IT9019331A1 - Procedimento per la preparazione di levo e destro fenfluramina - Google Patents
Procedimento per la preparazione di levo e destro fenfluraminaInfo
- Publication number
- IT9019331A1 IT9019331A1 IT019331A IT1933190A IT9019331A1 IT 9019331 A1 IT9019331 A1 IT 9019331A1 IT 019331 A IT019331 A IT 019331A IT 1933190 A IT1933190 A IT 1933190A IT 9019331 A1 IT9019331 A1 IT 9019331A1
- Authority
- IT
- Italy
- Prior art keywords
- levo
- phenfluramine
- preparation procedure
- right preparation
- enantiomer forms
- Prior art date
Links
- DBGIVFWFUFKIQN-UHFFFAOYSA-N (+-)-Fenfluramine Chemical compound CCNC(C)CC1=CC=CC(C(F)(F)F)=C1 DBGIVFWFUFKIQN-UHFFFAOYSA-N 0.000 title abstract 2
- 229960001582 fenfluramine Drugs 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C211/00—Compounds containing amino groups bound to a carbon skeleton
- C07C211/01—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms
- C07C211/26—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms of an unsaturated carbon skeleton containing at least one six-membered aromatic ring
- C07C211/29—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms of an unsaturated carbon skeleton containing at least one six-membered aromatic ring the carbon skeleton being further substituted by halogen atoms or by nitro or nitroso groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Saccharide Compounds (AREA)
Priority Applications (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IT19331A IT1238686B (it) | 1990-02-09 | 1990-02-09 | Procedimento per la preparazione di levo e destro fenfluramina |
| AT91100712T ATE124680T1 (de) | 1990-02-09 | 1991-01-21 | Verfahren zur herstellung von links- und rechtsdrehendem fenfluramin. |
| DE69110917T DE69110917T2 (de) | 1990-02-09 | 1991-01-21 | Verfahren zur Herstellung von links- und rechtsdrehendem Fenfluramin. |
| EP91100712A EP0441160B1 (en) | 1990-02-09 | 1991-01-21 | Process for preparing levo and dextro fenfluramine |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IT19331A IT1238686B (it) | 1990-02-09 | 1990-02-09 | Procedimento per la preparazione di levo e destro fenfluramina |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| IT9019331A0 IT9019331A0 (it) | 1990-02-09 |
| IT9019331A1 true IT9019331A1 (it) | 1991-08-09 |
| IT1238686B IT1238686B (it) | 1993-09-01 |
Family
ID=11156806
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IT19331A IT1238686B (it) | 1990-02-09 | 1990-02-09 | Procedimento per la preparazione di levo e destro fenfluramina |
Country Status (4)
| Country | Link |
|---|---|
| EP (1) | EP0441160B1 (it) |
| AT (1) | ATE124680T1 (it) |
| DE (1) | DE69110917T2 (it) |
| IT (1) | IT1238686B (it) |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IT1292595B1 (it) * | 1997-06-03 | 1999-02-08 | Alfa Chem Ital | Processo per la produzione della dexfenfluramina cloridrato. |
| ITMI20010047A1 (it) | 2001-01-12 | 2002-07-12 | Consiglio Nazionale Ricerche | Procedimento di preparazione degli enantiomeri di 1-(3-trifluo-rometilfenil)-propan-2-olo |
| US9549909B2 (en) | 2013-05-03 | 2017-01-24 | The Katholieke Universiteit Leuven | Method for the treatment of dravet syndrome |
| HUE066912T2 (hu) | 2015-08-24 | 2024-09-28 | Zogenix International Ltd | Lennox-Gastaut szindróma kezelési eljárása fenfluramin alkalmazásával |
| EP3170807B1 (en) | 2015-11-23 | 2019-12-11 | Frau Pharma S.r.l. | New method for synthesis of fenfluramine |
| PT4293009T (pt) | 2015-12-22 | 2025-09-08 | Zogenix International Ltd | Composições de fenfluramina e métodos de preparação das mesmas |
| WO2017112701A1 (en) | 2015-12-22 | 2017-06-29 | Zogenix International Limited | Metabolism resistant fenfluramine analogs and methods of using the same |
| AU2017315273B2 (en) | 2016-08-24 | 2021-04-29 | Zogenix International Limited | Formulation for inhibiting formation of 5-HT 2B agonists and methods of using same |
| CA3062247A1 (en) | 2017-05-09 | 2018-11-15 | Zogenix International Limited | Methods of treating doose syndrome using fenfluramine |
| US10682317B2 (en) | 2017-09-26 | 2020-06-16 | Zogenix International Limited | Ketogenic diet compatible fenfluramine formulation |
| US20190091179A1 (en) | 2017-09-26 | 2019-03-28 | Zogenix International Limited | Congnitive function with fenfluramine |
| WO2019067413A1 (en) | 2017-09-26 | 2019-04-04 | Zogenix International Limited | USE OF A FENFLURAMINE FORMULATION TO REDUCE THE NUMBER AND FREQUENCIES OF CONVULSIVE CRISES IN PATIENT POPULATIONS |
| EP3790537A1 (en) | 2018-05-11 | 2021-03-17 | Zogenix International Limited | Compositions and methods for treating seizure-induced sudden death |
| EP3820459A1 (en) | 2018-07-10 | 2021-05-19 | Zogenix International Limited | Fenfluramine for use for treating epilepsy or epileptic encephalopathy in patients without pulmonary hypertension |
| AU2019384963B2 (en) | 2018-11-19 | 2022-05-26 | Zogenix International Limited | Methods of treating Rett syndrome using fenfluramine |
| CA3153099A1 (en) | 2019-09-17 | 2021-03-25 | Zogenix International Limited | Methods of treating epileptic patients with fenfluramine |
| US20210299064A1 (en) | 2020-02-05 | 2021-09-30 | Zogenix International Limited | Method of treating patients with lennox-gastaut syndrome |
| US11612574B2 (en) | 2020-07-17 | 2023-03-28 | Zogenix International Limited | Method of treating patients infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BE788850A (fr) * | 1972-09-15 | 1973-03-15 | Hoffmann La Roche | Derives d'acide benzoique |
| KR890003368A (ko) * | 1987-08-06 | 1989-04-14 | 원본미기재 | 특정의 치환된 페닐알킬아미노(및 아미노산) 유도체 및 기타 세로토닌농도 저하제로 오심 및 구토를 치료하는 방법 |
-
1990
- 1990-02-09 IT IT19331A patent/IT1238686B/it active IP Right Grant
-
1991
- 1991-01-21 DE DE69110917T patent/DE69110917T2/de not_active Expired - Fee Related
- 1991-01-21 AT AT91100712T patent/ATE124680T1/de active
- 1991-01-21 EP EP91100712A patent/EP0441160B1/en not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| ATE124680T1 (de) | 1995-07-15 |
| EP0441160A1 (en) | 1991-08-14 |
| EP0441160B1 (en) | 1995-07-05 |
| IT9019331A0 (it) | 1990-02-09 |
| DE69110917T2 (de) | 1995-12-14 |
| IT1238686B (it) | 1993-09-01 |
| DE69110917D1 (de) | 1995-08-10 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 0001 | Granted | ||
| TA | Fee payment date (situation as of event date), data collected since 19931001 |
Effective date: 19950227 |