NO995822L - Sulfatsalt av en HIV-proteaseinhibitor som har forbedret oral absorpsjon og biotilgjengelighet - Google Patents
Sulfatsalt av en HIV-proteaseinhibitor som har forbedret oral absorpsjon og biotilgjengelighetInfo
- Publication number
- NO995822L NO995822L NO995822A NO995822A NO995822L NO 995822 L NO995822 L NO 995822L NO 995822 A NO995822 A NO 995822A NO 995822 A NO995822 A NO 995822A NO 995822 L NO995822 L NO 995822L
- Authority
- NO
- Norway
- Prior art keywords
- protease inhibitor
- sulfate salt
- hiv protease
- bioavailability
- oral absorption
- Prior art date
Links
- 229940122440 HIV protease inhibitor Drugs 0.000 title abstract 4
- 239000004030 hiv protease inhibitor Substances 0.000 title abstract 4
- 150000003467 sulfuric acid derivatives Chemical class 0.000 title abstract 4
- 238000010521 absorption reaction Methods 0.000 title abstract 2
- 229940126062 Compound A Drugs 0.000 abstract 2
- NLDMNSXOCDLTTB-UHFFFAOYSA-N Heterophylliin A Natural products O1C2COC(=O)C3=CC(O)=C(O)C(O)=C3C3=C(O)C(O)=C(O)C=C3C(=O)OC2C(OC(=O)C=2C=C(O)C(O)=C(O)C=2)C(O)C1OC(=O)C1=CC(O)=C(O)C(O)=C1 NLDMNSXOCDLTTB-UHFFFAOYSA-N 0.000 abstract 2
- 208000030507 AIDS Diseases 0.000 abstract 1
- 208000031886 HIV Infections Diseases 0.000 abstract 1
- 208000037357 HIV infectious disease Diseases 0.000 abstract 1
- QAOWNCQODCNURD-UHFFFAOYSA-N Sulfuric acid Chemical compound OS(O)(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-N 0.000 abstract 1
- 238000010171 animal model Methods 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 210000004211 gastric acid Anatomy 0.000 abstract 1
- 208000033519 human immunodeficiency virus infectious disease Diseases 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 235000011149 sulphuric acid Nutrition 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Virology (AREA)
- Animal Behavior & Ethology (AREA)
- General Chemical & Material Sciences (AREA)
- Public Health (AREA)
- AIDS & HIV (AREA)
- Engineering & Computer Science (AREA)
- Tropical Medicine & Parasitology (AREA)
- Molecular Biology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US4795097P | 1997-05-29 | 1997-05-29 | |
| GBGB9714320.0A GB9714320D0 (en) | 1997-07-07 | 1997-07-07 | Hiv protease inhibitor |
| PCT/US1998/010633 WO1998054178A1 (en) | 1997-05-29 | 1998-05-26 | Sulfate salt of an hiv protease inhibitor having an improved oral absorption and bioavailability |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| NO995822D0 NO995822D0 (no) | 1999-11-26 |
| NO995822L true NO995822L (no) | 2000-01-28 |
Family
ID=26311845
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO995822A NO995822L (no) | 1997-05-29 | 1999-11-26 | Sulfatsalt av en HIV-proteaseinhibitor som har forbedret oral absorpsjon og biotilgjengelighet |
Country Status (22)
| Country | Link |
|---|---|
| EP (1) | EP0986554A1 (id) |
| JP (1) | JP3267632B2 (id) |
| KR (1) | KR20010013042A (id) |
| CN (1) | CN1257497A (id) |
| AU (1) | AU730245B2 (id) |
| BG (1) | BG103923A (id) |
| BR (1) | BR9809498A (id) |
| CA (1) | CA2291086A1 (id) |
| EA (1) | EA199901095A1 (id) |
| EE (1) | EE9900543A (id) |
| HR (1) | HRP980283A2 (id) |
| HU (1) | HUP0004621A3 (id) |
| ID (1) | ID23858A (id) |
| IL (1) | IL132779A0 (id) |
