IT1120404B - Ossime o-sostituite derivate dall'a cido 7-ammino tiazolil acetammido cefalosporanico composizioni farmaceutiche che le contengono e loro procedimento di preparazione - Google Patents

Ossime o-sostituite derivate dall'a cido 7-ammino tiazolil acetammido cefalosporanico composizioni farmaceutiche che le contengono e loro procedimento di preparazione

Info

Publication number: IT1120404B
Authority: IT; Italy
Prior art keywords: carbon atoms; group; alkyl; image; cido
Prior art date: 1978-03-31

Application number

IT48557/79A

Other languages

English (en)

Other versions

IT7948557A0 (it

Original Assignee

Roussel Uclaf

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1978-03-31

Filing date

1979-03-30

Publication date

1986-03-26

1978-03-31 Priority claimed from FR7809617A external-priority patent/FR2432521A1/fr

1979-03-30 Application filed by Roussel Uclaf filed Critical Roussel Uclaf

1979-03-30 Publication of IT7948557A0 publication Critical patent/IT7948557A0/it

1986-03-26 Application granted granted Critical

1986-03-26 Publication of IT1120404B publication Critical patent/IT1120404B/it

Links

DLFVBJFMPXGRIB-UHFFFAOYSA-N Acetamide Chemical compound CC(N)=O DLFVBJFMPXGRIB-UHFFFAOYSA-N 0.000 title 2
239000008194 pharmaceutical composition Substances 0.000 title 1
-1 1-pyridinyl Chemical group 0.000 abstract 5
125000004432 carbon atom Chemical group C* 0.000 abstract 5
125000000217 alkyl group Chemical group 0.000 abstract 3
UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 2
239000002253 acid Substances 0.000 abstract 2
229910052739 hydrogen Inorganic materials 0.000 abstract 2
239000001257 hydrogen Substances 0.000 abstract 2
229910052757 nitrogen Inorganic materials 0.000 abstract 2
IJGRMHOSHXDMSA-UHFFFAOYSA-N nitrogen Substances N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 abstract 2
231100000252 nontoxic Toxicity 0.000 abstract 2
230000003000 nontoxic effect Effects 0.000 abstract 2
GQRKZEFABAMBAC-LHIURRSHSA-N (6r)-7-[[2-(2-amino-1,3-thiazol-4-yl)acetyl]amino]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid Chemical class S1C(N)=NC(CC(=O)NC2C(N3C(=CCS[C@@H]32)C(O)=O)=O)=C1 GQRKZEFABAMBAC-LHIURRSHSA-N 0.000 abstract 1
FYYHWMGAXLPEAU-UHFFFAOYSA-N Magnesium Chemical compound [Mg] FYYHWMGAXLPEAU-UHFFFAOYSA-N 0.000 abstract 1
229910003202 NH4 Inorganic materials 0.000 abstract 1
125000002252 acyl group Chemical group 0.000 abstract 1
229910052783 alkali metal Inorganic materials 0.000 abstract 1
150000001340 alkali metals Chemical class 0.000 abstract 1
229910052784 alkaline earth metal Inorganic materials 0.000 abstract 1
150000001342 alkaline earth metals Chemical class 0.000 abstract 1
125000004414 alkyl thio group Chemical group 0.000 abstract 1
150000001412 amines Chemical class 0.000 abstract 1
230000000844 anti-bacterial effect Effects 0.000 abstract 1
125000001309 chloro group Chemical group Cl* 0.000 abstract 1
125000000753 cycloalkyl group Chemical group 0.000 abstract 1
150000002148 esters Chemical class 0.000 abstract 1
239000000543 intermediate Substances 0.000 abstract 1
229910052749 magnesium Inorganic materials 0.000 abstract 1
239000011777 magnesium Substances 0.000 abstract 1
125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 abstract 1
QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 abstract 1
150000002923 oximes Chemical class 0.000 abstract 1
125000005544 phthalimido group Chemical group 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
- A61K31/542—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame ortho- or peri-condensed with heterocyclic ring systems
- A61K31/545—Compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins, cefaclor, or cephalexine
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D277/587—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with aliphatic hydrocarbon radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms, said aliphatic radicals being substituted in the alpha-position to the ring by a hetero atom, e.g. with m >= 0, Z being a singly or a doubly bound hetero atom

