public Health (AREA)
Molecular Biology (AREA)
Genetics & Genomics (AREA)
Biophysics (AREA)
Biochemistry (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Cardiology (AREA)
Heart & Thoracic Surgery (AREA)
Vascular Medicine (AREA)
Urology & Nephrology (AREA)
Rheumatology (AREA)
Pain & Pain Management (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Peptides Or Proteins (AREA)

NO932326A 1992-06-25 1993-06-24 Hydroksaminsyrederivater NO932326L (no)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
GB929213473A GB9213473D0 (en)	1992-06-25	1992-06-25	Hydroxamic acid derivatives
GB939307081A GB9307081D0 (en)	1992-06-25	1993-04-05	Hydroxamic acid derivatives

Publications (2)

Publication Number	Publication Date
NO932326D0 NO932326D0 (no)	1993-06-24
NO932326L true NO932326L (no)	1993-12-27

Family

ID=26301123

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
NO932326A NO932326L (no)	1992-06-25	1993-06-24	Hydroksaminsyrederivater

Country Status (19)

Country	Link
EP (1)	EP0575844B1 (is)
JP (1)	JP2594014B2 (is)
CN (1)	CN1054599C (is)
AT (1)	ATE162514T1 (is)
AU (1)	AU666727B2 (is)
BG (1)	BG97895A (is)
CA (1)	CA2098166A1 (is)
CZ (1)	CZ118393A3 (is)
DE (1)	DE69316456T2 (is)
DK (1)	DK0575844T3 (is)
ES (1)	ES2112929T3 (is)
FI (1)	FI932950A7 (is)
GR (1)	GR3026623T3 (is)
HU (1)	HU9301773D0 (is)
IL (1)	IL106059A0 (is)
IS (1)	IS4041A (is)
NO (1)	NO932326L (is)
NZ (1)	NZ247926A (is)
SK (1)	SK64993A3 (is)

