IS7393A - Aðferð til að draga makrólíð út úr lífmassa - Google Patents

Aðferð til að draga makrólíð út úr lífmassa

Info

Publication number: IS7393A
Authority: IS; Iceland
Prior art keywords: biomass; macrolide; extracting; extracting macrolide; biomatter
Prior art date: 2002-02-13

Application number

IS7393A

Other languages

English (en)

Inventor

Keri Vilmos

Deak Lajos

Szabo Csaba

Original Assignee

Teva Gyogyszergy βr Részvényt βrsas βg

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2002-02-13

Filing date

2004-08-11

Publication date

2004-08-11

2004-08-11 Application filed by Teva Gyogyszergy βr Részvényt βrsas βg filed Critical Teva Gyogyszergy βr Részvényt βrsas βg

2004-08-11 Publication of IS7393A publication Critical patent/IS7393A/is

Links

239000003120 macrolide antibiotic agent Substances 0.000 title abstract 2
239000002028 Biomass Substances 0.000 title 1
QJJXYPPXXYFBGM-LFZNUXCKSA-N Tacrolimus Chemical compound C1C[C@@H](O)[C@H](OC)C[C@@H]1\C=C(/C)[C@@H]1[C@H](C)[C@@H](O)CC(=O)[C@H](CC=C)/C=C(C)/C[C@H](C)C[C@H](OC)[C@H]([C@H](C[C@H]2C)OC)O[C@@]2(O)C(=O)C(=O)N2CCCC[C@H]2C(=O)O1 QJJXYPPXXYFBGM-LFZNUXCKSA-N 0.000 abstract 1
229960001967 tacrolimus Drugs 0.000 abstract 1
QJJXYPPXXYFBGM-SHYZHZOCSA-N tacrolimus Natural products CO[C@H]1C[C@H](CC[C@@H]1O)C=C(C)[C@H]2OC(=O)[C@H]3CCCCN3C(=O)C(=O)[C@@]4(O)O[C@@H]([C@H](C[C@H]4C)OC)[C@@H](C[C@H](C)CC(=C[C@@H](CC=C)C(=O)C[C@H](O)[C@H]2C)C)OC QJJXYPPXXYFBGM-SHYZHZOCSA-N 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D267/00—Heterocyclic compounds containing rings of more than six members having one nitrogen atom and one oxygen atom as the only ring hetero atoms
- C07D267/22—Eight-membered rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
- C07D498/18—Bridged systems
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D11/00—Solvent extraction
- B01D11/02—Solvent extraction of solids
- B01D11/0288—Applications, solvents
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D9/00—Crystallisation
- B01D9/0004—Crystallisation cooling by heat exchange
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D9/00—Crystallisation
- B01D9/005—Selection of auxiliary, e.g. for control of crystallisation nuclei, of crystal growth, of adherence to walls; Arrangements for introduction thereof
- B01D9/0054—Use of anti-solvent
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S435/00—Chemistry: molecular biology and microbiology
- Y10S435/8215—Microorganisms
- Y10S435/822—Microorganisms using bacteria or actinomycetales
- Y10S435/886—Streptomyces
- Y10S435/898—Streptomyces hygroscopicus

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Chemical Kinetics & Catalysis (AREA)
Crystallography & Structural Chemistry (AREA)
Physics & Mathematics (AREA)
Thermal Sciences (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Saccharide Compounds (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Extraction Or Liquid Replacement (AREA)

IS7393A 2002-02-13 2004-08-11 Aðferð til að draga makrólíð út úr lífmassa IS7393A (is)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US35695902P	2002-02-13	2002-02-13
PCT/US2003/004222 WO2003068980A2 (en)	2002-02-13	2003-02-12	Method for extracting a macrolide from biomatter

Publications (1)

Publication Number	Publication Date
IS7393A true IS7393A (is)	2004-08-11

Family

ID=27734710

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
IS7393A IS7393A (is)	2002-02-13	2004-08-11	Aðferð til að draga makrólíð út úr lífmassa

Country Status (15)