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Medicinal Chemistry (AREA)
Animal Behavior & Ethology (AREA)
Life Sciences & Earth Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Epidemiology (AREA)
Oncology (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Communicable Diseases (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Cephalosporin Compounds (AREA)
Thiazole And Isothizaole Compounds (AREA)

IT48557/79A 1978-03-31 1979-03-30 Ossime o-sostituite derivate dall'a cido 7-ammino tiazolil acetammido cefalosporanico composizioni farmaceutiche che le contengono e loro procedimento di preparazione IT1120404B (it)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
FR7809617A FR2432521A1 (fr)	1978-03-31	1978-03-31	Nouvelles oximes o-substituees derivees de l'acide 7-amino thiazolyl acetamido cephalosporanique, leur procede de preparation et leur application comme medicaments
FR7824563A FR2438050A2 (fr)	1978-03-31	1978-08-24	Nouvelles oximes o-substituees derivees de l'acide 7-aminothiazolyl acetamido cephalosporanique, leur procede de preparation et leur application comme medicaments

Publications (2)

Publication Number	Publication Date
IT7948557A0 IT7948557A0 (it)	1979-03-30
IT1120404B true IT1120404B (it)	1986-03-26

Family

ID=26220530

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
IT48557/79A IT1120404B (it)	1978-03-31	1979-03-30	Ossime o-sostituite derivate dall'a cido 7-ammino tiazolil acetammido cefalosporanico composizioni farmaceutiche che le contengono e loro procedimento di preparazione

Country Status (9)

Country	Link
US (1)	US4439433A (it)
JP (1)	JPH02138283A (it)
CA (1)	CA1152061A (it)
CH (2)	CH638811A5 (it)
DK (1)	DK130879A (it)
ES (1)	ES479037A1 (it)
IT (1)	IT1120404B (it)
PT (1)	PT69421A (it)
SE (1)	SE448379B (it)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4409214A (en) *	1979-11-19	1983-10-11	Fujisawa Pharmaceutical, Co., Ltd.	7-Acylamino-3-vinylcephalosporanic acid derivatives and processes for the preparation thereof
IE55406B1 (en) *	1982-08-07	1990-09-12	Tanabe Seiyaku Co	Novel cephalosporin compounds and preparation thereof
JPS6142335A (ja) *	1984-08-03	1986-02-28	Sumitomo Chem Co Ltd	キレ−ト化剤に吸着した金属の溶離方法
DK500285A (da) *	1984-11-02	1986-05-03	Glaxo Group Ltd	Cephalosporinantibiotika
GB8626245D0 (en) *	1985-11-27	1986-12-03	Ici Pharma	Cephalosporin compounds
ZA923818B (en) *	1991-05-30	1993-11-25	Bristol Myers Squibb Co	Chemical modification of 2"-amino group in elsamicin A
US5237055A (en) *	1991-05-30	1993-08-17	Bristol-Myers Squibb Company	Chemical modification of 2"-amino group in elsamicin A

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE2714880A1 (de) *	1977-04-02	1978-10-26	Hoechst Ag	Cephemderivate und verfahren zu ihrer herstellung
US4284631A (en) *	1978-07-31	1981-08-18	Fujisawa Pharmaceutical Co., Ltd.	7-Substituted cephem compounds and pharmaceutical antibacterial compositions containing them

