IT1210874B - Sale di magnesio dell'acido chenodesossicolico e dell'acido ursodesossicolico, processo per lasua preparazione e composizioni terapeutiche che lo contengono come principio attivo. - Google Patents

Sale di magnesio dell'acido chenodesossicolico e dell'acido ursodesossicolico, processo per lasua preparazione e composizioni terapeutiche che lo contengono come principio attivo.

Info

Publication number: IT1210874B
Authority: IT; Italy
Prior art keywords: acid; magnesium salt; ursodexoxylic; lasual; kenodexoxylic
Prior art date: 1982-04-15

Application number

IT8220757A

Other languages

English (en)

Other versions

IT8220757A0 (it

Inventor

Aldo Grazia

Andrea Bottazzi

Original Assignee

Istituto Chemioterapico

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1982-04-15

Filing date

1982-04-15

Publication date

1989-09-29

1982-04-15 Application filed by Istituto Chemioterapico filed Critical Istituto Chemioterapico

1982-04-15 Priority to IT8220757A priority Critical patent/IT1210874B/it

1982-04-15 Publication of IT8220757A0 publication Critical patent/IT8220757A0/it

1983-03-29 Priority to DE8383103133T priority patent/DE3362246D1/de

1983-03-29 Priority to AT8383103133T priority patent/ATE18235T1/de

1983-03-29 Priority to EP83103133A priority patent/EP0092073B1/en

1989-09-29 Application granted granted Critical

1989-09-29 Publication of IT1210874B publication Critical patent/IT1210874B/it

Links

159000000003 magnesium salts Chemical class 0.000 title abstract 2
239000000203 mixture Substances 0.000 title abstract 2
239000002253 acid Substances 0.000 title 2
239000004480 active ingredient Substances 0.000 title 1
230000001225 therapeutic effect Effects 0.000 title 1
RUDATBOHQWOJDD-UHFFFAOYSA-N (3beta,5beta,7alpha)-3,7-Dihydroxycholan-24-oic acid Natural products OC1CC2CC(O)CCC2(C)C2C1C1CCC(C(CCC(O)=O)C)C1(C)CC2 RUDATBOHQWOJDD-UHFFFAOYSA-N 0.000 abstract 4
RUDATBOHQWOJDD-BSWAIDMHSA-N chenodeoxycholic acid Chemical compound C([C@H]1C[C@H]2O)[C@H](O)CC[C@]1(C)[C@@H]1[C@@H]2[C@@H]2CC[C@H]([C@@H](CCC(O)=O)C)[C@@]2(C)CC1 RUDATBOHQWOJDD-BSWAIDMHSA-N 0.000 abstract 2
229960001091 chenodeoxycholic acid Drugs 0.000 abstract 2
RUDATBOHQWOJDD-UZVSRGJWSA-N ursodeoxycholic acid Chemical compound C([C@H]1C[C@@H]2O)[C@H](O)CC[C@]1(C)[C@@H]1[C@@H]2[C@@H]2CC[C@H]([C@@H](CCC(O)=O)C)[C@@]2(C)CC1 RUDATBOHQWOJDD-UZVSRGJWSA-N 0.000 abstract 2
229960001661 ursodiol Drugs 0.000 abstract 2
FYYHWMGAXLPEAU-UHFFFAOYSA-N Magnesium Chemical compound [Mg] FYYHWMGAXLPEAU-UHFFFAOYSA-N 0.000 abstract 1
210000000941 bile Anatomy 0.000 abstract 1
230000015572 biosynthetic process Effects 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
229940079593 drug Drugs 0.000 abstract 1
239000003814 drug Substances 0.000 abstract 1
229910052749 magnesium Inorganic materials 0.000 abstract 1
239000011777 magnesium Substances 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J51/00—Normal steroids with unmodified cyclopenta(a)hydrophenanthrene skeleton not provided for in groups C07J1/00 - C07J43/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J9/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane
- C07J9/005—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane containing a carboxylic function directly attached or attached by a chain containing only carbon atoms to the cyclopenta[a]hydrophenanthrene skeleton

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
General Health & Medical Sciences (AREA)
Steroid Compounds (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Pyridine Compounds (AREA)

IT8220757A 1982-04-15 1982-04-15 Sale di magnesio dell'acido chenodesossicolico e dell'acido ursodesossicolico, processo per lasua preparazione e composizioni terapeutiche che lo contengono come principio attivo. IT1210874B (it)

