IS5270A - (R)-3-N,N-dísýklóbútýlamínó-8-flúor-3,4-díhýdró-2H-1-bensópýran-5-karboxamíðhýdrógentartrat, aðferðvið framleiðslu þess og lyfjablöndur sem innihalda það - Google Patents

(R)-3-N,N-dísýklóbútýlamínó-8-flúor-3,4-díhýdró-2H-1-bensópýran-5-karboxamíðhýdrógentartrat, aðferðvið framleiðslu þess og lyfjablöndur sem innihalda það

Info

Publication number: IS5270A
Authority: IS; Iceland
Prior art keywords: dicyclobutylamino; benzopyran; dihydro; fluoro; pharmaceutical preparations
Prior art date: 1997-05-30

Application number

IS5270A

Other languages

English (en)

Other versions

IS1943B (is

Inventor

Nyqvist Håkan

D. Sohn Daniel

Original Assignee

Astra Aktiebolag

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1997-05-30

Filing date

1999-11-24

Publication date

1999-11-24

1999-11-24 Application filed by Astra Aktiebolag filed Critical Astra Aktiebolag

1999-11-24 Publication of IS5270A publication Critical patent/IS5270A/is

2004-08-13 Publication of IS1943B publication Critical patent/IS1943B/is

Links

238000000034 method Methods 0.000 title 1
OWQRJIMXYPCDLO-UHFFFAOYSA-N n',n'-di(cyclobutyl)-8-fluoro-3,4-dihydro-2h-chromene-5-carbohydrazide;2,3-dihydroxybutanedioic acid Chemical compound OC(=O)C(O)C(O)C(O)=O.C1=2CCCOC=2C(F)=CC=C1C(=O)NN(C1CCC1)C1CCC1 OWQRJIMXYPCDLO-UHFFFAOYSA-N 0.000 title 1
239000000825 pharmaceutical preparation Substances 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
- C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
- C07D311/58—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/04—Drugs for disorders of the urinary system for urolithiasis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives

Landscapes

Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Chemical Kinetics & Catalysis (AREA)
Animal Behavior & Ethology (AREA)
Medicinal Chemistry (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Psychiatry (AREA)
Urology & Nephrology (AREA)
Pain & Pain Management (AREA)
Heart & Thoracic Surgery (AREA)
Hospice & Palliative Care (AREA)
Child & Adolescent Psychology (AREA)
Diabetes (AREA)
Hematology (AREA)
Obesity (AREA)
Cardiology (AREA)
Nutrition Science (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Pyrane Compounds (AREA)

IS5270A 1997-05-30 1999-11-24 (R)-3-N,N-dísýklóbútýlamínó-8-flúor-3,4-díhýdró-2H-1-bensópýran-5-karboxamíðhýdrógentartrat, aðferðvið framleiðslu þess og lyfjablöndur sem innihalda það IS1943B (is)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
SE9702066A SE510305C2 (sv)	1997-05-30	1997-05-30	Nytt salt
PCT/SE1998/000907 WO1998054166A1 (en)	1997-05-30	1998-05-15	A new salt

Publications (2)

Publication Number	Publication Date
IS5270A true IS5270A (is)	1999-11-24
IS1943B IS1943B (is)	2004-08-13

Family

ID=20407187

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
IS5270A IS1943B (is)	1997-05-30	1999-11-24	(R)-3-N,N-dísýklóbútýlamínó-8-flúor-3,4-díhýdró-2H-1-bensópýran-5-karboxamíðhýdrógentartrat, aðferðvið framleiðslu þess og lyfjablöndur sem innihalda það

Country Status (33)

