IS8058A - Sýklísk súlfónamíð til að hamla gamma seytiasa - Google Patents
Sýklísk súlfónamíð til að hamla gamma seytiasaInfo
- Publication number
- IS8058A IS8058A IS8058A IS8058A IS8058A IS 8058 A IS8058 A IS 8058A IS 8058 A IS8058 A IS 8058A IS 8058 A IS8058 A IS 8058A IS 8058 A IS8058 A IS 8058A
- Authority
- IS
- Iceland
- Prior art keywords
- gamma secretion
- inhibit gamma
- cyclic sulfonamide
- inhibit
- sulfonamide
- Prior art date
Links
- -1 Cyclic sulfonamide Chemical class 0.000 title 1
- 230000028327 secretion Effects 0.000 title 1
- 229940124530 sulfonamide Drugs 0.000 title 1
- 208000024827 Alzheimer disease Diseases 0.000 abstract 1
- 102000002659 Amyloid Precursor Protein Secretases Human genes 0.000 abstract 1
- 108010043324 Amyloid Precursor Protein Secretases Proteins 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 230000002265 prevention Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D279/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one sulfur atom as the only ring hetero atoms
- C07D279/02—1,2-Thiazines; Hydrogenated 1,2-thiazines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- Neurosurgery (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biomedical Technology (AREA)
- Medicinal Chemistry (AREA)
- Neurology (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Heterocyclic Compounds Containing Sulfur Atoms (AREA)
- Enzymes And Modification Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Pyrane Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB0311341A GB0311341D0 (en) | 2003-05-16 | 2003-05-16 | Therapeutic agents |
| GB0327055A GB0327055D0 (en) | 2003-11-20 | 2003-11-20 | Therapeutic agents |
| PCT/GB2004/002013 WO2004101539A1 (en) | 2003-05-16 | 2004-05-07 | Cyclic sulfonamides for inhibition of gamma-secretase |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| IS8058A true IS8058A (is) | 2005-09-30 |
Family
ID=33420897
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IS8058A IS8058A (is) | 2003-05-16 | 2005-09-30 | Sýklísk súlfónamíð til að hamla gamma seytiasa |
Country Status (16)
| Country | Link |
|---|---|
| US (3) | US7410964B2 (is) |
| EP (2) | EP1638951B1 (is) |
| JP (1) | JP4818114B2 (is) |
| KR (1) | KR20060013404A (is) |
| AT (1) | ATE386028T1 (is) |
| AU (1) | AU2004238607B2 (is) |
| BR (1) | BRPI0409969A (is) |
| CA (1) | CA2525841C (is) |
| DE (1) | DE602004011767T2 (is) |
| IL (1) | IL171977A (is) |
| IS (1) | IS8058A (is) |
| MX (1) | MXPA05012323A (is) |
| NO (1) | NO20055979L (is) |
| NZ (1) | NZ542797A (is) |
| RU (1) | RU2334743C2 (is) |
| WO (2) | WO2004101539A1 (is) |
Families Citing this family (57)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB0108591D0 (en) * | 2001-04-05 | 2001-05-23 | Merck Sharp & Dohme | Therapeutic agents |
| GB0120347D0 (en) | 2001-08-21 | 2001-10-17 | Merck Sharp & Dohme | Therapeutic agents |
