IS6138A - Kínólín afleiður sem latar fyrir MEK ensím - Google Patents

Kínólín afleiður sem latar fyrir MEK ensím

Info

Publication number: IS6138A
Authority: IS; Iceland
Prior art keywords: carbon atoms; ring; group; groups; alkyl
Prior art date: 1999-05-08

Application number

IS6138A

Other languages

English (en)

Inventor

Thomas Boyle Francis

Hopkinson Gibson Keith

Philip Poyser Jeffrey

Turner Paul

Original Assignee

Astrazeneca Ab

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1999-05-08

Filing date

2001-10-30

Publication date

2001-10-30

2001-10-30 Application filed by Astrazeneca Ab filed Critical Astrazeneca Ab

2001-10-30 Publication of IS6138A publication Critical patent/IS6138A/is

Links

229940027991 antiseptic and disinfectant quinoline derivative Drugs 0.000 title 1
125000002943 quinolinyl group Chemical class N1=C(C=CC2=CC=CC=C12)* 0.000 title 1
125000004432 carbon atom Chemical group C* 0.000 abstract 4
125000000217 alkyl group Chemical group 0.000 abstract 2
150000001875 compounds Chemical class 0.000 abstract 2
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 2
125000004076 pyridyl group Chemical group 0.000 abstract 2
UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
150000001204 N-oxides Chemical class 0.000 abstract 1
125000000753 cycloalkyl group Chemical group 0.000 abstract 1
239000003814 drug Substances 0.000 abstract 1
125000000623 heterocyclic group Chemical group 0.000 abstract 1
229910052739 hydrogen Inorganic materials 0.000 abstract 1
239000001257 hydrogen Substances 0.000 abstract 1
230000005764 inhibitory process Effects 0.000 abstract 1
QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 abstract 1
125000000962 organic group Chemical group 0.000 abstract 1
-1 pyimidinyl Chemical group 0.000 abstract 1
125000000714 pyrimidinyl group Chemical group 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1
125000003107 substituted aryl group Chemical group 0.000 abstract 1
125000005346 substituted cycloalkyl group Chemical group 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
- C07D215/54—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Chemical Kinetics & Catalysis (AREA)
Public Health (AREA)
Medicinal Chemistry (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Enzymes And Modification Thereof (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Quinoline Compounds (AREA)
Luminescent Compositions (AREA)
Saccharide Compounds (AREA)

IS6138A 1999-05-08 2001-10-30 Kínólín afleiður sem latar fyrir MEK ensím IS6138A (is)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
GBGB9910577.7A GB9910577D0 (en)	1999-05-08	1999-05-08	Chemical compounds
PCT/GB2000/001697 WO2000068201A1 (en)	1999-05-08	2000-05-03	Quinoline derivatives as inhibitors of mek enzymes

Publications (1)

Publication Number	Publication Date
IS6138A true IS6138A (is)	2001-10-30

Family

ID=10852987

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
IS6138A IS6138A (is)	1999-05-08	2001-10-30	Kínólín afleiður sem latar fyrir MEK ensím

Country Status (26)

Country	Link
EP (2)	EP1584619A1 (is)
JP (1)	JP2002544196A (is)
KR (1)	KR100667719B1 (is)
CN (1)	CN1219768C (is)
AT (1)	ATE319688T1 (is)
AU (1)	AU772846B2 (is)
BG (1)	BG106073A (is)
BR (1)	BR0010391A (is)
CA (1)	CA2372663A1 (is)
CZ (1)	CZ20013997A3 (is)
DE (1)	DE60026509T2 (is)
DK (1)	DK1178967T3 (is)
EE (1)	EE200100589A (is)
ES (1)	ES2258455T3 (is)
GB (2)	GB9910577D0 (is)
HU (1)	HUP0201219A3 (is)
IL (1)	IL146317A0 (is)
IS (1)	IS6138A (is)
NO (1)	NO321696B1 (is)
NZ (1)	NZ514980A (is)
PL (1)	PL352413A1 (is)
PT (1)	PT1178967E (is)
SK (1)	SK16102001A3 (is)
TR (1)	TR200103186T2 (is)
WO (1)	WO2000068201A1 (is)
ZA (1)	ZA200108971B (is)