1979
- 1979-02-12 SE SE7901203A patent/SE448379B/sv not_active IP Right Cessation
- 1979-03-29 ES ES479037A patent/ES479037A1/es not_active Expired
- 1979-03-30 CA CA000324690A patent/CA1152061A/fr not_active Expired
- 1979-03-30 CH CH300879A patent/CH638811A5/fr not_active IP Right Cessation
- 1979-03-30 DK DK130878A patent/DK130879A/da not_active Application Discontinuation
- 1979-03-30 PT PT69421A patent/PT69421A/pt unknown
- 1979-03-30 IT IT48557/79A patent/IT1120404B/it active
1981
- 1981-05-27 US US06/267,638 patent/US4439433A/en not_active Expired - Fee Related
1983
- 1983-04-11 CH CH194983A patent/CH642648A5/fr not_active IP Right Cessation
1989
- 1989-09-28 JP JP1250789A patent/JPH02138283A/ja active Pending

Also Published As

Publication number	Publication date
ES479037A1 (es)	1979-07-01
PT69421A (fr)	1979-04-01
SE7901203L (sv)	1979-10-01
CA1152061A (fr)	1983-08-16
CH642648A5 (fr)	1984-04-30
CH638811A5 (fr)	1983-10-14
IT7948557A0 (it)	1979-03-30
JPH02138283A (ja)	1990-05-28
US4439433A (en)	1984-03-27
DK130879A (da)	1979-10-01
SE448379B (sv)	1987-02-16

Publication	Publication Date	Title
ES8704955A1 (es)	1987-04-16	Un proceso para la produccion de un compuesto de cefalospo- rina
HU185850B (en)	1985-04-28	Process for preparing 7-/ /thiazol-4-yl/-acetamido- or hydroxy-imino- or alkoxy-imino-acetamido/ -delta up 3 -cefem-4-carboxylic acid derivatives
GB2017702A (en)	1979-10-10	O-substituted oxime derivatives of 7-[[2-(2-amino-thiazol-4-yl)-2- hydroxyimino-acetyl]-amino]-ceph- 3-em-4-carboxylic acid
IT1120404B (it)	1986-03-26	Ossime o-sostituite derivate dall'a cido 7-ammino tiazolil acetammido cefalosporanico composizioni farmaceutiche che le contengono e loro procedimento di preparazione
IE40162L (en)	1975-01-27	Cephalosporin compounds
JPS5589282A (en)	1980-07-05	Ergolene derivative*its manufacture and medical composition containing it and having antihypertensive and antiprolactin activity
ES484074A1 (es)	1980-06-16	Un procedimiento de preparacion de nuevas cefalosporinas
SE8406517L (sv)	1984-12-20	Alkyloximsubstituerade 7-(2-amino-4-tiazolyl)-acetamido-cefalosporansyraderivat, framstellning och anvendning derav sasom lekemedel samt kompositioner innehallande dessa foreningar
PT77021B (fr)	1986-04-11	Procede de preparation de nouvelles benzothiopyranopyridinones et de leurs sels
FI851308A0 (fi)	1985-04-01	Foerfarande foer framstaellning av nya 1,2,4-tiadiaziner.
US3763152A (en)	1973-10-02	Neutral cephalosporin anhydrides
ES8102133A1 (es)	1980-12-16	Procedimiento de preparacion de nuevas oximas
ES484224A1 (es)	1980-05-16	Un procedimiento de preparacion de nuevas oximas derivadas del acido 3-azidometil-7-amino-tiazolil-acetamido-cefalospo-ranico
JPS6139952B2 (it)	1986-09-06
US3926983A (en)	1975-12-16	3-Heterothio{8 (alkoxycarbonyl)thioacetyl{9 cephalosporanic derivatives
AU535927B2 (en)	1984-04-12	2-phenylamino-imidazolines
FR2381750A1 (fr)	1978-09-22	Phenylacetonitriles substitues et leur preparation
FI810713L (fi)	1981-09-09	Nya 1-(acylamino-aryloxi-)2-hydroxi-3-alkinylaminopropaner och foerfarande foer deras framstaellning
GB2029824A (en)	1980-03-26	7-( alpha -oximino- alpha -2-amino-4-thiazolyl-acetamido)-cephens
MXPA96005773A (en)	1998-02-01	Cephalosporine compounds and processes for the preparation of mis
GB2210877A (en)	1989-06-21	Cephalosporins
JPS6442490A (en)	1989-02-14	Substituted oxycarbonylaminocephem compound