IT1256743B - Composizioni farmaceutiche a rilascio controllato contenenti nicergolina - Google Patents

Composizioni farmaceutiche a rilascio controllato contenenti nicergolina

Info

Publication number
IT1256743B
IT1256743B ITMI922885A ITMI922885A IT1256743B IT 1256743 B IT1256743 B IT 1256743B IT MI922885 A ITMI922885 A IT MI922885A IT MI922885 A ITMI922885 A IT MI922885A IT 1256743 B IT1256743 B IT 1256743B
Authority
IT
Italy
Prior art keywords
pharmaceutical compositions
controlled release
nicergolin
compositions containing
release pharmaceutical
Prior art date
Application number
ITMI922885A
Other languages
English (en)
Inventor
Giorgio Pifferi
Original Assignee
Giorgio Pifferi
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Giorgio Pifferi filed Critical Giorgio Pifferi
Publication of ITMI922885A0 publication Critical patent/ITMI922885A0/it
Priority to ITMI922885A priority Critical patent/IT1256743B/it
Priority to EP93120199A priority patent/EP0602619A1/en
Priority to CZ932775A priority patent/CZ277593A3/cs
Priority to PL93301513A priority patent/PL301513A1/xx
Priority to JP5343465A priority patent/JPH0748256A/ja
Priority to CN93112890A priority patent/CN1093254A/zh
Priority to HU9303633A priority patent/HUT66371A/hu
Priority to KR1019930028487A priority patent/KR950016748A/ko
Publication of ITMI922885A1 publication Critical patent/ITMI922885A1/it
Application granted granted Critical
Publication of IT1256743B publication Critical patent/IT1256743B/it

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5005—Wall or coating material
    • A61K9/5021—Organic macromolecular compounds
    • A61K9/5026—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5073—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings
    • A61K9/5078—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings with drug-free core
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/48—Ergoline derivatives, e.g. lysergic acid, ergotamine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1617—Organic compounds, e.g. phospholipids, fats
    • A61K9/1623—Sugars or sugar alcohols, e.g. lactose; Derivatives thereof; Homeopathic globules
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1652—Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Diabetes (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Si descrivono composizioni farmaceutiche orali a rilascio controllato contenenti come principio attivo nicergolina o un suo sale farmaceuticamente accettabile comprendenti miscele di microgranuli caricati con nicergolina o un suo sale e rivestiti con un film costituito da:- 100-97% di un copolimero neutro a peso molecolare medio di 800.000 formato da acrilato di etile e metacrilato di metile; - 0-3% di sostanze idrosolubili.
ITMI922885A 1992-12-18 1992-12-18 Composizioni farmaceutiche a rilascio controllato contenenti nicergolina IT1256743B (it)

Priority Applications (8)

Application Number Priority Date Filing Date Title
ITMI922885A IT1256743B (it) 1992-12-18 1992-12-18 Composizioni farmaceutiche a rilascio controllato contenenti nicergolina
EP93120199A EP0602619A1 (en) 1992-12-18 1993-12-15 Controlled-release pharmaceutical compositions containing nicergoline
JP5343465A JPH0748256A (ja) 1992-12-18 1993-12-16 ニセルゴリンを含有する制御放出性の製薬組成物
PL93301513A PL301513A1 (en) 1992-12-18 1993-12-16 Controllably released pharmaceutical composition containing nitroglycerin
CZ932775A CZ277593A3 (en) 1992-12-18 1993-12-16 Pharmaceutical preparation for peroral administration
CN93112890A CN1093254A (zh) 1992-12-18 1993-12-17 含有麦角溴烟酯的控释药物组合物
HU9303633A HUT66371A (en) 1992-12-18 1993-12-17 Controlled-release pharmaceutical compositions containing nicergoline
KR1019930028487A KR950016748A (ko) 1992-12-18 1993-12-18 니세르골린을 함유하는 방출-조절성 약제학적 조성물

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ITMI922885A IT1256743B (it) 1992-12-18 1992-12-18 Composizioni farmaceutiche a rilascio controllato contenenti nicergolina

Publications (3)

Publication Number Publication Date
ITMI922885A0 ITMI922885A0 (it) 1992-12-18
ITMI922885A1 ITMI922885A1 (it) 1994-06-18
IT1256743B true IT1256743B (it) 1995-12-15

Family

ID=11364487

Family Applications (1)

Application Number Title Priority Date Filing Date
ITMI922885A IT1256743B (it) 1992-12-18 1992-12-18 Composizioni farmaceutiche a rilascio controllato contenenti nicergolina

Country Status (8)

Country Link
EP (1) EP0602619A1 (it)
JP (1) JPH0748256A (it)
KR (1) KR950016748A (it)
CN (1) CN1093254A (it)
CZ (1) CZ277593A3 (it)
HU (1) HUT66371A (it)
IT (1) IT1256743B (it)
PL (1) PL301513A1 (it)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2786101B1 (fr) 1998-11-24 2002-07-05 Aventis Laboratoire Utilisation de la nicergoline dans le traitement de la spasticite
FR2786100B1 (fr) * 1998-11-24 2002-03-01 Aventis Laboratoire Nouvelle application therapeutique de la nicergoline
JP3718398B2 (ja) * 2000-01-11 2005-11-24 信越化学工業株式会社 フィルムコーティング剤及び経口固形製剤
JP5228359B2 (ja) * 2007-04-12 2013-07-03 ニプロ株式会社 主薬粒子及びその製造方法ならびに口腔内崩壊錠
CN102228450B (zh) * 2011-06-28 2012-10-31 重庆市庆余堂制药有限公司 尼麦角林胶囊及其生产方法
CN106333927A (zh) 2015-07-08 2017-01-18 昆山龙灯瑞迪制药有限公司 修饰释放的尼麦角林组合物
CN111904938A (zh) * 2020-05-15 2020-11-10 山东方明药业集团股份有限公司 一种尼麦角林片剂的制备方法
CN113081993A (zh) * 2021-04-15 2021-07-09 海南通用三洋药业有限公司 一种尼麦角林片剂的制备方法
CN113398089A (zh) * 2021-06-29 2021-09-17 海南通用三洋药业有限公司 一种尼麦角林胶囊的制备方法和尼麦角林胶囊
CN119185230A (zh) * 2024-10-12 2024-12-27 宝利化（南京）制药有限公司 一种甲磺酸二氢麦角碱控释片及其制备方法

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5015480A (en) * 1987-11-25 1991-05-14 Eli Lilly And Company Film coating formulations

Also Published As

Publication number Publication date
ITMI922885A0 (it) 1992-12-18
KR950016748A (ko) 1995-07-20
HU9303633D0 (en) 1994-04-28
JPH0748256A (ja) 1995-02-21
CN1093254A (zh) 1994-10-12
HUT66371A (en) 1994-11-28
CZ277593A3 (en) 1994-07-13
ITMI922885A1 (it) 1994-06-18
EP0602619A1 (en) 1994-06-22
PL301513A1 (en) 1994-06-27

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Legal Events

Date Code Title Description
0001 Granted
TA Fee payment date (situation as of event date), data collected since 19931001

Effective date: 19961223