IT1226726B - Composti attivi come inibitori della biosintesi del colesterolo. - Google Patents

Composti attivi come inibitori della biosintesi del colesterolo.

Info

Publication number: IT1226726B
Authority: IT; Italy
Prior art keywords: active compounds; biosynthesis inhibitors; cholesterol biosynthesis; cholesterol; inhibitors
Prior art date: 1988-07-29

Application number

IT8821542A

Other languages

English (en)

Other versions

IT8821542A0 (it

Inventor

Giorgio Bertolini

Cesare Casagrande

Francesco Santangelo

Original Assignee

Zambon Spa

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1988-07-29

Filing date

1988-07-29

Publication date

1991-02-05

1988-07-29 Application filed by Zambon Spa filed Critical Zambon Spa

1988-07-29 Priority to IT8821542A priority Critical patent/IT1226726B/it

1988-07-29 Publication of IT8821542A0 publication Critical patent/IT8821542A0/it

1989-07-25 Priority to EP19890201957 priority patent/EP0352864A3/en

1989-07-27 Priority to US07/385,369 priority patent/US4940800A/en

1989-07-28 Priority to JP89197895A priority patent/JPH02250870A/ja

1990-05-04 Priority to US07/519,444 priority patent/US5196440A/en

1991-02-05 Application granted granted Critical

1991-02-05 Publication of IT1226726B publication Critical patent/IT1226726B/it

1991-06-21 Priority to US07/719,103 priority patent/US5468746A/en

Links

HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 title 2
230000015572 biosynthetic process Effects 0.000 title 1
235000012000 cholesterol Nutrition 0.000 title 1
150000001875 compounds Chemical class 0.000 title 1
239000003112 inhibitor Substances 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
- C07F7/02—Silicon compounds
- C07F7/08—Compounds having one or more C—Si linkages
- C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
- C07F7/1804—Compounds having Si-O-C linkages

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Diabetes (AREA)
Hematology (AREA)
Obesity (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Steroid Compounds (AREA)

IT8821542A 1988-07-28 1988-07-29 Composti attivi come inibitori della biosintesi del colesterolo. IT1226726B (it)

Priority Applications (6)

Application Number	Priority Date	Filing Date	Title
IT8821542A IT1226726B (it)	1988-07-29	1988-07-29	Composti attivi come inibitori della biosintesi del colesterolo.
EP19890201957 EP0352864A3 (en)	1988-07-29	1989-07-25	Compounds active as inhibitors of the cholesterol biosynthesis
US07/385,369 US4940800A (en)	1988-07-29	1989-07-27	Beazimidazole compounds active as inhibitors of the cholesterol biosynthesis
JP89197895A JPH02250870A (ja)	1988-07-28	1989-07-28	コレステロール生合成抑制性化合物
US07/519,444 US5196440A (en)	1988-07-29	1990-05-04	Compounds active as inhibitors of the cholesterol biosynthesis
US07/719,103 US5468746A (en)	1988-07-29	1991-06-21	Compounds active on the cardiovascular system

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
IT8821542A IT1226726B (it)	1988-07-29	1988-07-29	Composti attivi come inibitori della biosintesi del colesterolo.

Publications (2)

Publication Number	Publication Date
IT8821542A0 IT8821542A0 (it)	1988-07-29
IT1226726B true IT1226726B (it)	1991-02-05

Family

ID=11183343

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
IT8821542A IT1226726B (it)	1988-07-28	1988-07-29	Composti attivi come inibitori della biosintesi del colesterolo.

Country Status (4)

Country	Link
US (1)	US4940800A (it)
EP (1)	EP0352864A3 (it)
JP (1)	JPH02250870A (it)
IT (1)	IT1226726B (it)

Families Citing this family (39)

