IT1216687B - Complessi di platino (ii), loro preparazione e impiego come antitumorali. - Google Patents

Complessi di platino (ii), loro preparazione e impiego come antitumorali.

Info

Publication number
IT1216687B
IT1216687B IT8820074A IT2007488A IT1216687B IT 1216687 B IT1216687 B IT 1216687B IT 8820074 A IT8820074 A IT 8820074A IT 2007488 A IT2007488 A IT 2007488A IT 1216687 B IT1216687 B IT 1216687B
Authority
IT
Italy
Prior art keywords
complexes
platinum
preparation
chem
residue
Prior art date
Application number
IT8820074A
Other languages
English (en)
Other versions
IT8820074A0 (it
Inventor
Silvano Spinelli
Alessandro Pasini
Ernesto Menta
Franco Zunino
Sergio Tognella
Original Assignee
Boehringer Biochemia Srl
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Biochemia Srl filed Critical Boehringer Biochemia Srl
Publication of IT8820074A0 publication Critical patent/IT8820074A0/it
Priority to IT8820074A priority Critical patent/IT1216687B/it
Priority to EP89903737A priority patent/EP0415939A1/en
Priority to DE68911745T priority patent/DE68911745T2/de
Priority to PCT/EP1989/000330 priority patent/WO1989009218A1/en
Priority to EP89105369A priority patent/EP0341409B1/en
Priority to JP1503437A priority patent/JPH03503529A/ja
Priority to HU892555A priority patent/HU206220B/hu
Priority to ES89105369T priority patent/ES2061756T3/es
Priority to AU32927/89A priority patent/AU633817B2/en
Priority to AT89105369T priority patent/ATE99315T1/de
Priority to ZA892398A priority patent/ZA892398B/xx
Application granted granted Critical
Publication of IT1216687B publication Critical patent/IT1216687B/it
Priority to DK235690A priority patent/DK235690A/da
Priority to US07/585,118 priority patent/US5104895A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F15/00—Compounds containing elements of Groups 8, 9, 10 or 18 of the Periodic Table
    • C07F15/0006—Compounds containing elements of Groups 8, 9, 10 or 18 of the Periodic Table compounds of the platinum group
    • C07F15/0086—Platinum compounds
    • C07F15/0093—Platinum compounds without a metal-carbon linkage
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
IT8820074A 1988-04-01 1988-04-01 Complessi di platino (ii), loro preparazione e impiego come antitumorali. IT1216687B (it)

Priority Applications (13)

Application Number Priority Date Filing Date Title
IT8820074A IT1216687B (it) 1988-04-01 1988-04-01 Complessi di platino (ii), loro preparazione e impiego come antitumorali.
HU892555A HU206220B (en) 1988-04-01 1989-03-25 Process for producing platinum(ii) complexes and pharmaceutical compositions comprising such compounds as active ingredient
AU32927/89A AU633817B2 (en) 1988-04-01 1989-03-25 Platinum(ii) complexes, their preparation and use as anti-tumour agents
PCT/EP1989/000330 WO1989009218A1 (en) 1988-04-01 1989-03-25 Platinum(ii) complexes, their preparation and use as anti-tumour agents
EP89105369A EP0341409B1 (en) 1988-04-01 1989-03-25 Platinum (II) complexes, their preparation and use as antitumour agents
JP1503437A JPH03503529A (ja) 1988-04-01 1989-03-25 白金（２）錯体、その製造法および抗腫瘍剤としての利用
EP89903737A EP0415939A1 (en) 1988-04-01 1989-03-25 Platinum(ii) complexes, their preparation and use as anti-tumour agents
ES89105369T ES2061756T3 (es) 1988-04-01 1989-03-25 Complejos de platino (ii), su preparacion y uso como agentes anti-tumor.
DE68911745T DE68911745T2 (de) 1988-04-01 1989-03-25 Platin(II)-Komplexe, Verfahren zu ihrer Herstellung und Anwendung als Antitumormittel.
AT89105369T ATE99315T1 (de) 1988-04-01 1989-03-25 Platin(ii)-komplexe, verfahren zu ihrer herstellung und anwendung als antitumormittel.
ZA892398A ZA892398B (en) 1988-04-01 1989-03-31 Platinum(ii)complexes,their preparations and use as anti-tumour agents
DK235690A DK235690A (da) 1988-04-01 1990-09-28 Platin(ii)-komplekser, deres fremstilling og anvendelse som antitumormidler
US07/585,118 US5104895A (en) 1988-04-01 1990-11-05 Platinum(ii) complexes, their preparation and use as anti-tumor agents

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT8820074A IT1216687B (it) 1988-04-01 1988-04-01 Complessi di platino (ii), loro preparazione e impiego come antitumorali.

Publications (2)

Publication Number Publication Date
IT8820074A0 IT8820074A0 (it) 1988-04-01
IT1216687B true IT1216687B (it) 1990-03-08

Family

ID=11163596

Family Applications (1)

Application Number Title Priority Date Filing Date
IT8820074A IT1216687B (it) 1988-04-01 1988-04-01 Complessi di platino (ii), loro preparazione e impiego come antitumorali.