Country	Link
US (1)	US7432074B2 (is)
EP (1)	EP1474404A4 (is)
JP (1)	JP4261365B2 (is)
KR (1)	KR20040086369A (is)
CN (1)	CN100338043C (is)
AU (1)	AU2003213024A1 (is)
CA (1)	CA2475383C (is)
HR (1)	HRP20040765A2 (is)
IL (1)	IL163481A (is)
IS (1)	IS7393A (is)
MX (1)	MXPA04007847A (is)
NO (1)	NO20043788L (is)
PL (1)	PL374059A1 (is)
WO (1)	WO2003068980A2 (is)
ZA (1)	ZA200406350B (is)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US7452692B2 (en) *	2002-02-13	2008-11-18	Teva Gyógyszergyár Zártkörüen Müködö Részvénytársaság	Method for extracting a macrolide from biomatter
EP1474404A4 (en)	2002-02-13	2006-01-11	Biogal Gyogyszergyar	PROCESS FOR EXTRACTION OF A BIOLOGICAL MATERIAL
US20060169199A1 (en) *	2003-03-31	2006-08-03	Vilmos Keri	Crystallization and purification of macrolides
KR20050114262A (ko) *	2003-03-31	2005-12-05	테바 기오기스제르갸르 레스즈베니타르사사그	마크로라이드의 결정화 및 정제
EP1558622B1 (en) *	2003-07-24	2007-11-14	TEVA Gyógyszergyár Zártkörüen Müködö Részvénytársaság	Method of purifying macrolides
CA2548297C (en) *	2003-12-05	2011-06-14	Biocon Limited	Process for the purification of macrolides
KR100485877B1 (ko) *	2003-12-30	2005-04-28	종근당바이오 주식회사	타크롤리무스를 생산하는 미생물 및 이를 이용한타크롤리무스의 대량 생산방법
EP1756290B1 (en) *	2004-04-12	2016-05-04	Biocon Limited	Streptomyces sp. bicc 7522 and its use for the production of macrolides
JP2008512125A (ja) *	2004-09-10	2008-04-24	アイバックスファーマシューティカルズスポレツノストエスルチェニムオメゼニム	マクロリド化合物を単離する方法
MX2007002808A (es) *	2004-09-10	2007-10-10	Ivax Pharmaceuticals Sro	Proceso para el aislamiento de tacrolimus cristalino.
WO2006060615A1 (en) *	2004-12-01	2006-06-08	Teva Gyógyszergyár Zàrtköruen Muködo Rèszvènytàrsasàg	Non-hygroscopic and powdery amorphous pimecrolimus
TW200637835A (en) *	2004-12-22	2006-11-01	Teva Gyogyszergyar Zartkoruen Mukodo Reszvenytarsasag	Method of purifying tacrolimus
WO2006083486A1 (en) *	2005-01-05	2006-08-10	TEVA GYÓGYSZERGYÁR ZÁRTKöR..EN M..k..D.. RÉSZVÉNYTÁRSASÁG	Amorphous tacrolimus and preparation thereof
CN108384819B (zh) *	2017-02-03	2021-06-25	上海医药工业研究院	一种用于发酵他克莫司的培养基以及发酵方法
CN112390817B (zh) *	2019-08-19	2023-07-07	鲁南制药集团股份有限公司	一种盐析萃取他克莫司发酵液的方法
CN112730704B (zh) *	2021-02-04	2022-08-16	福建省微生物研究所	一种他克莫司软膏有关物质测定的前处理方法
CN115536672B (zh) *	2022-10-12	2024-05-14	国药集团川抗制药有限公司	他克莫司粗品的提取方法和应用

