IS8058A - Sýklísk súlfónamíð til að hamla gamma seytiasa - Google Patents
Sýklísk súlfónamíð til að hamla gamma seytiasaInfo
- Publication number
- IS8058A IS8058A IS8058A IS8058A IS8058A IS 8058 A IS8058 A IS 8058A IS 8058 A IS8058 A IS 8058A IS 8058 A IS8058 A IS 8058A IS 8058 A IS8058 A IS 8058A
- Authority
- IS
- Iceland
- Prior art keywords
- gamma secretion
- inhibit gamma
- cyclic sulfonamide
- inhibit
- sulfonamide
- Prior art date
Links
- -1 Cyclic sulfonamide Chemical class 0.000 title 1
- 230000028327 secretion Effects 0.000 title 1
- 229940124530 sulfonamide Drugs 0.000 title 1
- 208000024827 Alzheimer disease Diseases 0.000 abstract 1
- 102000002659 Amyloid Precursor Protein Secretases Human genes 0.000 abstract 1
- 108010043324 Amyloid Precursor Protein Secretases Proteins 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 230000002265 prevention Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D279/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one sulfur atom as the only ring hetero atoms
- C07D279/02—1,2-Thiazines; Hydrogenated 1,2-thiazines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- Neurosurgery (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biomedical Technology (AREA)
- Medicinal Chemistry (AREA)
- Neurology (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Heterocyclic Compounds Containing Sulfur Atoms (AREA)
- Enzymes And Modification Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pyrane Compounds (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB0311341A GB0311341D0 (en) | 2003-05-16 | 2003-05-16 | Therapeutic agents |
| GB0327055A GB0327055D0 (en) | 2003-11-20 | 2003-11-20 | Therapeutic agents |
| PCT/GB2004/002013 WO2004101539A1 (en) | 2003-05-16 | 2004-05-07 | Cyclic sulfonamides for inhibition of gamma-secretase |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| IS8058A true IS8058A (is) | 2005-09-30 |
Family
ID=33420897
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IS8058A IS8058A (is) | 2003-05-16 | 2005-09-30 | Sýklísk súlfónamíð til að hamla gamma seytiasa |
Country Status (16)
| Country | Link |
|---|---|
| US (3) | US7410964B2 (is) |
| EP (2) | EP1644346A1 (is) |
| JP (1) | JP4818114B2 (is) |
| KR (1) | KR20060013404A (is) |
| AT (1) | ATE386028T1 (is) |
| AU (1) | AU2004238607B2 (is) |
| BR (1) | BRPI0409969A (is) |
| CA (1) | CA2525841C (is) |
| DE (1) | DE602004011767T2 (is) |
| IL (1) | IL171977A (is) |
| IS (1) | IS8058A (is) |
| MX (1) | MXPA05012323A (is) |
| NO (1) | NO20055979L (is) |
| NZ (1) | NZ542797A (is) |
| RU (1) | RU2334743C2 (is) |
| WO (2) | WO2004101539A1 (is) |
Families Citing this family (56)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB0108591D0 (en) | 2001-04-05 | 2001-05-23 | Merck Sharp & Dohme | Therapeutic agents |
| GB0120347D0 (en) | 2001-08-21 | 2001-10-17 | Merck Sharp & Dohme | Therapeutic agents |
