IT1205031B - Derivati dell' etere immidazochinolinilico ad azione farmaceutica e procedimento per la loro preparazione - Google Patents

Derivati dell' etere immidazochinolinilico ad azione farmaceutica e procedimento per la loro preparazione

Info

Publication number
IT1205031B
IT1205031B IT20650/87A IT2065087A IT1205031B IT 1205031 B IT1205031 B IT 1205031B IT 20650/87 A IT20650/87 A IT 20650/87A IT 2065087 A IT2065087 A IT 2065087A IT 1205031 B IT1205031 B IT 1205031B
Authority
IT
Italy
Prior art keywords
immidazokinolinyl
procedure
preparation
ether derivatives
pharmaceutical action
Prior art date
Application number
IT20650/87A
Other languages
English (en)
Other versions
IT8720650A0 (it
Inventor
Nicholas Meanwell
John J Wright
Original Assignee
Bristol Myers Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol Myers Co filed Critical Bristol Myers Co
Publication of IT8720650A0 publication Critical patent/IT8720650A0/it
Application granted granted Critical
Publication of IT1205031B publication Critical patent/IT1205031B/it

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hospice & Palliative Care (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
IT20650/87A 1986-05-23 1987-05-22 Derivati dell' etere immidazochinolinilico ad azione farmaceutica e procedimento per la loro preparazione IT1205031B (it)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US06/866,813 US4775674A (en) 1986-05-23 1986-05-23 Imidazoquinolinylether derivatives useful as phosphodiesterase and blood aggregation inhibitors

Publications (2)

Publication Number Publication Date
IT8720650A0 IT8720650A0 (it) 1987-05-22
IT1205031B true IT1205031B (it) 1989-03-10

Family

ID=25348473

Family Applications (1)

Application Number Title Priority Date Filing Date
IT20650/87A IT1205031B (it) 1986-05-23 1987-05-22 Derivati dell' etere immidazochinolinilico ad azione farmaceutica e procedimento per la loro preparazione

Country Status (24)

Country Link
US (1) US4775674A (it)
JP (1) JPS62283972A (it)
KR (1) KR900008567B1 (it)
AT (1) AT392790B (it)
AU (1) AU603577B2 (it)
BE (1) BE1002033A4 (it)
CA (1) CA1289137C (it)
CH (1) CH675246A5 (it)
DE (1) DE3717291A1 (it)
DK (1) DK166084C (it)
ES (1) ES2005588A6 (it)
FI (1) FI86723C (it)
FR (1) FR2603586B1 (it)
GB (1) GB2190676B (it)
GR (1) GR870803B (it)
HU (1) HU197570B (it)
IL (1) IL82612A0 (it)
IT (1) IT1205031B (it)
LU (1) LU86896A1 (it)
NL (1) NL8701226A (it)
NZ (1) NZ220345A (it)
PT (1) PT84938B (it)
SE (1) SE465163B (it)
ZA (1) ZA873583B (it)