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DE2121517C3 (de)	1971-04-30	1974-06-27	Leningradskij Nautschno-Issledowatelskij Institut Antibiotikow, Ssr, Leningrad (Sowjetunion)	Verfahren zur Gewinnung von Amphoterizin B
US3993749A (en) *	1974-04-12	1976-11-23	Ayerst Mckenna And Harrison Ltd.	Rapamycin and process of preparation
US4160861A (en)	1977-10-03	1979-07-10	Merck & Co., Inc.	Method for the separation of antibiotic macrolides
JPS591694B2 (ja) *	1981-12-28	1984-01-13	三菱瓦斯化学株式会社	４−ヒドロキシ−２，４，６−トリメチルシクロヘキサ−２，５−ジエン−１−オンの製造法
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JP2639737B2 (ja)	1990-01-23	1997-08-13	寳酒造株式会社	新規ｒ１０６類化合物
JP3067183B2 (ja)	1990-09-18	2000-07-17	藤沢薬品工業株式会社	Ｆｒ９００５０６物質の製造法
US5116756A (en)	1991-01-28	1992-05-26	Merck & Co., Inc.	Process for producing FK-506
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FI934447A7 (fi) *	1991-04-11	1993-10-08	Pfizer	Uusi immuunivastetta heikentävä aine lajilta Streptomyces braegensis
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JP2564765B2 (ja)	1992-03-02	1996-12-18	ファイザー・インコーポレーテッド	マクロライド系抗生物質のフルオロ糖誘導体
FI944014A0 (fi)	1992-03-02	1994-09-01	Pfizer	Makrolidien desosaminojohdannaiset immuunivastetta heikentävinä aineina ja sieniä vastustavina aineina
US5264355A (en)	1992-07-02	1993-11-23	Merck & Co., Inc.	Methlating enzyme from streptomyces MA6858
UA41884C2 (uk) *	1993-11-05	2001-10-15	Амерікан Хоум Продактс Корпорейшн	Спосіб відокремлення рапаміцину від кислотних, основних та неполярних нейтральних домішок, присутніх в концентраті екстрактів ферментаційного бульйону або маточних розчинів
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DE4425066A1 (de) *	1994-07-15	1996-01-18	Solvay Fluor & Derivate	Anwendungen und Zusammensetzungen mit Difluormethoxy-2,2,2-trifluorethan
GB9618952D0 (en)	1996-09-11	1996-10-23	Sandoz Ltd	Process
US5616595A (en) *	1995-06-07	1997-04-01	Abbott Laboratories	Process for recovering water insoluble compounds from a fermentation broth
EP1117801B1 (en)	1998-10-02	2006-11-29	Kosan Biosciences, Inc.	Polyketide synthase enzymes and recombinant dna constructs therefor, for the production of compounds related to fk-506 and fk-520
GB9826882D0 (en)	1998-12-07	1999-01-27	Novartis Ag	Organic compounds
PT1183261E (pt)	1999-05-25	2004-11-30	Fujisawa Pharmaceutical Co	Metodo para separar compostos organicos analogos
TW553946B (en)	1999-09-08	2003-09-21	Fujisawa Pharmaceutical Co	Method for separating lactone-containing high-molecular weight compounds
ES2177373B1 (es)	1999-11-26	2003-11-01	Astur Pharma Sa	Preparacion de azitromicina en su forma no cristalina
WO2001062949A1 (en) *	2000-02-24	2001-08-30	Biogal Gyogyszergyar Rt	Method of purifying a fermentation broth
EP1474404A4 (en)	2002-02-13	2006-01-11	Biogal Gyogyszergyar	PROCESS FOR EXTRACTION OF A BIOLOGICAL MATERIAL

2003
- 2003-02-12 EP EP03709066A patent/EP1474404A4/en not_active Withdrawn
- 2003-02-12 AU AU2003213024A patent/AU2003213024A1/en not_active Abandoned
- 2003-02-12 US US10/366,266 patent/US7432074B2/en not_active Expired - Fee Related
- 2003-02-12 WO PCT/US2003/004222 patent/WO2003068980A2/en not_active Ceased
- 2003-02-12 ZA ZA200406350A patent/ZA200406350B/en unknown
- 2003-02-12 CN CNB038073277A patent/CN100338043C/zh not_active Expired - Fee Related
- 2003-02-12 KR KR10-2004-7012482A patent/KR20040086369A/ko not_active Abandoned
- 2003-02-12 HR HR20040765A patent/HRP20040765A2/hr not_active Application Discontinuation
- 2003-02-12 JP JP2003568091A patent/JP4261365B2/ja not_active Expired - Fee Related
- 2003-02-12 PL PL03374059A patent/PL374059A1/xx not_active Application Discontinuation
- 2003-02-12 CA CA002475383A patent/CA2475383C/en not_active Expired - Fee Related
- 2003-02-12 MX MXPA04007847A patent/MXPA04007847A/es active IP Right Grant
2004
- 2004-08-11 IS IS7393A patent/IS7393A/is unknown
- 2004-08-12 IL IL163481A patent/IL163481A/en not_active IP Right Cessation
- 2004-09-09 NO NO20043788A patent/NO20043788L/no not_active Application Discontinuation

Also Published As

Publication number	Publication date
CN100338043C (zh)	2007-09-19
KR20040086369A (ko)	2004-10-08
WO2003068980A2 (en)	2003-08-21
EP1474404A4 (en)	2006-01-11
MXPA04007847A (es)	2005-02-24
CA2475383C (en)	2009-12-22
JP2005525105A (ja)	2005-08-25
IL163481A (en)	2010-04-29
US7432074B2 (en)	2008-10-07
US20030166924A1 (en)	2003-09-04
HRP20040765A2 (en)	2005-02-28
WO2003068980A3 (en)	2003-12-31
CN1649852A (zh)	2005-08-03
JP4261365B2 (ja)	2009-04-30
ZA200406350B (en)	2006-11-29
NO20043788L (no)	2004-09-09
CA2475383A1 (en)	2003-08-21
AU2003213024A1 (en)	2003-09-04
PL374059A1 (en)	2005-09-19
EP1474404A2 (en)	2004-11-10

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