| GB0223039D0 (en) | 2002-10-04 | 2002-11-13 | Merck Sharp & Dohme | Therapeutic compounds |
| US7521481B2 (en) | 2003-02-27 | 2009-04-21 | Mclaurin Joanne | Methods of preventing, treating and diagnosing disorders of protein aggregation |
| EP1644346A1 (en) * | 2003-05-16 | 2006-04-12 | MERCK SHARP & DOHME LTD. | Cyclic sulfonamides for inhibition of gamma-secretase |
| EP1812007B1 (en) | 2004-11-02 | 2011-09-07 | Northwestern University | Pyridazine compounds and methods |
| EP1888050B1 (en) | 2005-05-17 | 2012-03-21 | Merck Sharp & Dohme Ltd. | cis-4-[(4-chlorophenyl)sulfonyl]-4-(2,5-difluorophenyl)cyclohexanepropanoic acid for the treatment of cancer |
| EP1888078A2 (en) * | 2005-05-17 | 2008-02-20 | Merck Sharp & Dohme Ltd. | Sulphone derivatives for treatment of cancer |
| GB0512049D0 (en) * | 2005-06-14 | 2005-07-20 | Merck Sharp & Dohme | Chemical process |
| EP1976843B1 (en) | 2006-01-20 | 2013-09-04 | Merck Sharp & Dohme Corp. | Carbocyclic and heterocyclic arylsulfones as gamma secretase inhibitors |
| JP5379692B2 (ja) | 2006-11-09 | 2013-12-25 | プロビオドルグ エージー | 潰瘍、癌及び他の疾患の治療のためのグルタミニルシクラーゼの阻害薬としての３−ヒドロキシ−１，５−ジヒドロ−ピロール−２−オン誘導体 |
| EP2091948B1 (en) | 2006-11-30 | 2012-04-18 | Probiodrug AG | Novel inhibitors of glutaminyl cyclase |
| AU2008215948A1 (en) | 2007-02-12 | 2008-08-21 | Merck & Co., Inc. | Piperazine derivatives for treatment of AD and related conditions |
| CA2679446C (en) | 2007-03-01 | 2016-05-17 | Probiodrug Ag | New use of glutaminyl cyclase inhibitors |
| US9656991B2 (en) | 2007-04-18 | 2017-05-23 | Probiodrug Ag | Inhibitors of glutaminyl cyclase |
| EP2435416B1 (en) * | 2007-07-05 | 2016-03-30 | Merck Sharp & Dohme Corp. | Tetrahydropyranochromene gamma secretase inhibitors |
| EP2178882B1 (en) | 2007-07-17 | 2013-04-17 | Merck Sharp & Dohme Corp. | Benzenesulfonyl-chromane, thiochromane, tetrahydronaphthalene and related gamma secretase inhibitors |
| US8461389B2 (en) | 2008-04-18 | 2013-06-11 | University College Dublin, National University Of Ireland, Dublin | Psycho-pharmaceuticals |
| EP2375895A4 (en) * | 2008-12-11 | 2012-05-30 | Merck Sharp & Dohme | METHOD FOR THE TREATMENT OF MORBUS ALZHEIMER AND RELATED SUFFERINGS |
| US8691825B2 (en) | 2009-04-01 | 2014-04-08 | Merck Sharp & Dohme Corp. | Inhibitors of AKT activity |
| BR112012008346B1 (pt) | 2009-09-11 | 2021-12-21 | Vivoryon Therapeutics N.V. | Derivados heterocíclicos, seu processo de preparação, e composição farmacêutica |
| EP2488028B1 (en) | 2009-10-14 | 2020-08-19 | Merck Sharp & Dohme Corp. | Substituted piperidines that increase p53 activity and the uses thereof |
| EP2528890A1 (en) * | 2010-01-29 | 2012-12-05 | Pfizer Inc. | Aminocyclohexanes and aminotetrahydropyrans and related compounds as gamma-secretase modulators |
| WO2011107530A2 (en) | 2010-03-03 | 2011-09-09 | Probiodrug Ag | Novel inhibitors |
| DK2545047T3 (da) | 2010-03-10 | 2014-07-28 | Probiodrug Ag | Heterocycliske inhibitorer af glutaminylcyclase (QC, EC 2.3.2.5) |
