IS6637A - 3-azabicyclo [3.1.0] hexane derivatives useful in treatment - Google Patents

3-azabicyclo [3.1.0] hexane derivatives useful in treatment

Info

Publication number: IS6637A
Authority: IS; Iceland
Prior art keywords: azabicyclo; treatment; derivatives useful; hexane derivatives; hexane
Prior art date: 2000-06-23

Application number

IS6637A

Other languages

Icelandic (is)

Inventor

Joseph Banks Bernard

James Critcher Douglas

Edward Fenwick Ashley

Morris Gethin David

Paul Gibson Stephen

Lunn Graham

Original Assignee

Pfizer Inc.

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2000-06-23

Filing date

2002-11-28

Publication date

2002-11-28

2002-11-28 Application filed by Pfizer Inc. filed Critical Pfizer Inc.

2002-11-28 Publication of IS6637A publication Critical patent/IS6637A/en

Links

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/04—Antipruritics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/32—Alcohol-abuse
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/34—Tobacco-abuse
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/36—Opioid-abuse
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/52—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring condensed with a ring other than six-membered
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Engineering & Computer Science (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Bioinformatics & Cheminformatics (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Neurosurgery (AREA)
Neurology (AREA)
Addiction (AREA)
Biomedical Technology (AREA)
Psychiatry (AREA)
Dermatology (AREA)
Pain & Pain Management (AREA)
Reproductive Health (AREA)
Endocrinology (AREA)
Gynecology & Obstetrics (AREA)
Hospice & Palliative Care (AREA)
Otolaryngology (AREA)
Cardiology (AREA)
Nutrition Science (AREA)
Heart & Thoracic Surgery (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Plural Heterocyclic Compounds (AREA)
Indole Compounds (AREA)

IS6637A 2000-06-23 2002-11-28 3-azabicyclo [3.1.0] hexane derivatives useful in treatment IS6637A (en)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
GBGB0015562.2A GB0015562D0 (en)	2000-06-23	2000-06-23	Heterocycles
PCT/IB2001/001035 WO2001098267A1 (en)	2000-06-23	2001-06-07	3-azabicyclo (3.1.0) hexane derivatives having opioid receptor affinity

Publications (1)

Publication Number	Publication Date
IS6637A true IS6637A (en)	2002-11-28

Family

ID=9894368

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
IS6637A IS6637A (en)	2000-06-23	2002-11-28	3-azabicyclo [3.1.0] hexane derivatives useful in treatment

Country Status (34)

