IT1227155B - Procedimento di sintesi di vinblastina e vincristina. - Google Patents

Procedimento di sintesi di vinblastina e vincristina.

Info

Publication number: IT1227155B
Authority: IT; Italy
Prior art keywords: vinblastin; vincristine; synthesis procedure; synthesis; procedure
Prior art date: 1987-08-06

Application number

IT8821678A

Other languages

English (en)

Italian (it)

Other versions

IT8821678A0 (it

Inventor

James P Kutney

Lewis S L Choi

Jun Nakano

Hiroki Tsukamoto

Camille A Boulet

Michael Mchugh

Original Assignee

Univ British Columbia

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1987-08-06

Filing date

1988-08-05

Publication date

1991-03-19

1988-08-05 Application filed by Univ British Columbia filed Critical Univ British Columbia

1988-08-05 Publication of IT8821678A0 publication Critical patent/IT8821678A0/it

1991-03-19 Application granted granted Critical

1991-03-19 Publication of IT1227155B publication Critical patent/IT1227155B/it

Links

230000015572 biosynthetic process Effects 0.000 title 1
238000000034 method Methods 0.000 title 1
238000003786 synthesis reaction Methods 0.000 title 1
JXLYSJRDGCGARV-CFWMRBGOSA-N vinblastine Chemical compound C([C@H](C[C@]1(C(=O)OC)C=2C(=CC3=C([C@]45[C@H]([C@@]([C@H](OC(C)=O)[C@]6(CC)C=CCN([C@H]56)CC4)(O)C(=O)OC)N3C)C=2)OC)C[C@@](C2)(O)CC)N2CCC2=C1NC1=CC=CC=C21 JXLYSJRDGCGARV-CFWMRBGOSA-N 0.000 title 1
229960003048 vinblastine Drugs 0.000 title 1
229960004528 vincristine Drugs 0.000 title 1
OGWKCGZFUXNPDA-XQKSVPLYSA-N vincristine Chemical compound C([N@]1C[C@@H](C[C@]2(C(=O)OC)C=3C(=CC4=C([C@]56[C@H]([C@@]([C@H](OC(C)=O)[C@]7(CC)C=CCN([C@H]67)CC5)(O)C(=O)OC)N4C=O)C=3)OC)C[C@@](C1)(O)CC)CC1=C2NC2=CC=CC=C12 OGWKCGZFUXNPDA-XQKSVPLYSA-N 0.000 title 1
OGWKCGZFUXNPDA-UHFFFAOYSA-N vincristine Natural products C1C(CC)(O)CC(CC2(C(=O)OC)C=3C(=CC4=C(C56C(C(C(OC(C)=O)C7(CC)C=CCN(C67)CC5)(O)C(=O)OC)N4C=O)C=3)OC)CN1CCC1=C2NC2=CC=CC=C12 OGWKCGZFUXNPDA-UHFFFAOYSA-N 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
- C07D519/04—Dimeric indole alkaloids, e.g. vincaleucoblastine

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

IT8821678A 1987-08-06 1988-08-05 Procedimento di sintesi di vinblastina e vincristina. IT1227155B (it)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
CA000543832A CA1341262C (fr)	1987-08-06	1987-08-06	Nouveau procede de synthese de 3',4'-anhydrovinblastine de la vinblastine et de la vincristine

Publications (2)

Publication Number	Publication Date
IT8821678A0 IT8821678A0 (it)	1988-08-05
IT1227155B true IT1227155B (it)	1991-03-19

Family

ID=4136214

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
IT8821678A IT1227155B (it)	1987-08-06	1988-08-05	Procedimento di sintesi di vinblastina e vincristina.

Country Status (12)

Country	Link
JP (1)	JPH0613532B2 (fr)
AU (1)	AU617342B2 (fr)
BE (1)	BE1003228A4 (fr)
CA (1)	CA1341262C (fr)
CH (1)	CH676711A5 (fr)
DE (1)	DE3826412A1 (fr)
GB (1)	GB2215331B (fr)
HU (1)	HU208829B (fr)
IT (1)	IT1227155B (fr)
NL (1)	NL8801966A (fr)
SE (1)	SE467875B (fr)
ZA (1)	ZA885765B (fr)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5047528A (en) *	1987-01-22	1991-09-10	University Of Bristish Columbia	Process of synthesis of vinblastine and vincristine
USRE37449E1 (en)	1987-02-06	2001-11-13	University Of British Columbia	Process of synthesis of 3′,4′-anhydrovinblastine, vinblastine and vincristine
US5432279A (en) *	1989-03-04	1995-07-11	Mitsui Petrochemical Industries, Inc.	Process for the preparation of binary indole alkaloids
CA2056799C (fr) *	1990-11-30	2002-01-01	Hiroshi Ikawa	Derives de 1,4-dihydropyridine et methode de preparation
JP3010151U (ja) *	1994-04-26	1995-04-25	スミ子片山	切込みのついた筒形食器収納ケース。
FR2779146B1 (fr) *	1998-06-02	2002-01-18	Roowin	Nouveaux derives de vinca-alcaloides et procedes de preparation