Country	Link
US (2)	US6858645B2 (is)
EP (1)	EP0984952B1 (is)
JP (1)	JP3554338B2 (is)
KR (1)	KR20010013127A (is)
CN (1)	CN1198814C (is)
AR (1)	AR012751A1 (is)
AT (1)	ATE228121T1 (is)
AU (1)	AU729301B2 (is)
BG (1)	BG64051B1 (is)
BR (1)	BR9809519A (is)
CA (1)	CA2291732C (is)
DE (1)	DE69809547T2 (is)
DK (1)	DK0984952T3 (is)
EE (1)	EE03874B1 (is)
ES (1)	ES2187030T3 (is)
HU (1)	HUP0001878A3 (is)
ID (1)	ID23794A (is)
IL (1)	IL133234A (is)
IS (1)	IS1943B (is)
MY (1)	MY117960A (is)
NO (1)	NO995853L (is)
NZ (1)	NZ501075A (is)
PL (1)	PL337181A1 (is)
PT (1)	PT984952E (is)
RU (1)	RU2193560C2 (is)
SE (1)	SE510305C2 (is)
SK (1)	SK282755B6 (is)
TR (1)	TR199902926T2 (is)
TW (1)	TW510899B (is)
UA (1)	UA53720C2 (is)
WO (1)	WO1998054166A1 (is)
YU (1)	YU62499A (is)
ZA (1)	ZA984486B (is)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
SE0102887D0 (sv) *	2001-08-29	2001-08-29	Astrazeneca Ab	New formulation
SE0102888D0 (sv) *	2001-08-29	2001-08-29	Astrazeneca Ab	New formulation
SE0102886D0 (sv) *	2001-08-29	2001-08-29	Astrazeneca Ab	New formulation
CN1674880A (zh) *	2002-08-15	2005-09-28	惠氏公司	用于治疗体温调节机能障碍的5HT2a受体的激动作用
SE0301795D0 (sv) *	2003-06-19	2003-06-19	Astrazeneca Ab	New use I
SE0301796D0 (sv) *	2003-06-19	2003-06-19	Astrazeneca Ab	New use II
EP2022110B1 (en) *	2006-05-11	2011-10-12	Johnson Controls Saft Advanced Power Solutions LLC	Modular battery system
JP5163931B2 (ja) *	2007-03-08	2013-03-13	株式会社リコー	定着装置及び画像形成装置
EP2065385A1 (en) *	2007-11-28	2009-06-03	Laboratorios SALVAT, S.A.	Stable crystalline salt of (R)-3-fluorophenyl-3,4,5-trifluorobenzylcarbamic acid 1-azabiciyclo [2.2.2]oct-3-yl ester
CN103788043B (zh) *	2008-11-28	2016-02-03	中国医学科学院药物研究所	硝克柳胺化合物晶iv型、其制法和其药物组合物与用途
ES2711144T3 (es) *	2013-04-26	2019-04-30	Sanofi Sa	Sal de tartrato de [(s)-2-[metil-3-(2-oxo-pirrolidin-1-il)-bencenosulfonilamino]-3-(4-metilpiperacin-1-il)-3-oxo-propil]amida de ácido 5-cloro-tiofeno-2-carboxílico

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
IE63474B1 (en) *	1987-12-24	1995-04-19	Wyeth John & Brother Ltd	Heterocyclic compounds
US5616610A (en)	1989-12-22	1997-04-01	Astra Aktiebolag	(R)-5-carbamoyl-8-fluoro-3-N,N-disubstituted-amino-3,4-dihydro-2H-1-benzopyrans
US5420151A (en) *	1989-12-22	1995-05-30	Aktiebolaget Astra	Chroman derivatives
RU2047614C1 (ru) *	1992-06-15	1995-11-10	Джон Вайс энд Бразер Лимитед	Гетероциклические соединения, или их фармацевтически приемлемые аддитивные соли кислоты, или n-оксид гетероциклического соединения, или его аддитивная соль кислоты
IT1282705B1 (it)	1996-02-28	1998-03-31	Recordati Chem Pharm	Uso di antagonisti del recettore serotoninergico 5-ht\|a per il trattamento dell'incontinenza urinaria
US5990114A (en)	1996-02-28	1999-11-23	Recordati, S.A., Chemical And Pharmaceutical Company	Use of 5-HT1A receptor antagonists for the treatment of urinary incontinence

