IT1187833B - Procedimento per l ottenimento di polidesossiribonucleotidi non informazionali sostanzialmente puri e dotati di attivita biologiche e prodotto relativo - Google Patents
Procedimento per l ottenimento di polidesossiribonucleotidi non informazionali sostanzialmente puri e dotati di attivita biologiche e prodotto relativoInfo
- Publication number
- IT1187833B IT1187833B IT8568074A IT6807485A IT1187833B IT 1187833 B IT1187833 B IT 1187833B IT 8568074 A IT8568074 A IT 8568074A IT 6807485 A IT6807485 A IT 6807485A IT 1187833 B IT1187833 B IT 1187833B
- Authority
- IT
- Italy
- Prior art keywords
- pdrn
- informational
- inhibition
- sepn
- liq
- Prior art date
Links
- 108091028664 Ribonucleotide Proteins 0.000 title 1
- LLHRMWHYJGLIEV-UHFFFAOYSA-N desoxy Chemical group COC1=CC(CCN)=CC(OC)=C1C LLHRMWHYJGLIEV-UHFFFAOYSA-N 0.000 title 1
- 239000002336 ribonucleotide Substances 0.000 title 1
- 125000002652 ribonucleotide group Chemical group 0.000 title 1
- 230000005764 inhibitory process Effects 0.000 abstract 3
- 206010061218 Inflammation Diseases 0.000 abstract 2
- 238000000338 in vitro Methods 0.000 abstract 2
- 230000004054 inflammatory process Effects 0.000 abstract 2
- PUAQLLVFLMYYJJ-UHFFFAOYSA-N 2-aminopropiophenone Chemical compound CC(N)C(=O)C1=CC=CC=C1 PUAQLLVFLMYYJJ-UHFFFAOYSA-N 0.000 abstract 1
- 102000016911 Deoxyribonucleases Human genes 0.000 abstract 1
- 108010053770 Deoxyribonucleases Proteins 0.000 abstract 1
- 241000124008 Mammalia Species 0.000 abstract 1
- 241000700605 Viruses Species 0.000 abstract 1
- 229910052784 alkaline earth metal Inorganic materials 0.000 abstract 1
- -1 alkaline earth metal salt Chemical class 0.000 abstract 1
- 230000002391 anti-complement effect Effects 0.000 abstract 1
- 108010008730 anticomplement Proteins 0.000 abstract 1
- 230000004071 biological effect Effects 0.000 abstract 1
- 230000015572 biosynthetic process Effects 0.000 abstract 1
- 238000010668 complexation reaction Methods 0.000 abstract 1
- 201000003079 ectropion Diseases 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 238000010828 elution Methods 0.000 abstract 1
- 238000001727 in vivo Methods 0.000 abstract 1
- 230000002779 inactivation Effects 0.000 abstract 1
- 230000003902 lesion Effects 0.000 abstract 1
- 239000000463 material Substances 0.000 abstract 1
- 229910052751 metal Inorganic materials 0.000 abstract 1
- 239000002184 metal Substances 0.000 abstract 1
- 150000002739 metals Chemical class 0.000 abstract 1
- 230000005012 migration Effects 0.000 abstract 1
- 238000013508 migration Methods 0.000 abstract 1
- 210000002826 placenta Anatomy 0.000 abstract 1
- 230000017854 proteolysis Effects 0.000 abstract 1
- 238000004537 pulping Methods 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 239000007787 solid Substances 0.000 abstract 1
- 239000000126 substance Substances 0.000 abstract 1
- 230000001225 therapeutic effect Effects 0.000 abstract 1
- 230000009466 transformation Effects 0.000 abstract 1
- 238000000844 transformation Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
- C12N15/1003—Extracting or separating nucleic acids from biological samples, e.g. pure separation or isolation methods; Conditions, buffers or apparatuses therefor
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Genetics & Genomics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biochemistry (AREA)
- Biomedical Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Molecular Biology (AREA)
- Biotechnology (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- General Engineering & Computer Science (AREA)
- Biophysics (AREA)
- Hematology (AREA)
- Virology (AREA)
- Crystallography & Structural Chemistry (AREA)
- Physics & Mathematics (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Plant Pathology (AREA)
- Microbiology (AREA)
- Analytical Chemistry (AREA)
- Diabetes (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Saccharide Compounds (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Priority Applications (6)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IT8568074A IT1187833B (it) | 1985-12-12 | 1985-12-12 | Procedimento per l ottenimento di polidesossiribonucleotidi non informazionali sostanzialmente puri e dotati di attivita biologiche e prodotto relativo |
| ES86202241T ES2048142T3 (es) | 1985-12-12 | 1986-12-11 | Procedimiento de obtencion de polidesoxirribonucleotidos sustancialmente puros y no informacionales que tienen actividades biologicas, y producto respectivo. |
| EP86202241A EP0226254B1 (en) | 1985-12-12 | 1986-12-11 | Process for obtaining non informational substantially pure polydesoxyribonucleotides having biologic activities, and respective product |
| AT86202241T ATE98252T1 (de) | 1985-12-12 | 1986-12-11 | Verfahren zur herstellung von substantiell reinen nicht fuer transpiration geeigneten polydesoxyribonukleotiden mit biologischen aktivitaeten und respektives produkt. |
| DE3689375T DE3689375T2 (de) | 1985-12-12 | 1986-12-11 | Verfahren zur Herstellung von substantiell reinen nicht für Transpiration geeigneten Polydesoxyribonukleotiden mit biologischen Aktivitäten und respektives Produkt. |
