IT1268954B1 - Processo per la preparazione di acido ialuronico mediante sintesienzimatica e relative composizioni farmaceutiche - Google Patents

Processo per la preparazione di acido ialuronico mediante sintesienzimatica e relative composizioni farmaceutiche

Info

Publication number
IT1268954B1
IT1268954B1 IT1994PD000042A ITPD940042A IT1268954B1 IT 1268954 B1 IT1268954 B1 IT 1268954B1 IT 1994PD000042 A IT1994PD000042 A IT 1994PD000042A IT PD940042 A ITPD940042 A IT PD940042A IT 1268954 B1 IT1268954 B1 IT 1268954B1
Authority
IT
Italy
Prior art keywords
preparation
pharmaceutical compositions
hyaluronic acid
enzymatic synthesis
related pharmaceutical
Prior art date
Application number
IT1994PD000042A
Other languages
English (en)
Inventor
Manfred Lansing
Peter Prehm
Michael O'regan
Irene Martini
Original Assignee
Fidia Advanced Biopolymers Srl
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Fidia Advanced Biopolymers Srl filed Critical Fidia Advanced Biopolymers Srl
Priority to IT1994PD000042A priority Critical patent/IT1268954B1/it
Publication of ITPD940042A0 publication Critical patent/ITPD940042A0/it
Priority to AU20699/95A priority patent/AU2069995A/en
Priority to PCT/EP1995/000935 priority patent/WO1995024497A2/en
Publication of ITPD940042A1 publication Critical patent/ITPD940042A1/it
Application granted granted Critical
Publication of IT1268954B1 publication Critical patent/IT1268954B1/it

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/14—Macromolecular materials
    • A61L27/20—Polysaccharides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • A61K31/726—Glycosaminoglycans, i.e. mucopolysaccharides
    • A61K31/728—Hyaluronic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
    • A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
    • A61L15/22—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing macromolecular materials
    • A61L15/28—Polysaccharides or their derivatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A61L31/04—Macromolecular materials
    • A61L31/042—Polysaccharides
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N11/00—Carrier-bound or immobilised enzymes; Carrier-bound or immobilised microbial cells; Preparation thereof
    • C12N11/02—Enzymes or microbial cells immobilised on or in an organic carrier
    • C12N11/10—Enzymes or microbial cells immobilised on or in an organic carrier the carrier being a carbohydrate
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00—Preparation of compounds containing saccharide radicals
    • C12P19/26—Preparation of nitrogen-containing carbohydrates

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Wood Science & Technology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Dermatology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Hematology (AREA)
  • Biomedical Technology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Transplantation (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Materials Engineering (AREA)
  • Vascular Medicine (AREA)
  • Surgery (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
IT1994PD000042A 1994-03-11 1994-03-11 Processo per la preparazione di acido ialuronico mediante sintesienzimatica e relative composizioni farmaceutiche IT1268954B1 (it)

Priority Applications (3)

Application Number Priority Date Filing Date Title
IT1994PD000042A IT1268954B1 (it) 1994-03-11 1994-03-11 Processo per la preparazione di acido ialuronico mediante sintesienzimatica e relative composizioni farmaceutiche
AU20699/95A AU2069995A (en) 1994-03-11 1995-03-10 Enzymatic preparation of polysaccharides
PCT/EP1995/000935 WO1995024497A2 (en) 1994-03-11 1995-03-10 Enzymatic preparation of polysaccharides

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT1994PD000042A IT1268954B1 (it) 1994-03-11 1994-03-11 Processo per la preparazione di acido ialuronico mediante sintesienzimatica e relative composizioni farmaceutiche

Publications (3)

Publication Number Publication Date
ITPD940042A0 ITPD940042A0 (it) 1994-03-11
ITPD940042A1 ITPD940042A1 (it) 1995-09-11
IT1268954B1 true IT1268954B1 (it) 1997-03-18

Family

ID=11390593

Family Applications (1)

Application Number Title Priority Date Filing Date
IT1994PD000042A IT1268954B1 (it) 1994-03-11 1994-03-11 Processo per la preparazione di acido ialuronico mediante sintesienzimatica e relative composizioni farmaceutiche

Country Status (3)

Country Link
AU (1) AU2069995A (it)
IT (1) IT1268954B1 (it)
WO (1) WO1995024497A2 (it)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7462606B2 (en) 2002-03-12 2008-12-09 Fidia Farmaceutici S.P.A. Ester derivatives of hyaluronic acid for the preparation of hydrogel materials by photocuring