Families Citing this family (42)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5892112A (en) *	1990-11-21	1999-04-06	Glycomed Incorporated	Process for preparing synthetic matrix metalloprotease inhibitors
GB9401129D0 (en) *	1994-01-21	1994-03-16	British Bio Technology	Hydroxamic acid derivatives as metalloproteinase inhibitors
GB2315750B (en) *	1994-01-22	1998-07-01	British Biotech Pharm	Metalloproteinase inhibitors
EP0905126B1 (en) *	1994-01-22	2002-12-04	British Biotech Pharmaceuticals Limited	Metalloproteinase inhibitors
US5514716A (en) *	1994-02-25	1996-05-07	Sterling Winthrop, Inc.	Hydroxamic acid and carboxylic acid derivatives, process for their preparation and use thereof
GB9501737D0 (en) *	1994-04-25	1995-03-22	Hoffmann La Roche	Hydroxamic acid derivatives
US6028110A (en) *	1994-05-28	2000-02-22	British Biotech Pharmaceuticals Ltd.	Succinyl hydroxamic acid, N-formyl-N-hydroxy amino carboxylic acid and succinic acid amide derivatives as metalloprotease inhibitors
GB9411088D0 (en) *	1994-06-03	1994-07-27	Hoffmann La Roche	Hydroxylamine derivatives
GB9411598D0 (en) *	1994-06-09	1994-08-03	Hoffmann La Roche	Hydroxamic acid derivatives
US5831004A (en) *	1994-10-27	1998-11-03	Affymax Technologies N.V.	Inhibitors of metalloproteases, pharmaceutical compositions comprising same and methods of their use
US5840698A (en) *	1994-10-27	1998-11-24	Affymax Technologies N.V.	Inhibitors of collagenase-1 and stormelysin-I metalloproteases, pharmaceutical compositions comprising same and methods of their use
GB9423914D0 (en) *	1994-11-26	1995-01-11	British Biotech Pharm	Polyether derivatives as metalloproteinase inhibitors
US5639746A (en) *	1994-12-29	1997-06-17	The Procter & Gamble Company	Hydroxamic acid-containing inhibitors of matrix metalloproteases
US5672598A (en) *	1995-03-21	1997-09-30	The Procter & Gamble Company	Lactam-containing hydroxamic acids
US5703092A (en) *	1995-04-18	1997-12-30	The Dupont Merck Pharmaceutical Company	Hydroxamic acid compounds as metalloprotease and TNF inhibitors
GB9507799D0 (en) *	1995-04-18	1995-05-31	British Biotech Pharm	Metalloproteinase inhibitors
US5691381A (en) *	1995-04-18	1997-11-25	The Dupont Merck Pharmaceutical Company	Hydroxamic and carbocyclic acids as metalloprotease inhibitors
WO1996033968A1 (en) *	1995-04-25	1996-10-31	Fuji Yakuhin Kogyo Kabushiki Kaisha	Highly water-soluble metalloproteinase inhibitor
WO1996033733A1 (en) *	1995-04-25	1996-10-31	Fuji Yakuhin Kogyo Kabushiki Kaisha	Novel remedy for skin deficiencies
EP0824543A1 (en) *	1995-05-10	1998-02-25	Chiroscience Limited	Peptide compounds which inhibit metalloproteinase and tnf liberation, and their therapeutic use
US5677282A (en) *	1995-06-07	1997-10-14	Proscript, Inc.	Amino acid amides of 1,3,4-thiadiazoles as matrix metalloproteinase
US5917090A (en) *	1995-06-30	1999-06-29	British Biotech Pharmaceuticals Ltd.	Matrix metalloproteinase inhibitors
ATE205184T1 (de)	1995-11-23	2001-09-15	British Biotech Pharm	Metalloproteinase inhibitoren
BR9713182A (pt) *	1996-08-28	1999-11-03	Procter & Gamble	Amidas de ácido fosfìnico como inibidores de metalo protease de matriz
RU2203274C2 (ru) *	1996-08-28	2003-04-27	Дзе Проктер Энд Гэмбл Компани	Спироциклические ингибиторы металлопротеаз
ATE226573T1 (de)	1996-08-28	2002-11-15	Procter & Gamble	Heterozyklische metalloproteaseinhibitoren
DE69716934T2 (de) *	1996-08-28	2003-07-31	The Procter & Gamble Company, Cincinnati	1,3-diheterozyklische metalloprotease inhibitoren
KR100339296B1 (ko) *	1996-08-28	2002-06-03	데이비드 엠 모이어	헤테로고리성 메탈로프로테아제 억제제
IL128337A0 (en)	1996-09-10	2000-01-31	British Biotech Pharm	Cytostatic hydroxamic acid derivatives
US6462023B1 (en)	1996-09-10	2002-10-08	British Biotech Pharmaceuticals, Ltd.	Cytostatic agents
US5952320A (en) *	1997-01-07	1999-09-14	Abbott Laboratories	Macrocyclic inhibitors of matrix metalloproteinases and TNFα secretion
US5985911A (en) *	1997-01-07	1999-11-16	Abbott Laboratories	C-terminal ketone inhibitors of matrix metalloproteinases and TNFα secretion
ZA9818B (en) *	1997-01-07	1998-07-02	Abbott Lab	C-terminal ketone inhibitors of matrix metalloproteinases and tnf alpha secretion
CA2298617A1 (en)	1997-07-31	1999-02-11	Yetunde Olabisi Taiwo	Acyclic metalloprotease inhibitors
US6329418B1 (en)	1998-04-14	2001-12-11	The Procter & Gamble Company	Substituted pyrrolidine hydroxamate metalloprotease inhibitors
US6288261B1 (en)	1998-12-18	2001-09-11	Abbott Laboratories	Inhibitors of matrix metalloproteinases
BR0008716A (pt)	1999-03-03	2002-09-24	Procter & Gamble	Inibidores de metaloprotease contendo alquenil ou alquinil
JP2001055327A (ja) *	1999-06-11	2001-02-27	Fuji Chemical Industries Ltd	新規なヒドロキサム酸誘導体を含む医薬
US6696456B1 (en)	1999-10-14	2004-02-24	The Procter & Gamble Company	Beta disubstituted metalloprotease inhibitors
NZ520657A (en)	2000-03-21	2004-11-26	Procter & Gamble	Heterocyclic side chain containing, N-substituted metalloprotease inhibitors
WO2001070693A2 (en)	2000-03-21	2001-09-27	The Procter & Gamble Company	Difluorobutyric acid derivatives and their use as metalloprotease inhibitors
GB0421308D0 (en) *	2004-09-24	2004-10-27	Amersham Plc	Enzyme inhibitor imaging agents