| JP61300193A JPS62155293A (ja) | 1985-12-12 | 1986-12-18 | 生物活性を有する実質的に純粋な非情報的ポリデオキシリボヌクレオチドおよびその生産方法 |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IT8568074A IT1187833B (it) | 1985-12-12 | 1985-12-12 | Procedimento per l ottenimento di polidesossiribonucleotidi non informazionali sostanzialmente puri e dotati di attivita biologiche e prodotto relativo |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IT8568074A0 IT8568074A0 (it) | 1985-12-19 |
| IT1187833B true IT1187833B (it) | 1987-12-23 |
Family
ID=11307651
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IT8568074A IT1187833B (it) | 1985-12-12 | 1985-12-12 | Procedimento per l ottenimento di polidesossiribonucleotidi non informazionali sostanzialmente puri e dotati di attivita biologiche e prodotto relativo |
Country Status (6)
| Country | Link |
|---|---|
| EP (1) | EP0226254B1 (it) |
| JP (1) | JPS62155293A (it) |
| AT (1) | ATE98252T1 (it) |
| DE (1) | DE3689375T2 (it) |
| ES (1) | ES2048142T3 (it) |
| IT (1) | IT1187833B (it) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ITRM20090485A1 (it) * | 2009-09-23 | 2011-03-24 | Nicola Valerio Di | Composizione comprendente un componente ematico e suo uso per il trattamento delle malattie degenerative articolari |
| ITRM20100295A1 (it) * | 2010-06-01 | 2011-12-02 | Nicola Valerio Di | Composizione comprendente un componente ematico e suo uso per il trattamento delle malattie degenerative articolari |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA1297431C (en) * | 1987-04-24 | 1992-03-17 | F. Hoffmann-La Roche Ag | Process for the isolation of nucleic acids |
| EP0338591A3 (en) * | 1988-04-21 | 1991-09-04 | Microprobe Corporation | Nucleic acid extraction method |
| IT1391866B1 (it) | 2008-10-30 | 2012-01-27 | Mastelli S R L | Composizione iniettabile di polinucleotidi per il trattamento di patologie osteoarticolari. |
| EP2480239A1 (en) * | 2009-09-23 | 2012-08-01 | Valerio Di Nicola | Composition comprising a haematic component and its use for the treatment of degenerative joint disease |
| IT1401218B1 (it) * | 2010-07-14 | 2013-07-12 | Mastelli S R L | Composizione ad attivita' bio-rigenerativa, riparativa ed eutrofizzante. |
| IT1406068B1 (it) | 2010-07-22 | 2014-02-06 | Medestea Int Spa | Polidesossiribonucleotidi (pdrn) per l'impiego nel trattamento di condizioni di acidosi e composizioni a base di polidesossiribonucleotidi per il suddetto impiego |
| ITUB20155754A1 (it) * | 2015-11-20 | 2017-05-20 | Mastelli S R L | Composizione per il trattamento di malattie imfiammatorie intestinali. |
| KR102234367B1 (ko) * | 2020-09-07 | 2021-03-31 | 바이오메디팜 어업회사법인 주식회사 | 연어의 정소로부터 고순도 피디알엔의 추출 방법 |
| IT202100001496A1 (it) | 2021-01-26 | 2022-07-26 | I R A St Ricerche Applicate S P A | Processo per la produzione di un gel a base di polinucleotidi e suo uso nel trattamento di patologie osteoarticolari |
| CN117396180A (zh) * | 2021-06-02 | 2024-01-12 | 株式会社Lg生活健康 | 模拟紫河车的化妆料组合物 |
| CN120484034B (zh) * | 2025-07-10 | 2025-11-28 | 恒昱生物制药(山东)有限公司 | 一种多聚脱氧核糖核苷酸灭活工艺及应用 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BE620479A (it) * | ||||
| IT1043823B (it) * | 1970-11-03 | 1980-02-29 | Prephar | Procedimento per l estrazione di acidi nucleici da organi animali |
| US3899481A (en) * | 1970-11-03 | 1975-08-12 | Crinos Industria Farmaco | Process for the controlled partial degradation of deoxyribonucleic acid extracted from animal organs |
| BE780872A (fr) * | 1972-03-17 | Crinos Industria Farmaco | Procede d'extraction de sels alcalins de l'acide desoxyribonucleique a partir d'organes d'animaux. |
-
1985
- 1985-12-12 IT IT8568074A patent/IT1187833B/it active
-
1986
- 1986-12-11 AT AT86202241T patent/ATE98252T1/de not_active IP Right Cessation
- 1986-12-11 EP EP86202241A patent/EP0226254B1/en not_active Revoked
- 1986-12-11 DE DE3689375T patent/DE3689375T2/de not_active Revoked
- 1986-12-11 ES ES86202241T patent/ES2048142T3/es not_active Expired - Lifetime
- 1986-12-18 JP JP61300193A patent/JPS62155293A/ja active Pending
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ITRM20090485A1 (it) * | 2009-09-23 | 2011-03-24 | Nicola Valerio Di | Composizione comprendente un componente ematico e suo uso per il trattamento delle malattie degenerative articolari |
| ITRM20100295A1 (it) * | 2010-06-01 | 2011-12-02 | Nicola Valerio Di | Composizione comprendente un componente ematico e suo uso per il trattamento delle malattie degenerative articolari |
Also Published As
| Publication number | Publication date |
|---|---|
| DE3689375T2 (de) | 1994-06-23 |
| ATE98252T1 (de) | 1993-12-15 |
| EP0226254A2 (en) | 1987-06-24 |
| EP0226254A3 (en) | 1988-11-23 |
| IT8568074A0 (it) | 1985-12-19 |
| JPS62155293A (ja) | 1987-07-10 |
| ES2048142T3 (es) | 1994-03-16 |
| DE3689375D1 (de) | 1994-01-20 |
| EP0226254B1 (en) | 1993-12-08 |
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Legal Events
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| TA | Fee payment date (situation as of event date), data collected since 19931001 |
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