Country	Link
EP (1)	EP1292574A1 (en)
JP (1)	JP2004512263A (en)
KR (1)	KR20040002386A (en)
CN (1)	CN1639121A (en)
AP (1)	AP2002002698A0 (en)
AR (1)	AR028969A1 (en)
AU (1)	AU781837B2 (en)
BG (1)	BG107329A (en)
BR (1)	BR0111867A (en)
CA (1)	CA2412188A1 (en)
CZ (1)	CZ20023967A3 (en)
DO (1)	DOP2001000187A (en)
DZ (1)	DZ3368A1 (en)
EA (1)	EA005117B1 (en)
GB (1)	GB0015562D0 (en)
HR (1)	HRP20020998A2 (en)
HU (1)	HUP0301228A3 (en)
IL (1)	IL153427A0 (en)
IS (1)	IS6637A (en)
MA (1)	MA26915A1 (en)
MX (1)	MXPA02012878A (en)
NO (1)	NO20026168L (en)
NZ (1)	NZ523141A (en)
OA (1)	OA12293A (en)
PA (1)	PA8519401A1 (en)
PE (1)	PE20020253A1 (en)
PL (1)	PL365956A1 (en)
SK (1)	SK17172002A3 (en)
TN (1)	TNSN01094A1 (en)
UA (1)	UA73176C2 (en)
UY (1)	UY26787A1 (en)
WO (1)	WO2001098267A1 (en)
YU (1)	YU91802A (en)
ZA (1)	ZA200210278B (en)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
EA006708B1 (en) *	2001-10-22	2006-02-24	Пфайзер Продактс Инк.	3-AZABICYCLO (3.1.0) DERIVATIVES OF HEXANE AS ANTAGONISTS OPIOID RECEPTOR
WO2003097051A2 (en) *	2002-05-17	2003-11-27	Merck Patent Gmbh	Use of compounds that are effective as selective opiate receptor modulators
DE10259245A1 (en)	2002-12-17	2004-07-01	Merck Patent Gmbh	Derivatives of asimadolin with covalently bound acids
PT1745040E (en)	2004-02-23	2010-03-08	Glaxo Group Ltd	Azabicyclo(3.1.0) hexane derivatives useful as modulators of dopamine d3 receptors
GB0507680D0 (en) *	2005-04-15	2005-05-25	Glaxo Group Ltd	Compounds
EP1891056B1 (en) *	2005-06-14	2010-10-13	Glaxo Group Limited	Novel compounds
WO2007113258A1 (en) *	2006-04-03	2007-10-11	Glaxo Group Limited	Azabicyclo [3. 1. o] hexane derivatives as modulators of dopamine d3 receptors
CA2682608A1 (en)	2007-03-30	2008-10-09	Tioga Pharmaceuticals, Inc.	Kappa-opiate agonists for the treatment of diarrhea-predominant and alternating irritable bowel syndrome
TWI423801B (en) *	2007-08-27	2014-01-21	Theravance Inc	8-azabicyclo[3.2.1]octyl-2-hydroxybenzamide compounds as mu opioid receptor antagonists
EP2580201B1 (en)	2010-06-11	2017-08-02	Rhodes Technologies	Transition metal-catalyzed processes for the preparation of n-allyl compounds and use thereof
BR112013007566A2 (en)	2010-09-28	2016-08-02	Panacea Biotec Ltd	new bicyclic compounds
CN105764888B (en) *	2013-11-20	2018-04-06	株式会社三和化学研究所	A kind of new 3 azabicyclos [3.1.0] hexame derivatives and its medical usage
CN107428687B (en)	2015-05-20	2021-06-11	宇部兴产株式会社	Crystal of salt of 3-azabicyclo [3.1.0] hexane derivative and medical application thereof
CN110446495B (en)	2017-02-17	2023-09-05	特维娜有限公司	Delta opioid receptor modulating compound containing 7-membered azaheterocyclic ring and its use and preparation method
AU2018221148B2 (en)	2017-02-17	2022-05-05	Trevena, Inc.	5-membered aza-heterocyclic containing delta-opioid receptor modulating compounds, methods of using and making the same
JPWO2018159716A1 (en)	2017-03-02	2019-12-26	株式会社三和化学研究所	Drugs for alcohol use disorders
CN108250088B (en) *	2018-01-04	2020-10-30	四川之江高新材料股份有限公司	The preparation method of N,N,N'-trimethyl-N'-hydroxyethyl bisaminoethyl ether
CN115825305B (en) *	2022-10-21	2024-09-20	昆明理工大学	A molecularly imprinted solid phase microextraction fiber and its preparation method and application

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3065230A (en) *	1959-03-16	1962-11-20	Burroughs Wellcome Co	Azabicyclohexanes and method of preparing them
DE3851081T2 (en) *	1987-04-16	1995-02-16	Lilly Co Eli	Piperidines as opioid antagonists.
US5159081A (en) *	1991-03-29	1992-10-27	Eli Lilly And Company	Intermediates of peripherally selective n-carbonyl-3,4,4-trisubstituted piperidine opioid antagonists
DE4341403A1 (en) *	1993-12-04	1995-06-08	Basf Ag	N-substituted 3-azabicycloalkane derivatives, their preparation and use
TWI244481B (en) *	1998-12-23	2005-12-01	Pfizer	3-azabicyclo[3.1.0]hexane derivatives useful in therapy
PE20001420A1 (en) *	1998-12-23	2000-12-18	Pfizer	CCR5 MODULATORS

