IT1215527B - Sistema terapeutico per la cessione controllata di farmaci. - Google Patents

Sistema terapeutico per la cessione controllata di farmaci.

Info

Publication number: IT1215527B
Authority: IT; Italy
Prior art keywords: methylcellulose; delivery device; crosslinked; core; controlled release
Prior art date: 1987-05-29

Application number

IT8720708A

Other languages

English (en)

Other versions

IT8720708A0 (it

Inventor

Aldo La Manna

Ubaldo Conte

Paolo Colombo

Andrea Gazzaniga

Giancarlo Santus

Maria Edvige Sangalli

Original Assignee

Recordati Chem Pharm

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1987-05-29

Filing date

1987-05-29

Publication date

1990-02-14

1987-05-29 Application filed by Recordati Chem Pharm filed Critical Recordati Chem Pharm

1987-05-29 Priority to IT8720708A priority Critical patent/IT1215527B/it

1987-05-29 Publication of IT8720708A0 publication Critical patent/IT8720708A0/it

1987-06-15 Priority to EP87830223A priority patent/EP0250374B1/en

1987-06-15 Priority to ES87830223T priority patent/ES2022454B3/es

1987-06-15 Priority to DE8787830223T priority patent/DE3769707D1/de

1987-06-15 Priority to AT87830223T priority patent/ATE63060T1/de

1990-02-14 Application granted granted Critical

1990-02-14 Publication of IT1215527B publication Critical patent/IT1215527B/it

Links

238000013270 controlled release Methods 0.000 title abstract 2
238000012377 drug delivery Methods 0.000 title abstract 2
LYCAIKOWRPUZTN-UHFFFAOYSA-N Ethylene glycol Chemical compound OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 abstract 3
WSFSSNUMVMOOMR-UHFFFAOYSA-N Formaldehyde Chemical compound O=C WSFSSNUMVMOOMR-UHFFFAOYSA-N 0.000 abstract 3
229920000609 methyl cellulose Polymers 0.000 abstract 3
239000001923 methylcellulose Substances 0.000 abstract 3
235000010981 methylcellulose Nutrition 0.000 abstract 3
229920002153 Hydroxypropyl cellulose Polymers 0.000 abstract 2
LEQAOMBKQFMDFZ-UHFFFAOYSA-N glyoxal Chemical compound O=CC=O LEQAOMBKQFMDFZ-UHFFFAOYSA-N 0.000 abstract 2
239000001863 hydroxypropyl cellulose Substances 0.000 abstract 2
235000010977 hydroxypropyl cellulose Nutrition 0.000 abstract 2
239000001866 hydroxypropyl methyl cellulose Substances 0.000 abstract 2
229920003088 hydroxypropyl methyl cellulose Polymers 0.000 abstract 2
235000010979 hydroxypropyl methyl cellulose Nutrition 0.000 abstract 2
UFVKGYZPFZQRLF-UHFFFAOYSA-N hydroxypropyl methyl cellulose Chemical compound OC1C(O)C(OC)OC(CO)C1OC1C(O)C(O)C(OC2C(C(O)C(OC3C(C(O)C(O)C(CO)O3)O)C(CO)O2)O)C(CO)O1 UFVKGYZPFZQRLF-UHFFFAOYSA-N 0.000 abstract 2
239000011159 matrix material Substances 0.000 abstract 2
229920000642 polymer Polymers 0.000 abstract 2
229920002451 polyvinyl alcohol Polymers 0.000 abstract 2
235000019422 polyvinyl alcohol Nutrition 0.000 abstract 2
LNAZSHAWQACDHT-XIYTZBAFSA-N (2r,3r,4s,5r,6s)-4,5-dimethoxy-2-(methoxymethyl)-3-[(2s,3r,4s,5r,6r)-3,4,5-trimethoxy-6-(methoxymethyl)oxan-2-yl]oxy-6-[(2r,3r,4s,5r,6r)-4,5,6-trimethoxy-2-(methoxymethyl)oxan-3-yl]oxyoxane Chemical compound CO[C@@H]1[C@@H](OC)[C@H](OC)[C@@H](COC)O[C@H]1O[C@H]1[C@H](OC)[C@@H](OC)[C@H](O[C@H]2[C@@H]([C@@H](OC)[C@H](OC)O[C@@H]2COC)OC)O[C@@H]1COC LNAZSHAWQACDHT-XIYTZBAFSA-N 0.000 abstract 1
SGTNSNPWRIOYBX-UHFFFAOYSA-N 2-(3,4-dimethoxyphenyl)-5-{[2-(3,4-dimethoxyphenyl)ethyl](methyl)amino}-2-(propan-2-yl)pentanenitrile Chemical compound C1=C(OC)C(OC)=CC=C1CCN(C)CCCC(C#N)(C(C)C)C1=CC=C(OC)C(OC)=C1 SGTNSNPWRIOYBX-UHFFFAOYSA-N 0.000 abstract 1
229920001817 Agar Polymers 0.000 abstract 1