| GB0223039D0 (en) | 2002-10-04 | 2002-11-13 | Merck Sharp & Dohme | Therapeutic compounds |
| US7521481B2 (en) | 2003-02-27 | 2009-04-21 | Mclaurin Joanne | Methods of preventing, treating and diagnosing disorders of protein aggregation |
| MXPA05012323A (es) * | 2003-05-16 | 2006-01-30 | Merck Sharp & Dohme | Sulfonamidas ciclicas para la inhibicion de gama-secretasa. |
| JP2008518955A (ja) | 2004-11-02 | 2008-06-05 | ノースウェスタン ユニバーシティ | ピリダジン化合物および方法 |
| ES2382814T3 (es) | 2005-05-17 | 2012-06-13 | Merck Sharp & Dohme Ltd. | Ácido cis-4-[(4-clorofenil)sulfonil]-4-(2,5-difluorofenil)ciclohexanopropanoico para el tratamiento del cáncer |
| WO2006123183A2 (en) * | 2005-05-17 | 2006-11-23 | Merck Sharp & Dohme Limited | Sulphone derivatives for treatment of cancer |
| GB0512049D0 (en) * | 2005-06-14 | 2005-07-20 | Merck Sharp & Dohme | Chemical process |
| CN102702044A (zh) * | 2006-01-20 | 2012-10-03 | 先灵公司 | 作为γ分泌酶抑制剂的碳环和杂环芳基砜化合物 |
| US8278345B2 (en) | 2006-11-09 | 2012-10-02 | Probiodrug Ag | Inhibitors of glutaminyl cyclase |
| ATE554085T1 (de) | 2006-11-30 | 2012-05-15 | Probiodrug Ag | Neue inhibitoren von glutaminylcyclase |
| CA2676715A1 (en) | 2007-02-12 | 2008-08-21 | Merck & Co., Inc. | Piperazine derivatives for treatment of ad and related conditions |
| JP5930573B2 (ja) | 2007-03-01 | 2016-06-15 | プロビオドルグ エージー | グルタミニルシクラーゼ阻害剤の新規使用 |
| EP2142514B1 (en) | 2007-04-18 | 2014-12-24 | Probiodrug AG | Thiourea derivatives as glutaminyl cyclase inhibitors |
| WO2009008980A2 (en) | 2007-07-05 | 2009-01-15 | Schering Corporation | Tetrahydropyranochromene gamma secretase inhibitors |
| EP2178882B1 (en) | 2007-07-17 | 2013-04-17 | Merck Sharp & Dohme Corp. | Benzenesulfonyl-chromane, thiochromane, tetrahydronaphthalene and related gamma secretase inhibitors |
| EP2291181B9 (en) | 2008-04-18 | 2013-09-11 | University College Dublin National University Of Ireland, Dublin | Captodiamine for the treatment of depression symptoms |
| WO2010068564A1 (en) * | 2008-12-11 | 2010-06-17 | Merck Sharp & Dohme Corp. | Method for treating alzheimer's disease and related conditions |
| WO2010114780A1 (en) | 2009-04-01 | 2010-10-07 | Merck Sharp & Dohme Corp. | Inhibitors of akt activity |
| JP5934645B2 (ja) | 2009-09-11 | 2016-06-15 | プロビオドルグ エージー | グルタミニルシクラーゼ阻害剤としてのヘテロ環式誘導体 |
| PE20121172A1 (es) | 2009-10-14 | 2012-09-05 | Merck Sharp & Dohme | Piperidinas sustituidas con actividad en la hdm2 |
| JP2013518094A (ja) * | 2010-01-29 | 2013-05-20 | ファイザー・インク | γ−セクレターゼモジュレーターとしてのアミノシクロヘキサンおよびアミノテトラヒドロピランならびに関連化合物 |
| JP6026284B2 (ja) | 2010-03-03 | 2016-11-16 | プロビオドルグ エージー | グルタミニルシクラーゼの阻害剤 |
| NZ602312A (en) | 2010-03-10 | 2014-02-28 | Probiodrug Ag | Heterocyclic inhibitors of glutaminyl cyclase (qc, ec 2.3.2.5) |
| WO2011131748A2 (en) | 2010-04-21 | 2011-10-27 | Probiodrug Ag | Novel inhibitors |
| WO2011163330A1 (en) | 2010-06-24 | 2011-12-29 | Merck Sharp & Dohme Corp. | Novel heterocyclic compounds as erk inhibitors |
