IT1255389B - Idrossiammidi della biotina un processo per la loro preparazione e composizioni terapeutiche che li contengono come principi attivi per il trattamento del diabete e delle relative complicanze - Google Patents
Idrossiammidi della biotina un processo per la loro preparazione e composizioni terapeutiche che li contengono come principi attivi per il trattamento del diabete e delle relative complicanzeInfo
- Publication number
- IT1255389B IT1255389B ITMI922232A ITMI922232A IT1255389B IT 1255389 B IT1255389 B IT 1255389B IT MI922232 A ITMI922232 A IT MI922232A IT MI922232 A ITMI922232 A IT MI922232A IT 1255389 B IT1255389 B IT 1255389B
- Authority
- IT
- Italy
- Prior art keywords
- contain
- preparation
- treatment
- diabetes
- therapeutic compositions
- Prior art date
Links
- 206010012601 diabetes mellitus Diseases 0.000 title abstract 2
- 238000000034 method Methods 0.000 title abstract 2
- 239000000203 mixture Substances 0.000 title abstract 2
- 230000001225 therapeutic effect Effects 0.000 title abstract 2
- YBJHBAHKTGYVGT-ZKWXMUAHSA-N (+)-Biotin Chemical compound N1C(=O)N[C@@H]2[C@H](CCCCC(=O)O)SC[C@@H]21 YBJHBAHKTGYVGT-ZKWXMUAHSA-N 0.000 title 1
- 235000000638 D-biotin Nutrition 0.000 title 1
- 239000011665 D-biotin Substances 0.000 title 1
- NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical compound N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 abstract 4
- 102000004877 Insulin Human genes 0.000 abstract 2
- 108090001061 Insulin Proteins 0.000 abstract 2
- 229940125396 insulin Drugs 0.000 abstract 2
- XWTRCWQHEXIEGU-UFLZEWODSA-N 5-[(3as,4s,6ar)-2-oxo-1,3,3a,4,6,6a-hexahydrothieno[3,4-d]imidazol-4-yl]pentanoic acid;hydroxylamine Chemical class ON.N1C(=O)N[C@@H]2[C@H](CCCCC(=O)O)SC[C@@H]21 XWTRCWQHEXIEGU-UFLZEWODSA-N 0.000 abstract 1
- 239000004480 active ingredient Substances 0.000 abstract 1
- 230000001684 chronic effect Effects 0.000 abstract 1
- 230000001419 dependent effect Effects 0.000 abstract 1
- 230000007170 pathology Effects 0.000 abstract 1
- 208000027232 peripheral nervous system disease Diseases 0.000 abstract 1
- 208000033808 peripheral neuropathy Diseases 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Diabetes (AREA)
- Public Health (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Endocrinology (AREA)
- Obesity (AREA)
- Emergency Medicine (AREA)
- Hematology (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Idrossiammidi della biotina, un processo per la loro preparazione e relative composizioni terapeutiche che li contengono come principi attivi per il trattamento del diabete insulino-dipendente e insulino-indipendente e delle relative complicanze, quali le neuropatie periferiche, patologie croniche ed invalidanti.
Priority Applications (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ITMI922232A IT1255389B (it) | 1992-09-28 | 1992-09-28 | Idrossiammidi della biotina un processo per la loro preparazione e composizioni terapeutiche che li contengono come principi attivi per il trattamento del diabete e delle relative complicanze |
| EP93115556A EP0590563A1 (en) | 1992-09-28 | 1993-09-27 | Biotin amides, a process for their preparation and therapeutical compositions containing them as the active principles for the treatment of diabetes and relative complicating diseases |
| CA002107180A CA2107180A1 (en) | 1992-09-28 | 1993-09-28 | Biotin amides, a process for their preparation and therapeutical compositions containing them as the active principles for the treatment of diabetes and relative complicating diseases |
| JP5264271A JPH072867A (ja) | 1992-09-28 | 1993-09-28 | ビオチンアミド誘導体の製造方法及び、それらを含有する糖尿病及び糖尿病合併症の治療剤 |
| US08/825,458 US5814650A (en) | 1992-09-28 | 1997-03-28 | Biotin amides able to control glucidic metabolisms under dysmetabolic conditions and relative therapeutical compositions |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ITMI922232A IT1255389B (it) | 1992-09-28 | 1992-09-28 | Idrossiammidi della biotina un processo per la loro preparazione e composizioni terapeutiche che li contengono come principi attivi per il trattamento del diabete e delle relative complicanze |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| ITMI922232A0 ITMI922232A0 (it) | 1992-09-28 |
| ITMI922232A1 ITMI922232A1 (it) | 1994-03-28 |
| IT1255389B true IT1255389B (it) | 1995-10-31 |
Family
ID=11364020
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ITMI922232A IT1255389B (it) | 1992-09-28 | 1992-09-28 | Idrossiammidi della biotina un processo per la loro preparazione e composizioni terapeutiche che li contengono come principi attivi per il trattamento del diabete e delle relative complicanze |
Country Status (4)
| Country | Link |
|---|---|
| EP (1) | EP0590563A1 (it) |
| JP (1) | JPH072867A (it) |
| CA (1) | CA2107180A1 (it) |
| IT (1) | IT1255389B (it) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2004203863A (ja) * | 2002-12-09 | 2004-07-22 | Taisho Pharmaceut Co Ltd | 抗糖尿病用組成物 |
| KR100699278B1 (ko) * | 2005-05-12 | 2007-03-23 | 학교법인 포항공과대학교 | 수화젤레이터로 유용한 바이오틴-아미노산 결합체 및이로부터 제조된 수화젤 |
| KR100778633B1 (ko) * | 2007-04-13 | 2007-11-28 | 성균관대학교산학협력단 | 비오틴과 비오틴-폴리에틸렌글리콜이 접합된 glp-1유도체, 이의 제조방법 및 이를 포함하는 약학 조성물 |
| CN109890384A (zh) * | 2016-09-01 | 2019-06-14 | Jds治疗有限公司 | 生物素镁组合物和使用方法 |
| CN119462688B (zh) * | 2024-11-08 | 2026-03-10 | 青岛大学 | 一种生物素化氨基酸衍生物的制备方法 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IL76234A0 (en) * | 1985-08-28 | 1986-01-31 | Yeda Res & Dev | New biotinylation reagents |
| US4709037A (en) * | 1987-02-17 | 1987-11-24 | Hoechst Celanese Corporation | Biotinylating agents |
| US4977288A (en) * | 1988-01-29 | 1990-12-11 | President And Fellows Of Harvard College | M-aminophenyltrialkylstannane |
| US4908453A (en) * | 1989-01-23 | 1990-03-13 | E. I. Du Pont De Nemours And Company | Reagents for the preparation of 5'-biotinylated oligonucleotides |
-
1992
- 1992-09-28 IT ITMI922232A patent/IT1255389B/it active IP Right Grant
-
1993
- 1993-09-27 EP EP93115556A patent/EP0590563A1/en active Pending
- 1993-09-28 JP JP5264271A patent/JPH072867A/ja active Pending
- 1993-09-28 CA CA002107180A patent/CA2107180A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| JPH072867A (ja) | 1995-01-06 |
| EP0590563A1 (en) | 1994-04-06 |
| ITMI922232A1 (it) | 1994-03-28 |
| CA2107180A1 (en) | 1994-03-29 |
| ITMI922232A0 (it) | 1992-09-28 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 0001 | Granted | ||
| TA | Fee payment date (situation as of event date), data collected since 19931001 |
Effective date: 19970929 |