IS7698A - Pýrasól efnasambönd sem umbreytingar vaxtaþátta (TGF) hindrar - Google Patents

Pýrasól efnasambönd sem umbreytingar vaxtaþátta (TGF) hindrar

Info

Publication number: IS7698A
Authority: IS; Iceland
Prior art keywords: tgf; metabolism; growth factor; inhibit growth; pyrazole compounds
Prior art date: 2002-09-18

Application number

IS7698A

Other languages

English (en)

Inventor

John Munchhof Michael

Cook Blumberg Laura

Original Assignee

Pfizer Products Inc.

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2002-09-18

Filing date

2005-02-17

Publication date

2005-02-17

2005-02-17 Application filed by Pfizer Products Inc. filed Critical Pfizer Products Inc.

2005-02-17 Publication of IS7698A publication Critical patent/IS7698A/is

Links

239000003102 growth factor Substances 0.000 title 1
230000004060 metabolic process Effects 0.000 title 1
150000003217 pyrazoles Chemical class 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings

Landscapes

Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Engineering & Computer Science (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Chemical Kinetics & Catalysis (AREA)
Bioinformatics & Cheminformatics (AREA)
Diabetes (AREA)
Heart & Thoracic Surgery (AREA)
Urology & Nephrology (AREA)
Dermatology (AREA)
Endocrinology (AREA)
Cardiology (AREA)
Vascular Medicine (AREA)
Emergency Medicine (AREA)
Obesity (AREA)
Pulmonology (AREA)
Hematology (AREA)
Gastroenterology & Hepatology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)

IS7698A 2002-09-18 2005-02-17 Pýrasól efnasambönd sem umbreytingar vaxtaþátta (TGF) hindrar IS7698A (is)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
US41214602P	2002-09-18	2002-09-18
US48454303P	2003-07-02	2003-07-02
PCT/IB2003/003933 WO2004026306A2 (en)	2002-09-18	2003-09-08	Pyrazole derivatives as transforming growth factor (tgf) inhibitors

Publications (1)

Publication Number	Publication Date
IS7698A true IS7698A (is)	2005-02-17

Family

ID=32033585

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
IS7698A IS7698A (is)	2002-09-18	2005-02-17	Pýrasól efnasambönd sem umbreytingar vaxtaþátta (TGF) hindrar

Country Status (27)

Country	Link
US (4)	US6958354B2 (is)
EP (2)	EP2165708A3 (is)
JP (1)	JP4519657B2 (is)
KR (1)	KR20050044807A (is)
CN (1)	CN1681501A (is)
AP (1)	AP2005003263A0 (is)
AR (1)	AR041272A1 (is)
AT (1)	ATE450258T1 (is)
AU (1)	AU2003259475A1 (is)
BR (1)	BR0314302A (is)
CA (1)	CA2496295C (is)
CO (1)	CO5550456A2 (is)
DE (1)	DE60330362D1 (is)
EA (1)	EA200500377A1 (is)
EC (1)	ECSP055679A (is)
ES (1)	ES2335099T3 (is)
HR (1)	HRP20050247A2 (is)
IS (1)	IS7698A (is)
MA (1)	MA27440A1 (is)
MX (1)	MXPA05002376A (is)
NO (1)	NO20050838L (is)
OA (1)	OA12929A (is)
PA (1)	PA8583201A1 (is)
PE (1)	PE20040988A1 (is)
PL (1)	PL375979A1 (is)
UY (1)	UY27985A1 (is)
WO (1)	WO2004026306A2 (is)