2000
- 2000-06-23 GB GBGB0015562.2A patent/GB0015562D0/en not_active Ceased
2001
- 2001-06-06 DO DO2001000187A patent/DOP2001000187A/en unknown
- 2001-06-07 HU HU0301228A patent/HUP0301228A3/en unknown
- 2001-06-07 JP JP2002504223A patent/JP2004512263A/en not_active Withdrawn
- 2001-06-07 EP EP01936728A patent/EP1292574A1/en not_active Withdrawn
- 2001-06-07 OA OA1200200386A patent/OA12293A/en unknown
- 2001-06-07 DZ DZ013368A patent/DZ3368A1/en active
- 2001-06-07 KR KR1020027017503A patent/KR20040002386A/en not_active Ceased
- 2001-06-07 CA CA002412188A patent/CA2412188A1/en not_active Abandoned
- 2001-06-07 NZ NZ523141A patent/NZ523141A/en unknown
- 2001-06-07 PL PL01365956A patent/PL365956A1/en not_active Application Discontinuation
- 2001-06-07 HR HR20020998A patent/HRP20020998A2/en not_active Application Discontinuation
- 2001-06-07 MX MXPA02012878A patent/MXPA02012878A/en unknown
- 2001-06-07 SK SK1717-2002A patent/SK17172002A3/en unknown
- 2001-06-07 IL IL15342701A patent/IL153427A0/en unknown
- 2001-06-07 YU YU91802A patent/YU91802A/en unknown
- 2001-06-07 AU AU62591/01A patent/AU781837B2/en not_active Ceased
- 2001-06-07 CN CNA018116086A patent/CN1639121A/en active Pending
- 2001-06-07 AP APAP/P/2002/002698A patent/AP2002002698A0/en unknown
- 2001-06-07 EA EA200201269A patent/EA005117B1/en not_active IP Right Cessation
- 2001-06-07 WO PCT/IB2001/001035 patent/WO2001098267A1/en not_active Ceased
- 2001-06-07 CZ CZ20023967A patent/CZ20023967A3/en unknown
- 2001-06-07 BR BR0111867-6A patent/BR0111867A/en not_active IP Right Cessation
- 2001-06-12 PA PA20018519401A patent/PA8519401A1/en unknown
- 2001-06-21 AR ARP010102957A patent/AR028969A1/en unknown
- 2001-06-21 PE PE2001000604A patent/PE20020253A1/en not_active Application Discontinuation
- 2001-06-21 UY UY26787A patent/UY26787A1/en not_active Application Discontinuation
- 2001-06-22 TN TNTNSN01094A patent/TNSN01094A1/en unknown
- 2001-07-06 UA UA20021210406A patent/UA73176C2/en unknown
2002
- 2002-11-28 IS IS6637A patent/IS6637A/en unknown
- 2002-11-28 BG BG107329A patent/BG107329A/en unknown
- 2002-12-16 MA MA26955A patent/MA26915A1/en unknown
- 2002-12-19 ZA ZA200210278A patent/ZA200210278B/en unknown
- 2002-12-20 NO NO20026168A patent/NO20026168L/en not_active Application Discontinuation