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4743587A (en) *	1985-09-10	1988-05-10	G. D. Searle & Co.	Hydroxamic acid based collagenase inhibitors
GB8601368D0 (en) *	1986-01-21	1986-02-26	Ici America Inc	Hydroxamic acids
US4771038A (en) *	1986-01-21	1988-09-13	Ici Americas Inc.	Hydroxamic acids
DK77487A (da) *	1986-03-11	1987-09-12	Hoffmann La Roche	Hydroxylaminderivater
GB8630721D0 (en) *	1986-12-23	1987-02-04	Unilever Plc	Cosmetic compositions
US5189178A (en) *	1990-11-21	1993-02-23	Galardy Richard E	Matrix metalloprotease inhibitors
ES2069833T3 (es) *	1990-12-03	1995-05-16	Celltech Ltd	Derivados peptidilicos.

1993
- 1993-05-31 AU AU39931/93A patent/AU666727B2/en not_active Ceased
- 1993-06-07 CZ CZ931183A patent/CZ118393A3/cs unknown
- 1993-06-10 CA CA002098166A patent/CA2098166A1/en not_active Abandoned
- 1993-06-14 ES ES93109443T patent/ES2112929T3/es not_active Expired - Lifetime
- 1993-06-14 DK DK93109443T patent/DK0575844T3/da active
- 1993-06-14 DE DE69316456T patent/DE69316456T2/de not_active Expired - Fee Related
- 1993-06-14 AT AT93109443T patent/ATE162514T1/de not_active IP Right Cessation
- 1993-06-14 EP EP93109443A patent/EP0575844B1/en not_active Expired - Lifetime
- 1993-06-18 HU HU9301773A patent/HU9301773D0/hu unknown
- 1993-06-18 IL IL106059A patent/IL106059A0/xx unknown
- 1993-06-18 NZ NZ247926A patent/NZ247926A/en unknown
- 1993-06-22 BG BG97895A patent/BG97895A/xx unknown
- 1993-06-22 SK SK649-93A patent/SK64993A3/sk unknown
- 1993-06-23 JP JP5174673A patent/JP2594014B2/ja not_active Expired - Fee Related
- 1993-06-23 CN CN93107609A patent/CN1054599C/zh not_active Expired - Fee Related
- 1993-06-24 IS IS4041A patent/IS4041A/is unknown
- 1993-06-24 FI FI932950A patent/FI932950A7/fi unknown
- 1993-06-24 NO NO932326A patent/NO932326L/no unknown
1998
- 1998-04-10 GR GR980400819T patent/GR3026623T3/el unknown

Also Published As

Publication number	Publication date
IS4041A (is)	1993-12-26
CA2098166A1 (en)	1993-12-26
ATE162514T1 (de)	1998-02-15
DK0575844T3 (da)	1998-09-14
AU3993193A (en)	1994-01-06
CN1082027A (zh)	1994-02-16
FI932950A7 (fi)	1993-12-26
EP0575844A3 (is)	1994-03-09
JP2594014B2 (ja)	1997-03-26
ES2112929T3 (es)	1998-04-16
FI932950A0 (fi)	1993-06-24
AU666727B2 (en)	1996-02-22
BG97895A (en)	1994-06-30
JPH0687813A (ja)	1994-03-29
GR3026623T3 (en)	1998-07-31
CN1054599C (zh)	2000-07-19
IL106059A0 (en)	1993-10-20
DE69316456T2 (de)	1998-07-09
EP0575844B1 (en)	1998-01-21
HU9301773D0 (en)	1993-09-28
EP0575844A2 (en)	1993-12-29
NZ247926A (en)	1995-10-26
DE69316456D1 (de)	1998-02-26
SK64993A3 (en)	1994-01-12
NO932326D0 (no)	1993-06-24
CZ118393A3 (en)	1994-02-16