Country Status (12)

Country Link
US (1) US5104895A (it)
EP (2) EP0415939A1 (it)
JP (1) JPH03503529A (it)
AT (1) ATE99315T1 (it)
AU (1) AU633817B2 (it)
DE (1) DE68911745T2 (it)
DK (1) DK235690A (it)
ES (1) ES2061756T3 (it)
HU (1) HU206220B (it)
IT (1) IT1216687B (it)
WO (1) WO1989009218A1 (it)
ZA (1) ZA892398B (it)

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IT1238693B (it) * 1990-02-16 1993-09-01 Montedipe Srl Mescole a base di polimeri vinilaromatici ad elevate caratteristiche meccaniche
EP0550385A1 (de) * 1991-12-19 1993-07-07 Ciba-Geigy Ag Peroral zu verabreichende pharmazeutische Zusammensetzungen, die Methandiphosphonsäure-Derivate und 18-Krone-6 Ether enthalten
US6900012B1 (en) 1997-06-03 2005-05-31 The University Of Chicago Plant artificial chromosome compositions and methods
US7166733B2 (en) * 2000-01-04 2007-01-23 Access Pharmaceuticals, Inc. O,O'-Amidomalonate and N,O-Amidomalonate platinum complexes
US7138520B2 (en) * 2003-01-13 2006-11-21 Massachusetts Institute Of Technology Coordination complexes having tethered therapeutic agents and/or targeting moieties, and methods of making and using the same
JP2007505837A (ja) * 2003-09-15 2007-03-15 オードウェイ リサーチ インスティテュート 甲状腺ホルモンアナログおよび新脈管形成における使用の方法
US9198887B2 (en) 2003-09-15 2015-12-01 Nanopharmaceuticals Llc Thyroid hormone analogs and methods of use
US8071134B2 (en) * 2003-09-15 2011-12-06 Ordway Research Institute, Inc. Thyroid hormone analogs and methods of use
US8668926B1 (en) 2003-09-15 2014-03-11 Shaker A. Mousa Nanoparticle and polymer formulations for thyroid hormone analogs, antagonists, and formulations thereof
HRP20140361T1 (hr) * 2003-12-16 2014-05-23 Nektar Therapeutics Monodisperzne smjese pegiliranog naloksola
ES2568516T3 (es) * 2005-04-19 2016-04-29 Merck Patent Gmbh Antioxidantes
US20090022806A1 (en) * 2006-12-22 2009-01-22 Mousa Shaker A Nanoparticle and polymer formulations for thyroid hormone analogs, antagonists and formulations and uses thereof
US9498536B2 (en) 2005-09-15 2016-11-22 Nanopharmaceuticals Llc Method and composition of thyroid hormone analogues and nanoformulations thereof for treating anti-inflammatory disorders
US10130686B2 (en) 2005-09-15 2018-11-20 Nanopharmaceuticals Llc Method and composition of thyroid hormone analogues and nanoformulations thereof for treating inflammatory disorders
US9220788B2 (en) * 2009-06-17 2015-12-29 Nanopharmaceuticals Llc Nanoparticle and polymer formulations for thyroid hormone analogs, antagonists, and formulations and uses thereof
WO2007035612A2 (en) 2005-09-16 2007-03-29 Ordway Research Institute, Inc. Polyphenol conjugates as rgd-binding compounds and methods of use
JP2010513526A (ja) * 2006-12-22 2010-04-30 シーエルエフ メディカル テクノロジー アクセラレーション プログラム インコーポレイテッド 甲状腺ホルモン類縁体、拮抗剤および製剤のためのナノ粒子及び重合体製剤ならびにその使用
US20110105445A1 (en) * 2008-03-12 2011-05-05 University Of Maryland, Baltimore Androgen receptor inactivation contributes to antitumor efficacy of cyp17 inhibitors in prostate cancer
US20100048524A1 (en) 2008-03-14 2010-02-25 Angela Brodie Novel C-17-Heteroaryl Steroidal CYP17 Inhibitors/Antiandrogens;Synthesis In Vitro Biological Activities, Pharmacokinetics and Antitumor Activity
WO2010075332A1 (en) * 2008-12-23 2010-07-01 Charitable Leadership Foundation Small molecule ligands of the integrin rgd recognition site and methods of use
WO2010091306A1 (en) 2009-02-05 2010-08-12 Tokai Pharmaceuticals Novel prodrugs of steroidal cyp17 inhibitors/antiandrogens
US9180107B2 (en) * 2009-03-31 2015-11-10 Nanopharmaceuticals Llc Combination treatment of cancer with cetuximab and tetrac
US8802240B2 (en) 2011-01-06 2014-08-12 Nanopharmaceuticals Llc Uses of formulations of thyroid hormone analogs and nanoparticulate forms thereof to increase chemosensitivity and radiosensitivity in tumor or cancer cells
EP2968370A4 (en) 2013-03-14 2016-09-21 Univ Maryland AGENT FOR ANDROGEN RECEPTOR DOWNWARD CONTROL AND USES THEREOF
EP3033088A4 (en) 2013-08-12 2017-03-08 Tokai Pharmaceuticals, Inc. Biomarkers for treatment of neoplastic disorders using androgen-targeted therapies
WO2015074050A1 (en) 2013-11-18 2015-05-21 Nanopharmaceuticals Llc Methods for screening patients for resistance to angioinhibition, treatment and prophylaxis thereof
US10201616B2 (en) 2016-06-07 2019-02-12 Nanopharmaceuticals, Llc Non-cleavable polymer conjugated with αVβ3 integrin thyroid antagonists
US11351137B2 (en) 2018-04-11 2022-06-07 Nanopharmaceuticals Llc Composition and method for dual targeting in treatment of neuroendocrine tumors
US10328043B1 (en) 2018-04-11 2019-06-25 Nanopharmaceuticals, Llc. Composition and method for dual targeting in treatment of neuroendocrine tumors
US10961204B1 (en) 2020-04-29 2021-03-30 Nanopharmaceuticals Llc Composition of scalable thyrointegrin antagonists with improved blood brain barrier penetration and retention into brain tumors
US11723888B2 (en) 2021-12-09 2023-08-15 Nanopharmaceuticals Llc Polymer conjugated thyrointegrin antagonists

