IT1264083B1 - Procedimento per la produzione in piante di anticorpi ingegnerizzati, anticorpi prodotti e loro uso in diagnosi e terapia. - Google Patents

Procedimento per la produzione in piante di anticorpi ingegnerizzati, anticorpi prodotti e loro uso in diagnosi e terapia.

Info

Publication number
IT1264083B1
IT1264083B1 IT93RM000818A ITRM930818A IT1264083B1 IT 1264083 B1 IT1264083 B1 IT 1264083B1 IT 93RM000818 A IT93RM000818 A IT 93RM000818A IT RM930818 A ITRM930818 A IT RM930818A IT 1264083 B1 IT1264083 B1 IT 1264083B1
Authority
IT
Italy
Prior art keywords
antibody
plants
production
diagnosis
therapy
Prior art date
Application number
IT93RM000818A
Other languages
English (en)
Inventor
Patrizia Galeffi
Pier Giorgio Natali
Original Assignee
Enea Ente Nuove Tec
Ist Fisioterap Ospitalroma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Enea Ente Nuove Tec, Ist Fisioterap Ospitalroma filed Critical Enea Ente Nuove Tec
Priority to IT93RM000818A priority Critical patent/IT1264083B1/it
Publication of ITRM930818A0 publication Critical patent/ITRM930818A0/it
Priority to EP94830567A priority patent/EP0657538A3/en
Publication of ITRM930818A1 publication Critical patent/ITRM930818A1/it
Application granted granted Critical
Publication of IT1264083B1 publication Critical patent/IT1264083B1/it

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
    • C12N15/8241—Phenotypically and genetically modified plants via recombinant DNA technology
    • C12N15/8242—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits
    • C12N15/8257—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits for the production of primary gene products, e.g. pharmaceutical products, interferon
    • C12N15/8258—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits for the production of primary gene products, e.g. pharmaceutical products, interferon for the production of oral vaccines (antigens) or immunoglobulins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/32—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against translation products of oncogenes

Landscapes

  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Immunology (AREA)
  • Biomedical Technology (AREA)
  • Biophysics (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • Microbiology (AREA)
  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Cell Biology (AREA)
  • Oncology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Breeding Of Plants And Reproduction By Means Of Culturing (AREA)

Abstract

E' descritto un procedimento per la produzione di anticorpi ad uso diagnostico e terapeutico in piante. Preferibilmente gli anticorpi dell'invenzione riconoscono l'oncogene HERZ presente in tumori della mammella e ovaie.
IT93RM000818A 1993-12-10 1993-12-10 Procedimento per la produzione in piante di anticorpi ingegnerizzati, anticorpi prodotti e loro uso in diagnosi e terapia. IT1264083B1 (it)

Priority Applications (2)

Application Number Priority Date Filing Date Title
IT93RM000818A IT1264083B1 (it) 1993-12-10 1993-12-10 Procedimento per la produzione in piante di anticorpi ingegnerizzati, anticorpi prodotti e loro uso in diagnosi e terapia.
EP94830567A EP0657538A3 (en) 1993-12-10 1994-12-07 Process for the production of genetically engineered antibodies in plants, genetically engineered antibodies and their use in diagnosis and therapy.

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT93RM000818A IT1264083B1 (it) 1993-12-10 1993-12-10 Procedimento per la produzione in piante di anticorpi ingegnerizzati, anticorpi prodotti e loro uso in diagnosi e terapia.

Publications (3)

Publication Number Publication Date
ITRM930818A0 ITRM930818A0 (it) 1993-12-10
ITRM930818A1 ITRM930818A1 (it) 1995-06-10
IT1264083B1 true IT1264083B1 (it) 1996-09-10

Family

ID=11402090

Family Applications (1)

Application Number Title Priority Date Filing Date
IT93RM000818A IT1264083B1 (it) 1993-12-10 1993-12-10 Procedimento per la produzione in piante di anticorpi ingegnerizzati, anticorpi prodotti e loro uso in diagnosi e terapia.

Country Status (2)

Country Link
EP (1) EP0657538A3 (it)
IT (1) IT1264083B1 (it)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4956282A (en) * 1985-07-29 1990-09-11 Calgene, Inc. Mammalian peptide expression in plant cells
WO1997029200A1 (de) * 1996-02-08 1997-08-14 Institut für Pflanzengenetik und Kulturpflanzenforschung Kassetten zur expression von lagerstabilen proteinen in pflanzen
US5990385A (en) * 1997-11-10 1999-11-23 Her Majesty The Queen In Right Of Canada, As Represented By The Minister Of Agriculture And Agri-Food Protein production in transgenic alfalfa plants
US20030049262A1 (en) * 1998-10-02 2003-03-13 Susan Love Methods for identification, diagnosis, and treatment of breast cancer
EP1118669A3 (en) * 1999-12-17 2001-08-29 Unilever Plc Production of camelid antibodies in plants
WO2011057360A1 (en) * 2009-11-16 2011-05-19 Acyte Biotech Pty Ltd Recombinant antibody vector
US10982221B2 (en) * 2014-01-27 2021-04-20 Arizona Board Of Regents On Behalf Of Arizona State University Plant-derived antibodies and derivatives that reduce risk of antibody-dependent enhancement (ADE) of infection

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE69033842T2 (de) * 1989-08-04 2002-06-20 Schering Ag Äusserliche domäne von c-erbb-2:gp75
US5202422A (en) * 1989-10-27 1993-04-13 The Scripps Research Institute Compositions containing plant-produced glycopolypeptide multimers, multimeric proteins and method of their use
AU662311B2 (en) * 1991-02-05 1995-08-31 Novartis Ag Recombinant antibodies specific for a growth factor receptor
IT1248361B (it) * 1991-06-28 1995-01-05 Enea Vettori plasmidici per l'espressione di geni in piante
CA2372813A1 (en) * 1992-02-06 1993-08-19 L.L. Houston Biosynthetic binding protein for cancer marker

Also Published As

Publication number Publication date
ITRM930818A1 (it) 1995-06-10
EP0657538A3 (en) 1996-03-06
EP0657538A2 (en) 1995-06-14
ITRM930818A0 (it) 1993-12-10

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Legal Events

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0001 Granted