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1999
- 1999-05-08 GB GBGB9910577.7A patent/GB9910577D0/en not_active Ceased
2000
- 2000-04-19 GB GBGB0009532.3A patent/GB0009532D0/en not_active Ceased
- 2000-05-03 IL IL14631700A patent/IL146317A0/xx unknown
- 2000-05-03 CN CNB008099596A patent/CN1219768C/zh not_active Expired - Fee Related
- 2000-05-03 ES ES00927491T patent/ES2258455T3/es not_active Expired - Lifetime
- 2000-05-03 KR KR1020017014244A patent/KR100667719B1/ko not_active Expired - Fee Related
- 2000-05-03 AU AU45891/00A patent/AU772846B2/en not_active Ceased
- 2000-05-03 CZ CZ20013997A patent/CZ20013997A3/cs unknown
- 2000-05-03 DK DK00927491T patent/DK1178967T3/da active
- 2000-05-03 EP EP05013587A patent/EP1584619A1/en not_active Withdrawn
- 2000-05-03 BR BR0010391-8A patent/BR0010391A/pt not_active Application Discontinuation
- 2000-05-03 HU HU0201219A patent/HUP0201219A3/hu unknown
- 2000-05-03 DE DE60026509T patent/DE60026509T2/de not_active Expired - Fee Related
- 2000-05-03 EP EP00927491A patent/EP1178967B1/en not_active Expired - Lifetime
- 2000-05-03 EE EEP200100589A patent/EE200100589A/xx unknown
- 2000-05-03 WO PCT/GB2000/001697 patent/WO2000068201A1/en not_active Ceased
- 2000-05-03 NZ NZ514980A patent/NZ514980A/en unknown
- 2000-05-03 AT AT00927491T patent/ATE319688T1/de not_active IP Right Cessation
- 2000-05-03 TR TR2001/03186T patent/TR200103186T2/xx unknown
- 2000-05-03 PT PT00927491T patent/PT1178967E/pt unknown
- 2000-05-03 PL PL00352413A patent/PL352413A1/xx not_active Application Discontinuation
- 2000-05-03 CA CA002372663A patent/CA2372663A1/en not_active Abandoned
- 2000-05-03 JP JP2000617181A patent/JP2002544196A/ja active Pending
- 2000-05-03 SK SK1610-2001A patent/SK16102001A3/sk unknown
2001
- 2001-10-30 IS IS6138A patent/IS6138A/is unknown
- 2001-10-30 ZA ZA200108971A patent/ZA200108971B/en unknown
- 2001-11-01 BG BG106073A patent/BG106073A/xx unknown
- 2001-11-07 NO NO20015448A patent/NO321696B1/no unknown

Also Published As

Publication number	Publication date
TR200103186T2 (tr)	2002-04-22
KR100667719B1 (ko)	2007-02-28
JP2002544196A (ja)	2002-12-24
CA2372663A1 (en)	2000-11-16
SK16102001A3 (sk)	2002-06-04
EE200100589A (et)	2003-02-17
NO20015448L (no)	2002-01-07
NO20015448D0 (no)	2001-11-07
EP1584619A1 (en)	2005-10-12
ZA200108971B (en)	2003-01-30
AU772846B2 (en)	2004-05-06
CZ20013997A3 (cs)	2002-02-13
CN1365355A (zh)	2002-08-21
GB9910577D0 (en)	1999-07-07
IL146317A0 (en)	2002-07-25
CN1219768C (zh)	2005-09-21
BR0010391A (pt)	2002-07-02
AU4589100A (en)	2000-11-21
GB0009532D0 (en)	2000-06-07
PL352413A1 (en)	2003-08-25
EP1178967B1 (en)	2006-03-08
DE60026509D1 (de)	2006-05-04
DK1178967T3 (da)	2006-06-26
WO2000068201A1 (en)	2000-11-16
ES2258455T3 (es)	2006-09-01
KR20010110811A (ko)	2001-12-13
ATE319688T1 (de)	2006-03-15
DE60026509T2 (de)	2006-11-16
NO321696B1 (no)	2006-06-26
PT1178967E (pt)	2006-06-30
BG106073A (en)	2002-05-31
NZ514980A (en)	2003-10-31
EP1178967A1 (en)	2002-02-13
HUP0201219A2 (en)	2002-09-28
HUP0201219A3 (en)	2003-05-28

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EE200100589A (et)	2003-02-17	Kinoliini derivaadid MEK ensüümide inhibiitoritena
ATE250582T1 (de)	2003-10-15	Chinolinderivate als mek enzym-inhibitoren
IL146326A0 (en)	2002-07-25	Quinoline derivatives as inhibitors of mek enzymes
FI942635A0 (fi)	1994-06-03	Piperatsiinijohdannaiset 5HT1A-antagonisteina
DE69232336D1 (de)	2002-02-14	Stickstoff enthaltende hydrocyclische verbindungen
ATE497948T1 (de)	2011-02-15	Bicyclische verbindungen
FI914910A0 (fi)	1991-10-17	Heterocykliska foereningar.
AU6158486A (en)	1987-02-26	Dihydro pyridine derivatives
ATE504572T1 (de)	2011-04-15	Derivate von aromatische heterocyclen enthaltende integraseinhibitoren
DE69429185D1 (de)	2002-01-03	Imidazolidinon-derivate, deren säure-additionssalze und mittel gegen senile demenz
DK0481742T3 (da)	1997-12-29	Piperazinderivater
NO20053302L (no)	2005-07-05	Imidazolderivater med affinitet for alfa 2-reseptoraktivitet.