IT1209512B - Procedimento selettivo per il blocco di ricettori di 5ht2. - Google Patents

Procedimento selettivo per il blocco di ricettori di 5ht2.

Info

Publication number: IT1209512B
Authority: IT; Italy
Prior art keywords: receptors; blocking; selective procedure; selective; procedure
Prior art date: 1983-03-10

Application number

IT8419995A

Other languages

English (en)

Other versions

IT8419995A0 (it

Inventor

Marlene Lois Cohen

Ray Ward Fuller

Original Assignee

Lilly Co Eli

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1983-03-10

Filing date

1984-03-09

Publication date

1989-08-30

1984-03-09 Application filed by Lilly Co Eli filed Critical Lilly Co Eli

1984-03-09 Publication of IT8419995A0 publication Critical patent/IT8419995A0/it

1989-08-30 Application granted granted Critical

1989-08-30 Publication of IT1209512B publication Critical patent/IT1209512B/it

Links

102000056834 5-HT2 Serotonin Receptors Human genes 0.000 title abstract 2
108091005479 5-HT2 receptors Proteins 0.000 title abstract 2
230000000903 blocking effect Effects 0.000 title 1
125000006273 (C1-C3) alkyl group Chemical group 0.000 abstract 1
125000006699 (C1-C3) hydroxyalkyl group Chemical group 0.000 abstract 1
125000003903 2-propenyl group Chemical group [H]C([*])([H])C([H])=C([H])[H] 0.000 abstract 1
AWFDCTXCTHGORH-HGHGUNKESA-N 6-[4-[(6ar,9r,10ar)-5-bromo-7-methyl-6,6a,8,9,10,10a-hexahydro-4h-indolo[4,3-fg]quinoline-9-carbonyl]piperazin-1-yl]-1-methylpyridin-2-one Chemical class O=C([C@H]1CN([C@H]2[C@@H](C=3C=CC=C4NC(Br)=C(C=34)C2)C1)C)N(CC1)CCN1C1=CC=CC(=O)N1C AWFDCTXCTHGORH-HGHGUNKESA-N 0.000 abstract 1
125000004990 dihydroxyalkyl group Chemical group 0.000 abstract 1
125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 1
108020003175 receptors Proteins 0.000 abstract 1
102000005962 receptors Human genes 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D457/00—Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula:, e.g. lysergic acid
- C07D457/04—Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula:, e.g. lysergic acid with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 8
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Medicinal Chemistry (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Engineering & Computer Science (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Bioinformatics & Cheminformatics (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Heart & Thoracic Surgery (AREA)
Neurosurgery (AREA)
Child & Adolescent Psychology (AREA)
Diabetes (AREA)
Hematology (AREA)
Obesity (AREA)
Psychiatry (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Cardiology (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Diaphragms For Electromechanical Transducers (AREA)
Investigation Of Foundation Soil And Reinforcement Of Foundation Soil By Compacting Or Drainage (AREA)
Prostheses (AREA)
Holo Graphy (AREA)
Eye Examination Apparatus (AREA)

IT8419995A 1983-03-10 1984-03-09 Procedimento selettivo per il blocco di ricettori di 5ht2. IT1209512B (it)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US06/473,882 US4563461A (en)	1983-03-10	1983-03-10	Selective method for blocking 5HT2 receptors

Publications (2)

Publication Number	Publication Date
IT8419995A0 IT8419995A0 (it)	1984-03-09
IT1209512B true IT1209512B (it)	1989-08-30

Family

ID=23881404

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
IT8419995A IT1209512B (it)	1983-03-10	1984-03-09	Procedimento selettivo per il blocco di ricettori di 5ht2.

Country Status (6)

