IT1208736B - Alogenuri dell'estere del 2-n,n,n,dimetil-alchil-amminoetanolo con acido acetico variamente sostituito e composizioni farmaceutiche che licontengono ad attivita' antiinfiammatoria e antisettica - Google Patents

Alogenuri dell'estere del 2-n,n,n,dimetil-alchil-amminoetanolo con acido acetico variamente sostituito e composizioni farmaceutiche che licontengono ad attivita' antiinfiammatoria e antisettica

Info

Publication number: IT1208736B
Authority: IT; Italy
Prior art keywords: dimethyl; acetic acid; alchyl; aminoethanol; inflammatory
Prior art date: 1986-03-04

Application number

IT8647711A

Other languages

English (en)

Other versions

IT8647711A0 (it

Inventor

Reiner Alberto

Original Assignee

Sigma Tau Ind Farmaceuti

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1986-03-04

Filing date

1986-03-04

Publication date

1989-07-10

1986-03-04 Application filed by Sigma Tau Ind Farmaceuti filed Critical Sigma Tau Ind Farmaceuti

1986-03-04 Priority to IT8647711A priority Critical patent/IT1208736B/it

1986-03-04 Publication of IT8647711A0 publication Critical patent/IT8647711A0/it

1987-02-27 Priority to AT87830068T priority patent/ATE56945T1/de

1987-02-27 Priority to ES87830068T priority patent/ES2017529B3/es

1987-02-27 Priority to EP87830068A priority patent/EP0237495B1/en

1987-02-27 Priority to DE8787830068T priority patent/DE3765142D1/de

1989-07-10 Application granted granted Critical

1989-07-10 Publication of IT1208736B publication Critical patent/IT1208736B/it

1990-09-27 Priority to GR90400682T priority patent/GR3000878T3/el

Links

QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 title abstract 5
230000003110 anti-inflammatory effect Effects 0.000 title abstract 2
230000002421 anti-septic effect Effects 0.000 title abstract 2
239000008194 pharmaceutical composition Substances 0.000 title 1
-1 p-isobutylphenyl Chemical group 0.000 abstract 3
125000006273 (C1-C3) alkyl group Chemical group 0.000 abstract 1
125000000218 acetic acid group Chemical class C(C)(=O)* 0.000 abstract 1
125000000217 alkyl group Chemical group 0.000 abstract 1
150000002148 esters Chemical class 0.000 abstract 1
229910052739 hydrogen Inorganic materials 0.000 abstract 1
239000001257 hydrogen Substances 0.000 abstract 1
125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
- C07D209/18—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D209/26—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with an acyl radical attached to the ring nitrogen atom

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Indole Compounds (AREA)
Agricultural Chemicals And Associated Chemicals (AREA)

IT8647711A 1986-03-04 1986-03-04 Alogenuri dell'estere del 2-n,n,n,dimetil-alchil-amminoetanolo con acido acetico variamente sostituito e composizioni farmaceutiche che licontengono ad attivita' antiinfiammatoria e antisettica IT1208736B (it)

Priority Applications (6)

Application Number	Priority Date	Filing Date	Title
IT8647711A IT1208736B (it)	1986-03-04	1986-03-04	Alogenuri dell'estere del 2-n,n,n,dimetil-alchil-amminoetanolo con acido acetico variamente sostituito e composizioni farmaceutiche che licontengono ad attivita' antiinfiammatoria e antisettica
AT87830068T ATE56945T1 (de)	1986-03-04	1987-02-27	Halogenide des esters aus 2-n,n,n-dimethyl-alkyl- amino-aethanol mit substituierter essigsaeure, sowie diese enthaltende arzneimittel mit entzuendungshemmender und antiseptischer wirkung.
ES87830068T ES2017529B3 (es)	1986-03-04	1987-02-27	Halogenuros del ester de 2 n,n,n-dimetilo-alquilamino-etanol con acido acetico sustituido y composiciones farmaceuticas que tienen actividades antiinflamatorias y antisepticas que contienen dichos compuestos.
EP87830068A EP0237495B1 (en)	1986-03-04	1987-02-27	Halogenides of the ester of 2,n,n,n-dimethyl-alkyl-amino-ethanol with substituted acetic acid and pharmaceutical compositions having antiinflammatory and antiseptic activities containing same
DE8787830068T DE3765142D1 (de)	1986-03-04	1987-02-27	Halogenide des esters aus 2-n,n,n-dimethyl-alkyl-amino-aethanol mit substituierter essigsaeure, sowie diese enthaltende arzneimittel mit entzuendungshemmender und antiseptischer wirkung.
GR90400682T GR3000878T3 (en)	1986-03-04	1990-09-27	Halogenides of the ester of 2,n,n,n-dimethyl-alkyl-amino-ethanol with substituted acetic acid and pharmaceutical compositions having antiinflammatory and antiseptic activities containing same