ZNZYKNKBJPZETN-WELNAUFTSA-N Dialdehyde 11678 Chemical compound N1C2=CC=CC=C2C2=C1[C@H](C[C@H](/C(=C/O)C(=O)OC)[C@@H](C=C)C=O)NCC2 ZNZYKNKBJPZETN-WELNAUFTSA-N 0.000 abstract 1
239000001856 Ethyl cellulose Substances 0.000 abstract 1
ZZSNKZQZMQGXPY-UHFFFAOYSA-N Ethyl cellulose Chemical compound CCOCC1OC(OC)C(OCC)C(OCC)C1OC1C(O)C(O)C(OC)C(CO)O1 ZZSNKZQZMQGXPY-UHFFFAOYSA-N 0.000 abstract 1
SXRSQZLOMIGNAQ-UHFFFAOYSA-N Glutaraldehyde Chemical compound O=CCCCC=O SXRSQZLOMIGNAQ-UHFFFAOYSA-N 0.000 abstract 1
229920000663 Hydroxyethyl cellulose Polymers 0.000 abstract 1
239000004354 Hydroxyethyl cellulose Substances 0.000 abstract 1
239000004372 Polyvinyl alcohol Substances 0.000 abstract 1
229920002125 Sokalan® Polymers 0.000 abstract 1
DPXJVFZANSGRMM-UHFFFAOYSA-N acetic acid;2,3,4,5,6-pentahydroxyhexanal;sodium Chemical compound [Na].CC(O)=O.OCC(O)C(O)C(O)C(O)C=O DPXJVFZANSGRMM-UHFFFAOYSA-N 0.000 abstract 1
239000002253 acid Substances 0.000 abstract 1
229920006243 acrylic copolymer Polymers 0.000 abstract 1
239000004480 active ingredient Substances 0.000 abstract 1
239000011149 active material Substances 0.000 abstract 1
239000008272 agar Substances 0.000 abstract 1
125000005263 alkylenediamine group Chemical group 0.000 abstract 1
125000000129 anionic group Chemical group 0.000 abstract 1
230000004888 barrier function Effects 0.000 abstract 1
239000001768 carboxy methyl cellulose Substances 0.000 abstract 1
125000002091 cationic group Chemical group 0.000 abstract 1
238000000576 coating method Methods 0.000 abstract 1
229920001577 copolymer Polymers 0.000 abstract 1
IZEKFCXSFNUWAM-UHFFFAOYSA-N dipyridamole Chemical compound C=12N=C(N(CCO)CCO)N=C(N3CCCCC3)C2=NC(N(CCO)CCO)=NC=1N1CCCCC1 IZEKFCXSFNUWAM-UHFFFAOYSA-N 0.000 abstract 1
229960002768 dipyridamole Drugs 0.000 abstract 1
229940079593 drug Drugs 0.000 abstract 1
239000003814 drug Substances 0.000 abstract 1
KSCFJBIXMNOVSH-UHFFFAOYSA-N dyphylline Chemical compound O=C1N(C)C(=O)N(C)C2=C1N(CC(O)CO)C=N2 KSCFJBIXMNOVSH-UHFFFAOYSA-N 0.000 abstract 1
229920001249 ethyl cellulose Polymers 0.000 abstract 1
235000019325 ethyl cellulose Nutrition 0.000 abstract 1
SPIUTQOUKAMGCX-UHFFFAOYSA-N flavoxate Chemical compound C1=CC=C2C(=O)C(C)=C(C=3C=CC=CC=3)OC2=C1C(=O)OCCN1CCCCC1 SPIUTQOUKAMGCX-UHFFFAOYSA-N 0.000 abstract 1
229960000855 flavoxate Drugs 0.000 abstract 1
239000012530 fluid Substances 0.000 abstract 1
235000011389 fruit/vegetable juice Nutrition 0.000 abstract 1
230000002496 gastric effect Effects 0.000 abstract 1
210000004051 gastric juice Anatomy 0.000 abstract 1
229940015043 glyoxal Drugs 0.000 abstract 1
239000000017 hydrogel Substances 0.000 abstract 1
235000019447 hydroxyethyl cellulose Nutrition 0.000 abstract 1
239000000463 material Substances 0.000 abstract 1
125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 1
239000000203 mixture Substances 0.000 abstract 1
ZIUHHBKFKCYYJD-UHFFFAOYSA-N n,n'-methylenebisacrylamide Chemical compound C=CC(=O)NCNC(=O)C=C ZIUHHBKFKCYYJD-UHFFFAOYSA-N 0.000 abstract 1
229920002401 polyacrylamide Polymers 0.000 abstract 1
229920000058 polyacrylate Polymers 0.000 abstract 1
239000004584 polyacrylic acid Substances 0.000 abstract 1
229920000036 polyvinylpyrrolidone Polymers 0.000 abstract 1
239000001267 polyvinylpyrrolidone Substances 0.000 abstract 1
235000013855 polyvinylpyrrolidone Nutrition 0.000 abstract 1
235000019812 sodium carboxymethyl cellulose Nutrition 0.000 abstract 1
229920001027 sodium carboxymethylcellulose Polymers 0.000 abstract 1
230000008961 swelling Effects 0.000 abstract 1
229960001722 verapamil Drugs 0.000 abstract 1