| EP3330377A1 (en) | 2010-08-02 | 2018-06-06 | Sirna Therapeutics, Inc. | Rna interference mediated inhibition of catenin (cadherin-associated protein), beta 1 (ctnnb1) gene expression using short interfering nucleic acid (sina) |
| US9029341B2 (en) | 2010-08-17 | 2015-05-12 | Sirna Therapeutics, Inc. | RNA interference mediated inhibition of hepatitis B virus (HBV) gene expression using short interfering nucleic acid (siNA) |
| EP2613782B1 (en) | 2010-09-01 | 2016-11-02 | Merck Sharp & Dohme Corp. | Indazole derivatives useful as erk inhibitors |
| US9242981B2 (en) | 2010-09-16 | 2016-01-26 | Merck Sharp & Dohme Corp. | Fused pyrazole derivatives as novel ERK inhibitors |
| WO2012058210A1 (en) | 2010-10-29 | 2012-05-03 | Merck Sharp & Dohme Corp. | RNA INTERFERENCE MEDIATED INHIBITION OF GENE EXPRESSION USING SHORT INTERFERING NUCLEIC ACIDS (siNA) |
| WO2012087772A1 (en) | 2010-12-21 | 2012-06-28 | Schering Corporation | Indazole derivatives useful as erk inhibitors |
| EP2686313B1 (en) | 2011-03-16 | 2016-02-03 | Probiodrug AG | Benzimidazole derivatives as inhibitors of glutaminyl cyclase |
| EP2770987B1 (en) | 2011-10-27 | 2018-04-04 | Merck Sharp & Dohme Corp. | Novel compounds that are erk inhibitors |
| US20150299696A1 (en) | 2012-05-02 | 2015-10-22 | Sirna Therapeutics, Inc. | SHORT INTERFERING NUCLEIC ACID (siNA) COMPOSITIONS |
| RU2660429C2 (ru) | 2012-09-28 | 2018-07-06 | Мерк Шарп И Доум Корп. | Новые соединения, которые являются ингибиторами erk |
| RS56680B1 (sr) | 2012-11-28 | 2018-03-30 | Merck Sharp & Dohme | Kompozicije i postupci za lečenje kancera |
| KR102196882B1 (ko) | 2012-12-20 | 2020-12-30 | 머크 샤프 앤드 돔 코포레이션 | Hdm2 억제제로서의 치환된 이미다조피리딘 |
| WO2014120748A1 (en) | 2013-01-30 | 2014-08-07 | Merck Sharp & Dohme Corp. | 2,6,7,8 substituted purines as hdm2 inhibitors |
| WO2015034925A1 (en) | 2013-09-03 | 2015-03-12 | Moderna Therapeutics, Inc. | Circular polynucleotides |
| EP3525785B1 (en) | 2016-10-12 | 2025-08-27 | Merck Sharp & Dohme LLC | Kdm5 inhibitors |
| ES2812698T3 (es) | 2017-09-29 | 2021-03-18 | Probiodrug Ag | Inhibidores de glutaminil ciclasa |
| US10947234B2 (en) | 2017-11-08 | 2021-03-16 | Merck Sharp & Dohme Corp. | PRMT5 inhibitors |
| EP3706747B1 (en) | 2017-11-08 | 2025-09-03 | Merck Sharp & Dohme LLC | Prmt5 inhibitors |
| EP3833668B1 (en) | 2018-08-07 | 2025-03-19 | Merck Sharp & Dohme LLC | Prmt5 inhibitors |
| US11981701B2 (en) | 2018-08-07 | 2024-05-14 | Merck Sharp & Dohme Llc | PRMT5 inhibitors |
| US12552826B2 (en) | 2018-08-07 | 2026-02-17 | Merck Sharp & Dohme Llc | PRMT5 inhibitors |
| US12173026B2 (en) | 2018-08-07 | 2024-12-24 | Merck Sharp & Dohme Llc | PRMT5 inhibitors |
| US12441730B2 (en) | 2019-12-17 | 2025-10-14 | Merck Sharp & Dohme Llc | PRMT5 inhibitors |
| BR112022012015A2 (pt) | 2019-12-17 | 2022-08-30 | Merck Sharp & Dohme Llc | Inibidores de prmt5 |