1997
- 1997-05-30 SE SE9702066A patent/SE510305C2/sv not_active IP Right Cessation
1998
- 1998-05-13 TW TW087107397A patent/TW510899B/zh active
- 1998-05-15 DK DK98925993T patent/DK0984952T3/da active
- 1998-05-15 EE EEP199900549A patent/EE03874B1/xx not_active IP Right Cessation
- 1998-05-15 UA UA99127241A patent/UA53720C2/uk unknown
- 1998-05-15 ID IDW991407A patent/ID23794A/id unknown
- 1998-05-15 PL PL98337181A patent/PL337181A1/xx unknown
- 1998-05-15 NZ NZ501075A patent/NZ501075A/en unknown
- 1998-05-15 EP EP98925993A patent/EP0984952B1/en not_active Expired - Lifetime
- 1998-05-15 DE DE69809547T patent/DE69809547T2/de not_active Expired - Fee Related
- 1998-05-15 CA CA002291732A patent/CA2291732C/en not_active Expired - Fee Related
- 1998-05-15 IL IL13323498A patent/IL133234A/en not_active IP Right Cessation
- 1998-05-15 US US09/077,718 patent/US6858645B2/en not_active Expired - Fee Related
- 1998-05-15 CN CNB988056631A patent/CN1198814C/zh not_active Expired - Fee Related
- 1998-05-15 YU YU62499A patent/YU62499A/sh unknown
- 1998-05-15 JP JP50056099A patent/JP3554338B2/ja not_active Expired - Fee Related
- 1998-05-15 AT AT98925993T patent/ATE228121T1/de not_active IP Right Cessation
- 1998-05-15 WO PCT/SE1998/000907 patent/WO1998054166A1/en not_active Ceased
- 1998-05-15 ES ES98925993T patent/ES2187030T3/es not_active Expired - Lifetime
- 1998-05-15 PT PT98925993T patent/PT984952E/pt unknown
- 1998-05-15 TR TR1999/02926T patent/TR199902926T2/xx unknown
- 1998-05-15 BR BR9809519-6A patent/BR9809519A/pt not_active IP Right Cessation
- 1998-05-15 SK SK1594-99A patent/SK282755B6/sk unknown
- 1998-05-15 RU RU99128026/04A patent/RU2193560C2/ru not_active IP Right Cessation
- 1998-05-15 AU AU77923/98A patent/AU729301B2/en not_active Ceased
- 1998-05-15 HU HU0001878A patent/HUP0001878A3/hu unknown
- 1998-05-15 KR KR19997011107A patent/KR20010013127A/ko not_active Abandoned
- 1998-05-26 ZA ZA984486A patent/ZA984486B/xx unknown
- 1998-05-26 AR ARP980102434A patent/AR012751A1/es unknown
- 1998-05-29 MY MYPI98002400A patent/MY117960A/en unknown
1999
- 1999-11-24 IS IS5270A patent/IS1943B/is unknown
- 1999-11-29 NO NO995853A patent/NO995853L/no not_active Application Discontinuation
- 1999-12-03 BG BG103949A patent/BG64051B1/bg unknown
2004
- 2004-10-12 US US10/964,388 patent/US20050085532A1/en not_active Abandoned

Also Published As

Publication number	Publication date
JP3554338B2 (ja)	2004-08-18
JP2002501527A (ja)	2002-01-15
KR20010013127A (ko)	2001-02-26
US20030109576A1 (en)	2003-06-12
EP0984952B1 (en)	2002-11-20
AR012751A1 (es)	2000-11-08
CA2291732A1 (en)	1998-12-03
ZA984486B (en)	1998-11-30
HUP0001878A2 (hu)	2001-05-28
UA53720C2 (uk)	2003-02-17
TR199902926T2 (xx)	2000-03-21
PL337181A1 (en)	2000-08-14
DE69809547D1 (de)	2003-01-02
IS1943B (is)	2004-08-13
ATE228121T1 (de)	2002-12-15
SE510305C2 (sv)	1999-05-10
AU729301B2 (en)	2001-02-01
BG103949A (en)	2000-07-31
MY117960A (en)	2004-08-30
NZ501075A (en)	2001-08-31
EE9900549A (et)	2000-06-15
US6858645B2 (en)	2005-02-22
CN1198814C (zh)	2005-04-27
HUP0001878A3 (en)	2002-04-29
NO995853L (no)	2000-01-31
BR9809519A (pt)	2000-06-20
SE9702066L (sv)	1998-12-01
IL133234A (en)	2004-05-12
SK159499A3 (en)	2000-10-09
ES2187030T3 (es)	2003-05-16
EP0984952A1 (en)	2000-03-15
AU7792398A (en)	1998-12-30
DE69809547T2 (de)	2003-08-21
EE03874B1 (et)	2002-10-15
YU62499A (sh)	2002-06-19
CA2291732C (en)	2003-12-30
SE9702066D0 (sv)	1997-05-30
ID23794A (id)	2000-05-11
WO1998054166A1 (en)	1998-12-03
PT984952E (pt)	2003-03-31
US20050085532A1 (en)	2005-04-21
DK0984952T3 (da)	2003-02-24
SK282755B6 (sk)	2002-12-03
RU2193560C2 (ru)	2002-11-27
HK1025575A1 (en)	2000-11-17
NO995853D0 (no)	1999-11-29
TW510899B (en)	2002-11-21
IL133234A0 (en)	2001-03-19
CN1258290A (zh)	2000-06-28
BG64051B1 (bg)	2003-11-28

