IS5240A - Súlfatsalt af HIV próteasa lata sem hefur bætta upptöku um munn og líffræðilega upptöku - Google Patents

Súlfatsalt af HIV próteasa lata sem hefur bætta upptöku um munn og líffræðilega upptöku

Info

Publication number
IS5240A
IS5240A IS5240A IS5240A IS5240A IS 5240 A IS5240 A IS 5240A IS 5240 A IS5240 A IS 5240A IS 5240 A IS5240 A IS 5240A IS 5240 A IS5240 A IS 5240A
Authority
IS
Iceland
Prior art keywords
protease inhibitor
hiv protease
sulfate salt
improved oral
biological uptake
Prior art date
Application number
IS5240A
Other languages
English (en)
Icelandic (is)
Inventor
Askin David
R. Hoerrner Scott
M. Purick Robert
Reider Paul
J. Varsolona Richard
P. Volante Ralph
Original Assignee
Merck & Co., Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB9714320.0A external-priority patent/GB9714320D0/en
Application filed by Merck & Co., Inc. filed Critical Merck & Co., Inc.
Publication of IS5240A publication Critical patent/IS5240A/is

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Virology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • AIDS & HIV (AREA)
  • Engineering & Computer Science (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Molecular Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
IS5240A 1997-05-29 1999-11-09 Súlfatsalt af HIV próteasa lata sem hefur bætta upptöku um munn og líffræðilega upptöku IS5240A (is)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US4795097P 1997-05-29 1997-05-29
GBGB9714320.0A GB9714320D0 (en) 1997-07-07 1997-07-07 Hiv protease inhibitor
PCT/US1998/010633 WO1998054178A1 (en) 1997-05-29 1998-05-26 Sulfate salt of an hiv protease inhibitor having an improved oral absorption and bioavailability

Publications (1)

Publication Number Publication Date
IS5240A true IS5240A (is) 1999-11-09

Family

ID=26311845

Family Applications (1)

Application Number Title Priority Date Filing Date
IS5240A IS5240A (is) 1997-05-29 1999-11-09 Súlfatsalt af HIV próteasa lata sem hefur bætta upptöku um munn og líffræðilega upptöku

Country Status (22)

Country Link
EP (1) EP0986554A1 (id)
JP (1) JP3267632B2 (id)
KR (1) KR20010013042A (id)
CN (1) CN1257497A (id)
AU (1) AU730245B2 (id)
BG (1) BG103923A (id)
BR (1) BR9809498A (id)
CA (1) CA2291086A1 (id)
EA (1) EA199901095A1 (id)
EE (1) EE9900543A (id)
HR (1) HRP980283A2 (id)
HU (1) HUP0004621A3 (id)
ID (1) ID23858A (id)
IL (1) IL132779A0 (id)
IS (1) IS5240A (id)
NO (1) NO995822L (id)
PE (1) PE75099A1 (id)
PL (1) PL336847A1 (id)
SK (1) SK163299A3 (id)
TR (1) TR199902816T2 (id)
TW (1) TW438799B (id)
WO (1) WO1998054178A1 (id)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2295068T3 (es) * 1999-11-24 2008-04-16 MERCK & CO., INC. Gamma-hidroxi-2-(fluoroalquilaminocarbonil)-1-piperazinpentanamidas como inhibidores de la proteasa del vih.
US20020082421A1 (en) * 2000-09-14 2002-06-27 Abdel-Magid Ahmed F. Novel solid salt forms of N-[2-[4-[2-(1- methylethoxy)phenyl]-1-piperazinyl]-2-oxo-1piperidineacetamide

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2174921T3 (es) * 1993-12-15 2002-11-16 Merck & Co Inc Inhibidores de la proteasa del vih.

Also Published As

Publication number Publication date
IL132779A0 (en) 2001-03-19
WO1998054178A1 (en) 1998-12-03
SK163299A3 (en) 2000-07-11
JP3267632B2 (ja) 2002-03-18
AU7595998A (en) 1998-12-30
CN1257497A (zh) 2000-06-21
EA199901095A1 (ru) 2000-08-28
EP0986554A1 (en) 2000-03-22
TR199902816T2 (xx) 2000-02-21
ID23858A (id) 2000-05-25
HUP0004621A2 (hu) 2002-03-28
CA2291086A1 (en) 1998-12-03
AU730245B2 (en) 2001-03-01
BR9809498A (pt) 2000-06-20
EE9900543A (et) 2000-06-15
HUP0004621A3 (en) 2002-04-29
NO995822D0 (no) 1999-11-26
TW438799B (en) 2001-06-07
PL336847A1 (en) 2000-07-17
PE75099A1 (es) 1999-08-11
KR20010013042A (ko) 2001-02-26
HRP980283A2 (en) 1999-08-31
JP2000513747A (ja) 2000-10-17
BG103923A (en) 2000-06-30
NO995822L (no) 2000-01-28

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