IS6521A - Aðferð til að hreinsa gerjunarseyði - Google Patents

Aðferð til að hreinsa gerjunarseyði

Info

Publication number
IS6521A
IS6521A IS6521A IS6521A IS6521A IS 6521 A IS6521 A IS 6521A IS 6521 A IS6521 A IS 6521A IS 6521 A IS6521 A IS 6521A IS 6521 A IS6521 A IS 6521A
Authority
IS
Iceland
Prior art keywords
fermentation extract
purifying fermentation
purifying
extract
fermentation
Prior art date
Application number
IS6521A
Other languages
English (en)
Inventor
Keri Vilmos
Deak Lajos
Forgacs Ilona
Original Assignee
Teva Gyogyszergy βr Részvényt βrsas βg
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Teva Gyogyszergy βr Részvényt βrsas βg filed Critical Teva Gyogyszergy βr Részvényt βrsas βg
Publication of IS6521A publication Critical patent/IS6521A/is

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/02—Oxygen as only ring hetero atoms
    • C12P17/06—Oxygen as only ring hetero atoms containing a six-membered hetero ring, e.g. fluorescein
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/02—Oxygen as only ring hetero atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
    • C07D309/16—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D309/28—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D309/30—Oxygen atoms, e.g. delta-lactones

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Genetics & Genomics (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Public Health (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyrane Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
IS6521A 2000-02-24 2002-08-22 Aðferð til að hreinsa gerjunarseyði IS6521A (is)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US18452200P 2000-02-24 2000-02-24
PCT/US2001/002505 WO2001062949A1 (en) 2000-02-24 2001-01-25 Method of purifying a fermentation broth

Publications (1)

Publication Number Publication Date
IS6521A true IS6521A (is) 2002-08-22

Family

ID=22677241

Family Applications (1)

Application Number Title Priority Date Filing Date
IS6521A IS6521A (is) 2000-02-24 2002-08-22 Aðferð til að hreinsa gerjunarseyði

Country Status (18)