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4279817A (en) *	1975-05-30	1981-07-21	The United States Of America As Represented By The Department Of Health & Human Services	Method for producing dimer alkaloids
HU195513B (en) *	1984-10-16	1988-05-30	Richter Gedeon Vegyeszet	Process for producing stable solutions of alkaloides with bis-indole skeleton
AU590873B2 (en) *	1985-03-12	1989-11-23	University Of Vermont And State Agricultural College, The	Synthesis of vinblastine and vincristine type compounds
CA1341261C (fr) *	1987-01-22	2001-06-26	James P. Kutney	Procede pour la synthese de 3',4'-anhydrovinblastine, de la vinblastine et de la vincristine

1987
- 1987-08-06 CA CA000543832A patent/CA1341262C/fr not_active Expired - Fee Related
1988
- 1988-08-03 SE SE8802813A patent/SE467875B/sv not_active IP Right Cessation
- 1988-08-03 DE DE3826412A patent/DE3826412A1/de not_active Ceased
- 1988-08-05 CH CH2974/88A patent/CH676711A5/de not_active IP Right Cessation
- 1988-08-05 IT IT8821678A patent/IT1227155B/it active
- 1988-08-05 BE BE8800908A patent/BE1003228A4/fr not_active IP Right Cessation
- 1988-08-05 NL NL8801966A patent/NL8801966A/nl not_active Application Discontinuation
- 1988-08-05 ZA ZA885765A patent/ZA885765B/xx unknown
- 1988-08-05 AU AU20512/88A patent/AU617342B2/en not_active Ceased
- 1988-08-06 JP JP63196999A patent/JPH0613532B2/ja not_active Expired - Lifetime
- 1988-08-08 GB GB8818765A patent/GB2215331B/en not_active Expired - Lifetime
- 1988-08-08 HU HU884126A patent/HU208829B/hu not_active IP Right Cessation

Also Published As

Publication number	Publication date
CH676711A5 (fr)	1991-02-28
GB8818765D0 (en)	1988-09-07
NL8801966A (nl)	1989-03-01
AU2051288A (en)	1989-02-09
HU208829B (en)	1994-01-28
SE8802813D0 (sv)	1988-08-03
JPH0613532B2 (ja)	1994-02-23
HUT50351A (en)	1990-01-29
GB2215331B (en)	1992-01-02
SE8802813L (sv)	1989-02-07
BE1003228A4 (fr)	1992-02-04
ZA885765B (en)	1989-09-27
IT8821678A0 (it)	1988-08-05
JPH01151590A (ja)	1989-06-14
DE3826412A1 (de)	1989-02-16
GB2215331A (en)	1989-09-20
SE467875B (sv)	1992-09-28
AU617342B2 (en)	1991-11-28
CA1341262C (fr)	2001-06-26

Legal Events

Date	Code	Title	Description
1999-10-27	TA	Fee payment date (situation as of event date), data collected since 19931001	Effective date: 19970829

Publication	Publication Date	Title
FI881153A7 (fi)	1988-09-14	Fiskodlingsbur foer placering utanfoer kusten.
FI904258A0 (fi)	1990-08-29	Mitomycin c stabila loesningar.
DK531588D0 (da)	1988-09-23	Bestraalingsstander
DE3768089D1 (de)	1991-03-28	Prospektionsverfahren.
DE3779921D1 (de)	1992-07-23	Schmuckstueck.
IT1215751B (it)	1990-02-22	Procedimento di sintesi di vinblastina e vincristina.
DE3885475D1 (de)	1993-12-16	Eintaschverfahren.
IT1227155B (it)	1991-03-19	Procedimento di sintesi di vinblastina e vincristina.
FI880563A7 (fi)	1988-08-12	Bicykliska beta-laktamkarboxylsyror.
FI883435A0 (fi)	1988-07-20	Styrsystem foer fluider under tryck.
DE3772639D1 (de)	1991-10-10	Schmuckartikel.
IT8847862A0 (it)	1988-04-18	Antenna
DE3887775D1 (de)	1994-03-24	Pyrometer.
FI880488A7 (fi)	1988-08-07	Analysfoerfarande.
FI882734A0 (fi)	1988-06-09	Foerfarande foer anvaendning av peroxid-dismutas under kirurgiska ingrepp.
FI906365L (fi)	1991-06-23	Borsttvaettmaskin foer slaktdjur.
DE3863530D1 (de)	1991-08-08	Furazanylharnstoffe.
DE3769515D1 (de)	1991-05-29	Anhaenger.
IS1522B (is)	1992-12-15	Tvöfalt flutningsker
FI895299A0 (fi)	1989-11-07	Gasgenerator.
ES1002097Y (es)	1990-02-16	Cantimplora
IT209979Z2 (it)	1988-11-14	Coprimaterasso.
ES1001763Y (es)	1989-02-01	Cartera
KR890010078U (ko)	1989-07-07	지갑
BR8602775A (pt)	1988-02-02	Trampolim metalico