Landscapes

Medicinal Preparation (AREA)

IT8720708A 1986-06-17 1987-05-29 Sistema terapeutico per la cessione controllata di farmaci. IT1215527B (it)

Priority Applications (5)

Application Number	Priority Date	Filing Date	Title
IT8720708A IT1215527B (it)	1987-05-29	1987-05-29	Sistema terapeutico per la cessione controllata di farmaci.
EP87830223A EP0250374B1 (en)	1986-06-17	1987-06-15	Therapeutic system for controlled release of drugs
ES87830223T ES2022454B3 (es)	1986-06-17	1987-06-15	Sistema terapeutico para la liberacion controlada de drogas.
DE8787830223T DE3769707D1 (de)	1986-06-17	1987-06-15	Therapeutisches system mit geregelter wirkstoffabgabe.
AT87830223T ATE63060T1 (de)	1986-06-17	1987-06-15	Therapeutisches system mit geregelter wirkstoffabgabe.

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
IT8720708A IT1215527B (it)	1987-05-29	1987-05-29	Sistema terapeutico per la cessione controllata di farmaci.

Publications (2)

Publication Number	Publication Date
IT8720708A0 IT8720708A0 (it)	1987-05-29
IT1215527B true IT1215527B (it)	1990-02-14

Family

ID=11170877

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
IT8720708A IT1215527B (it)	1986-06-17	1987-05-29	Sistema terapeutico per la cessione controllata di farmaci.

Country Status (1)

Country	Link
IT (1)	IT1215527B (it)

1987
- 1987-05-29 IT IT8720708A patent/IT1215527B/it active

Also Published As

Publication number	Publication date
IT8720708A0 (it)	1987-05-29

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