IT1254295B - Procedimento per la preparazione di vaccini, e vaccini cosi' ottenibili. - Google Patents
Procedimento per la preparazione di vaccini, e vaccini cosi' ottenibili.Info
- Publication number
- IT1254295B IT1254295B ITRM920074A ITRM920074A IT1254295B IT 1254295 B IT1254295 B IT 1254295B IT RM920074 A ITRM920074 A IT RM920074A IT RM920074 A ITRM920074 A IT RM920074A IT 1254295 B IT1254295 B IT 1254295B
- Authority
- IT
- Italy
- Prior art keywords
- pathogenic agent
- aforesaid
- phages
- capsid
- immunisation
- Prior art date
Links
- 229960005486 vaccine Drugs 0.000 title abstract 4
- 238000000034 method Methods 0.000 title abstract 3
- 239000003795 chemical substances by application Substances 0.000 abstract 4
- 230000001717 pathogenic effect Effects 0.000 abstract 4
- 210000000234 capsid Anatomy 0.000 abstract 3
- 102000015636 Oligopeptides Human genes 0.000 abstract 2
- 108010038807 Oligopeptides Proteins 0.000 abstract 2
- 238000002649 immunization Methods 0.000 abstract 2
- 230000003472 neutralizing effect Effects 0.000 abstract 2
- 230000001681 protective effect Effects 0.000 abstract 2
- 108091034117 Oligonucleotide Proteins 0.000 abstract 1
- 230000000890 antigenic effect Effects 0.000 abstract 1
- 238000009472 formulation Methods 0.000 abstract 1
- 239000012634 fragment Substances 0.000 abstract 1
- 230000002068 genetic effect Effects 0.000 abstract 1
- 238000010353 genetic engineering Methods 0.000 abstract 1
- 239000000463 material Substances 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 239000013612 plasmid Substances 0.000 abstract 1
- 108090000623 proteins and genes Proteins 0.000 abstract 1
- 210000002966 serum Anatomy 0.000 abstract 1
- 238000012795 verification Methods 0.000 abstract 1
Landscapes
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Abstract
Procedimento per la preparazione di vaccini contro uno specifico agente patogeno, caratterizzato essenzialmente dalle seguenti operazioni:- identificazione di almeno un anticorpo con attività neutralizzante o protettiva nei confronti di detto agente patogeno;- costruzione di librerie di fagi che espongono sulla superficie del capside oligopeptidi, espressi da inserti oligonucleotidici a sequenza casuale introdotti in un gene codificante per il capside fagico con tecniche di manipolazione genetica (ad esempio utilizzando il plasmide pC89 con la mappa genetica indicata in figura);- selezione dei fagi che espongono sulla superficie del capside oligopeptidi antigenici riconosciuti da detto anticorpo;- immunizzazione di un organismo che si vuole proteggere mediante i fagi selezionati e/ o loro frammenti e/o loro derivati;- verifica della presenza, nel siero dell'organismo immunizzato, di anticorpi neutralizzanti o protettivi nei confronti del suddetto agente patogeno; e - uso del materiale impiegato nella suddetta immunizzazione per la formulazione di un vaccino contro il suddetto specifico agente patogeno.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ITRM920074A IT1254295B (it) | 1992-02-03 | 1992-02-03 | Procedimento per la preparazione di vaccini, e vaccini cosi' ottenibili. |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ITRM920074A IT1254295B (it) | 1992-02-03 | 1992-02-03 | Procedimento per la preparazione di vaccini, e vaccini cosi' ottenibili. |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| ITRM920074A0 ITRM920074A0 (it) | 1992-02-03 |
| ITRM920074A1 ITRM920074A1 (it) | 1993-08-03 |
| IT1254295B true IT1254295B (it) | 1995-09-14 |
Family
ID=11400647
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ITRM920074A IT1254295B (it) | 1992-02-03 | 1992-02-03 | Procedimento per la preparazione di vaccini, e vaccini cosi' ottenibili. |
Country Status (1)
| Country | Link |
|---|---|
| IT (1) | IT1254295B (it) |
-
1992
- 1992-02-03 IT ITRM920074A patent/IT1254295B/it active IP Right Grant
Also Published As
