IT1246992B - Procedimento per la preparazione di acidi difosfonici e loro sali - Google Patents

Procedimento per la preparazione di acidi difosfonici e loro sali

Info

Publication number
IT1246992B
IT1246992B ITFI910003A ITFI910003A IT1246992B IT 1246992 B IT1246992 B IT 1246992B IT FI910003 A ITFI910003 A IT FI910003A IT FI910003 A ITFI910003 A IT FI910003A IT 1246992 B IT1246992 B IT 1246992B
Authority
IT
Italy
Prior art keywords
salts
procedure
preparation
diphosphonic acids
formula
Prior art date
Application number
ITFI910003A
Other languages
English (en)
Inventor
Giuseppe Guainai-Ricci
Sergio Rosini
Original Assignee
Gentili Ist Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Gentili Ist Spa filed Critical Gentili Ist Spa
Publication of ITFI910003A0 publication Critical patent/ITFI910003A0/it
Priority to ITFI910003A priority Critical patent/IT1246992B/it
Priority to AT92830001T priority patent/ATE121410T1/de
Priority to ES92830001T priority patent/ES2072126T3/es
Priority to DK92830001.1T priority patent/DK0494844T3/da
Priority to DE69202062T priority patent/DE69202062T2/de
Priority to EP92830001A priority patent/EP0494844B1/en
Priority to CA002058905A priority patent/CA2058905A1/en
Priority to JP4000676A priority patent/JP3046438B2/ja
Publication of ITFI910003A1 publication Critical patent/ITFI910003A1/it
Application granted granted Critical
Publication of IT1246992B publication Critical patent/IT1246992B/it

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
    • C07F9/3804—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)] not used, see subgroups
    • C07F9/3839—Polyphosphonic acids
    • C07F9/3873—Polyphosphonic acids containing nitrogen substituent, e.g. N.....H or N-hydrocarbon group which can be substituted by halogen or nitro(so), N.....O, N.....S, N.....C(=X)- (X =O, S), N.....N, N...C(=X)...N (X =O, S)

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Saccharide Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Un procedimento per la produzione, su scala industriale, di acidi aminodifosfonici secondo la formula (FORMULA) in cui N è compreso tra 2 e 8, a partire da acidi aminocarbossilici, trialogenuri di fosforo e acido fosforoso, con o senza solvente, usando un eccesso di acido fosforoso (rapporti molari dei reagenti compresi tra 1:3:2 e 1:20:6). Il procedimento può essere applicato agevolmente su larga scala e da rese migliori del prodotto, che può essere ottenuto sotto forma di sale direttamente dall'ambiente di reazione senza isolare l'acido corrispondente.
ITFI910003A 1991-01-08 1991-01-08 Procedimento per la preparazione di acidi difosfonici e loro sali IT1246992B (it)

Priority Applications (8)

Application Number Priority Date Filing Date Title
ITFI910003A IT1246992B (it) 1991-01-08 1991-01-08 Procedimento per la preparazione di acidi difosfonici e loro sali
DE69202062T DE69202062T2 (de) 1991-01-08 1992-01-02 Verfahren zur Herstellung von Diphosphonsäuren und Salzen davon.
ES92830001T ES2072126T3 (es) 1991-01-08 1992-01-02 Procedimiento para la preparacion de acidos difosfonicos y sus sales.
DK92830001.1T DK0494844T3 (da) 1991-01-08 1992-01-02 Fremgangsmåde til fremstilling af diphosphonsyre og salte deraf
AT92830001T ATE121410T1 (de) 1991-01-08 1992-01-02 Verfahren zur herstellung von diphosphonsäuren und salzen davon.
EP92830001A EP0494844B1 (en) 1991-01-08 1992-01-02 Process for the preparation of diphosphonic acids and salts thereof
CA002058905A CA2058905A1 (en) 1991-01-08 1992-01-07 Process for the preparation of diphosphonic acids and salts thereof
JP4000676A JP3046438B2 (ja) 1991-01-08 1992-01-07 アミノジホスホン酸類の製造法