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
IT8647711A IT1208736B (it)	1986-03-04	1986-03-04	Alogenuri dell'estere del 2-n,n,n,dimetil-alchil-amminoetanolo con acido acetico variamente sostituito e composizioni farmaceutiche che licontengono ad attivita' antiinfiammatoria e antisettica

Publications (2)

Publication Number	Publication Date
IT8647711A0 IT8647711A0 (it)	1986-03-04
IT1208736B true IT1208736B (it)	1989-07-10

Family

ID=11262040

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
IT8647711A IT1208736B (it)	1986-03-04	1986-03-04	Alogenuri dell'estere del 2-n,n,n,dimetil-alchil-amminoetanolo con acido acetico variamente sostituito e composizioni farmaceutiche che licontengono ad attivita' antiinfiammatoria e antisettica

Country Status (6)

Country	Link
EP (1)	EP0237495B1 (it)
AT (1)	ATE56945T1 (it)
DE (1)	DE3765142D1 (it)
ES (1)	ES2017529B3 (it)
GR (1)	GR3000878T3 (it)
IT (1)	IT1208736B (it)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JPS6452742A (en) *	1987-04-27	1989-02-28	Syntex Pharma Int	Omega-quaternary ammonium alkyl ester and thioester of acidic non-steroidal antiinflammatory
IL89848A (en) *	1988-04-07	1997-08-14	Sepracor	Chiral ester derivatives
US5196568A (en) *	1988-04-07	1993-03-23	Sepracor, Inc.	Compounds useful in enzymatic resolution systems and their preparation
US20090221703A1 (en)	2006-07-09	2009-09-03	Chongxi Yu	High penetration composition and uses thereof
US20090238763A1 (en)	2006-07-09	2009-09-24	Chongxi Yu	High penetration compositions and uses thereof
HUE033687T2 (en) *	2006-07-18	2017-12-28	Techfields Biochem Co Ltd	Ibuprofen positively charged water soluble prodrugs with very fast skin penetration rates
CN103772258B (zh) *	2006-08-08	2016-09-28	于崇曦	具有快速皮肤穿透速度的带正电荷的芳基和杂芳基乙酸类前药
CN103772259B (zh) *	2006-08-08	2016-08-31	于崇曦	具有快速皮肤穿透速度的带正电荷的芳基和杂芳基乙酸类前药
JP2010529101A (ja)	2007-06-04	2010-08-26	テックフィールズインコーポレイテッド	非常に速い皮膚及び膜浸透速度を有するｎｓａｉａプロドラッグ及びその新規医薬使用
CN108191846B (zh)	2008-12-04	2021-08-20	于崇曦	高穿透性组合物及其应用

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4150137A (en) *	1975-12-24	1979-04-17	Hisamitsu Pharmaceutical Co. Inc.	Pyridylalkyl esters of 2-(p-isobutylphenyl)acetic acid and propionic acids and use
DE3023206A1 (de) *	1979-11-02	1982-01-14	Efeka Friedrich & Kaufmann GmbH & Co KG, 3000 Hannover	Indometacin-ester, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel

1986
- 1986-03-04 IT IT8647711A patent/IT1208736B/it active
1987
- 1987-02-27 DE DE8787830068T patent/DE3765142D1/de not_active Expired - Lifetime
- 1987-02-27 EP EP87830068A patent/EP0237495B1/en not_active Expired - Lifetime
- 1987-02-27 ES ES87830068T patent/ES2017529B3/es not_active Expired - Lifetime
- 1987-02-27 AT AT87830068T patent/ATE56945T1/de not_active IP Right Cessation
1990
- 1990-09-27 GR GR90400682T patent/GR3000878T3/el unknown

Also Published As

Publication number	Publication date
EP0237495A2 (en)	1987-09-16
EP0237495A3 (en)	1988-06-22
GR3000878T3 (en)	1991-11-15
EP0237495B1 (en)	1990-09-26
DE3765142D1 (de)	1990-10-31
IT8647711A0 (it)	1986-03-04
ES2017529B3 (es)	1991-02-16
ATE56945T1 (de)	1990-10-15

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Legal Events

Date	Code	Title	Description
1999-10-27	TA	Fee payment date (situation as of event date), data collected since 19931001	Effective date: 19940208