Country	Link
US (1)	US4563461A (it)
EP (1)	EP0122044B1 (it)
JP (1)	JPS59175431A (it)
AT (1)	ATE35506T1 (it)
DE (2)	DE3472529D1 (it)
IT (1)	IT1209512B (it)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4675322A (en) *	1984-12-10	1987-06-23	Eli Lilly And Company	1-Substituted-6-n-propyl-8β-methylthio-methylergolines
US4714704A (en) *	1985-10-01	1987-12-22	Eli Lilly And Company	Alkoxy cycloalkanol esters of dihydrolysergic acid useful as 5HT receptor antagonists
US4713385A (en) *	1985-10-01	1987-12-15	Eli Lilly And Company	Alkoxy and dialkoxyalkyl esters of dihydrolysergic acid and related compounds useful as 5HT receptor antagonists
US4939258A (en) *	1985-10-01	1990-07-03	Eli Lilly And Company	Cycloalkanol esters of dihydrolysergic acid
US4847261A (en) *	1985-10-01	1989-07-11	Eli Lilly And Company	Alkoxy cycloalkanol esters of dihydrolysergic acid having peripheral serotonin antagonists properties
US4845224A (en) *	1985-10-01	1989-07-04	Eli Lilly And Company	Cycloalkanol esters of dihydrolysergic acid having peripheral serotonin antagonist properties
US4968802A (en) *	1985-10-01	1990-11-06	Eli Lilly And Company	Process of making alkoxy cycloalkanol esters of dihydrolysergic acid
US4772709A (en) *	1985-10-01	1988-09-20	Eli Lilly And Company	Process of making ketoalkanol esters of dihydrolysergic acid
US4820713A (en) *	1985-10-01	1989-04-11	Eli Lilly And Company	Ketoalkanol esters of dihydrolysergic acid useful as 5HT receptor antagonists
US4683236A (en) *	1985-10-01	1987-07-28	Eli Lilly And Company	Cycloalkanol esters of dihydrolysergic acid useful as 5Ht2 receptor antagonists
IL80193A0 (en) *	1985-10-01	1986-12-31	Lilly Co Eli	Esters of dihydrolysergic acid
US4906639A (en) *	1985-10-01	1990-03-06	Eli Lilly And Company	Cycloalkanol esters of dihydrolysergic acid
US4810710A (en) *	1985-10-01	1989-03-07	Eli Lilly And Company	4-hydroxycyclohexyl 1-isopropyl-9,10-dihydro-lysergate for the treatment of migraine
US4713384A (en) *	1985-10-01	1987-12-15	Eli Lilly And Company	Selective method for blocking 5HT2 receptors
US4762842A (en) *	1985-10-01	1988-08-09	Eli Lilly And Company	Selective method for blocking 5HT2 receptors
US4683237A (en) *	1985-12-20	1987-07-28	Eli Lilly And Company	Fluoroalkyl esters of dihydrolysergic acid useful as 5HT2 receptor antagonists
US4704395A (en) *	1985-12-20	1987-11-03	Eli Lilly And Company	Cyclic ether esters of 2-substituted-6-(substituted and unsubstituted) dihydrolysergic acid useful as 5HT receptor antagonists
US4704396A (en) *	1985-12-20	1987-11-03	Eli Lilly And Company	Phenacyl esters of 1-substituted-6-(substituted and unsubstituted) dihydrolysergic acids useful as 5HT receptor antagonists
EP0228876A3 (en) *	1985-12-20	1989-03-22	Eli Lilly And Company	Esters of dihydrolysergic acid and related compounds
US5006526A (en) *	1988-10-17	1991-04-09	Louisiana State University	Method of treating a vertebrate animal to reduce plasma triglycerides and cholesterol levels and to alleviate and prevent atherosclerosis
US5688807A (en) *	1994-03-11	1997-11-18	Eli Lilly And Company	Method for treating 5HT2B receptor related conditions
US5886003A (en) *	1996-03-25	1999-03-23	Eli Lilly And Company	Methods of treating or ameliorating the symptoms of venomous bites and stings
DE10212564B4 (de) *	2002-03-12	2007-04-19	Neurobiotec Gmbh	1-Allyl-ergotalkaloid-Derivate und ihre Verwendung zur Prophylaxe und Therapie von Migräne

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3228941A (en) *		1966-01-11		Methyl and i,g-dimethyl-ergoline i derivatives
US3249617A (en) *		1966-05-03		Alkylated d-lyserglc acid
CH344731A (de) *	1956-05-18	1960-02-29	Sandoz Ag	Verfahren zur Herstellung von neuen, am Indolstickstoff alkylierten Derivaten der Lysergsäure-Reihe
US3580916A (en) *	1969-02-20	1971-05-25	Lilly Co Eli	Hydroxyesters of hexa- and octahydroindoloquinolines
US3879554A (en) *	1970-03-20	1975-04-22	Farmaceutici Italia	Use of 1,6-dimethyl-8-{62 -(5-bromonicotinoyloxymethyl)-10 {60 -methoxyergoline in treating cerebral and peripheral metabolic vascular disorders
GB1290203A (it) *	1970-09-01	1972-09-20
BE792515A (fr) *	1971-12-10	1973-06-08	Sandoz Sa	Nouveaux derives de l'acide lysergique, leur preparation et leur application comme medicaments
JPS5443649B2 (it) *	1973-06-05	1979-12-21
US4153700A (en) *	1975-08-27	1979-05-08	Lake Shore Roentgenology Ltd.	Treatment of the acute after-effects resulting from alcohol ingestion
YU40004B (en) *	1977-07-21	1985-06-30	Lek Tovarna Farmacevtskih	Praocess for preparing n-substituted esters of 9,10-dihydrlysergic acid
US4166182A (en) *	1978-02-08	1979-08-28	Eli Lilly And Company	6-n-propyl-8-methoxymethyl or methylmercaptomethylergolines and related compounds