| IS (1) | IS5240A (id) |
| NO (1) | NO995822L (id) |
| PE (1) | PE75099A1 (id) |
| PL (1) | PL336847A1 (id) |
| SK (1) | SK163299A3 (id) |
| TR (1) | TR199902816T2 (id) |
| TW (1) | TW438799B (id) |
| WO (1) | WO1998054178A1 (id) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6642237B1 (en) | 1999-11-24 | 2003-11-04 | Merck & Co., Inc. | Gamma-hydroxy-2-(fluoroalkylaminocarbonyl)-1-piperazinepentanamides and uses thereof |
| US20020082421A1 (en) * | 2000-09-14 | 2002-06-27 | Abdel-Magid Ahmed F. | Novel solid salt forms of N-[2-[4-[2-(1- methylethoxy)phenyl]-1-piperazinyl]-2-oxo-1piperidineacetamide |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP3000564B2 (ja) * | 1993-12-15 | 2000-01-17 | メルク エンド カンパニー インコーポレーテッド | Ｈｉｖプロテアーゼ阻害剤 |
-
1998
- 1998-05-20 TW TW087107834A patent/TW438799B/zh active
- 1998-05-26 ID IDW991462A patent/ID23858A/id unknown
- 1998-05-26 EP EP98923741A patent/EP0986554A1/en not_active Withdrawn
- 1998-05-26 CN CN98805372A patent/CN1257497A/zh active Pending
- 1998-05-26 AU AU75959/98A patent/AU730245B2/en not_active Ceased
- 1998-05-26 HU HU0004621A patent/HUP0004621A3/hu unknown
- 1998-05-26 PL PL98336847A patent/PL336847A1/xx unknown
- 1998-05-26 IL IL13277998A patent/IL132779A0/xx unknown
- 1998-05-26 TR TR1999/02816T patent/TR199902816T2/xx unknown
- 1998-05-26 EE EEP199900543A patent/EE9900543A/xx unknown
- 1998-05-26 BR BR9809498-0A patent/BR9809498A/pt not_active Application Discontinuation
- 1998-05-26 JP JP50079999A patent/JP3267632B2/ja not_active Expired - Fee Related
- 1998-05-26 SK SK1632-99A patent/SK163299A3/sk unknown
- 1998-05-26 KR KR1019997011018A patent/KR20010013042A/ko not_active Withdrawn
- 1998-05-26 EA EA199901095A patent/EA199901095A1/ru unknown
- 1998-05-26 WO PCT/US1998/010633 patent/WO1998054178A1/en not_active Ceased
- 1998-05-26 CA CA002291086A patent/CA2291086A1/en not_active Abandoned
- 1998-05-28 HR HR9714320.0A patent/HRP980283A2/hr not_active Application Discontinuation
- 1998-05-28 PE PE1998000432A patent/PE75099A1/es not_active Application Discontinuation
-
1999
- 1999-11-09 IS IS5240A patent/IS5240A/is unknown
- 1999-11-24 BG BG103923A patent/BG103923A/xx unknown
- 1999-11-26 NO NO995822A patent/NO995822L/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| HUP0004621A2 (hu) | 2002-03-28 |
| KR20010013042A (ko) | 2001-02-26 |
| EE9900543A (et) | 2000-06-15 |
| CA2291086A1 (en) | 1998-12-03 |
| WO1998054178A1 (en) | 1998-12-03 |
| PE75099A1 (es) | 1999-08-11 |
| BG103923A (en) | 2000-06-30 |
| BR9809498A (pt) | 2000-06-20 |
| CN1257497A (zh) | 2000-06-21 |
| PL336847A1 (en) | 2000-07-17 |
| NO995822D0 (no) | 1999-11-26 |
| TW438799B (en) | 2001-06-07 |
| HRP980283A2 (en) | 1999-08-31 |
| HUP0004621A3 (en) | 2002-04-29 |
| IS5240A (is) | 1999-11-09 |
| AU730245B2 (en) | 2001-03-01 |
| IL132779A0 (en) | 2001-03-19 |
| EA199901095A1 (ru) | 2000-08-28 |
| EP0986554A1 (en) | 2000-03-22 |
| ID23858A (id) | 2000-05-25 |
| JP2000513747A (ja) | 2000-10-17 |
| AU7595998A (en) | 1998-12-30 |
| SK163299A3 (en) | 2000-07-11 |
| JP3267632B2 (ja) | 2002-03-18 |
| TR199902816T2 (xx) | 2000-02-21 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FC2A | Withdrawal, rejection or dismissal of laid open patent application |