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MXPA05002981A (es)	2002-09-18	2005-06-22	Pfizer Prod Inc	Nuevos compuestos de imidazol como inhibidores del factor de crecimiento transformante (tgf).
AU2003256003A1 (en)	2002-09-18	2004-04-08	Pfizer Products Inc.	Novel oxazole and thiazole compounds as transforming growth factor (TGF) inhibitors
CA2496295C (en) *	2002-09-18	2010-11-23	Michael John Munchhof	Novels pyrazole compounds as transforming growth factor (tgf) inhibitors
CL2004000234A1 (es) *	2003-02-12	2005-04-15	Biogen Idec Inc	Compuestos derivados 3-(piridin-2-il)-4-heteroaril-pirazol sustituidos, antagonistas de aik5 y/o aik4; composicion farmaceutica y uso del compuesto en el tratamiento de desordenes fibroticos como esclerodermia, lupus nefritico, cicatrizacion de herid
PA8595001A1 (es) *	2003-03-04	2004-09-28	Pfizer Prod Inc	Nuevos compuestos heteroaromaticos condensados que son inhibidores del factor de crecimiento transforante (tgf)
GB0313915D0 (en) *	2003-06-16	2003-07-23	Smithkline Beecham Corp	Compounds
AU2005280167A1 (en) *	2004-08-31	2006-03-09	Biogen Idec Ma Inc.	Pyrimidinylpyrazoles as TGF-beta inhibitors
US20070275968A1 (en) *	2004-09-07	2007-11-29	Hitoshi Kurata	Substituted Biphenyl Derivative
AU2005295734A1 (en) *	2004-10-15	2006-04-27	Biogen Idec Ma Inc.	Methods of treating vascular injuries
TW200639163A (en)	2005-02-04	2006-11-16	Genentech Inc	RAF inhibitor compounds and methods
CN101330914A (zh) *	2005-12-16	2008-12-24	爱尔康公司	使用alk5调节剂控制眼内压
DK2089367T3 (da)	2006-10-31	2012-02-06	Pfizer Prod Inc	Pyrazolinforbindelser som mineralocorticoidreceptor-antagonister
WO2009016460A2 (en) *	2007-08-01	2009-02-05	Pfizer Inc.	Pyrazole compounds and their use as raf inhibitors
PL3089971T3 (pl)	2014-01-01	2021-01-25	Medivation Technologies Llc	Związki i sposoby ich zastosowania
ES2918924T3 (es)	2015-04-01	2022-07-21	Rigel Pharmaceuticals Inc	Inhibidores de TGF-beta
US10669528B2 (en)	2015-06-25	2020-06-02	Children's Medical Center Corporation	Methods and compositions relating to hematopoietic stem cell expansion, enrichment, and maintenance
EP4049665B1 (en)	2016-03-15	2025-03-12	The Children's Medical Center Corporation	Methods and compositions relating to hematopoietic stem cell expansion
DK3470409T3 (da) *	2016-06-13	2020-05-11	Genfleet Therapeutics Shanghai Inc	Benzotriazol-afledt Alfa- og Beta-umættet amidforbindelse anvendt som TGF-BRI-hæmmer
US11266647B2 (en) *	2016-10-26	2022-03-08	Icahn School Of Medicine At Mount Sinai	Method for increasing cell proliferation in pancreatic beta cells, treatment method, and composition
AU2017357333A1 (en) *	2016-11-14	2019-05-02	Jiangsu Hengrui Medicine Co., Ltd.	3,4-bipyridyl pyrazole derivative, and preparation method therefor and medical application thereof
WO2019100062A1 (en)	2017-11-20	2019-05-23	Ichan School Of Medicine At Mount Sinai	Kinase inhibitor compounds and compositions and methods of use
WO2019114792A1 (zh) *	2017-12-13	2019-06-20	劲方医药科技(上海)有限公司	一种TGF-βRI抑制剂的晶型、盐型及其制备方法
WO2019136320A1 (en)	2018-01-05	2019-07-11	Icahn School Of Medicine At Mount Sinai	Method of increasing proliferation of pancreatic beta cells, treatment method, and composition
CN112135613A (zh)	2018-03-20	2020-12-25	西奈山伊坎医学院	激酶抑制剂化合物和组合物及使用方法
WO2020003219A1 (en) *	2018-06-29	2020-01-02	Oat & Iil India Laboratories Private Limited	Substituted pyrazole derivatives as insecticides and fungicides
CA3121202A1 (en)	2018-11-30	2020-06-04	Nuvation Bio Inc.	Pyrrole and pyrazole compounds and methods of use thereof
BR112021011224A2 (pt)	2018-12-11	2021-08-24	Theravance Biopharma R&D Ip, Llc	Inibidores de alk5
CN110467601B (zh) *	2019-08-29	2021-07-02	杭州市西溪医院	一种吡唑联吡啶酮类化合物、中间体及其制备方法及应用
KR20220104208A (ko)	2019-11-22	2022-07-26	세라밴스 바이오파마 알앤디 아이피, 엘엘씨	Alk5 억제제로서 치환된 1,5-나프티리딘 또는 퀴놀린
WO2021105317A1 (en)	2019-11-28	2021-06-03	Origo Biopharma, S.L.	Benzylamide derivatives as inhibitors of transforming growth factor-beta receptor i/alk5
EP3978487A1 (en)	2020-09-30	2022-04-06	Origo Biopharma, S.L.	2-(3-pyridin-2-yl-4-quinolin-4-yl-pyrazol-1-yl)-acetamide derivatives as inhibitors of transforming growth factor-beta receptor i/alk5