Also Published As

Publication number	Publication date
OA12293A (en)	2004-03-18
MXPA02012878A (en)	2003-05-14
TNSN01094A1 (en)	2005-11-10
SK17172002A3 (en)	2004-09-08
UA73176C2 (en)	2005-06-15
HUP0301228A2 (en)	2003-08-28
NO20026168D0 (en)	2002-12-20
HRP20020998A2 (en)	2004-02-29
DOP2001000187A (en)	2002-03-30
HUP0301228A3 (en)	2005-08-29
KR20040002386A (en)	2004-01-07
AU6259101A (en)	2002-01-02
MA26915A1 (en)	2004-12-20
BR0111867A (en)	2003-07-01
ZA200210278B (en)	2003-12-19
AU781837B2 (en)	2005-06-16
AP2002002698A0 (en)	2002-12-31
NO20026168L (en)	2003-02-18
CA2412188A1 (en)	2001-12-27
AR028969A1 (en)	2003-05-28
PL365956A1 (en)	2005-01-24
GB0015562D0 (en)	2000-08-16
EP1292574A1 (en)	2003-03-19
PE20020253A1 (en)	2002-04-08
UY26787A1 (en)	2002-01-31
DZ3368A1 (en)	2001-12-27
NZ523141A (en)	2005-06-24
WO2001098267A1 (en)	2001-12-27
BG107329A (en)	2003-07-31
PA8519401A1 (en)	2002-12-30
IL153427A0 (en)	2003-07-06
WO2001098267A8 (en)	2003-02-27
EA005117B1 (en)	2004-10-28
CZ20023967A3 (en)	2004-02-18
YU91802A (en)	2006-05-25
CN1639121A (en)	2005-07-13
JP2004512263A (en)	2004-04-22
EA200201269A1 (en)	2003-06-26

Publication	Publication Date	Title
IS5922A (en)	2001-04-20	3-azabicyclo [3.1.0] hexane derivatives as opiate receptors
IS6637A (en)	2002-11-28	3-azabicyclo [3.1.0] hexane derivatives useful in treatment
IL160707A0 (en)	2004-08-31	1, 8-naphthyridine derivatives as antidiabetics
IL159890A0 (en)	2004-06-20	Dolastatin 10 derivatives
AU6053701A (en)	2001-12-17	2-aminocarbonyl-9h-purine derivatives
HRP20030055A2 (en)	2005-02-28	4-phenyl-pyridine derivatives
MXPA03004644A (en)	2003-09-05	Phenylacetamido- pyrazole derivatives and their use as antitumor agents.
IL150841A0 (en)	2003-02-12	1h-imidazopyridine derivatives
AU2001230026A1 (en)	2001-08-14	2,4-diaminothiazole derivatives
HUP0203961A3 (en)	2003-05-28	3-phenoxy-1-phenyl acetylene derivatives and their use as herbicedes
EP1284735A4 (en)	2006-01-11	Apomorphine derivatives and methods for their use
AU3166401A (en)	2001-08-20	Indol-3-yl derivatives
AU1397802A (en)	2002-04-22	Substituted c-cyclohexylmethylamine derivatives
IS6438A (en)	2002-06-20	New asabicyclooctane derivatives useful in the treatment of arrhythmias
AR028607A1 (en)	2003-05-14	DERIVATIVES OF 1,4-DIAZEPAN-2,5-DIONA
IL154675A0 (en)	2003-09-17	N-(3,5-dichloro-2-methoxyphenyl)-4-methoxy-3-piperazin-1-yl-benzenesulfonamide
SI1246791T1 (en)	2005-06-30	Aminomethyl-phenyl-cyclohexanone derivatives
GB0009831D0 (en)	2000-06-07	Versatile agricultural machine
IS6663A (en)	2002-12-23	Indole derivatives useful in the treatment of MTK disorders
IL146157A0 (en)	2002-07-25	Improvements to el type pulverizers
IL151598A0 (en)	2003-04-10	2-phenylpyran-4-one derivatives
IL176074A0 (en)	2006-10-05	1,2,3,4-tetrahydroisoquinoline derivatives, preparations thereof and uses thereof
PL347407A1 (en)	2001-11-19	Method of obtaining derivatives of 5,6,7,8-tetrahydronaphtalen-2-ole
GB2350361B (en)	2003-12-03	3,4,5-tricyanophenyl derivatives
DK1274687T3 (en)	2005-05-23	1,2,3,4-tetrahydroisoquinoline derivatives