IT1204461B - Derivati eterociclici - Google Patents

Derivati eterociclici

Info

Publication number: IT1204461B
Authority: IT; Italy
Prior art keywords: sub; alkyl; group; straight; branched
Prior art date: 1986-02-20

Application number

IT8619485A

Other languages

English (en)

Other versions

IT8619485A0 (it

Inventor

Claudio Semeraro

Dino Micheli

Daniele Pieraccioli

Giovanni Gaviraghi

Alan David Borthwick

Original Assignee

Glaxo Spa

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1986-02-20

Filing date

1986-02-20

Publication date

1989-03-01

1986-02-20 Application filed by Glaxo Spa filed Critical Glaxo Spa

1986-02-20 Priority to IT8619485A priority Critical patent/IT1204461B/it

1986-02-20 Publication of IT8619485A0 publication Critical patent/IT8619485A0/it

1987-02-13 Priority to IL81565A priority patent/IL81565A/xx

1987-02-19 Priority to AT87301434T priority patent/ATE100083T1/de

1987-02-19 Priority to DE87301434T priority patent/DE3788738T2/de

1987-02-19 Priority to EP87301434A priority patent/EP0238211B1/en

1987-02-20 Priority to JP62035944A priority patent/JPS62252782A/ja

1989-03-01 Application granted granted Critical

1989-03-01 Publication of IT1204461B publication Critical patent/IT1204461B/it

1990-09-19 Priority to US07/587,159 priority patent/US5051432A/en

Links

125000000217 alkyl group Chemical group 0.000 abstract 10
BHPQYMZQTOCNFJ-UHFFFAOYSA-N Calcium cation Chemical compound [Ca+2] BHPQYMZQTOCNFJ-UHFFFAOYSA-N 0.000 abstract 2
229910001424 calcium ion Inorganic materials 0.000 abstract 2
150000001875 compounds Chemical class 0.000 abstract 2
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 2
208000024172 Cardiovascular disease Diseases 0.000 abstract 1
UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
206010020772 Hypertension Diseases 0.000 abstract 1
125000003545 alkoxy group Chemical group 0.000 abstract 1
125000003236 benzoyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C(*)=O 0.000 abstract 1
125000000753 cycloalkyl group Chemical group 0.000 abstract 1
125000005843 halogen group Chemical group 0.000 abstract 1
229910052739 hydrogen Inorganic materials 0.000 abstract 1
239000001257 hydrogen Substances 0.000 abstract 1
230000004941 influx Effects 0.000 abstract 1
230000003834 intracellular effect Effects 0.000 abstract 1
125000001570 methylene group Chemical group [H]C([H])([*:1])[*:2] 0.000 abstract 1
150000002825 nitriles Chemical group 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/80—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
- C07D211/84—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen directly attached to ring carbon atoms
- C07D211/90—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Animal Behavior & Ethology (AREA)
Life Sciences & Earth Sciences (AREA)
Cardiology (AREA)
Heart & Thoracic Surgery (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Urology & Nephrology (AREA)
Vascular Medicine (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Hydrogenated Pyridines (AREA)
Plural Heterocyclic Compounds (AREA)

IT8619485A 1986-02-20 1986-02-20 Derivati eterociclici IT1204461B (it)

Priority Applications (7)

Application Number	Priority Date	Filing Date	Title
IT8619485A IT1204461B (it)	1986-02-20	1986-02-20	Derivati eterociclici
IL81565A IL81565A (en)	1986-02-20	1987-02-13	Dihydropyridine-dicarboxylic acid esters,their preparation and pharmaceutical compositions containing them
AT87301434T ATE100083T1 (de)	1986-02-20	1987-02-19	Dihydropyridine, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel.
DE87301434T DE3788738T2 (de)	1986-02-20	1987-02-19	Dihydropyridine, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel.
EP87301434A EP0238211B1 (en)	1986-02-20	1987-02-19	Dihydropyridines, process for their preparation and their use as medicaments
JP62035944A JPS62252782A (ja)	1986-02-20	1987-02-20	複素環誘導体
US07/587,159 US5051432A (en)	1986-02-20	1990-09-19	Heterocyclic 1,4 dihydropyridine derivatives

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
IT8619485A IT1204461B (it)	1986-02-20	1986-02-20	Derivati eterociclici

Publications (2)

Publication Number	Publication Date
IT8619485A0 IT8619485A0 (it)	1986-02-20
IT1204461B true IT1204461B (it)	1989-03-01

Family

ID=11158424

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
IT8619485A IT1204461B (it)	1986-02-20	1986-02-20	Derivati eterociclici

Country Status (7)