| Publication number | Publication date |
|---|---|
| ITRM920074A1 (it) | 1993-08-03 |
| ITRM920074A0 (it) | 1992-02-03 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| McClements et al. | Immunization with DNA vaccines encoding glycoprotein D or glycoprotein B, alone or in combination, induces protective immunity in animal models of herpes simplex virus-2 disease. | |
| Kniess et al. | Distribution of linear antigenic sites on glycoprotein gp55 of human cytomegalovirus | |
| Lee et al. | Optimal induction of hepatitis C virus envelope-specific immunity by bicistronic plasmid DNA inoculation with the granulocyte-macrophage colony-stimulating factor gene | |
| Suter et al. | BAC-VAC, a novel generation of (DNA) vaccines: a bacterial artificial chromosome (BAC) containing a replication-competent, packaging-defective virus genome induces protective immunity against herpes simplex virus 1 | |
| BR9406595A (pt) | Processo para a preparação dos imunógenos ou reagentes para diagnóstico que mimetizam um antigeno ou um organismo patogênico especifico para uma doença fagos vacinas contra um agente patogênico especifico e plasmideos pc89 modificados | |
| WO1994026886B1 (en) | Process for the preparation of immunogens or diagnostic reagents, and immunogens or diagnostic reagents thereby obtainable | |
| HUT71320A (en) | Novel plasmid for production of crm protein and diphtheria toxin | |
| PL392964A1 (pl) | Antygen reaktywny wobec surowicy hiperimmunologicznej zastosowanie tego antygenu do produkcji preparatu farmaceutycznego, fragment hiperimmunologiczny antygenu, epitopy pomocnicze antygenu, szczepionka zawierająca antygen reaktywny wobec surowicy hiperimmunologicznej, preparat zawierający przeciwciała, sposób wytwarzania tego preparatu, zastosowanie preparatu do leczenia infekcji gronkowcowych oraz sposób przesiewania | |
| WO1997048370A3 (en) | Vaccines comprising synthetic genes | |
| WO1997009428A3 (en) | Compounds and methods for immunotherapy and diagnosis of tuberculosis | |
| WO1998037095A3 (en) | Recombinant pox virus for immunization against muc1 tumor-associated antigen | |
| NO924780L (no) | Ekspresjon av spesifikke immunogener ved bruk av virusantigener | |
| WO2002026250A3 (en) | Vaccines for proliferative ileitis | |
| Scheiblhofer et al. | Removal of the circumsporozoite protein (CSP) glycosylphosphatidylinositol signal sequence from a CSP DNA vaccine enhances induction of CSP‐specific Th2 type immune responses and improvesprotection against malaria infection | |
| JP4653934B2 (ja) | バクテリオファージによって仲介される免疫化方法 | |
| CA2327835A1 (en) | Methods and modified cells for the treatment of cancer | |
| MX9801089A (es) | Proteina hibrida que comprende epitopes estimulantes de celula auxiliar t y epitopes de celula b de la proteina de membrana externa mayor chlamydia trachomatis y su uso como vacuna. | |
| Bailer et al. | Herpesviral vectors and their application in oncolytic therapy, vaccination, and gene transfer | |
| IT1254295B (it) | Procedimento per la preparazione di vaccini, e vaccini cosi' ottenibili. | |
| Mester et al. | Immunity induced by DNA immunization with herpes simplex virus type 2 glycoproteins B and C | |
| AU3379693A (en) | Vaccines and diagnostic assays for haemophilus influenzae | |
| WO1998001558A3 (en) | Protein and peptide vaccines for inducing mucosal immunity | |
| AU3478393A (en) | Vaccine containing acemannan as an adjuvant | |
| DK0499681T3 (da) | pCTD-plasmid isoleret fra Chlamydia trachomatis serotype D, dets gener og proteiner, som kodes af dem; rekombinante plasmid | |
| US5632992A (en) | Process for the expression of herpes simplex virus type 1 glycoprotein E and method of use |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 0001 | Granted | ||
| TA | Fee payment date (situation as of event date), data collected since 19931001 |
Effective date: 19970130 |