IS7642A - Aðferð til að aðskilja milliefni sem nota má til framleiðslu á essítalóprami - Google Patents

Aðferð til að aðskilja milliefni sem nota má til framleiðslu á essítalóprami

Info

Publication number: IS7642A
Authority: IS; Iceland
Prior art keywords: acitalopram; production; separating intermediates; intermediates; separating
Prior art date: 2002-08-12

Application number

IS7642A

Other languages

English (en)

Inventor

Taoka Naoaki

Kato Takahisa

Yamamoto Shogo

Yoshida Takashi

Takeda Toshihiro

Ueda Yasuyoshi

Petersen Hans

Dancer Robert

Ahmadian Haleh

Ole Lyngsø Lars

Original Assignee

H. Lundbeck A/S

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2002-08-12

Filing date

2005-01-12

Publication date

2005-01-12

2005-01-12 Application filed by H. Lundbeck A/S filed Critical H. Lundbeck A/S

2005-01-12 Publication of IS7642A publication Critical patent/IS7642A/is

Links

239000000543 intermediate Substances 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B57/00—Separation of optically-active compounds
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C255/00—Carboxylic acid nitriles
- C07C255/49—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
- C07C255/53—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton containing cyano groups and hydroxy groups bound to the carbon skeleton
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C253/00—Preparation of carboxylic acid nitriles
- C07C253/30—Preparation of carboxylic acid nitriles by reactions not involving the formation of cyano groups
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C253/00—Preparation of carboxylic acid nitriles
- C07C253/32—Separation; Purification; Stabilisation; Use of additives
- C07C253/34—Separation; Purification
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C255/00—Carboxylic acid nitriles
- C07C255/01—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms
- C07C255/32—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms having cyano groups bound to acyclic carbon atoms of a carbon skeleton containing at least one six-membered aromatic ring
- C07C255/34—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms having cyano groups bound to acyclic carbon atoms of a carbon skeleton containing at least one six-membered aromatic ring with cyano groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by unsaturated carbon chains
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C255/00—Carboxylic acid nitriles
- C07C255/49—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
- C07C255/58—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton containing cyano groups and singly-bound nitrogen atoms, not being further bound to other hetero atoms, bound to the carbon skeleton
- C07C255/59—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton containing cyano groups and singly-bound nitrogen atoms, not being further bound to other hetero atoms, bound to the carbon skeleton the carbon skeleton being further substituted by singly-bound oxygen atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D307/87—Benzo [c] furans; Hydrogenated benzo [c] furans
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P13/00—Preparation of nitrogen-containing organic compounds
- C12P13/001—Amines; Imines
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P13/00—Preparation of nitrogen-containing organic compounds
- C12P13/002—Nitriles (-CN)
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P13/00—Preparation of nitrogen-containing organic compounds
- C12P13/008—Preparation of nitrogen-containing organic compounds containing a N-O bond, e.g. nitro (-NO2), nitroso (-NO)
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P13/00—Preparation of nitrogen-containing organic compounds
- C12P13/02—Amides, e.g. chloramphenicol or polyamides; Imides or polyimides; Urethanes, i.e. compounds comprising N-C=O structural element or polyurethanes
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P41/00—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture
- C12P41/006—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture by reactions involving C-N bonds, e.g. nitriles, amides, hydantoins, carbamates, lactames, transamination reactions, or keto group formation from racemic mixtures
- C12P41/007—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture by reactions involving C-N bonds, e.g. nitriles, amides, hydantoins, carbamates, lactames, transamination reactions, or keto group formation from racemic mixtures by reactions involving acyl derivatives of racemic amines
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P7/00—Preparation of oxygen-containing organic compounds
- C12P7/02—Preparation of oxygen-containing organic compounds containing a hydroxy group
- C12P7/22—Preparation of oxygen-containing organic compounds containing a hydroxy group aromatic
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/07—Optical isomers

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Wood Science & Technology (AREA)
Engineering & Computer Science (AREA)
Zoology (AREA)
Chemical Kinetics & Catalysis (AREA)
Health & Medical Sciences (AREA)
General Health & Medical Sciences (AREA)
General Chemical & Material Sciences (AREA)
Biotechnology (AREA)
Biochemistry (AREA)
Bioinformatics & Cheminformatics (AREA)
General Engineering & Computer Science (AREA)
Microbiology (AREA)
Genetics & Genomics (AREA)
Analytical Chemistry (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Hydrogenated Pyridines (AREA)