| US12595248B2 (en) | 2019-12-17 | 2026-04-07 | Merck Sharp & Dohme Llc | PRMT5 inhibitors |
| WO2021126731A1 (en) | 2019-12-17 | 2021-06-24 | Merck Sharp & Dohme Corp. | Prmt5 inhibitors |
| WO2022015670A1 (en) * | 2020-07-14 | 2022-01-20 | Nikang Therapeutics, Inc. | Pyrido[2,3-d]pyrimidin-7(8h)-one derivatives as cyclin-dependent kinase 2 inhibitors |
| US20240116945A1 (en) | 2022-09-02 | 2024-04-11 | Merck Sharp & Dohme Llc | Exatecan-derived topoisomerase-1 inhibitors pharmaceutical compositions, and uses thereof |
| WO2024091437A1 (en) | 2022-10-25 | 2024-05-02 | Merck Sharp & Dohme Llc | Exatecan-derived adc linker-payloads, pharmaceutical compositions, and uses thereof |
| GEAP202516798A (en) | 2022-12-14 | 2025-10-27 | Merck Sharp & Dohme Llc | Auristatin linker-payloads, pharmaceutical compositions, and uses thereof |
Family Cites Families (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2833776A (en) * | 1958-05-06 | Aryl-substituted psperidylpropanols | ||
| US3992536A (en) * | 1972-11-11 | 1976-11-16 | Boehringer Ingelheim Gmbh | Pharmaceutical compositions containing a 1-phenyl-2,2,4,4-C1 -C2 alkyl-3-[4-phenyl of pyridyl)-piperazino]-cyclobutanol-(1) and method of use |
| US3869434A (en) * | 1973-11-19 | 1975-03-04 | Phillips Petroleum Co | Soluble arylene sulfide polymers |
| DE2528285A1 (de) * | 1975-06-25 | 1977-01-20 | Basf Ag | Verfahren zur herstellung von 1,2,4-dihydrotriazin-4-oxid-spiro- (3,1')- eckige klammer auf oximino- (2')-cycloalkanen eckige klammer zu |
| FR2528433A1 (fr) * | 1982-06-15 | 1983-12-16 | Provesan Sa | Nouveaux derives d'oxazinobenzothiazine-6,6-dioxyde, leur preparation et leur application en tant que medicaments |
| DE3347126A1 (de) * | 1983-12-22 | 1985-07-11 | Schering AG, 1000 Berlin und 4709 Bergkamen | 11ss-aryl-estradiene, deren herstellung und diese enthaltende pharmazeutische praeparate |
| DE4035961A1 (de) * | 1990-11-02 | 1992-05-07 | Thomae Gmbh Dr K | Cyclische iminoderivate, diese verbindungen enthaltende arzneimittel und verfahren zu ihrer herstellung |
| RU2215004C2 (ru) * | 1997-07-16 | 2003-10-27 | Ново Нордиск А/С | Конденсированное производное 1,2,4-тиадиазина, фармацевтическая композиция и способ получения лекарственного препарата |
| NZ514453A (en) | 1999-02-26 | 2003-04-29 | Merck & Co Inc | Novel sulfonamide compounds and uses thereof |
| WO2001070677A1 (en) * | 2000-03-20 | 2001-09-27 | Merck Sharp & Dohme Limited | Sulphonamido-substituted bridged bicycloalkyl derivatives |
| FR2812291B1 (fr) * | 2000-07-28 | 2002-12-13 | Adir | Nouveaux derives de benzothiadiazine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
| CA2427206C (en) | 2000-11-02 | 2011-06-28 | Merck Sharp & Dohme Limited | Sulfamides as gamma-secretase inhibitors |
| GB0108591D0 (en) | 2001-04-05 | 2001-05-23 | Merck Sharp & Dohme | Therapeutic agents |
| GB0108592D0 (en) * | 2001-04-05 | 2001-05-23 | Merck Sharp & Dohme | Therapeutic agents |