1983
- 1983-03-10 US US06/473,882 patent/US4563461A/en not_active Expired - Fee Related
1984
- 1984-03-09 IT IT8419995A patent/IT1209512B/it active
- 1984-03-09 AT AT84301586T patent/ATE35506T1/de not_active IP Right Cessation
- 1984-03-09 DE DE8484301586T patent/DE3472529D1/de not_active Expired
- 1984-03-09 JP JP59046388A patent/JPS59175431A/ja active Pending
- 1984-03-09 DE DE19843408730 patent/DE3408730A1/de not_active Withdrawn
- 1984-03-09 EP EP84301586A patent/EP0122044B1/en not_active Expired

Also Published As

Publication number	Publication date
IT8419995A0 (it)	1984-03-09
EP0122044B1 (en)	1988-07-06
EP0122044A1 (en)	1984-10-17
ATE35506T1 (de)	1988-07-15
DE3408730A1 (de)	1984-09-13
US4563461A (en)	1986-01-07
JPS59175431A (ja)	1984-10-04
DE3472529D1 (en)	1988-08-11

Publication	Publication Date	Title
IT1209512B (it)	1989-08-30	Procedimento selettivo per il blocco di ricettori di 5ht2.
BG60249B2 (en)	1994-03-24	Thiazole compound for treatment of ulcers
NO934800L (no)	1993-12-23	Anvendelse av tetrahydrokarbazonderivater som 5HT1-reseptoragonister
IT1171879B (it)	1987-06-10	Derivati di 2-ammino-3-acilammino-6-benzilammino-piridina aventi azione antiepilettica
IE840182L (en)	1984-08-01	Des-proline vasopressin antagonists
ES519650A0 (es)	1984-03-16	Un procedimiento para obtener derivados de indanilbenzamida.
MX9101236A (es)	1992-05-04	Procedimiento para la preparacion de compuestos azabiciclicos
DK0404359T3 (da)	1994-07-25	Dibenzothiazepin-derivater, der er nyttige som antispasmodiske midler
ATE87921T1 (de)	1993-04-15	Cycloalkylamide von (8beta)-1-alkyl-6(substituierten) ergolinen.
FI952420A0 (fi)	1995-05-18	Glukopyranosidibentsotiofeenit
ES2132245T3 (es)	1999-08-16	Derivados de 1-azaadamantano como agonistas o antagonistas de 5-ht.
DK160093C (da)	1991-06-24	Analogifremgangsmaade til fremstilling af 2-(2-(1,4-benzodioxanyl))-2-imidazolderivater
ES511365A0 (es)	1983-03-01	"procedimiento de preparacion de derivados de fenetanolamina".
EA200101180A1 (ru)	2002-04-25	Производные тио-оксиндола
SE8301725D0 (sv)	1983-03-28	Substituerade 3,4-diamino-1,2,5-tiadiazoler med histamin-h?712-receptor-antagonistaktivitet
ES509555A0 (es)	1983-06-16	"procedimiento para la preparacion de nuevas cefalosporinas".
FR2572074B1 (fr)	1987-07-17	Derives du thiadiazole actifs sur le systeme nerveux central, procede d'obtention et compositions pharmaceutiques les contenant
ES8504829A1 (es)	1985-05-01	Un procedimiento para la preparacion de un acido -hidroxietilfosfinico
ES2004215A6 (es)	1988-12-16	Procedimiento para preparar quinazolinas tetraciclicas
DK573981A (da)	1982-07-03	Fremgangsmaade til fremstilling af cis-c-3",c4"-carbonatderivater af o-demethyl-oleandomycin og mellemprodukter herfor
DE3362723D1 (en)	1986-04-30	Pyrido-triazoloquinazolines, their preparation and use
ZA817670B (en)	1982-11-24	2-(n-aryl,n-1,2,3-thiadiazolylcarbonyl)-aminobutyrolactones,their preparation,fungicidal agents containing these compounds,and their use as fungicides
ES2019841A6 (es)	1991-07-01	Procedimiento para preparar derivados de tieno-triazolo-diazepina.