IT1204352B - Procedimento per la preparazione di 4-(n-metil-n-nicotinoil)-amino-2,3-dimetil-1-fenil-3-pirazolin-5-one e composto cosi' ottenuto - Google Patents

Procedimento per la preparazione di 4-(n-metil-n-nicotinoil)-amino-2,3-dimetil-1-fenil-3-pirazolin-5-one e composto cosi' ottenuto

Info

Publication number: IT1204352B
Authority: IT; Italy
Prior art keywords: prepd; iii; methylnifenazine; hrs; koh
Prior art date: 1986-05-15

Application number

IT20439/86A

Other languages

English (en)

Other versions

IT8620439A0 (it

Inventor

Lucia Mazzoni

Original Assignee

Ibis Ist Biochim Speriment

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1986-05-15

Filing date

1986-05-15

Publication date

1989-03-01

1986-05-15 Application filed by Ibis Ist Biochim Speriment filed Critical Ibis Ist Biochim Speriment

1986-05-15 Priority to IT20439/86A priority Critical patent/IT1204352B/it

1986-05-15 Publication of IT8620439A0 publication Critical patent/IT8620439A0/it

1986-06-16 Priority to BE0/216789A priority patent/BE904930A/fr

1989-03-01 Application granted granted Critical

1989-03-01 Publication of IT1204352B publication Critical patent/IT1204352B/it

Links

GCIGZRAXWDUHRE-UHFFFAOYSA-N n-(1,5-dimethyl-3-oxo-2-phenylpyrazol-4-yl)-n-methylpyridine-3-carboxamide Chemical compound CC=1N(C)N(C=2C=CC=CC=2)C(=O)C=1N(C)C(=O)C1=CC=CN=C1 GCIGZRAXWDUHRE-UHFFFAOYSA-N 0.000 title abstract 2
UHOVQNZJYSORNB-UHFFFAOYSA-N Benzene Chemical compound C1=CC=CC=C1 UHOVQNZJYSORNB-UHFFFAOYSA-N 0.000 abstract 6
150000008064 anhydrides Chemical class 0.000 abstract 3
JILCEWWZTBBOFS-UHFFFAOYSA-N 4-(methylamino)antipyrine Chemical compound O=C1C(NC)=C(C)N(C)N1C1=CC=CC=C1 JILCEWWZTBBOFS-UHFFFAOYSA-N 0.000 abstract 2
PVNIIMVLHYAWGP-UHFFFAOYSA-N Niacin Chemical compound OC(=O)C1=CC=CN=C1 PVNIIMVLHYAWGP-UHFFFAOYSA-N 0.000 abstract 2
230000000202 analgesic effect Effects 0.000 abstract 1
230000003110 anti-inflammatory effect Effects 0.000 abstract 1
230000001754 anti-pyretic effect Effects 0.000 abstract 1
239000002221 antipyretic Substances 0.000 abstract 1
RIFGWPKJUGCATF-UHFFFAOYSA-N ethyl chloroformate Chemical compound CCOC(Cl)=O RIFGWPKJUGCATF-UHFFFAOYSA-N 0.000 abstract 1
230000007062 hydrolysis Effects 0.000 abstract 1
238000006460 hydrolysis reaction Methods 0.000 abstract 1
235000001968 nicotinic acid Nutrition 0.000 abstract 1
239000011664 nicotinic acid Substances 0.000 abstract 1
229960003512 nicotinic acid Drugs 0.000 abstract 1
238000010992 reflux Methods 0.000 abstract 1
KKVTYAVXTDIPAP-UHFFFAOYSA-M sodium;methanesulfonate Chemical compound [Na+].CS([O-])(=O)=O KKVTYAVXTDIPAP-UHFFFAOYSA-M 0.000 abstract 1
KFLRWGSAMLBHBV-UHFFFAOYSA-M sodium;pyridine-3-carboxylate Chemical compound [Na+].[O-]C(=O)C1=CC=CN=C1 KFLRWGSAMLBHBV-UHFFFAOYSA-M 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)

IT20439/86A 1986-05-15 1986-05-15 Procedimento per la preparazione di 4-(n-metil-n-nicotinoil)-amino-2,3-dimetil-1-fenil-3-pirazolin-5-one e composto cosi' ottenuto IT1204352B (it)

Priority Applications (2)

Application Number	Priority Date	Filing Date	Title
IT20439/86A IT1204352B (it)	1986-05-15	1986-05-15	Procedimento per la preparazione di 4-(n-metil-n-nicotinoil)-amino-2,3-dimetil-1-fenil-3-pirazolin-5-one e composto cosi' ottenuto
BE0/216789A BE904930A (fr)	1986-05-15	1986-06-16	4-(n-methyl-n-nicotinoyl)-amino-2,3-dimethyl-1-phenyl-3-pyrazoline-5-one et compose ainsi obtenu.

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
IT20439/86A IT1204352B (it)	1986-05-15	1986-05-15	Procedimento per la preparazione di 4-(n-metil-n-nicotinoil)-amino-2,3-dimetil-1-fenil-3-pirazolin-5-one e composto cosi' ottenuto

Publications (2)

Publication Number	Publication Date
IT8620439A0 IT8620439A0 (it)	1986-05-15
IT1204352B true IT1204352B (it)	1989-03-01

Family

ID=11166959

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
IT20439/86A IT1204352B (it)	1986-05-15	1986-05-15	Procedimento per la preparazione di 4-(n-metil-n-nicotinoil)-amino-2,3-dimetil-1-fenil-3-pirazolin-5-one e composto cosi' ottenuto

Country Status (2)

Country	Link
BE (1)	BE904930A (it)
IT (1)	IT1204352B (it)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
CN105801487B (zh) *	2014-12-31	2019-08-27	浙江海森药业股份有限公司	一种4-甲氨基安替比林的制备方法

1986
- 1986-05-15 IT IT20439/86A patent/IT1204352B/it active
- 1986-06-16 BE BE0/216789A patent/BE904930A/fr not_active IP Right Cessation

Also Published As

Publication number	Publication date
IT8620439A0 (it)	1986-05-15
BE904930A (fr)	1986-12-16

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