Country Link
US (1) US6387258B1 (is)
EP (1) EP1263979A4 (is)
JP (1) JP3740062B2 (is)
KR (1) KR20030013373A (is)
CN (1) CN1406283A (is)
AU (2) AU2001236543B2 (is)
CA (1) CA2400952A1 (is)
CZ (1) CZ20022779A3 (is)
HR (1) HRP20020683A2 (is)
HU (1) HUP0300073A3 (is)
IL (1) IL151290A0 (is)
IS (1) IS6521A (is)
PL (1) PL357946A1 (is)
RU (1) RU2265665C2 (is)
SK (1) SK12012002A3 (is)
WO (1) WO2001062949A1 (is)
YU (1) YU63602A (is)
ZA (1) ZA200206496B (is)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7452692B2 (en) * 2002-02-13 2008-11-18 Teva Gyógyszergyár Zártkörüen Müködö Részvénytársaság Method for extracting a macrolide from biomatter
KR20040086369A (ko) * 2002-02-13 2004-10-08 비오갈 기오기스제르갸르 알티. 바이오매터로부터 마크롤라이드를 추출하는 방법
ES2204285B1 (es) * 2002-05-20 2005-03-01 Ercros Industrial, S.A. Procedimiento para el aislamiento y purificacion de lovastatina.
KR100540761B1 (ko) * 2002-08-09 2006-01-16 코바이오텍 (주) 프라바스타틴 나트륨의 제조방법
US20060169199A1 (en) * 2003-03-31 2006-08-03 Vilmos Keri Crystallization and purification of macrolides
EP1513847A2 (en) * 2003-03-31 2005-03-16 Biogal Gyogyszergyar Rt. Crystallization and purification of macrolides
US20050003499A1 (en) * 2003-06-09 2005-01-06 Vilmos Keri Ion-exchange filtration of fermentation broth
US7220357B2 (en) * 2003-07-24 2007-05-22 Teva Gyógyszergyár Zártkörúen Múkó´dó´Résvénytársaság Method of purifying macrolides
ES2239533B1 (es) * 2004-03-01 2006-12-16 Ercros Industrial, S.A. Procedimiento para la obtencion de compactina.
WO2005111024A1 (en) * 2004-05-14 2005-11-24 Pfizer Products Inc. Pyrimidine derivatives for the treatment of abnormal cell growth
US20060142565A1 (en) * 2004-12-22 2006-06-29 Vilmos Keri Method of purifying tacrolimus
US8313934B2 (en) * 2007-09-27 2012-11-20 Ls9, Inc. Reduction of the toxic effect of impurities from raw materials by extractive fermentation
WO2009078033A2 (en) * 2007-12-18 2009-06-25 Themis Medicare Limited Isolation and recovery of simvastatin in lactone form or in the form of an acid salt from the harvested fermentation broth
EP2103309A3 (de) * 2008-03-19 2012-09-12 SCHWEIGERT, Florian Verfahren zur Extraktion und zum Nachweis von fettlöslichen Inhaltsstoffen aus biologischen Materialien
US20120156794A1 (en) * 2008-03-19 2012-06-21 Florian Schweigert Method for the extraction and detection of fat-soluble components from biological materials
IN2009MU00380A (is) * 2009-02-18 2010-04-02
EP2416793B1 (en) 2009-04-08 2021-10-20 Nanyang Polytechnic A plant extract comprising statins and preparation techniques and uses thereof
CN102746262B (zh) * 2011-04-22 2014-06-04 广东蓝宝制药有限公司 一种康百汀纯化方法
CN102993145B (zh) * 2011-09-19 2015-06-03 北大方正集团有限公司 一种提取纯化洛伐他汀的方法
CN102827123B (zh) * 2012-08-02 2015-04-22 丽珠集团新北江制药股份有限公司 美伐他汀的分离提取工艺
CN102875505B (zh) * 2012-08-02 2015-08-05 丽珠集团新北江制药股份有限公司 一种美伐他汀的提取精制工艺
US9861962B2 (en) * 2013-10-08 2018-01-09 Industry Foundation Of Chonnam National University Selective surface impregnation method for catalytically active materials on particulate catalyst support using mutual repulsive force and soblubility difference between hydrophilic solvent and hydrophobic solvent
RU2585234C2 (ru) * 2013-12-27 2016-05-27 Открытое акционерное общество "Красфарма" Способ получения компактина
RU2585233C2 (ru) * 2013-12-27 2016-05-27 Открытое акционерное общество "Красфарма" Промышленный способ получения компактина
CN106083789A (zh) * 2016-06-07 2016-11-09 山东鲁抗医药股份有限公司 从发酵液中沉淀分离提取洛伐他汀的方法
CN114133331A (zh) * 2021-12-10 2022-03-04 广东蓝宝制药有限公司 一种回收获得高纯度普伐他汀酯的方法

Family Cites Families (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5612114B2 (is) 1974-06-07 1981-03-18
US4049495A (en) 1974-06-07 1977-09-20 Sankyo Company Limited Physiologically active substances and fermentative process for producing the same
JPS5925599B2 (ja) 1979-02-20 1984-06-19 三共株式会社 新生理活性物質モナコリンｋおよびその製造法
US4319039A (en) 1979-06-15 1982-03-09 Merck & Co., Inc. Preparation of ammonium salt of hypocholesteremic fermentation product
US4294926A (en) 1979-06-15 1981-10-13 Merck & Co., Inc. Hypocholesteremic fermentation products and process of preparation
US4294846A (en) 1979-09-21 1981-10-13 Merck & Co., Inc. Hypocholesteremic fermentation products and products of preparation
US4342767A (en) 1980-01-23 1982-08-03 Merck & Co., Inc. Hypocholesteremic fermentation products
US4420491A (en) 1980-05-28 1983-12-13 Merck & Co., Inc. Hypocholesteremic fermentation products and process of preparation
US5202029A (en) 1991-03-13 1993-04-13 Caron Kabushiki Kaisha Process for purification of hmg-coa reductase inhibitors
HU208997B (en) 1992-06-17 1994-02-28 Gyogyszerkutato Intezet Microbiological method for producing mevinoline
HU210867B (en) * 1992-11-04 1995-10-30 Biogal Gyogyszergyar Method for extraction and purification of mevinolin from culture medium
SI9300047A (en) 1993-01-29 1994-09-30 Krka Microbiological method for preparation of lovostatin and/or mevinoline acid
SI9300303A (en) * 1993-06-08 1994-12-31 Krka Tovarna Zdravil Process for isolation of hypolipemic effective substance
US5409820A (en) 1993-08-06 1995-04-25 Apotex, Inc. Process for the production of lovastatin using Coniothyrium fuckelii
US5616595A (en) 1995-06-07 1997-04-01 Abbott Laboratories Process for recovering water insoluble compounds from a fermentation broth
US5989877A (en) * 1995-08-03 1999-11-23 Gist-Brocades B.V. Selective process for the deacylation of acylated compounds
NZ280074A (en) * 1995-09-21 1997-05-26 Apotex Inc Substituted For Sco "compactin" produced by penicillium adametzioides g smith
SI9800046A (sl) * 1998-02-18 1999-08-31 LEK, tovarna farmacevtskih in kemi�nih izdelkov, d.d. Postopek za pridobivanje inhibitorjev HMG-CoA reduktaze visoke čistosti
SK282679B6 (sk) * 1999-04-16 2002-11-06 Biotika, A. S. Spôsob izolácie lovastatínu z vyfermentovanej pôdy