| EP2560953B1 (en) | 2010-04-21 | 2016-01-06 | Probiodrug AG | Inhibitors of glutaminyl cyclase |
| WO2011163330A1 (en) | 2010-06-24 | 2011-12-29 | Merck Sharp & Dohme Corp. | Novel heterocyclic compounds as erk inhibitors |
| CN107090456B (zh) | 2010-08-02 | 2022-01-18 | 瑟纳治疗公司 | 使用短干扰核酸的RNA干扰介导的联蛋白（钙粘蛋白关联蛋白质），β1基因表达的抑制 |
| JP2013537423A (ja) | 2010-08-17 | 2013-10-03 | メルク・シャープ・エンド・ドーム・コーポレイション | 低分子干渉核酸（ｓｉＮＡ）を用いたＢ型肝炎ウイルス（ＨＢＶ）遺伝子発現のＲＮＡ干渉媒介性阻害 |
| WO2012030685A2 (en) | 2010-09-01 | 2012-03-08 | Schering Corporation | Indazole derivatives useful as erk inhibitors |
| EP2615916B1 (en) | 2010-09-16 | 2017-01-04 | Merck Sharp & Dohme Corp. | Fused pyrazole derivatives as novel erk inhibitors |
| DK2632472T3 (en) | 2010-10-29 | 2018-03-19 | Sirna Therapeutics Inc | RNA INTERFERENCE-MEDIATED INHIBITION OF GENE EXPRESSION USING SHORT INTERFERRING NUCLEIC ACIDS (SINA) |
| WO2012087772A1 (en) | 2010-12-21 | 2012-06-28 | Schering Corporation | Indazole derivatives useful as erk inhibitors |
| WO2012123563A1 (en) | 2011-03-16 | 2012-09-20 | Probiodrug Ag | Benz imidazole derivatives as inhibitors of glutaminyl cyclase |
| WO2013063214A1 (en) | 2011-10-27 | 2013-05-02 | Merck Sharp & Dohme Corp. | Novel compounds that are erk inhibitors |
| EP2844261B1 (en) | 2012-05-02 | 2018-10-17 | Sirna Therapeutics, Inc. | SHORT INTERFERING NUCLEIC ACID (siNA) COMPOSITIONS |
| CN105050598B (zh) | 2012-09-28 | 2018-04-27 | 默沙东公司 | 作为erk抑制剂的新型化合物 |
| RS56680B1 (sr) | 2012-11-28 | 2018-03-30 | Merck Sharp & Dohme | Kompozicije i postupci za lečenje kancera |
| US8846657B2 (en) | 2012-12-20 | 2014-09-30 | Merck Sharp & Dohme Corp. | Substituted imidazopyridines as HDM2 inhibitors |
| WO2014120748A1 (en) | 2013-01-30 | 2014-08-07 | Merck Sharp & Dohme Corp. | 2,6,7,8 substituted purines as hdm2 inhibitors |
| EP3041938A1 (en) | 2013-09-03 | 2016-07-13 | Moderna Therapeutics, Inc. | Circular polynucleotides |
| US10975084B2 (en) | 2016-10-12 | 2021-04-13 | Merck Sharp & Dohme Corp. | KDM5 inhibitors |
| PL3461819T3 (pl) | 2017-09-29 | 2020-11-30 | Probiodrug Ag | Inhibitory cyklazy glutaminylowej |
| EP3706742B1 (en) | 2017-11-08 | 2023-03-15 | Merck Sharp & Dohme LLC | Prmt5 inhibitors |
| US11098059B2 (en) | 2017-11-08 | 2021-08-24 | Merck Sharp & Dohme Corp. | PRMT5 inhibitors |
| EP3833667B1 (en) | 2018-08-07 | 2024-03-13 | Merck Sharp & Dohme LLC | Prmt5 inhibitors |
| EP3833668B1 (en) | 2018-08-07 | 2025-03-19 | Merck Sharp & Dohme LLC | Prmt5 inhibitors |
| CA3108388A1 (en) | 2018-08-07 | 2020-02-13 | Merck Sharp & Dohme Corp. | Prmt5 inhibitors |
| WO2020033285A1 (en) | 2018-08-07 | 2020-02-13 | Merck Sharp & Dohme Corp. | Prmt5 inhibitors |
| EP4076460B1 (en) | 2019-12-17 | 2026-01-21 | Merck Sharp & Dohme LLC | 1,4-dihydro-2h-spiro[isoquinoline-3,4'-piperidine derivatives as prmt5 inhibitors for the treatment of cancer |