IS7642A 2002-08-12 2005-01-12 Aðferð til að aðskilja milliefni sem nota má til framleiðslu á essítalóprami IS7642A (is)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
DKPA200201201		2002-08-12
PCT/DK2003/000537 WO2004014821A1 (en)	2002-08-12	2003-08-12	Method for the separation of intermediates which may be used for the preparation of escitalopram

Publications (1)

Publication Number	Publication Date
IS7642A true IS7642A (is)	2005-01-12

Family

ID=34717090

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
IS7642A IS7642A (is)	2002-08-12	2005-01-12	Aðferð til að aðskilja milliefni sem nota má til framleiðslu á essítalóprami

Country Status (23)

Country	Link
US (2)	US20070129561A1 (is)
EP (2)	EP1534654A1 (is)
JP (3)	JP4694837B2 (is)
KR (1)	KR20050053618A (is)
CN (2)	CN100548939C (is)
AR (1)	AR040970A1 (is)
AU (1)	AU2003250321B2 (is)
BR (1)	BR0313114A (is)
CA (1)	CA2495118C (is)
EA (1)	EA011762B1 (is)
IL (1)	IL166319A0 (is)
IS (1)	IS7642A (is)
ME (1)	ME00028B (is)
MX (1)	MXPA05001400A (is)
NO (1)	NO20051292L (is)
NZ (1)	NZ537785A (is)
PE (1)	PE20040991A1 (is)
PL (1)	PL374835A1 (is)
RS (1)	RS20050092A (is)
TW (1)	TWI306846B (is)
UA (1)	UA78840C2 (is)
WO (1)	WO2004014821A1 (is)
ZA (1)	ZA200500728B (is)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
AU2003223105A1 (en) *	2003-03-24	2004-10-18	Hetero Drugs Limited	Novel crystalline forms of (s)-citalopram oxalate
ES2228274B1 (es) *	2003-09-24	2006-06-01	Astur Pharma, S.A.	Sintesis quimioenzimatica de (+)-citalopram y (-)-citalopram.
TWI339651B (en)	2004-02-12	2011-04-01	Lundbeck & Co As H	Method for the separation of intermediates which may be used for the preparation of escitalopram
NZ549100A (en) *	2004-03-05	2010-02-26	Lundbeck & Co As H	Crystalline composition containing escitalopram oxalate
US20050196453A1 (en)	2004-03-05	2005-09-08	H. Lundbeck A/S	Crystalline composition containing escitalopram
ITMI20040717A1 (it) *	2004-04-09	2004-07-09	Adorkem Technology Spa	Procedimento chemo-enzimatico per la preparazione dell'escitalopram
ITMI20041872A1 (it)	2004-10-01	2005-01-01	Adorkem Technology Spa	Processo per la preparazione di citalopram e di scitalopram
EP1736550A1 (en) *	2005-06-22	2006-12-27	Adorkem Technology SpA	Chemoenzymatic process for the synthesis of escitalopram
GB0601286D0 (en)	2006-01-23	2006-03-01	Sandoz Ag	Asymmetric synthesis
WO2008059514A2 (en) *	2006-07-31	2008-05-22	Cadila Healthcare Limited	Process for preparing escitalopram
US7686946B2 (en)	2007-08-17	2010-03-30	Uop Llc	Method of altering a feed to a reaction zone
CN100548974C (zh) *	2007-10-11	2009-10-14	浙江大学	西酞普兰中间体的萃取分离方法
JP5563483B2 (ja) *	2008-01-25	2014-07-30	ゼノポート，インコーポレイティド	アシロキシアルキルカルバメートプロドラッグの合成に使用されるアシロキシアルキルチオカーボネートの鏡像異性的な分解
ITMI20120448A1 (it)	2012-01-30	2013-07-31	Carthesia Sas	Composizione liofilizzata di escitalopram ossalato per somministrazione sublinguale
ES2554563B2 (es) *	2014-05-05	2016-08-16	Universidad De Sevilla	Cepas bacterianas y sus usos en reacciones de acilación y/o desacilación
WO2017009866A1 (en) *	2015-07-11	2017-01-19	Ipca Laboratories Limited	Novel recovery and recycling process of racemic 4-(4-dimethylamino)-1-(4'-fluorophenyl)-1-(hydroxybutyl)-3-(hydroxymethyl)-benzonitrile