Priority Applications (4)

Application Number	Priority Date	Filing Date	Title
IT8220757A IT1210874B (it)	1982-04-15	1982-04-15	Sale di magnesio dell'acido chenodesossicolico e dell'acido ursodesossicolico, processo per lasua preparazione e composizioni terapeutiche che lo contengono come principio attivo.
DE8383103133T DE3362246D1 (en)	1982-04-15	1983-03-29	Magnesium salt of chenodeoxycholic acid and ursodeoxycholic acid, the process for its preparation, and therapeutic compositions which contain it as active principle
AT8383103133T ATE18235T1 (de)	1982-04-15	1983-03-29	Magnesiumsalz von chenodeoxychol- und ursodeoxycholsaeure, verfahren zu seiner herstellung und therapeutische zusammensetzungen die es enthalten.
EP83103133A EP0092073B1 (en)	1982-04-15	1983-03-29	Magnesium salt of chenodeoxycholic acid and ursodeoxycholic acid, the process for its preparation, and therapeutic compositions which contain it as active principle

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
IT8220757A IT1210874B (it)	1982-04-15	1982-04-15	Sale di magnesio dell'acido chenodesossicolico e dell'acido ursodesossicolico, processo per lasua preparazione e composizioni terapeutiche che lo contengono come principio attivo.

Publications (2)

Publication Number	Publication Date
IT8220757A0 IT8220757A0 (it)	1982-04-15
IT1210874B true IT1210874B (it)	1989-09-29

Family

ID=11171613

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
IT8220757A IT1210874B (it)	1982-04-15	1982-04-15	Sale di magnesio dell'acido chenodesossicolico e dell'acido ursodesossicolico, processo per lasua preparazione e composizioni terapeutiche che lo contengono come principio attivo.

Country Status (4)

Country	Link
EP (1)	EP0092073B1 (it)
AT (1)	ATE18235T1 (it)
DE (1)	DE3362246D1 (it)
IT (1)	IT1210874B (it)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE3742798C2 (de) *	1987-12-17	1997-02-13	Freedom Chemical Co	Verfahren zur Herstellung des Magnesium-Doppelsalzes der Chenodesoxycholsäure und Ursodesoxycholsäure
NZ240846A (en) *	1990-12-06	1994-04-27	Hoechst Ag	Dimeric bile acid derivatives; preparatory processes and pharmaceutical compositions
IT1254254B (it) *	1992-03-11	1995-09-14	Erregierre Ind Chim	Procedimento per la preparazione di acido iodesossicolico ad elevata purezza per impiego farmaceutico
EP1255566A2 (en) *	2000-02-04	2002-11-13	Seo Hong Yoo	Preparation of aqueous clear solution dosage forms with bile acids
CN102070694B (zh) *	2011-02-15	2012-09-05	苏州天绿生物制药有限公司	一种鹅去氧胆酸和熊去氧胆酸三水镁盐的制备方法
CN115181152A (zh) *	2021-04-01	2022-10-14	苏州恩泰新材料科技有限公司	一种鸭胆中提取鹅去氧胆酸的方法

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE254530C (it) *
US2429899A (en) *	1946-01-05	1947-10-28	White Lab Inc	Aluminum salts of bile acids

1982
- 1982-04-15 IT IT8220757A patent/IT1210874B/it active Protection Beyond IP Right Term
1983
- 1983-03-29 EP EP83103133A patent/EP0092073B1/en not_active Expired
- 1983-03-29 AT AT8383103133T patent/ATE18235T1/de not_active IP Right Cessation
- 1983-03-29 DE DE8383103133T patent/DE3362246D1/de not_active Expired

Also Published As

Publication number	Publication date
DE3362246D1 (en)	1986-04-03
EP0092073A1 (en)	1983-10-26
IT8220757A0 (it)	1982-04-15
ATE18235T1 (de)	1986-03-15
EP0092073B1 (en)	1988-03-30

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Legal Events

Date	Code	Title	Description
1992-02-20	ITCP	Complementary protection certificate	Free format text: CCP 34
1992-11-13	MEDD	Supplementary protection certificate for pharmaceutical products: granted	Free format text: CCP 34, 19920220; SCHWARZ PHARMA S.P.A.
1999-10-27	TA	Fee payment date (situation as of event date), data collected since 19931001	Effective date: 19970428