| WO2021126728A1 (en) | 2019-12-17 | 2021-06-24 | Merck Sharp & Dohme Corp. | Prmt5 inhibitors |
| JP7589247B2 (ja) | 2019-12-17 | 2024-11-25 | メルク・シャープ・アンド・ドーム・エルエルシー | Ｐｒｍｔ５阻害剤 |
| WO2022015670A1 (en) * | 2020-07-14 | 2022-01-20 | Nikang Therapeutics, Inc. | Pyrido[2,3-d]pyrimidin-7(8h)-one derivatives as cyclin-dependent kinase 2 inhibitors |
| GEAP202516720A (en) | 2022-09-02 | 2025-07-10 | Merck Sharp & Dohme Llc | Exatecan-derived topoisomerase-1 inhibitors pharmaceutical compositions, and uses thereof |
| IL320396A (en) | 2022-10-25 | 2025-06-01 | Merck Sharp & Dohme Llc | Charge-linkers of anti-drug conjugates derived from extacan, pharmaceutical compositions, and uses thereof |
| US20240207425A1 (en) | 2022-12-14 | 2024-06-27 | Merck Sharp & Dohme Llc | Auristatin linker-payloads, pharmaceutical compositions, and uses thereof |
Family Cites Families (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2833776A (en) * | 1958-05-06 | Aryl-substituted psperidylpropanols | ||
| US3992536A (en) * | 1972-11-11 | 1976-11-16 | Boehringer Ingelheim Gmbh | Pharmaceutical compositions containing a 1-phenyl-2,2,4,4-C1 -C2 alkyl-3-[4-phenyl of pyridyl)-piperazino]-cyclobutanol-(1) and method of use |
| US3869434A (en) * | 1973-11-19 | 1975-03-04 | Phillips Petroleum Co | Soluble arylene sulfide polymers |
| DE2528285A1 (de) * | 1975-06-25 | 1977-01-20 | Basf Ag | Verfahren zur herstellung von 1,2,4-dihydrotriazin-4-oxid-spiro- (3,1')- eckige klammer auf oximino- (2')-cycloalkanen eckige klammer zu |
| FR2528433A1 (fr) * | 1982-06-15 | 1983-12-16 | Provesan Sa | Nouveaux derives d'oxazinobenzothiazine-6,6-dioxyde, leur preparation et leur application en tant que medicaments |
| DE3347126A1 (de) * | 1983-12-22 | 1985-07-11 | Schering AG, 1000 Berlin und 4709 Bergkamen | 11ss-aryl-estradiene, deren herstellung und diese enthaltende pharmazeutische praeparate |
| DE4035961A1 (de) * | 1990-11-02 | 1992-05-07 | Thomae Gmbh Dr K | Cyclische iminoderivate, diese verbindungen enthaltende arzneimittel und verfahren zu ihrer herstellung |
| JP2001510195A (ja) * | 1997-07-16 | 2001-07-31 | ノボ ノルディスク アクティーゼルスカブ | 縮合化１，２，４−チアジアジン誘導体、その調製及び使用 |
| EP1159263A1 (en) | 1999-02-26 | 2001-12-05 | Merck & Co., Inc. | Novel sulfonamide compounds and uses thereof |
| US7365196B2 (en) | 2000-03-20 | 2008-04-29 | Merck Sharp & Dohme Ltd. | Sulphonamido-substituted bridged bicycloalkyl derivatives |
| FR2812291B1 (fr) * | 2000-07-28 | 2002-12-13 | Adir | Nouveaux derives de benzothiadiazine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
| DE60112957T2 (de) | 2000-11-02 | 2006-05-18 | Merck Sharp & Dohme Ltd., Hoddesdon | Sulfamide als gamma-secretase-inhibitoren |
| GB0108591D0 (en) | 2001-04-05 | 2001-05-23 | Merck Sharp & Dohme | Therapeutic agents |
| GB0108592D0 (en) * | 2001-04-05 | 2001-05-23 | Merck Sharp & Dohme | Therapeutic agents |
