IT1238686B - Procedimento per la preparazione di levo e destro fenfluramina - Google Patents

Procedimento per la preparazione di levo e destro fenfluramina

Info

Publication number
IT1238686B
IT1238686B IT19331A IT1933190A IT1238686B IT 1238686 B IT1238686 B IT 1238686B IT 19331 A IT19331 A IT 19331A IT 1933190 A IT1933190 A IT 1933190A IT 1238686 B IT1238686 B IT 1238686B
Authority
IT
Italy
Prior art keywords
levo
fenfluramina
procedure
preparation
enantiomer forms
Prior art date
Application number
IT19331A
Other languages
English (en)
Other versions
IT9019331A1 (it
IT9019331A0 (it
Inventor
Grato Magnone
Original Assignee
Lab Mag Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lab Mag Spa filed Critical Lab Mag Spa
Priority to IT19331A priority Critical patent/IT1238686B/it
Publication of IT9019331A0 publication Critical patent/IT9019331A0/it
Priority to AT91100712T priority patent/ATE124680T1/de
Priority to DE69110917T priority patent/DE69110917T2/de
Priority to EP91100712A priority patent/EP0441160B1/en
Publication of IT9019331A1 publication Critical patent/IT9019331A1/it
Application granted granted Critical
Publication of IT1238686B publication Critical patent/IT1238686B/it

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C211/00—Compounds containing amino groups bound to a carbon skeleton
    • C07C211/01—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms
    • C07C211/26—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms of an unsaturated carbon skeleton containing at least one six-membered aromatic ring
    • C07C211/29—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms of an unsaturated carbon skeleton containing at least one six-membered aromatic ring the carbon skeleton being further substituted by halogen atoms or by nitro or nitroso groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Saccharide Compounds (AREA)
IT19331A 1990-02-09 1990-02-09 Procedimento per la preparazione di levo e destro fenfluramina IT1238686B (it)

Priority Applications (4)

Application Number Priority Date Filing Date Title
IT19331A IT1238686B (it) 1990-02-09 1990-02-09 Procedimento per la preparazione di levo e destro fenfluramina
AT91100712T ATE124680T1 (de) 1990-02-09 1991-01-21 Verfahren zur herstellung von links- und rechtsdrehendem fenfluramin.
DE69110917T DE69110917T2 (de) 1990-02-09 1991-01-21 Verfahren zur Herstellung von links- und rechtsdrehendem Fenfluramin.
EP91100712A EP0441160B1 (en) 1990-02-09 1991-01-21 Process for preparing levo and dextro fenfluramine

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT19331A IT1238686B (it) 1990-02-09 1990-02-09 Procedimento per la preparazione di levo e destro fenfluramina

Publications (3)

Publication Number Publication Date
IT9019331A0 IT9019331A0 (it) 1990-02-09
IT9019331A1 IT9019331A1 (it) 1991-08-09
IT1238686B true IT1238686B (it) 1993-09-01

Family

ID=11156806

Family Applications (1)

Application Number Title Priority Date Filing Date
IT19331A IT1238686B (it) 1990-02-09 1990-02-09 Procedimento per la preparazione di levo e destro fenfluramina

Country Status (4)

Country Link
EP (1) EP0441160B1 (it)
AT (1) ATE124680T1 (it)
DE (1) DE69110917T2 (it)
IT (1) IT1238686B (it)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1292595B1 (it) * 1997-06-03 1999-02-08 Alfa Chem Ital Processo per la produzione della dexfenfluramina cloridrato.
ITMI20010047A1 (it) 2001-01-12 2002-07-12 Consiglio Nazionale Ricerche Procedimento di preparazione degli enantiomeri di 1-(3-trifluo-rometilfenil)-propan-2-olo
US9549909B2 (en) 2013-05-03 2017-01-24 The Katholieke Universiteit Leuven Method for the treatment of dravet syndrome
KR102481631B1 (ko) 2015-08-24 2022-12-27 조게닉스 인터내셔널 리미티드 펜플루라민을 사용하여 레녹스-가스토 증후군을 치료하는 방법
EP3170807B1 (en) 2015-11-23 2019-12-11 Frau Pharma S.r.l. New method for synthesis of fenfluramine
ES3024232T3 (en) * 2015-12-22 2025-06-04 Zogenix International Ltd Fenfluramine compositions and methods of preparing the same
WO2017112701A1 (en) 2015-12-22 2017-06-29 Zogenix International Limited Metabolism resistant fenfluramine analogs and methods of using the same
SG11201900975XA (en) 2016-08-24 2019-03-28 Zogenix International Ltd Formulation for inhibiting formation of 5-ht 2b agonists and methods of using same
JP2020519594A (ja) 2017-05-09 2020-07-02 ゾゲニクス インターナショナル リミテッド フェンフルラミンを用いるドゥーゼ症候群の治療方法
US20190091179A1 (en) 2017-09-26 2019-03-28 Zogenix International Limited Congnitive function with fenfluramine
WO2019067413A1 (en) 2017-09-26 2019-04-04 Zogenix International Limited USE OF A FENFLURAMINE FORMULATION TO REDUCE THE NUMBER AND FREQUENCIES OF CONVULSIVE CRISES IN PATIENT POPULATIONS
US10682317B2 (en) 2017-09-26 2020-06-16 Zogenix International Limited Ketogenic diet compatible fenfluramine formulation
WO2019216919A1 (en) 2018-05-11 2019-11-14 Zogenix International Limited Compositions and methods for treating seizure-induced sudden death
WO2020014075A1 (en) 2018-07-10 2020-01-16 Zogenix International Limited Fenfluramine for use for treating epilepsy or epileptic encephalopathy in patients without pulmonary hypertension
EA202191079A1 (ru) 2018-11-19 2021-09-20 Зодженикс Интернэшнл Лимитед Способы лечения синдрома ретта с применением фенфлурамина
US20210137853A1 (en) 2019-09-17 2021-05-13 Zogenix International Limited Methods of treating epileptic patients with fenfluramine
US20210299064A1 (en) 2020-02-05 2021-09-30 Zogenix International Limited Method of treating patients with lennox-gastaut syndrome
US11612574B2 (en) 2020-07-17 2023-03-28 Zogenix International Limited Method of treating patients infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE788850A (fr) * 1972-09-15 1973-03-15 Hoffmann La Roche Derives d'acide benzoique
KR890003368A (ko) * 1987-08-06 1989-04-14 원본미기재 특정의 치환된 페닐알킬아미노(및 아미노산) 유도체 및 기타 세로토닌농도 저하제로 오심 및 구토를 치료하는 방법

Also Published As

Publication number Publication date
ATE124680T1 (de) 1995-07-15
IT9019331A1 (it) 1991-08-09
IT9019331A0 (it) 1990-02-09
EP0441160B1 (en) 1995-07-05
DE69110917D1 (de) 1995-08-10
DE69110917T2 (de) 1995-12-14
EP0441160A1 (en) 1991-08-14

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Legal Events

Date Code Title Description
0001 Granted
TA Fee payment date (situation as of event date), data collected since 19931001

Effective date: 19950227