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL67789A (en) * 1983-01-31 1986-09-30 Yissum Res Dev Co Amino-substituted malonato platinum(ii)complexes and method for their preparation
US4565884A (en) * 1983-05-10 1986-01-21 Andrulis Research Corporation Bis-platinum complexes as antitumor agents
JPS61500909A (ja) * 1984-01-23 1986-05-08 インスチツ−ト　オブスチエイ　イ　ネオルガニチエスコイ　ヒミイ　イメ−ニ　エヌ．エス．クルナコワ　アカデミ−　ナウク　エスエスエスエル 混合カルボキシラト白金（２）錯体類およびその製法
GB8416048D0 (en) * 1984-06-22 1984-07-25 Johnson Matthey Plc Anti-tumour compounds of platinum
EP0169645A1 (en) * 1984-06-27 1986-01-29 Johnson Matthey Public Limited Company Platinum co-ordination compounds
DE3582961D1 (de) * 1984-06-27 1991-07-04 Johnson Matthey Plc Platinkoordinationsverbindungen.
DE3432320A1 (de) * 1984-09-03 1986-03-13 Behringwerke Ag, 3550 Marburg Cis-platin-komplexe mit einem pentaerythritderivat als liganden, verfahren zu ihrer herstellung und diese verbindungen enthaltendes pharmazeutisches mittel
US4665210A (en) * 1984-12-17 1987-05-12 American Cyanamid Company Platinum complexes of aliphatic tricarboxylic acids
US4737589A (en) * 1985-08-27 1988-04-12 Nippon Kayaku Kabushiki Kaisha Platinum Complexes
JPS62207283A (ja) * 1986-03-07 1987-09-11 Yoshinori Kitani 新規な白金錯体
DE3630497A1 (de) * 1986-09-08 1988-03-10 Behringwerke Ag Cis-platin-komplexe, verfahren zu ihrer herstellung und diese verbindungen enthaltende pharmazeutische mittel
JPS63203692A (ja) * 1987-02-19 1988-08-23 Nippon Kayaku Co Ltd 新規白金錯体
US4882447A (en) * 1987-02-20 1989-11-21 Tanabe Seiyaku Co., Ltd. Novel organic platinum complex and process for the preparation thereof
IL85595A0 (en) * 1987-03-06 1988-08-31 Tanabe Seiyaku Co Organic platinum complex and its preparation
US4904809A (en) * 1987-09-25 1990-02-27 Ss Pharmaceutical Co., Ltd. Platinum complex
EP0376076A1 (en) * 1988-12-27 1990-07-04 Ss Pharmaceutical Co., Ltd. Novel platinum complex
JP2740919B2 (ja) * 1989-03-30 1998-04-15 塩野義製薬株式会社 白金錯体およびこれらを有効成分として含有する抗腫瘍剤
US4994591A (en) * 1989-06-02 1991-02-19 The Research Foundation Of State University Of Ny Platinum complexes derived from b-silyamines

Also Published As

Publication number Publication date
AU633817B2 (en) 1993-02-11
AU3292789A (en) 1989-10-16
DE68911745D1 (de) 1994-02-10
EP0341409A1 (en) 1989-11-15
IT8820074A0 (it) 1988-04-01
HUT55401A (en) 1991-05-28
ES2061756T3 (es) 1994-12-16
ATE99315T1 (de) 1994-01-15
DK235690D0 (da) 1990-09-28
US5104895A (en) 1992-04-14
HU892555D0 (en) 1991-03-28
EP0415939A1 (en) 1991-03-13
DK235690A (da) 1990-09-28
DE68911745T2 (de) 1994-05-19
HU206220B (en) 1992-09-28
ZA892398B (en) 1989-11-29
EP0341409B1 (en) 1993-12-29
JPH03503529A (ja) 1991-08-08
WO1989009218A1 (en) 1989-10-05

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Legal Events

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TA Fee payment date (situation as of event date), data collected since 19931001

Effective date: 19950427