Also Published As

Publication number Publication date
JP3740062B2 (ja) 2006-01-25
HRP20020683A2 (en) 2004-12-31
CN1406283A (zh) 2003-03-26
IL151290A0 (en) 2003-04-10
EP1263979A4 (en) 2003-05-21
SK12012002A3 (sk) 2003-02-04
RU2002122746A (ru) 2004-02-20
HUP0300073A2 (en) 2003-05-28
ZA200206496B (en) 2003-09-23
CZ20022779A3 (cs) 2003-02-12
AU3654301A (en) 2001-09-03
HUP0300073A3 (en) 2004-10-28
JP2003523751A (ja) 2003-08-12
YU63602A (sh) 2006-01-16
KR20030013373A (ko) 2003-02-14
CA2400952A1 (en) 2001-08-30
PL357946A1 (en) 2004-08-09
EP1263979A1 (en) 2002-12-11
WO2001062949A1 (en) 2001-08-30
US6387258B1 (en) 2002-05-14
RU2265665C2 (ru) 2005-12-10
AU2001236543B2 (en) 2005-02-03

Similar Documents

Publication Publication Date Title
IS6521A (is) Aðferð til að hreinsa gerjunarseyði
DK1249151T3 (da) Fremgangsmåde til cellegenvalgssignalering
CY2013011I2 (el) Μεθοδος χορηγησης διφωσφονικων
AU7878301A (en) Method of amplifying nucleic acid
AU2001294175A1 (en) Method of purifying antibody
CY2007029I2 (el) Μεθοδος για την παρασκευη υποκατεστημενων οκτανοϋλ-αμιδιων
NO20032332D0 (no) Benzodiazepinderivatforbindelser, fremgangsmåte til fremstilling og anvendelse derav
PT1150966E (pt) Metodo de preparacao de 5-cianoftalido
IS6012A (is) Aðferð til útdráttar á málmi
NO20032822D0 (no) Fremgangsmåte for konsentrering av brukt syre
NO20015316L (no) Optimalisering av fermenteringsprosess
DK1345944T3 (da) Fremgangsmåde til isolering og oprensning af epothiloner
IS6036A (is) Örveruaðferð við að framleiða pravastatín
NO20031739D0 (no) Fremgangsmåte for rensing av plavastatin
DK1294659T3 (da) Fremgangsmåde til isolering af katamin
FI20000325A0 (fi) Menetelmä rakenteen rasituksen määrittämiseksi
MXPA01009272A (es) Procedimiento de deformacion permanente de materias queratinicas que utiliza un agente absorbente organico.
ID30377A (id) Metoda pengobatan neurodegenerasi
DK1341898T3 (da) Fremgangsmåde til aerob fermentering
FI20002695A0 (fi) Suodatusmenetelmä
IT1320125B1 (it) Metodo di separazione di zeoliti.
NO20011921D0 (no) Sulfidoamidokarboksylsyrer, metoder for fremstilling derav og anvendelser derav
DK1259523T3 (da) Pluraflaviner og derivater deraf, fremgangsmåde til fremstilling og anvendelse deraf
IS5048A (is) Aðferð til lyfjagreiningar
FI20002577A7 (fi) Menetelmä lähteä lentoon