| KR100927304B1 (ko) | 2001-12-27 | 2009-11-18 | 다이이찌 세이야꾸 가부시기가이샤 | β-아밀로이드 단백 생산·분비 저해제 |
| MXPA05012323A (es) | 2003-05-16 | 2006-01-30 | Merck Sharp & Dohme | Sulfonamidas ciclicas para la inhibicion de gama-secretasa. |
-
2004
- 2004-05-07 MX MXPA05012323A patent/MXPA05012323A/es active IP Right Grant
- 2004-05-07 RU RU2005139398/04A patent/RU2334743C2/ru not_active IP Right Cessation
- 2004-05-07 EP EP04731659A patent/EP1638951B1/en not_active Expired - Lifetime
- 2004-05-07 DE DE602004011767T patent/DE602004011767T2/de not_active Expired - Lifetime
- 2004-05-07 US US10/555,034 patent/US7410964B2/en not_active Expired - Lifetime
- 2004-05-07 BR BRPI0409969-9A patent/BRPI0409969A/pt not_active IP Right Cessation
- 2004-05-07 JP JP2006530479A patent/JP4818114B2/ja not_active Expired - Fee Related
- 2004-05-07 AU AU2004238607A patent/AU2004238607B2/en not_active Ceased
- 2004-05-07 CA CA2525841A patent/CA2525841C/en not_active Expired - Fee Related
- 2004-05-07 NZ NZ542797A patent/NZ542797A/en not_active IP Right Cessation
- 2004-05-07 KR KR1020057021877A patent/KR20060013404A/ko not_active Ceased
- 2004-05-07 WO PCT/GB2004/002013 patent/WO2004101539A1/en not_active Ceased
- 2004-05-07 AT AT04731659T patent/ATE386028T1/de not_active IP Right Cessation
- 2004-05-07 EP EP04731671A patent/EP1644346A1/en not_active Withdrawn
- 2004-05-07 WO PCT/GB2004/001973 patent/WO2004101538A1/en not_active Ceased
- 2004-05-14 US US10/845,833 patent/US7342009B2/en not_active Expired - Lifetime
-
2005
- 2005-09-30 IS IS8058A patent/IS8058A/is unknown
- 2005-11-15 IL IL171977A patent/IL171977A/en not_active IP Right Cessation
- 2005-12-15 NO NO20055979A patent/NO20055979L/no not_active Application Discontinuation
-
2007
- 2007-08-01 US US11/888,450 patent/US20080045515A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| US7410964B2 (en) | 2008-08-12 |
| CA2525841C (en) | 2012-10-16 |
| RU2005139398A (ru) | 2006-04-10 |
| JP2006528961A (ja) | 2006-12-28 |
| AU2004238607B2 (en) | 2010-05-27 |
| ATE386028T1 (de) | 2008-03-15 |
| DE602004011767T2 (de) | 2009-02-19 |
| US7342009B2 (en) | 2008-03-11 |
| BRPI0409969A (pt) | 2006-04-25 |
| IL171977A (en) | 2010-12-30 |
| NZ542797A (en) | 2007-12-21 |
| WO2004101539A1 (en) | 2004-11-25 |
| US20060281737A1 (en) | 2006-12-14 |
| MXPA05012323A (es) | 2006-01-30 |
| NO20055979L (no) | 2006-02-15 |
| WO2004101538A1 (en) | 2004-11-25 |
| EP1644346A1 (en) | 2006-04-12 |
| US20040230054A1 (en) | 2004-11-18 |
| US20080045515A1 (en) | 2008-02-21 |
| CA2525841A1 (en) | 2004-11-25 |
| DE602004011767D1 (de) | 2008-03-27 |
| AU2004238607A1 (en) | 2004-11-25 |
| JP4818114B2 (ja) | 2011-11-16 |
| EP1638951B1 (en) | 2008-02-13 |
| RU2334743C2 (ru) | 2008-09-27 |
| KR20060013404A (ko) | 2006-02-09 |
| IL171977A0 (en) | 2006-04-10 |
| EP1638951A1 (en) | 2006-03-29 |
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