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GB0027987D0 (en)	2000-11-16	2001-01-03	Smithkline Beecham Plc	Compounds
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GB0102672D0 (en) *	2001-02-02	2001-03-21	Glaxo Group Ltd	Compounds
JP2004521901A (ja) *	2001-02-02	2004-07-22	グラクソ　グループ　リミテッド	Ｔｇｆ阻害剤としてのピラゾール
ATE291020T1 (de) *	2001-02-02	2005-04-15	Smithkline Beecham Corp	Pyrazolderivate gegen tgf überexprimierung
AP2002002460A0 (en)	2001-03-09	2002-06-30	Pfizer Prod Inc	Novel benzimidazole anti-inflammatory compounds.
US7074801B1 (en) *	2001-04-26	2006-07-11	Eisai Co., Ltd.	Nitrogen-containing condensed cyclic compound having a pyrazolyl group as a substituent group and pharmaceutical composition thereof
AR039241A1 (es)	2002-04-04	2005-02-16	Biogen Inc	Heteroarilos trisustituidos y metodos para su produccion y uso de los mismos
EP1539748A1 (en)	2002-07-31	2005-06-15	Smithkline Beecham Corporation	2-phenylpyridin-4-yl derivatives as alk5 inhibitors
CA2496295C (en)	2002-09-18	2010-11-23	Michael John Munchhof	Novels pyrazole compounds as transforming growth factor (tgf) inhibitors
MXPA05002981A (es)	2002-09-18	2005-06-22	Pfizer Prod Inc	Nuevos compuestos de imidazol como inhibidores del factor de crecimiento transformante (tgf).
CA2497971A1 (en)	2002-09-18	2004-04-01	Pfizer Products Inc.	Triazole derivatives as transforming growth factor (tgf) inhibitors
EP1542995A1 (en)	2002-09-18	2005-06-22	Pfizer Products Inc.	Novel isothiazole and isoxazole compounds as transforming growth factor (tgf) inhibitors
AU2003256003A1 (en)	2002-09-18	2004-04-08	Pfizer Products Inc.	Novel oxazole and thiazole compounds as transforming growth factor (TGF) inhibitors
PA8595001A1 (es)	2003-03-04	2004-09-28	Pfizer Prod Inc	Nuevos compuestos heteroaromaticos condensados que son inhibidores del factor de crecimiento transforante (tgf)

2003
- 2003-09-08 CA CA2496295A patent/CA2496295C/en not_active Expired - Fee Related
- 2003-09-08 KR KR1020057004598A patent/KR20050044807A/ko not_active Ceased
- 2003-09-08 EP EP09177298A patent/EP2165708A3/en not_active Withdrawn
- 2003-09-08 AT AT03797443T patent/ATE450258T1/de not_active IP Right Cessation
- 2003-09-08 DE DE60330362T patent/DE60330362D1/de not_active Expired - Lifetime
- 2003-09-08 WO PCT/IB2003/003933 patent/WO2004026306A2/en not_active Ceased
- 2003-09-08 OA OA1200500078A patent/OA12929A/en unknown
- 2003-09-08 CN CNA038222655A patent/CN1681501A/zh active Pending
- 2003-09-08 ES ES03797443T patent/ES2335099T3/es not_active Expired - Lifetime
- 2003-09-08 HR HR20050247A patent/HRP20050247A2/hr not_active Application Discontinuation
- 2003-09-08 BR BR0314302-3A patent/BR0314302A/pt not_active IP Right Cessation
- 2003-09-08 PL PL03375979A patent/PL375979A1/xx not_active Application Discontinuation
- 2003-09-08 AU AU2003259475A patent/AU2003259475A1/en not_active Abandoned
- 2003-09-08 MX MXPA05002376A patent/MXPA05002376A/es active IP Right Grant
- 2003-09-08 EA EA200500377A patent/EA200500377A1/ru unknown
- 2003-09-08 EP EP03797443A patent/EP1542684B1/en not_active Expired - Lifetime
- 2003-09-08 AP AP2005003263A patent/AP2005003263A0/xx unknown
- 2003-09-08 JP JP2004568904A patent/JP4519657B2/ja not_active Expired - Fee Related
- 2003-09-15 PE PE2003000940A patent/PE20040988A1/es not_active Application Discontinuation
- 2003-09-16 UY UY27985A patent/UY27985A1/es not_active Application Discontinuation
- 2003-09-16 AR ARP030103356A patent/AR041272A1/es unknown
- 2003-09-17 PA PA20038583201A patent/PA8583201A1/es unknown
- 2003-09-17 US US10/667,189 patent/US6958354B2/en not_active Expired - Fee Related
2005
- 2005-02-16 NO NO20050838A patent/NO20050838L/no unknown
- 2005-02-17 IS IS7698A patent/IS7698A/is unknown
- 2005-03-16 CO CO05024529A patent/CO5550456A2/es not_active Application Discontinuation
- 2005-03-16 EC EC2005005679A patent/ECSP055679A/es unknown
- 2005-03-18 MA MA28154A patent/MA27440A1/fr unknown
- 2005-09-23 US US11/234,564 patent/US7151110B2/en not_active Expired - Fee Related
2006
- 2006-11-08 US US11/557,638 patent/US7638537B2/en not_active Expired - Fee Related
2009
- 2009-11-12 US US12/617,027 patent/US20100056571A1/en not_active Abandoned

