NO904569L - Benzimidazolderivater og fremgangsmaate for deres fremstilling. - Google Patents

Benzimidazolderivater og fremgangsmaate for deres fremstilling.

Info

Publication number: NO904569L
Authority: NO; Norway
Prior art keywords: group; procedures; preparation; derivatives; benzimidazold
Prior art date: 1989-10-24

Application number

NO90904569A

Other languages

English (en)

Other versions

NO177304C (no

NO904569D0 (no

NO177304B (no

Inventor

Takehiko Naka

Kohei Nishikawa

Original Assignee

Takeda Chemical Industries Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1989-10-24

Filing date

1990-10-23

Publication date

1991-04-25

1990-10-23 Application filed by Takeda Chemical Industries Ltd filed Critical Takeda Chemical Industries Ltd

1990-10-23 Publication of NO904569D0 publication Critical patent/NO904569D0/no

1991-04-25 Publication of NO904569L publication Critical patent/NO904569L/no

1995-05-15 Publication of NO177304B publication Critical patent/NO177304B/no

1995-08-23 Publication of NO177304C publication Critical patent/NO177304C/no

Links

238000000034 method Methods 0.000 title 1
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 2
102000005862 Angiotensin II Human genes 0.000 abstract 1
101800000733 Angiotensin-2 Proteins 0.000 abstract 1
208000024172 Cardiovascular disease Diseases 0.000 abstract 1
CZGUSIXMZVURDU-JZXHSEFVSA-N Ile(5)-angiotensin II Chemical compound C([C@@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC=1NC=NC=1)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CC=1C=CC=CC=1)C([O-])=O)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(N)=[NH2+])NC(=O)[C@@H]([NH3+])CC([O-])=O)C(C)C)C1=CC=C(O)C=C1 CZGUSIXMZVURDU-JZXHSEFVSA-N 0.000 abstract 1
229950006323 angiotensin ii Drugs 0.000 abstract 1
150000001450 anions Chemical class 0.000 abstract 1
230000003042 antagnostic effect Effects 0.000 abstract 1
239000003814 drug Substances 0.000 abstract 1
150000002460 imidazoles Chemical class 0.000 abstract 1
229940079865 intestinal antiinfectives imidazole derivative Drugs 0.000 abstract 1
125000000843 phenylene group Chemical group C1(=C(C=CC=C1)*)* 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1
125000006850 spacer group Chemical group 0.000 abstract 1
125000001424 substituent group Chemical group 0.000 abstract 1
125000000547 substituted alkyl group Chemical group 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing aromatic rings
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
- C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
- C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
- C07D235/06—Benzimidazoles; Hydrogenated benzimidazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
- C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
- C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
- C07D235/06—Benzimidazoles; Hydrogenated benzimidazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
- C07D235/08—Radicals containing only hydrogen and carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
- C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
- C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
- C07D235/06—Benzimidazoles; Hydrogenated benzimidazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
- C07D235/12—Radicals substituted by oxygen atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/645—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having two nitrogen atoms as the only ring hetero atoms
- C07F9/6503—Five-membered rings
- C07F9/6506—Five-membered rings having the nitrogen atoms in positions 1 and 3
- C07F9/65068—Five-membered rings having the nitrogen atoms in positions 1 and 3 condensed with carbocyclic rings or carbocyclic ring systems

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
General Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Veterinary Medicine (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Medicinal Chemistry (AREA)
Animal Behavior & Ethology (AREA)
General Chemical & Material Sciences (AREA)
Public Health (AREA)
Chemical Kinetics & Catalysis (AREA)
Heart & Thoracic Surgery (AREA)
Cardiology (AREA)
Urology & Nephrology (AREA)
Molecular Biology (AREA)
Biochemistry (AREA)
Reproductive Health (AREA)
Endocrinology (AREA)
Vascular Medicine (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Polyesters Or Polycarbonates (AREA)
Steroid Compounds (AREA)

NO904569A 1989-10-24 1990-10-23 Analogifremgangsmåte for fremstilling av terapeutisk aktive benzimidazolderivater NO177304C (no)

Applications Claiming Priority (6)

Application Number	Priority Date	Filing Date	Title
JP27738589		1989-10-24
JP32897489		1989-12-18
JP514790		1990-01-11
JP9167590		1990-04-05
JP9732490		1990-04-11
JP11314590		1990-04-27

Publications (4)

Publication Number	Publication Date
NO904569D0 NO904569D0 (no)	1990-10-23
NO904569L true NO904569L (no)	1991-04-25
NO177304B NO177304B (no)	1995-05-15
NO177304C NO177304C (no)	1995-08-23

Family

ID=27547894

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
NO904569A NO177304C (no)	1989-10-24	1990-10-23	Analogifremgangsmåte for fremstilling av terapeutisk aktive benzimidazolderivater

Country Status (14)

Country	Link
US (1)	US5128356A (no)
EP (1)	EP0425921B1 (no)
JP (1)	JP3099241B2 (no)
AT (1)	ATE126219T1 (no)
AU (1)	AU649418B2 (no)
CA (1)	CA2028302C (no)
DE (1)	DE69021502T2 (no)
FI (1)	FI102068B (no)
HU (1)	HUT55384A (no)
IE (1)	IE67956B1 (no)
IL (1)	IL95975A (no)
NO (1)	NO177304C (no)
NZ (1)	NZ235762A (no)
PT (2)	PT95655B (no)