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Publication number	Priority date	Publication date	Assignee	Title
IT1237792B (it) *	1989-12-21	1993-06-17	Zambon Spa	Composti attivi come inibitori dell'enzima hmg-coa reduttasi
US5387600A (en) *	1992-07-30	1995-02-07	Fuji Photo Film Co., Ltd.	Treating arteriosclerosis using benzimidazole compositions
US5998456A (en) *	1995-07-17	1999-12-07	Fuji Photo Film Co., Ltd.	Benzimidazole compounds containing 1,2,4-triazole ring, and compositions and methods of use containing the same
ZA967892B (en) *	1995-09-21	1998-03-18	Lilly Co Eli	Selective β3 adrenergic agonists.
US5808080A (en) *	1996-09-05	1998-09-15	Eli Lilly And Company	Selective β3 adrenergic agonists
DE69711519T2 (de)	1996-09-05	2002-10-31	Eli Lilly And Co., Indianapolis	Carbazolanaloge als selektive beta3-adrenergische Agonisten
US20010006644A1 (en)	1997-07-31	2001-07-05	David J. Bova	Combinations of hmg-coa reductase inhibitors and nicotinic acid and methods for treating hyperlipidemia once a day at night
CO5011072A1 (es) *	1997-12-05	2001-02-28	Lilly Co Eli	Etanolaminas pirazinil substituidas como agfonistas de los receptores
US7939105B2 (en)	1998-11-20	2011-05-10	Jagotec Ag	Process for preparing a rapidly dispersing solid drug dosage form
ES2328446T5 (es) *	2000-02-04	2014-02-27	Children's Hospital Research Foundation	Uso de lipasa ácida lisosomal para tratar la aterosclerosis y enfermedades asociadas
US8586094B2 (en)	2000-09-20	2013-11-19	Jagotec Ag	Coated tablets
IL159718A0 (en)	2001-07-06	2004-06-20	Teva Pharma	Synthesis of intermediates for preparation of stating derivatives
HRPK20040119B3 (en)	2001-07-06	2006-07-31	Ciba Specialty Chemicals Holding Inc.	Process for the preparation of intermediates useful in the synthesis of statin derivatives especially 7-amino 3,5-dihydroxy heptanoic acid derivatives, and intermediates thereof
CA2451159A1 (en)	2001-07-06	2003-01-16	Teva Pharmaceutical Industries Ltd.	Process for the preparation of 7-amino syn 3,5-dihydroxy heptanoic acid derivatives via 6-cyano syn 3,5-dihydroxy hexanoic acid derivatives
PT3072978T (pt)	2002-05-09	2018-10-15	Brigham & Womens Hospital Inc	1l1rl-1 como um marcador de doença cardiovascular
EP1961419B1 (en)	2002-12-20	2010-03-24	Pfizer Products Inc.	Dosage forms comprising a CETP inhibitor and an HMG-CoA reductase inhibitor
US20040132771A1 (en) *	2002-12-20	2004-07-08	Pfizer Inc	Compositions of choleseteryl ester transfer protein inhibitors and HMG-CoA reductase inhibitors
CA2510320C (en) *	2002-12-20	2012-10-09	St. James Associates Llc/Faber Research Series	Coated particles for sustained-release pharmaceutical administration
EP1510208A1 (en)	2003-08-22	2005-03-02	Fournier Laboratories Ireland Limited	Pharmaceutical composition comprising a combination of metformin and statin
EP1689383B1 (en)	2003-11-19	2012-10-31	Metabasis Therapeutics, Inc.	Novel phosphorus-containing thyromimetics
US7803838B2 (en) *	2004-06-04	2010-09-28	Forest Laboratories Holdings Limited	Compositions comprising nebivolol
CA2624601C (en)	2004-10-06	2018-07-03	The Brigham And Women's Hospital, Inc.	Relevance of achieved levels of markers of systemic inflammation following treatment
JP2008528626A (ja) *	2005-01-31	2008-07-31	マイランラボラトリーズインク．	ヒドロキシル化されたネビボロールを含む薬学的組成物
KR101310037B1 (ko)	2005-05-31	2013-09-24	밀란 인크.	네비볼롤을 함유하는 조성물
WO2007030375A2 (en) *	2005-09-08	2007-03-15	Children's Hospital Medical Center	Lysosomal acid lipase therapy for nafld and related diseases
US8119358B2 (en) *	2005-10-11	2012-02-21	Tethys Bioscience, Inc.	Diabetes-related biomarkers and methods of use thereof
US20090069275A1 (en) *	2006-02-17	2009-03-12	Rocca Jose G	Low flush niacin formulation
CA2659082A1 (en) *	2006-06-07	2007-12-21	Tethys Bioscience, Inc.	Markers associated with arteriovascular events and methods of use thereof
EP2057987B1 (en)	2006-08-30	2015-03-04	Kyushu University, National University Corporation	Pharmaceutical composition containing statin-encapsulated nanoparticle
MX2009009126A (es) *	2007-03-01	2009-10-28	Concourse Health Sciences Llc	Isomeros de niacinato de inositol y usos de los mismos.
BRPI0810409A2 (pt)	2007-04-18	2015-02-18	Thethys Bioscience Inc	Biomarcadores relacionados ao diabetes e métodos de uso destes
US20120046364A1 (en)	2009-02-10	2012-02-23	Metabasis Therapeutics, Inc.	Novel Sulfonic Acid-Containing Thyromimetics, and Methods for Their Use
TW201201764A (en)	2010-02-01	2012-01-16	Hospital For Sick Children	Remote ischemic conditioning for treatment and prevention of restenosis
SG10201908570RA (en)	2010-03-31	2019-11-28	Hospital For Sick Children	Use of remote ischemic conditioning to improve outcome after myocardial infarction
TWI621420B (zh)	2010-04-08	2018-04-21	病童醫院	遠距缺血處理於創傷性傷害的用途
WO2014022195A1 (en)	2012-08-01	2014-02-06	Tavakoli Zahra	Free flowing, frozen compositions comprising a therapeutic agent
CA2907765C (en)	2013-03-21	2021-07-06	Eupraxia Pharmaceuticals USA LLC	Injectable sustained release composition and method of using the same for treating inflammation in joints and pain associated therewith
TW201720427A (zh)	2015-10-27	2017-06-16	優普順藥物股份有限公司	局部麻醉劑之持續釋放調配物
WO2025147589A1 (en)	2024-01-05	2025-07-10	Osanni Bio, Inc.	Implants, compositions, and methods for treating retinal diseases and disorders