Family Cites Families (33)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB1526331A (en)	1976-01-14	1978-09-27	Kefalas As	Phthalanes
GB8419963D0 (en) *	1984-08-06	1984-09-12	Lundbeck & Co As H	Intermediate compound and method
GB8814057D0 (en) *	1988-06-14	1988-07-20	Lundbeck & Co As H	New enantiomers & their isolation
JP3097145B2 (ja)	1991-02-27	2000-10-10	日産化学工業株式会社	コーリーラクトンジオールの光学分割方法
SE511903C2 (sv)	1996-06-28	1999-12-13	Sca Hygiene Prod Ab	Absorberande alster innefattande en absorptionskropp med förbättrade vätskeinsläppsegenskaper
IT236075Y1 (it)	1997-06-26	2000-07-26	Emilio Brocco	Macchina segatrice per la divisione in lastre di blocchi di materialelapideo
UA62985C2 (en) *	1997-11-10	2004-01-15	Lunnbeck As H	A method for the preparation of citalopram
DK1042310T3 (da)	1997-11-11	2002-12-02	Lundbeck & Co As H	Fremgangsmåde til fremstilling af citalopram
JPH1129418A (ja) *	1998-06-12	1999-02-02	Takeda Chem Ind Ltd	農園芸用殺虫殺菌組成物
DE19832547A1 (de)	1998-07-21	2000-01-27	Basf Ag	Enzymhaltige Polymere
US6294571B1 (en) *	1998-09-11	2001-09-25	Independent Ink, Inc.	Method for using neem extracts and derivatives for protecting wood and other cellulosic composites
ES2189502T3 (es)	1998-10-20	2003-07-01	Lundbeck & Co As H	Metodo para la prevencion de citalopram.
AR022329A1 (es)	1999-01-29	2002-09-04	Lundbeck & Co As H	Metodo para la preparacion de 5-cianoftalida
DK1173431T4 (da) *	1999-04-14	2010-01-04	Lundbeck & Co As H	Fremgangsmåde til fremstilling af citalopram
ITMI991579A1 (it)	1999-06-25	2001-01-15	Lundbeck & Co As H	Metodo per la preparazione di citalopram
ITMI991581A1 (it)	1999-06-25	2001-01-15	Lundbeck & Co As H	Metodo per la preparazione di citalopram
ITMI991486A1 (it)	1999-07-06	2001-01-06	Vis Farmaceutici S P A	Processo per la sintesi di citalopram
DK1298124T3 (da) *	1999-10-25	2007-07-09	Lundbeck & Co As H	Fremgangsmåde til fremstilling af citalopram
CH692421A5 (de) *	1999-10-25	2002-06-14	Lundbeck & Co As H	Verfahren zur Herstellung von Citalopram.
FR2805812A1 (fr)	2000-02-24	2001-09-07	Lundbeck & Co As H	Procede de preparation du citalopram
IES20010157A2 (en)	2000-03-03	2002-03-06	Lundbeck & Co As H	Method for the preparation of citalopram
GB0005477D0 (en) *	2000-03-07	2000-04-26	Resolution Chemicals Limited	Process for the preparation of citalopram
KR20020080485A (ko)	2000-03-13	2002-10-23	하. 룬트벡 아크티에 셀스카브	5-치환 1-(4-플루오로페닐)-1,3-디히드로이소벤조푸란의단계적 알킬화
AU2001242298A1 (en)	2000-03-13	2001-09-24	H Lunbeck A/S	Method for the preparation of citalopram
ES2214400T3 (es)	2000-03-14	2004-09-16	H. Lundbeck A/S	Metodo para la preparacion de citalopram.
DE10190485T1 (de)	2000-03-16	2002-03-21	Lundbeck & Co As H	Verfahren zur Herstellung von 5-Cyano-1-(4-fluorphenyl)-1,3-dihydroisobenzofuranen
CA2354877C (en) *	2000-08-18	2006-05-02	H. Lundbeck A/S	Method for the preparation of citalopram
AR034612A1 (es)	2001-06-25	2004-03-03	Lundbeck & Co As H	Proceso para la preparacion del citalopram racemico y/o del s- o r-citalopram mediante la separacion de una mezcla de r- y s-citalopram
AR034759A1 (es) *	2001-07-13	2004-03-17	Lundbeck & Co As H	Metodo para la preparacion de escitalopram
PT1522539E (pt)	2001-07-31	2007-03-30	Lundbeck & Co As H	Composição cristalina contendo escitalopram
IS7239A (is) *	2001-12-14	2004-04-29	H. Lundbeck A/S	Aðferð til framleiðslu á essítalóprami
CA2381341A1 (en) *	2002-04-09	2003-10-09	Torcan Chemical Ltd.	Process and intermediates for preparing escitalopram
CN1510024A (zh) *	2002-12-24	2004-07-07	北京德众万全药物技术开发有限公司	可用于制备西酞普兰(s)-对映异构体的新的化合物及其制备方法