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ES2121773T3 (es) *	1990-06-08	1998-12-16	Hoechst Marion Roussel Inc	Derivados de bencimidazol, su procedimiento de preparacion, productos intermedios, su aplicacion como medicamentos y composiciones farmaceuticas que los contienen.
FR2674523A1 (fr) *	1991-03-28	1992-10-02	Roussel Uclaf	Nouveaux derives de benzimidazole, leur procede de preparation, les nouveaux intermediaires obtenus, leur application a titre de medicaments et les compositions pharmaceutiques les renfermant.
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US5015651A (en) *	1988-01-07	1991-05-14	E. I. Du Pont De Nemours And Company	Treatment of hypertension with 1,2,4-angiotensin II antagonists
JPH0273071A (ja) *	1988-09-09	1990-03-13	Sumitomo Chem Co Ltd	ベンズイミダゾール誘導体、その製造法およびそれを有効成分とする殺虫、殺ダニ剤
DE3928177A1 (de) *	1989-04-08	1991-02-28	Thomae Gmbh Dr K	Benzimidazole, diese verbindungen enthaltende arzneimittel und verfahren zu ihrer herstellung
EP0400835A1 (en) *	1989-05-15	1990-12-05	Merck & Co. Inc.	Substituted benzimidazoles as angiotensin II antagonists
GB8911854D0 (en) *	1989-05-23	1989-07-12	Ici Plc	Heterocyclic compounds
IE70593B1 (en) *	1989-09-29	1996-12-11	Eisai Co Ltd	Biphenylmethane derivative the use of it and pharmacological compositions containing same

1990
- 1990-10-12 IL IL95975A patent/IL95975A/xx not_active IP Right Cessation
- 1990-10-15 AU AU64612/90A patent/AU649418B2/en not_active Ceased
- 1990-10-19 DE DE69021502T patent/DE69021502T2/de not_active Expired - Fee Related
- 1990-10-19 AT AT90120054T patent/ATE126219T1/de not_active IP Right Cessation
- 1990-10-19 US US07/599,894 patent/US5128356A/en not_active Expired - Fee Related
- 1990-10-19 EP EP90120054A patent/EP0425921B1/en not_active Expired - Lifetime
- 1990-10-19 NZ NZ235762A patent/NZ235762A/en unknown
- 1990-10-23 PT PT95655A patent/PT95655B/pt not_active IP Right Cessation
- 1990-10-23 NO NO904569A patent/NO177304C/no not_active IP Right Cessation
- 1990-10-23 FI FI905215A patent/FI102068B/fi not_active IP Right Cessation
- 1990-10-23 JP JP02286299A patent/JP3099241B2/ja not_active Expired - Fee Related
- 1990-10-23 CA CA002028302A patent/CA2028302C/en not_active Expired - Fee Related
- 1990-10-23 IE IE380390A patent/IE67956B1/en not_active IP Right Cessation
- 1990-10-24 HU HU906539A patent/HUT55384A/hu unknown
1996
- 1996-05-24 PT PT101875A patent/PT101875B/pt not_active IP Right Cessation

Also Published As

Publication number	Publication date
HUT55384A (en)	1991-05-28
JP3099241B2 (ja)	2000-10-16
NZ235762A (en)	1992-04-28
PT101875A (pt)	1997-12-31
NO177304C (no)	1995-08-23
JPH049373A (ja)	1992-01-14
IE903803A1 (en)	1991-04-24
FI102068B1 (fi)	1998-10-15
ATE126219T1 (de)	1995-08-15
CA2028302A1 (en)	1991-04-25
AU6461290A (en)	1991-05-02
FI905215A0 (fi)	1990-10-23
IL95975A0 (en)	1991-07-18
NO904569D0 (no)	1990-10-23
IL95975A (en)	1997-06-10
PT95655B (pt)	1996-09-30
CA2028302C (en)	2002-01-15
DE69021502T2 (de)	1996-01-11
FI102068B (fi)	1998-10-15
US5128356A (en)	1992-07-07
DE69021502D1 (de)	1995-09-14
IE67956B1 (en)	1996-05-15
AU649418B2 (en)	1994-05-26
EP0425921B1 (en)	1995-08-09
EP0425921A1 (en)	1991-05-08
NO177304B (no)	1995-05-15
PT95655A (pt)	1991-09-13
HU906539D0 (en)	1991-04-29
PT101875B (pt)	1999-04-30

Legal Events

Date	Code	Title	Description
2003-06-02	MM1K	Lapsed by not paying the annual fees	Free format text: LAPSED IN APRIL 2003

Publication	Publication Date	Title
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NO893453L (no)	1990-03-01	Antibakterielle spiro-forbindelser og fremgangsmaate for deres fremstilling.
AU5117890A (en)	1990-09-13	Trifluromethylphenylazolylmethyloxiranes, the preparation thereof and the use thereof as crop protection agents
ATE93232T1 (de)	1993-09-15	Bis(methylendioxy)biphenyl-verbindungen.
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NZ221699A (en)	1990-03-27	Pyridazinone derivatives; pharmaceutical compositions and intermediates
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ATE69605T1 (de)	1991-12-15	Azolylpropenyl- und azolylmethyloxiran-derivate und diese enthaltende fungizide.
DK23089D0 (da)	1989-01-19	Thioformamidderivater og deres anvendelse
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ES2024332A6 (es)	1992-02-16	Procedimiento para la obtencion de nuevas sulfonamidas.
DK0391673T3 (da)	1993-06-28	Fremstilling af glutarsyrederivater
ES2012695A6 (es)	1990-04-01	Un procedimiento para la preparacion de 4-(6'-metoxi -2'- naftil)-but-3-en -2-ona.
DE3769383D1 (de)	1991-05-23	Herbizide cyclohexan-1,3-dion-derivate.
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MY104164A (en)	1994-02-28	Heterocyclic compounds.
EP0005980A3 (en)	1980-01-09	Derivatives of substituted n-alkyl imidazoles, their preparation and pharmaceutical use