Families Citing this family (57)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1306260C (en) * 1985-10-18 1992-08-11 Shionogi & Co., Ltd. Condensed imidazopyridine derivatives
JPH01189791A (ja) * 1988-01-26 1989-07-28 New Japan Radio Co Ltd 非接触ｉｄカード
US4943573A (en) * 1989-11-01 1990-07-24 Bristol-Myers Squibb Company Imidazo[4,5-b]quinolinyloxyalkanoic acid amides with enhanced water solubility
US5262540A (en) * 1989-12-20 1993-11-16 Bristol-Myers Squibb Company [2(4,5-diaryl-2 oxazoyl substituted phenoxy alkanoic acid and esters
PH31245A (en) * 1991-10-30 1998-06-18 Janssen Pharmaceutica Nv 1,3-Dihydro-2H-imidazoÄ4,5-BÜ-quinolin-2-one derivatives.
US5187188A (en) * 1992-04-03 1993-02-16 Bristol-Myers Squibb Company Oxazole carboxylic acid derivatives
US5552267A (en) * 1992-04-03 1996-09-03 The Trustees Of Columbia University In The City Of New York Solution for prolonged organ preservation
US5208237A (en) * 1992-04-03 1993-05-04 Bristol-Meyers Squibb Company 7-oxypropylsulfonamido-imidazo[4,5-b]quinolin-2-ones
US5196428A (en) * 1992-04-03 1993-03-23 Bristol-Myers Squibb Company Imidazo[4,5-b]qinolinyl oxy alkyl ureas
US5348960A (en) * 1992-04-03 1994-09-20 Bristol-Myers Squibb Company Imidazo[4,5-b]quinolinyl oxy alkyl tetrazolyl piperidine derivatives
US5158958A (en) * 1992-04-03 1992-10-27 Bristol-Myers Squibb Company Imidazo[4,5-b]quinolinyl oxy alkyl sulfonyl piperidine derivatives
TW593317B (en) 1993-06-21 2004-06-21 Janssen Pharmaceutica Nv Positive cardiac inotropic and lusitropic pyrroloquinolinone derivatives
US6541485B1 (en) 1999-06-10 2003-04-01 3M Innovative Properties Company Urea substituted imidazoquinolines
US6331539B1 (en) 1999-06-10 2001-12-18 3M Innovative Properties Company Sulfonamide and sulfamide substituted imidazoquinolines
US6573273B1 (en) 1999-06-10 2003-06-03 3M Innovative Properties Company Urea substituted imidazoquinolines
US6756382B2 (en) * 1999-06-10 2004-06-29 3M Innovative Properties Company Amide substituted imidazoquinolines
JP4767429B2 (ja) * 2001-03-02 2011-09-07 株式会社クラレ 架橋剤および架橋性重合体
AU2003297562A1 (en) * 2002-11-27 2004-06-23 Artesian Therapeutics, Inc. COMPOUNDS WITH MIXED PDE-INHIBITORY AND Beta-ADRENERGIC ANTAGONIST OR PARTIAL AGONIST ACTIVITY FOR TREATMENT OF HEART FAILURE
BRPI0413558A (pt) 2003-08-12 2006-10-17 3M Innovative Properties Co compostos contendo imidazo substituìdo por hidroxilamina
AU2004268625B2 (en) 2003-08-27 2011-03-31 3M Innovative Properties Company Aryloxy and arylalkyleneoxy substituted imidazoquinolines
AU2004270201A1 (en) 2003-09-05 2005-03-17 3M Innovative Properties Company Treatment for CD5+ B cell lymphoma
US7544697B2 (en) 2003-10-03 2009-06-09 Coley Pharmaceutical Group, Inc. Pyrazolopyridines and analogs thereof
AR046046A1 (es) 2003-10-03 2005-11-23 3M Innovative Properties Co Imidazoquinolinas alcoxi sustituidas. composiciones farmaceuticas.
EP1685129A4 (en) 2003-11-14 2008-10-22 3M Innovative Properties Co OXIMSUBSTITUTED IMIDAZORING CONNECTIONS
CA2545825A1 (en) 2003-11-14 2005-06-02 3M Innovative Properties Company Hydroxylamine substituted imidazo ring compounds
CA2547020C (en) 2003-11-25 2014-03-25 3M Innovative Properties Company 1h-imidazo[4,5-c]pyridine-4-amine derivatives as immune response modifier
JP2007517035A (ja) 2003-12-29 2007-06-28 スリーエム イノベイティブ プロパティズ カンパニー アリールアルケニルおよびアリールアルキニル置換されたイミダゾキノリン
EP1699788A2 (en) 2003-12-30 2006-09-13 3M Innovative Properties Company Imidazoquinolinyl, imidazopyridinyl and imidazonaphthyridinyl sulfonamides
WO2005094531A2 (en) 2004-03-24 2005-10-13 3M Innovative Properties Company Amide substituted imidazopyridines, imidazoquinolines, and imidazonaphthyridines
US8017779B2 (en) 2004-06-15 2011-09-13 3M Innovative Properties Company Nitrogen containing heterocyclyl substituted imidazoquinolines and imidazonaphthyridines
WO2006038923A2 (en) 2004-06-18 2006-04-13 3M Innovative Properties Company Aryl substituted imidazonaphthyridines
US8026366B2 (en) 2004-06-18 2011-09-27 3M Innovative Properties Company Aryloxy and arylalkyleneoxy substituted thiazoloquinolines and thiazolonaphthyridines
WO2006065280A2 (en) 2004-06-18 2006-06-22 3M Innovative Properties Company Isoxazole, dihydroisoxazole, and oxadiazole substituted imidazo ring compounds and methods
EP1831221B1 (en) 2004-12-30 2012-08-08 3M Innovative Properties Company Substituted chiral fused 1,2 imidazo 4,5-c ring compounds
JP5543068B2 (ja) 2004-12-30 2014-07-09 スリーエム イノベイティブ プロパティズ カンパニー キラル縮合［１，２］イミダゾ［４，５−ｃ］環状化合物
AU2006210392A1 (en) 2005-02-04 2006-08-10 Coley Pharmaceutical Group, Inc. Aqueous gel formulations containing immune response modifiers
AU2006213746A1 (en) 2005-02-11 2006-08-17 Coley Pharmaceutical Group, Inc. Oxime and hydroxylamine substituted imidazo(4,5-c) ring compounds and methods
AU2006232375A1 (en) 2005-04-01 2006-10-12 Coley Pharmaceutical Group, Inc. 1-substituted pyrazolo (3,4-c) ring compounds as modulators of cytokine biosynthesis for the treatment of viral infections and neoplastic diseases
EP1869043A2 (en) 2005-04-01 2007-12-26 Coley Pharmaceutical Group, Inc. Pyrazolopyridine-1,4-diamines and analogs thereof
EP2275095A3 (en) 2005-08-26 2011-08-17 Braincells, Inc. Neurogenesis by muscarinic receptor modulation
EP2258358A3 (en) 2005-08-26 2011-09-07 Braincells, Inc. Neurogenesis with acetylcholinesterase inhibitor
EP1940389A2 (en) 2005-10-21 2008-07-09 Braincells, Inc. Modulation of neurogenesis by pde inhibition
AU2006308889A1 (en) 2005-10-31 2007-05-10 Braincells, Inc. GABA receptor mediated modulation of neurogenesis
US20100216734A1 (en) 2006-03-08 2010-08-26 Braincells, Inc. Modulation of neurogenesis by nootropic agents
EP2382975A3 (en) 2006-05-09 2012-02-29 Braincells, Inc. Neurogenesis by modulating angiotensin
JP2009536667A (ja) 2006-05-09 2009-10-15 ブレインセルス，インコーポレイティド ５ｈｔ受容体介在性の神経新生
US7906506B2 (en) 2006-07-12 2011-03-15 3M Innovative Properties Company Substituted chiral fused [1,2] imidazo [4,5-c] ring compounds and methods
US8227603B2 (en) 2006-08-01 2012-07-24 Cytokinetics, Inc. Modulating skeletal muscle
PL2069352T3 (pl) 2006-08-02 2014-03-31 Cytokinetics Inc Określone cząstki chemiczne, kompozycje i sposoby
US8299248B2 (en) 2006-08-02 2012-10-30 Cytokinetics, Incorporated Certain 1H-imidazo[4,5-b]pyrazin-2(3H)-ones and 1H-imidazo[4,5-b]pyrazin-2-ols and methods for their use
AU2007292848A1 (en) 2006-09-08 2008-03-13 Braincells, Inc. Combinations containing a 4-acylaminopyridine derivative
US20100184806A1 (en) 2006-09-19 2010-07-22 Braincells, Inc. Modulation of neurogenesis by ppar agents
EP2139478A4 (en) * 2007-03-30 2010-05-05 Cytokinetics Inc CHEMICAL ENTITIES, COMPOSITIONS AND METHODS
WO2010099217A1 (en) 2009-02-25 2010-09-02 Braincells, Inc. Modulation of neurogenesis using d-cycloserine combinations
BR112014000742A2 (pt) 2011-07-13 2016-08-23 Andrew A Wolff terapia de combinação de als
WO2013106547A1 (en) 2012-01-10 2013-07-18 President And Fellows Of Harvard College Beta-cell replication promoting compounds and methods of their use
WO2024149378A1 (zh) * 2023-01-13 2024-07-18 上海超阳药业有限公司 喹啉酮化合物和萘啶酮化合物及其用途

