IT1247495B - Procedimento per la preparazione di l-1,2-diacetilglicerofosforilcolina monoidrata - Google Patents
Procedimento per la preparazione di l-1,2-diacetilglicerofosforilcolina monoidrataInfo
- Publication number
- IT1247495B IT1247495B ITMI911069A ITMI911069A IT1247495B IT 1247495 B IT1247495 B IT 1247495B IT MI911069 A ITMI911069 A IT MI911069A IT MI911069 A ITMI911069 A IT MI911069A IT 1247495 B IT1247495 B IT 1247495B
- Authority
- IT
- Italy
- Prior art keywords
- diacetylglycerophosphorylcholine
- monohydrate
- preparation
- reacted
- anhydrous
- Prior art date
Links
- 150000004682 monohydrates Chemical class 0.000 title 1
- ZMANZCXQSJIPKH-UHFFFAOYSA-N Triethylamine Chemical compound CCN(CC)CC ZMANZCXQSJIPKH-UHFFFAOYSA-N 0.000 abstract 3
- GETQZCLCWQTVFV-UHFFFAOYSA-N trimethylamine Chemical compound CN(C)C GETQZCLCWQTVFV-UHFFFAOYSA-N 0.000 abstract 2
- UXDDRFCJKNROTO-UHFFFAOYSA-N Glycerol 1,2-diacetate Chemical compound CC(=O)OCC(CO)OC(C)=O UXDDRFCJKNROTO-UHFFFAOYSA-N 0.000 abstract 1
- 238000009833 condensation Methods 0.000 abstract 1
- 230000005494 condensation Effects 0.000 abstract 1
- 238000002425 crystallisation Methods 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 239000012454 non-polar solvent Substances 0.000 abstract 1
- 239000002798 polar solvent Substances 0.000 abstract 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 1
Abstract
Processo per preparare la forma monoidrata di L-1,2-diacetilglicerofosforilcolina comprendente i seguenti passaggi:a) condensazione tra 1,2-diacetilglicerolo e 2-cloro-2-oxa-1, 3, 2-diossofosfolano in presenza di trietilammina in solventi apolari;b) il prodotto ottenuto nello stadio precedente viene fatto reagire con eccesso di trimetilammina sotto pressione per ottenere L-1,2-diacetilglicerofosforilcolina anidra;c) si fa reagire la L-1,2-diacetilglicerofosforilcolina anidra per il trattamento con piccole quantità di acqua e cristallizzazione da solvente polare.
Priority Applications (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ITMI911069A IT1247495B (it) | 1991-04-18 | 1991-04-18 | Procedimento per la preparazione di l-1,2-diacetilglicerofosforilcolina monoidrata |
| EP92102731A EP0502357A1 (en) | 1991-03-07 | 1992-02-19 | Optically active and racemic hydrated diacetylesters of alpha-glycero-phosphoryl-choline |
| CA002061643A CA2061643A1 (en) | 1991-03-07 | 1992-02-21 | Optically active and racemic hydrated diacetylesters of .alpha.-glycero-phosphoryl-choline |
| JP4083126A JPH0592982A (ja) | 1991-03-07 | 1992-03-05 | α−グリセロ−ホスホリル−コリンの光学活性ジアセチルエステル及びラセミ水和ジアセチルエステル |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ITMI911069A IT1247495B (it) | 1991-04-18 | 1991-04-18 | Procedimento per la preparazione di l-1,2-diacetilglicerofosforilcolina monoidrata |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| ITMI911069A0 ITMI911069A0 (it) | 1991-04-18 |
| ITMI911069A1 ITMI911069A1 (it) | 1992-10-18 |
| IT1247495B true IT1247495B (it) | 1994-12-17 |
Family
ID=11359665
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ITMI911069A IT1247495B (it) | 1991-03-07 | 1991-04-18 | Procedimento per la preparazione di l-1,2-diacetilglicerofosforilcolina monoidrata |
Country Status (1)
| Country | Link |
|---|---|
| IT (1) | IT1247495B (it) |
-
1991
- 1991-04-18 IT ITMI911069A patent/IT1247495B/it active IP Right Grant
Also Published As
| Publication number | Publication date |
|---|---|
| ITMI911069A1 (it) | 1992-10-18 |
| ITMI911069A0 (it) | 1991-04-18 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| ATE71352T1 (de) | Verfahren zur herstellung von alkoholaten. | |
| FR2438035A1 (fr) | Procede et intermediaires pour la preparation de derives 1a-hydroxyles de vitamines du groupe d | |
| BE876262A (fr) | Procede de preparation de l'acide (s,5s)- -amino-3-chloro-isoxazoline-5-acetique, nouveaux analogues de cet acide, et preparation de ces analogues | |
| FR2519974B1 (it) | ||
| ES8100284A1 (es) | Un procedimiento de preparacion de derivados del jurano | |
| FI904117A0 (fi) | Foerfarande foer framstaellning av alkoxialkylidenmalonsyraestrar. | |
| FR2446806A1 (fr) | Procede pour la fabrication d'acides aldoniques par voie enzymatique | |
| ES2118752T3 (es) | Procedimiento para la preparacion de 9-beta-d-arabinofuranosil-2-fluoroadenina-5'-fosfato. | |
| HUT51592A (en) | Process for production of derivatives of trans-1,1,2-triphenil-but-1-en | |
| DE3264063D1 (en) | Process for the preparation of alpha-dicyano-trimethylsilyloxy compounds | |
| CA2092407A1 (en) | Process for the preparation of 2,3-difluoro-6-nitrophenol | |
| SU836023A1 (ru) | Способ получени олигомерногоАцЕТАМидОХлОРфОСфАзЕНА | |
| JPS51113896A (en) | Process for preparing adenosine phosphoric acid derivatives | |
| ES2019603B3 (es) | 4-benciloxi-3-pirrolin-2-ona, su obtencion y aplicacion para la sintesis del acido tetram. | |
| ATE1094T1 (de) | Verfahren zur herstellung von n,n'-diformylhydrazin. | |
| ES2196370T3 (es) | Procedimiento de produccion de acido 2-hidroxinaftalen-3,6-dicarboxilico. | |
| EP0106282A3 (en) | Production of caerulein intermediate | |
| JPS572270A (en) | Preparation of 1-methyl-5- p-toluoyl pyrrole-2-acetic acid | |
| JPS5326659A (en) | Shadow mask | |
| MX9707400A (es) | Preparacion de derivados de 2-ciclopentanol cis-4-protegidos. | |
| DE3261924D1 (en) | Process for the preparation of 3,3-dimethylglutaric acid or its esters | |
| SU1085974A1 (ru) | Способ получени @ -глутаминовой кислоты | |
| HUT47116A (en) | Process for producing biotin-pentafluorophenyl esters | |
| JPS5599073A (en) | Production of artificial antigen containing melatonin residue | |
| IT1171620B (it) | Procedimento per la produzione di acido 6-idrossi-2-naftoico |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 0001 | Granted | ||
| TA | Fee payment date (situation as of event date), data collected since 19931001 |
Effective date: 19950428 |