Also Published As

Publication number	Publication date
MXPA05002376A (es)	2005-05-23
UY27985A1 (es)	2004-04-30
EP2165708A3 (en)	2010-07-28
EP1542684A2 (en)	2005-06-22
JP2006507353A (ja)	2006-03-02
AR041272A1 (es)	2005-05-11
WO2004026306A3 (en)	2004-07-01
KR20050044807A (ko)	2005-05-12
AU2003259475A1 (en)	2004-04-08
JP4519657B2 (ja)	2010-08-04
PA8583201A1 (es)	2004-04-23
EP1542684B1 (en)	2009-12-02
US20040116474A1 (en)	2004-06-17
CA2496295C (en)	2010-11-23
MA27440A1 (fr)	2005-07-01
US20060025451A1 (en)	2006-02-02
EP2165708A2 (en)	2010-03-24
ES2335099T3 (es)	2010-03-22
US7151110B2 (en)	2006-12-19
CN1681501A (zh)	2005-10-12
AP2005003263A0 (en)	2005-03-31
DE60330362D1 (de)	2010-01-14
CO5550456A2 (es)	2005-08-31
OA12929A (en)	2006-10-13
NO20050838L (no)	2005-05-18
CA2496295A1 (en)	2004-04-01
PL375979A1 (en)	2005-12-12
PE20040988A1 (es)	2004-12-25
EA200500377A1 (ru)	2005-08-25
ATE450258T1 (de)	2009-12-15
BR0314302A (pt)	2005-07-05
US20100056571A1 (en)	2010-03-04
HRP20050247A2 (en)	2005-10-31
US7638537B2 (en)	2009-12-29
WO2004026306A2 (en)	2004-04-01
US20070117850A1 (en)	2007-05-24
ECSP055679A (es)	2005-05-30
US6958354B2 (en)	2005-10-25

Publication	Publication Date	Title
IS7698A (is)	2005-02-17	Pýrasól efnasambönd sem umbreytingar vaxtaþátta (TGF) hindrar
IS7713A (is)	2005-02-24	Ný tríasól efnasambönd sem umbreytingar vaxtaþátta (TGF) hindrar
IS7712A (is)	2005-02-24	Ný ímídasól efnasambönd sem umbreytingar vaxtaþátta (TGF) hindrar
AU2003292429A8 (en)	2004-07-14	Pyrazole compounds
IS2589B (is)	2010-02-15	Tríasól afleiður sem hindrar á 11-beta-hýdroxýstera vetnissvifti-1
GB0229015D0 (en)	2003-01-15	New Compound
IS7884A (is)	2005-06-09	Díasepínóindól afleiður sem kínasa hindrar
PL377778A1 (pl)	2006-02-20	Pochodne pirazolu
AU2003287979A8 (en)	2004-05-25	Phenyl compounds
PL360521A1 (en)	2003-12-15	Self adhesive addition crosslinkg compound silicones
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AU2003216053A8 (en)	2003-09-02	Guanidino compounds
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AUPS058102A0 (en)	2002-03-14	Imidazole compounds