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3932407A (en) * 1973-11-19 1976-01-13 Bristol-Myers Company Optionally substituted 1,2,3,5-tetrahydroimidezo(2,1-b)-quinazolin-2-ones and 6(H)-1,2,3,4-tetrahydropyimido(2,1-b)quinazolin-2-ones
NL7807507A (nl) * 1977-07-25 1979-01-29 Hoffmann La Roche Tricyclische verbindingen.
IL62402A0 (en) * 1980-03-24 1981-05-20 Sterling Drug Inc Imidazo(4,5-b)pyridines,their preparation and pharmaceutical compositions containing them
US4490371A (en) * 1983-02-16 1984-12-25 Syntex (U.S.A.) Inc. N,N-Disubstituted-(2-oxo-1,2,3,5-tetrahydroimidazo-[2,1-B]quinazolinyl)oxyalkylamides
JPS604186A (ja) * 1983-06-21 1985-01-10 Dai Ichi Seiyaku Co Ltd イミダゾキナゾリン化合物
JPS6028979A (ja) * 1983-07-14 1985-02-14 Dai Ichi Seiyaku Co Ltd イミダゾキナゾリン類化合物
CA1254557A (en) * 1984-02-15 1989-05-23 Michael C. Venuti (2-oxo-1,2,3,5-tetrahydroimidazo-(2,1-b) quinazolinyl) oxyalkylamides
US4668686A (en) * 1985-04-25 1987-05-26 Bristol-Myers Company Imidazoquinoline antithrombrogenic cardiotonic agents