Publication	Publication Date	Title
IS5409A (is)	2000-03-16	Útskipt karboxamídóþíasól, framleiðsla þeirra og lyfjablöndur sem innihalda þau
HUP0103793A3 (en)	2003-09-29	N-(2-aryl-propionyl)-sulfonamids, their use and pharmaceutical preparations containing them
HUP0204519A3 (en)	2003-07-28	4,5-dihydro-1h-pyrazole derivatives having cb1-antagonistic activity, pharmaceutical compositions containing them and process for their preparations
DK0835246T3 (da)	2002-01-21	Aromatiske forbindelser og farmaceutiske præparater, der indeholder dem
NO20005430D0 (no)	2000-10-27	1-[(1-substituerte-4-piperidinyl)metyl]-4-piperidinderivater, fremgangsmÕter for fremstilling av disse, medisinske preparater inneholdende dem, og mellomprodukter
NO953260D0 (no)	1995-08-18	Glycinamid-derivater, fremgangsmåter for fremstilling derav og medisiner som inneholder dem
HUP9802422A3 (en)	2002-02-28	Substituted isoquinoline-3-carboxamide derivatives, process for producing them and pharmaceutical compositions containing them
DK1180518T3 (da)	2007-05-21	5-pyridyl-1,3-azolforbindelser, fremgangsmåde til fremstilling deraf og anvendelse deraf
HUP0003608A3 (en)	2001-06-28	Tetrahydroisoquinoline derivatives, process for producing them and pharmaceutical compositions containing them
IS5353A (is)	2000-01-19	Asýl-píperasínil-pýrimídínafleiður, framleiðsla og notkun þeirra sem lyfja
PL344346A1 (en)	2001-11-05	Platinum complex, its preparation and therapeutic application
DK1071433T3 (da)	2003-04-07	2',2'-difluornucleosider til immunosuppressiv behandling og kombinationspræparater
HUP0000762A3 (en)	2000-10-30	2-amino-6-(2-substituted-4-phenoxy)-substituted-pyridines, and pharmaceutical compositions containing them
ZA981163B (en)	1998-08-20	Gas treatment devices
NO20002181D0 (no)	2000-04-27	Steriliseringsinnpakning, anvendelse derav og fremgangsmÕte for sterilisering
NO20003662L (no)	2000-09-14	Syntetiske polysakkarider, fremgangsmÕte for fremstilling derav og farmasøytiske preparater inneholdende slike
IS5270A (is)	1999-11-24	(R)-3-N,N-dísýklóbútýlamínó-8-flúor-3,4-díhýdró-2H-1-bensópýran-5-karboxamíðhýdrógentartrat, aðferðvið framleiðslu þess og lyfjablöndur sem innihalda það
HUP9802408A3 (en)	1999-06-28	Naphthyl and dihydronaphthyl-derivatives, and pharmaceutical compositions, containing them
HUP0100964A3 (en)	2003-09-29	Pharmaceutical combinations containing tramadol
DK1054672T3 (da)	2007-04-10	Morfinsulfatmikrogranula, fremgangsmåde til fremstilling deraf og farmaceutiske præparater
DK0795547T3 (da)	2000-09-18	(Aminoalkyl- og acylaminoalkyl-oxy)benzyloxyquinoliner, fremgangsmåde til deres fremstilling og deres anvendelse som bradyk
NO975076D0 (no)	1997-11-04	Farmasöytisk preparat som inneholder tiagabinhydroklorid, og fremgangsmåte for dets fremstilling
NO960272D0 (no)	1996-01-23	Oksatiolaner, fremgangsmåte for deres fremstilling og farmasöytiske preparater som inneholder de samme
PL335089A1 (en)	2000-04-10	Pharmaceutic preparations for treating henicrania, containing ibuprofen and domperidone
NO20001288L (no)	2000-03-13	Substituerte 1,2,3,4,5,6-heksahydro-2,6-metano-3-benzazocin- 10-oler, fremgangsmõte for fremstilling derav og anvendelse som legemiddel