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ITFI910003A IT1246992B (it) 1991-01-08 1991-01-08 Procedimento per la preparazione di acidi difosfonici e loro sali

Publications (3)

Publication Number Publication Date
ITFI910003A0 ITFI910003A0 (it) 1991-01-08
ITFI910003A1 ITFI910003A1 (it) 1992-07-08
IT1246992B true IT1246992B (it) 1994-12-12

Family

ID=11349414

Family Applications (1)

Application Number Title Priority Date Filing Date
ITFI910003A IT1246992B (it) 1991-01-08 1991-01-08 Procedimento per la preparazione di acidi difosfonici e loro sali

Country Status (8)

Country Link
EP (1) EP0494844B1 (it)
JP (1) JP3046438B2 (it)
AT (1) ATE121410T1 (it)
CA (1) CA2058905A1 (it)
DE (1) DE69202062T2 (it)
DK (1) DK0494844T3 (it)
ES (1) ES2072126T3 (it)
IT (1) IT1246992B (it)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1044893C (zh) * 1993-09-01 1999-09-01 坂东化学株式会社 薄膜展宽装置用皮带
CA2197267C (en) * 1997-02-11 2000-02-08 Yong Tao Process for the production of 4-amino-1-hydroxybutylidene-1,1-bisphosphonic acid or salts thereof
ES2153794B1 (es) * 1999-08-06 2001-10-16 Medichem Sa Procedimiento para la obtencion del acido 4-amino-1-hidroxibutiliden-1,1-bisfosfonico y de su sal monosodica trihidratada.
PE20011061A1 (es) 2000-02-01 2001-11-20 Procter & Gamble Cristalizacion selectiva del acido 3-piridil-1-hidroxi-etiliden-1,1-bisfosfonico sodio como el hemipentahidrato o el monohidrato
US6562974B2 (en) * 2000-02-01 2003-05-13 The Procter & Gamble Company Process for making geminal bisphosphonates
HUP0300227A2 (hu) 2003-01-28 2004-09-28 Richter Gedeon Vegyészeti Gyár Rt. Eljárás nagy tisztaságú 2-szubsztituált -1-(hidroxi-etilidén)-1,1-biszfoszfonsavak és sóik előállítására
EP3553067A1 (en) 2018-04-10 2019-10-16 Abiogen Pharma S.p.A. Polymorph of sodium neridronate and preparation process thereof
IT201900008391A1 (it) * 2019-06-07 2020-12-07 Abiogen Pharma Spa Procedimento di preparazione del polimorfo f di sodio neridronato
US12653834B1 (en) 2025-05-29 2026-06-16 Ambros Therapeutics, Inc. Methods of selectively treating complex regional pain syndrome type I (CRPS-I) using bisphosphonate derivatives

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3016289A1 (de) * 1980-04-28 1981-10-29 Henkel KGaA, 4000 Düsseldorf Verfahren zur herstellung von omega -amino-1-hydroxyalkyliden-1,1-bis-phosphonsaeuren
IT1196315B (it) * 1984-10-29 1988-11-16 Gentili Ist Spa Procedimento per la preparazione di acidi difosfonici

Also Published As

Publication number Publication date
EP0494844A1 (en) 1992-07-15
CA2058905A1 (en) 1992-07-09
DK0494844T3 (da) 1995-07-10
JP3046438B2 (ja) 2000-05-29
ATE121410T1 (de) 1995-05-15
JPH04342596A (ja) 1992-11-30
DE69202062T2 (de) 1995-12-14
DE69202062D1 (de) 1995-05-24
EP0494844B1 (en) 1995-04-19
ITFI910003A1 (it) 1992-07-08
ES2072126T3 (es) 1995-07-01
ITFI910003A0 (it) 1991-01-08

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Legal Events

Date Code Title Description
0001 Granted
TA Fee payment date (situation as of event date), data collected since 19931001

Effective date: 19970128