Also Published As

Publication number Publication date
HUT43602A (en) 1987-11-30
NL8701226A (nl) 1987-12-16
US4775674A (en) 1988-10-04
ES2005588A6 (es) 1989-03-16
DK263587D0 (da) 1987-05-22
FR2603586B1 (fr) 1990-12-28
GB2190676A (en) 1987-11-25
IL82612A0 (en) 1987-11-30
NZ220345A (en) 1990-10-26
FI872220L (fi) 1987-11-24
ATA132087A (de) 1990-11-15
LU86896A1 (fr) 1988-01-20
DK166084B (da) 1993-03-08
PT84938A (en) 1987-06-01
IT8720650A0 (it) 1987-05-22
PT84938B (pt) 1990-02-08
FI86723B (fi) 1992-06-30
SE8702158D0 (sv) 1987-05-22
BE1002033A4 (fr) 1990-05-29
DK263587A (da) 1987-11-24
FR2603586A1 (fr) 1988-03-11
AU7299387A (en) 1987-11-26
KR870011137A (ko) 1987-12-21
AU603577B2 (en) 1990-11-22
HU197570B (en) 1989-04-28
JPS62283972A (ja) 1987-12-09
GB2190676B (en) 1990-05-30
GB8711839D0 (en) 1987-06-24
FI872220A0 (fi) 1987-05-20
CH675246A5 (it) 1990-09-14
KR900008567B1 (ko) 1990-11-24
AT392790B (de) 1991-06-10
DK166084C (da) 1993-08-02
CA1289137C (en) 1991-09-17
GR870803B (en) 1987-09-24
ZA873583B (en) 1988-04-27
SE8702158L (sv) 1987-11-24
SE465163B (sv) 1991-08-05
DE3717291A1 (de) 1987-11-26
FI86723C (fi) 1992-10-12

Similar Documents

Publication Publication Date Title
IT1205031B (it) Derivati dell' etere immidazochinolinilico ad azione farmaceutica e procedimento per la loro preparazione
IT8822399A0 (it) Derivati di monofosforil lipide a e procedimento per la loro preparazione.
ITTO920325A0 (it) Nuovi derivati basici dell'acido glutammico ed acido aspartico, proce-dimento per la loro preparazione e loro uso farmaceutico.
IT1187717B (it) Procedimento per la preparazione di derivati 3-sostituiti dell'1-amino-2-idrossi-propano
IT8767158A0 (it) Derivati benzofuranici procedimento per la loro preparazione e composizioni farmaceutiche e cosmetiche che li comprendono
IT1196488B (it) Poli-4-aminopirrol-2-carbossamido derivati e procedimento per la loro preparazione
ITMI910080A0 (it) Nuovi derivati arilvinilamidici e procedimento per la loro preparazione
IT8721691A0 (it) Derivati dell'ossima della 1,2,5,6-tetraidropirdin-3-carbossaldeide, loro procedimento di preparazione e loro impiegocome sostanze medicinali.
IT1229491B (it) Derivati della 1,2,5,6-tetraidropiridina, loro procedimento di preparazione e loro impiego come sostanze medicinali
IT8747874A0 (it) La loro preparazione derivati tiodiossolanici ad attivita' moculitica e procedimento per
IT1194793B (it) Derivati tiazolidinici ad attivita' farmacologica,procedimento per la loro preparazione e composizioni farmaceutiche contenenti detti derivati
IT8667976A0 (it) Derivati teofillinmetilditiolanici e teofillinmetilditianici procedimento per la loro preparazione e composizioni farmaceutiche che li comprendono
IT1164180B (it) Derivati n-carbammoilici dell'isotiazolo-(5,4b)piridin-one-3 e loro procedimento di preparazione
IT8449056A0 (it) Derivati dell'1,2-ditiolano,loro preparazione e loro impiego come medicamenti
IT1214726B (it) Derivati di glucosilmoranolina eprocedimento per la loro preparazione
IT8347588A0 (it) Derivati dell'indolina, loro preparazione e loro impiego come medicamenti
IT1196494B (it) Derivati dell'acito cef-3-em-4-carbossilico,procedimento per la loro preparazione e composizioni farmaceutiche che li contengono
IT1163943B (it) Derivati 15-cicloalifatici di 13,14-dideidro carboprostacicline e procedimento per la loro preparazione
IT1217342B (it) Derivati piperazinici e procedimento per la loro preparazione
IT1203976B (it) Derivati dell'ergolene, composizioni farmaceutiche che li contengono e procedimento per la preparazione dei medesimi
IT8548898A0 (it) Derivati dell'1,4-diidropiridina,loro preparazione e loro impiego come medicamenti
IT1148788B (it) Derivati dell'amminoisochinolina e procedimento per la loro preparazione
IT1199830B (it) 10 b-alchinil-4,9(11)-estradiene derivati e procedimento per la loro preparazione
IT1187729B (it) Derivati fenilpiridinici,loro preparazione e relative formulazioni farmaceutiche
IT8947562A0 (it) Derivati dell'ergolina, loro preparazione e loro impiego come medicamenti