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE2260327A1 (de) *	1972-12-09	1974-06-20	Hoechst Ag	Neue carbamidsaeureester
US4434174A (en) *	1980-02-11	1984-02-28	Berlex Laboratories, Inc.	Treating cardiovascular diseases with N-(3-phenoxy-2-hydroxypropyl)benzimidazole-1-alkanamines
US4613610A (en) *	1984-06-22	1986-09-23	Sandoz Pharmaceuticals Corp.	Cholesterol biosynthesis inhibiting pyrazole analogs of mevalonolactone and its derivatives
US4647576A (en) *	1984-09-24	1987-03-03	Warner-Lambert Company	Trans-6-[2-(substitutedpyrrol-1-yl)alkyl]-pyran-2-one inhibitors of cholesterol synthesis
US4668794A (en) *	1985-05-22	1987-05-26	Sandoz Pharm. Corp.	Intermediate imidazole acrolein analogs
JPS6322056A (ja) *	1986-04-30	1988-01-29	サンド・アクチエンゲゼルシヤフト	オレフイン性化合物の製造法
US4714762A (en) *	1986-10-31	1987-12-22	Warner-Lambert Company	Antiarteriosclerotic substituted benzimidazol-2-yl-and 3H-imidazo[4,5-b]pyridin-2-yl-phenoxy-alkanoic acids and salts and esters thereof

1988
- 1988-07-29 IT IT8821542A patent/IT1226726B/it active
1989
- 1989-07-25 EP EP19890201957 patent/EP0352864A3/en not_active Withdrawn
- 1989-07-27 US US07/385,369 patent/US4940800A/en not_active Expired - Fee Related
- 1989-07-28 JP JP89197895A patent/JPH02250870A/ja active Pending

Also Published As

Publication number	Publication date
EP0352864A2 (en)	1990-01-31
US4940800A (en)	1990-07-10
JPH02250870A (ja)	1990-10-08
EP0352864A3 (en)	1991-04-03
IT8821542A0 (it)	1988-07-29

Publication	Publication Date	Title
IT8821542A0 (it)	1988-07-29	Composti attivi come inibitori della biosintesi del colesterolo.
FI880031A7 (fi)	1988-07-08	Anjoniska aendgrupper innehaollande oligomera estrar foer anvaendning som rengoeringsmedel i detergentkompositioner.
FI884924A0 (fi)	1988-10-25	Humanimmuglobulin som producerats med hybrid-dna-teknik.
FI884063L (fi)	1989-03-05	Hydrokrackningskatalysatorer och -foerfaranden som anvaender icke-zeolitiska molekylsaoll.
ATE129716T1 (de)	1995-11-15	Alpha-glukosidase-inhibitoren.
FI880796A7 (fi)	1988-08-25	Maettade fettsyreamider som inhibitorer av acyl-coa:kolesterol-acyltransferaser.
DK15689A (da)	1989-07-22	Sukkerethere som blegestabile renseevneforstaerkere.
NO905090D0 (no)	1990-11-23	Interleukin-1 hemmere.
FI902042A0 (fi)	1990-04-23	Bencement som innehaoller celltillvaextstimulans.
FI884681A0 (fi)	1988-10-11	Polyamidbasfoereningar som gjorts eldfasta.
FI885454L (fi)	1989-05-26	Administrationssystem, som laongsamt frigoer substituerade dihydropyridiner.
FI874917L (fi)	1989-02-08	Fibermaterial som selektivt absorberar solvaerme.
FI881561A7 (fi)	1988-10-08	Cellulosabaserade livsmedelshoeljen som innehaoller foernaetade aeggvitefoereningar.
FI880960A0 (fi)	1988-03-02	Anvaendning av rnas l inhibitor som markeringsaemne i virusinfektioner.
FI884545A7 (fi)	1989-04-08	Farmaceutisk komposition, som innehaoller avsvaellande piperidinoalkanolfoereningar.
FI885070L (fi)	1989-05-05	Fotohaerdbar elektrostatisk tryckskiva, som innehaoller elektronacceptor eller -donator.
FI893189A0 (fi)	1989-06-29	Tetrahaloftalatestrar som brandskyddsvaetskor foer vissa hartser.
DK120388D0 (da)	1988-03-04	Skab, navnlig badevaerelsesskab
FI883254A0 (fi)	1988-07-07	Cytostatiskt aktiva antracyklinderivat.
FI894072A0 (fi)	1989-08-30	Polypeptider anvaendbara som vaccin.
FI884926L (fi)	1989-04-27	Kopolymerbestrykningskompositioner som innehaoller sulfoalkylmonomeremulsionsmedel.
FI881241L (fi)	1988-09-18	Laettkonstruktionskaerna, saerskilt som stoedkaerna i skida.
NO872985D0 (no)	1987-07-17	Inhibitor for polyuretanpropergoler.
FI884154L (fi)	1989-03-11	Elmaskin, som innefattar slitskilar.
IT211099Z2 (it)	1989-02-13	Cassetto per mobili.