2003
- 2003-08-11 TW TW092121967A patent/TWI306846B/zh not_active IP Right Cessation
- 2003-08-11 PE PE2003000799A patent/PE20040991A1/es not_active Application Discontinuation
- 2003-08-11 AR ARP030102904A patent/AR040970A1/es unknown
- 2003-08-12 WO PCT/DK2003/000537 patent/WO2004014821A1/en not_active Ceased
- 2003-08-12 NZ NZ537785A patent/NZ537785A/en unknown
- 2003-08-12 JP JP2004526641A patent/JP4694837B2/ja not_active Expired - Lifetime
- 2003-08-12 ME MEP-2008-16A patent/ME00028B/me unknown
- 2003-08-12 AU AU2003250321A patent/AU2003250321B2/en not_active Ceased
- 2003-08-12 CN CNB03819001XA patent/CN100548939C/zh not_active Expired - Lifetime
- 2003-08-12 PL PL03374835A patent/PL374835A1/xx unknown
- 2003-08-12 EP EP03783962A patent/EP1534654A1/en not_active Withdrawn
- 2003-08-12 CN CN2007101018055A patent/CN101045664B/zh not_active Expired - Lifetime
- 2003-08-12 KR KR1020057002554A patent/KR20050053618A/ko not_active Ceased
- 2003-08-12 IL IL16631903A patent/IL166319A0/xx unknown
- 2003-08-12 RS YUP-2005/0092A patent/RS20050092A/sr unknown
- 2003-08-12 CA CA2495118A patent/CA2495118C/en not_active Expired - Fee Related
- 2003-08-12 US US10/524,937 patent/US20070129561A1/en not_active Abandoned
- 2003-08-12 MX MXPA05001400A patent/MXPA05001400A/es active IP Right Grant
- 2003-08-12 EA EA200500349A patent/EA011762B1/ru not_active IP Right Cessation
- 2003-08-12 EP EP11165320A patent/EP2360150A1/en not_active Withdrawn
- 2003-08-12 BR BR0313114-9A patent/BR0313114A/pt not_active Application Discontinuation
- 2003-12-08 UA UAA200501846A patent/UA78840C2/uk unknown
2005
- 2005-01-12 IS IS7642A patent/IS7642A/is unknown
- 2005-01-25 ZA ZA200500728A patent/ZA200500728B/xx unknown
- 2005-03-14 NO NO20051292A patent/NO20051292L/no not_active Application Discontinuation
2010
- 2010-02-17 JP JP2010032381A patent/JP5520077B2/ja not_active Expired - Lifetime
- 2010-05-17 US US12/781,026 patent/US8067640B2/en not_active Expired - Fee Related
- 2010-11-25 JP JP2010262040A patent/JP2011055842A/ja active Pending

Also Published As

Publication number	Publication date
MXPA05001400A (es)	2005-04-28
MEP1608A (xx)	2010-02-10
EA011762B1 (ru)	2009-06-30
EP1534654A1 (en)	2005-06-01
IL166319A0 (en)	2006-01-15
CA2495118A1 (en)	2004-02-19
JP2010150270A (ja)	2010-07-08
ZA200500728B (en)	2006-07-26
CN100548939C (zh)	2009-10-14
ME00028B (me)	2010-02-10
UA78840C2 (en)	2007-04-25
NZ537785A (en)	2006-12-22
PL374835A1 (en)	2005-10-31
AU2003250321A1 (en)	2004-02-25
PE20040991A1 (es)	2004-12-27
JP2011055842A (ja)	2011-03-24
JP5520077B2 (ja)	2014-06-11
JP2005535322A (ja)	2005-11-24
HK1131514A1 (en)	2010-01-15
CA2495118C (en)	2010-11-30
CN101045664B (zh)	2011-06-15
US8067640B2 (en)	2011-11-29
TWI306846B (en)	2009-03-01
BR0313114A (pt)	2005-07-12
EA200500349A1 (ru)	2005-08-25
US20110065937A1 (en)	2011-03-17
JP4694837B2 (ja)	2011-06-08
NO20051292L (no)	2005-03-14
EP2360150A1 (en)	2011-08-24
AR040970A1 (es)	2005-04-27
CN1675144A (zh)	2005-09-28
AU2003250321B2 (en)	2009-06-25
KR20050053618A (ko)	2005-06-08
RS20050092A (sr)	2007-09-21
TW200418750A (en)	2004-10-01
HK1083828A1 (zh)	2006-07-14
CN101045664A (zh)	2007-10-03
US20070129561A1 (en)	2007-06-07
WO2004014821A1 (en)	2004-02-19

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IS7642A (is)	2005-01-12	Aðferð til að aðskilja milliefni sem nota má til framleiðslu á essítalóprami
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