Publication	Publication Date	Title
NO932326L (no)	1993-12-27	Hydroksaminsyrederivater
NO932117L (no)	1993-12-13	Hydroksaminsyrederivater
TW375609B (en)	1999-12-01	1-benzenesulfonyl-1,3-dihydro-indol-2-one derivatives, their preparation and pharmaceutical compositions in which they are present
DK0870765T3 (da)	2004-02-23	Aminothiazolderivat, lægemiddel indeholdende samme og mellemprodukt til fremstilling af forbindelsen
DK436081A (da)	1982-04-04	Substituerede acyl-derivater af 1,2,3,4-tetrahydroisoquinolin-3-carboxylsyrer og farmaceutisk acceptable salte deraf fremgangsmaade til deres fremstilling og deres anvendelse
DK0606024T3 (da)	1996-06-17	Erythromycinderivater, en fremgangsmåde til deres fremstilling samt deres anvendelse som lægemidler
DK34793D0 (da)	1993-03-25	Vandoploeseligt, farmaceutisk acceptabelt salt af et monoacylderivat af rapamycin, fremgangsmaade til dets fremstilling og injicerbart, farmaceutisk praeparat indeholdende det
NO923253L (no)	1993-02-24	Fremgangsmaate for fremstilling og anvendelse av 2-piperazinonforbindelser
RU93005332A (ru)	1996-02-27	Производные 4,1-бензоксазепина, фармацевтическая композиция, способ лечения
DE122008000051I1 (de)	2009-02-05	2-arylthiazolderivat sowie dieses enthaltendes arzneimittel
BR0108303A (pt)	2003-03-05	Derivados do 1h-imidazopiridina
NO923533L (no)	1993-03-15	Nye 5-amino-4-hydroksyheksansyrederivater som terapeutika
DK0605228T3 (da)	2000-06-05	Thiazolidindionderivater, deres fremstilling og anvendelse
NO954975L (no)	1996-06-10	Aromatisk substituerte w-amino-alkansyreamider og alkansyrediamider
TW375615B (en)	1999-12-01	Galanthamine derivatives and their use as medicaments
HUT59669A (en)	1992-06-29	Process for producing n-sulfonyl-indoline derivatives and pharmaceutical compositions containing them
KR880007461A (ko)	1988-08-27	헤테로 사이클-치환 디포스포네이트화합물 및 이의 약제학적 조성물
EP0943613A4 (en)	2002-07-10	Oxygenic heterocyclic compounds
DK270289A (da)	1989-12-04	Oligopeptider med cycliske, prolin-analoge aminosyrer og farmaceutisk acceptable salte deraf samt deres anvendelse
NO944121L (no)	1995-05-02	Epoksyravsyrederivater
ATE356816T1 (de)	2007-04-15	Trizyklische keto amid derivative als farnesyl protein transferase inhibitoren
HUP9900748A1 (hu)	1999-07-28	Pirrolidinszármazékok alkalmazása alkoholizmus kezelésére alkalmas gyógyszerkészítmények előállítására
SE8306764D0 (sv)	1983-12-07	Nya etendiamin- och guanidin-derivat
NO933478L (no)	1994-04-05	6-heterocyklisk-4-amino-1,2,2a,3,4,5-heksahydrobenz(CD)indoler for behandling av reisesyke og oppkast
MY134743A (en)	2007-12-31	Derivatives of hydroxyamino-succinic acid