| RU2304140C2 (ru) | 2001-12-27 | 2007-08-10 | Дайити Фармасьютикал Ко., Лтд. | ИНГИБИТОРЫ ПРОДУЦИРОВАНИЯ / СЕКРЕЦИИ β-АМИЛОИДНОГО БЕЛКА |
| EP1644346A1 (en) | 2003-05-16 | 2006-04-12 | MERCK SHARP & DOHME LTD. | Cyclic sulfonamides for inhibition of gamma-secretase |
-
2004
- 2004-05-07 EP EP04731671A patent/EP1644346A1/en not_active Withdrawn
- 2004-05-07 BR BRPI0409969-9A patent/BRPI0409969A/pt not_active IP Right Cessation
- 2004-05-07 RU RU2005139398/04A patent/RU2334743C2/ru not_active IP Right Cessation
- 2004-05-07 DE DE602004011767T patent/DE602004011767T2/de not_active Expired - Lifetime
- 2004-05-07 WO PCT/GB2004/002013 patent/WO2004101539A1/en not_active Ceased
- 2004-05-07 KR KR1020057021877A patent/KR20060013404A/ko not_active Ceased
- 2004-05-07 MX MXPA05012323A patent/MXPA05012323A/es active IP Right Grant
- 2004-05-07 AU AU2004238607A patent/AU2004238607B2/en not_active Ceased
- 2004-05-07 US US10/555,034 patent/US7410964B2/en not_active Expired - Lifetime
- 2004-05-07 AT AT04731659T patent/ATE386028T1/de not_active IP Right Cessation
- 2004-05-07 JP JP2006530479A patent/JP4818114B2/ja not_active Expired - Fee Related
- 2004-05-07 CA CA2525841A patent/CA2525841C/en not_active Expired - Fee Related
- 2004-05-07 EP EP04731659A patent/EP1638951B1/en not_active Expired - Lifetime
- 2004-05-07 WO PCT/GB2004/001973 patent/WO2004101538A1/en not_active Ceased
- 2004-05-07 NZ NZ542797A patent/NZ542797A/en not_active IP Right Cessation
- 2004-05-14 US US10/845,833 patent/US7342009B2/en not_active Expired - Lifetime
-
2005
- 2005-09-30 IS IS8058A patent/IS8058A/is unknown
- 2005-11-15 IL IL171977A patent/IL171977A/en not_active IP Right Cessation
- 2005-12-15 NO NO20055979A patent/NO20055979L/no not_active Application Discontinuation
-
2007
- 2007-08-01 US US11/888,450 patent/US20080045515A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| NO20055979L (no) | 2006-02-15 |
| IL171977A0 (en) | 2006-04-10 |
| BRPI0409969A (pt) | 2006-04-25 |
| JP2006528961A (ja) | 2006-12-28 |
| US7410964B2 (en) | 2008-08-12 |
| WO2004101538A1 (en) | 2004-11-25 |
| RU2005139398A (ru) | 2006-04-10 |
| US20040230054A1 (en) | 2004-11-18 |
| IL171977A (en) | 2010-12-30 |
| JP4818114B2 (ja) | 2011-11-16 |
| US20060281737A1 (en) | 2006-12-14 |
| ATE386028T1 (de) | 2008-03-15 |
| RU2334743C2 (ru) | 2008-09-27 |
| MXPA05012323A (es) | 2006-01-30 |
| CA2525841C (en) | 2012-10-16 |
| AU2004238607B2 (en) | 2010-05-27 |
| CA2525841A1 (en) | 2004-11-25 |
| EP1644346A1 (en) | 2006-04-12 |
| KR20060013404A (ko) | 2006-02-09 |
| DE602004011767D1 (de) | 2008-03-27 |
| AU2004238607A1 (en) | 2004-11-25 |
| DE602004011767T2 (de) | 2009-02-19 |
| EP1638951B1 (en) | 2008-02-13 |
| US7342009B2 (en) | 2008-03-11 |
| EP1638951A1 (en) | 2006-03-29 |
| WO2004101539A1 (en) | 2004-11-25 |
| US20080045515A1 (en) | 2008-02-21 |
| NZ542797A (en) | 2007-12-21 |
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