Country	Link
US (1)	US5051432A (it)
EP (1)	EP0238211B1 (it)
JP (1)	JPS62252782A (it)
AT (1)	ATE100083T1 (it)
DE (1)	DE3788738T2 (it)
IL (1)	IL81565A (it)
IT (1)	IT1204461B (it)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US20080089947A1 (en) *	2006-08-18	2008-04-17	Knox Clayton D	Calcium Influx Inhibitors in the Treatment of Ischemia

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3455945A (en) *	1967-06-07	1969-07-15	Smithkline Corp	4-(carboxy (and carbo-lower alkoxy)phenyl)-1,4-dihydropyridines
JPS55301A (en) *	1978-02-14	1980-01-05	Yamanouchi Pharmaceut Co Ltd	1,4-dihydropyridine-3,5-dicarboxylic ester derivative and its preparation
DE2847236A1 (de) *	1978-10-31	1980-05-14	Bayer Ag	Neue dihydropyridine mit substituierten estergruppierungen, mehrer verfahren zu ihrer herstellung sowie ihre verwendung als arzneimittel
JPS57171968A (en) *	1981-04-17	1982-10-22	Kyowa Hakko Kogyo Co Ltd	1,4-dihydropyridine derivative
NZ201395A (en) *	1981-07-30	1987-02-20	Bayer Ag	Pharmaceutical compositions containing 1,4-dihydropyridines and certain of these dihydropyridines
DE3207982A1 (de) *	1982-03-05	1983-09-08	Bayer Ag, 5090 Leverkusen	Neue 1,4-dihydropyridine, verfahren zu ihrer herstellung und ihrer verwendung in arzneimitteln
NZ212895A (en) *	1984-08-22	1988-07-28	Glaxo Spa	1,4-dihydropyridine derivatives and pharmaceutical compositions

1986
- 1986-02-20 IT IT8619485A patent/IT1204461B/it active
1987
- 1987-02-13 IL IL81565A patent/IL81565A/xx not_active IP Right Cessation
- 1987-02-19 EP EP87301434A patent/EP0238211B1/en not_active Expired - Lifetime
- 1987-02-19 DE DE87301434T patent/DE3788738T2/de not_active Expired - Fee Related
- 1987-02-19 AT AT87301434T patent/ATE100083T1/de active
- 1987-02-20 JP JP62035944A patent/JPS62252782A/ja active Pending
1990
- 1990-09-19 US US07/587,159 patent/US5051432A/en not_active Expired - Fee Related

Also Published As

Publication number	Publication date
US5051432A (en)	1991-09-24
JPS62252782A (ja)	1987-11-04
EP0238211B1 (en)	1994-01-12
DE3788738T2 (de)	1994-04-28
ATE100083T1 (de)	1994-01-15
IT8619485A0 (it)	1986-02-20
EP0238211A3 (en)	1988-09-07
DE3788738D1 (de)	1994-02-24
IL81565A (en)	1991-09-16
EP0238211A2 (en)	1987-09-23

Legal Events

Date	Code	Title	Description
1999-10-27	TA	Fee payment date (situation as of event date), data collected since 19931001	Effective date: 19940218

Publication	Publication Date	Title
SE8503888L (sv)	1986-02-23	Heterocykliska derivat
NO904569L (no)	1991-04-25	Benzimidazolderivater og fremgangsmaate for deres fremstilling.
LU91196I2 (fr)	2005-10-31	Picoxystrobin et ses dérivlés pharmaceutiquement acceptables(ACANTO).
NO972887L (no)	1997-08-20	Piperidineddiksyrederivater anvendelige som fibrinogen-antagonistmiddel
DE3776044D1 (de)	1992-02-27	Pyridazinon-derivate.
IT1204459B (it)	1989-03-01	Derivati eterociclici
AU576347B2 (en)	1988-08-25	3-phenyl-2-propeneamine derivatives
FI956151A0 (fi)	1995-12-20	Iskeemisissä taudeissa käyttökelpoisia bentseenijohdannaisia
DE69014930D1 (de)	1995-01-26	Aralkylamin-Verbindungen.
IT1204462B (it)	1989-03-01	Derivati eterociclici
EP0238211A3 (en)	1988-09-07	Dihydropyridines, process for their preparation and their use as medicaments
EA199900460A1 (ru)	2000-02-28	Производные бензолсульфоамида и лекарственные средства, содержащие упомянутые производные
IT1204460B (it)	1989-03-01	Derivati eterociclici
ATE96321T1 (de)	1993-11-15	Derivate von 5-hydroxy- und 5-methoxy-2-aminopyrimidin als inhibitoren der interleukin-1produktion.
JO1452B1 (en)	1988-03-10	Heterocyclic derivatives
ATE189813T1 (de)	2000-03-15	Prostaglandin-i-analoga
FI900796A0 (fi)	1990-02-16	Aralkylaminfoereningar.