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6455304B1 (en) 1994-07-01 2002-09-24 The Board Of Regents Of The University Of Oklahoma Hyaluronate synthase gene and uses thereof
US6951743B2 (en) 1997-10-31 2005-10-04 University Of Oklahoma Board Of Regents Hyaluronan synthase genes and expression thereof in bacillus hosts
US7091008B1 (en) 1994-07-01 2006-08-15 The Board Of Regents Of The University Of Oklahoma Hyaluronan synthase genes and expression thereof in Bacillus hosts
WO1997020061A1 (en) * 1995-11-30 1997-06-05 The Scripps Research Institute Synthesis of hyaluronic acid
IT1282219B1 (it) * 1995-12-20 1998-03-16 Fidia Advanced Biopolymers Srl Processo chimico fisico combinato per la preparazione di frazioni di acido ialuronico a basso peso molecolare caratterizzate da bassa
EP0861903A1 (en) * 1997-02-22 1998-09-02 Lansing, Manfred Method for reversible immobilizing oligo and/or polysaccharides
CN101113436B (zh) 1997-10-31 2013-02-06 俄克拉何马大学董事会 透明质酸合酶基因及其应用
CN1322121C (zh) 1997-10-31 2007-06-20 俄克拉何马大学董事会 透明质酸合酶基因及其应用
US7223571B2 (en) 1998-04-02 2007-05-29 The Board Of Regents Of The Universtiy Of Oklahoma Targeted glycosaminoglycan polymers by polymer grafting and methods of making and using same
US7060469B2 (en) 1998-04-02 2006-06-13 The Board Of Regents Of The University Of Oklahoma Polymer grafting by polysaccharide synthases
US20060188966A1 (en) 1998-04-02 2006-08-24 Deangelis Paul L Natural, chimeric and hybrid glycosaminoglycan polymers and methods of making and using same
AU774722B2 (en) * 1998-04-02 2004-07-08 Board Of Regents Of The University Of Oklahoma, The Polymer grafting by polysaccharide synthases
US6987023B2 (en) 1998-04-02 2006-01-17 The Board Of Regents Of The University Of Oklahoma DNA encoding hyaluronan synthase from Pasteurella multocida and methods of use
US7094581B2 (en) 1998-10-26 2006-08-22 The Board Of Regents Of The University Of Oklahoma Hyaluronan synthases and methods of making and using same
DE69940353D1 (en) * 1998-11-11 2009-03-12 Univ Oklahoma Polymerpfropfung mittels polysaccharide-synthase
US7642071B2 (en) 1999-04-01 2010-01-05 The Board Of Regents Of The University Of Oklahoma Methods of expressing gram-negative glycosaminoglycan synthase genes in gram-positive hosts
AU5407300A (en) 1999-06-30 2001-01-22 Novartis Ag Ophthalmic molding
US7534589B2 (en) 1999-11-10 2009-05-19 The Board Of Regents Of The University Of Oklahoma Polymer grafting by polysaccharide synthases
KR100501584B1 (ko) * 2000-02-03 2005-07-18 (주)케이비피 저분자 폴리만유로네이트의 제조방법, 혈청지질개선제로서의 이의 신규 용도 및 이를 함유하는 기능성식품 및 건강 보조 식품
DE10247073B4 (de) * 2002-10-09 2010-08-05 Mirshafiey, Abbas, Prof. Dr. Verfahren zur Herstellung von monomeren Uronsäuren, insbesondere D-Mannuronsäure und D-Guluronsäure und deren Verwendung als Arzneimittel
AU2003277820A1 (en) * 2002-10-09 2004-05-04 Westfalische Wilhelms-Universitat Munster Method for producing monomer uronic acids, especially d- mannuronic acid and d-guluronic acid and derivatives thereof, and the use of the same as medicaments
CA2705850C (en) 2007-11-13 2016-07-19 Bio-Technology General (Israel) Ltd. Dilute filtration sterilization process for viscoelastic biopolymers
ITMI20072348A1 (it) * 2007-12-17 2009-06-18 Medichem Srl Metodo per la rigenerazione cellulare di acido ialuronico e relativa composizione cosmetica
ES2658609T3 (es) 2008-09-02 2018-03-12 Tautona Group Lp Hilos de ácido hialurónico y/o derivados de los mismos, métodos para fabricar los mismos, y usos de los mismos
CN111676258A (zh) * 2020-07-13 2020-09-18 南京恒道医药科技有限公司 一种连续制备分离玻璃酸钠的方法

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NO161573C (no) * 1983-11-25 1989-08-30 Miles Inc Fremgangsmaate til fremstilling av hyaluronsyre.
ATE193551T1 (de) * 1991-03-18 2000-06-15 Scripps Research Inst Oligosaccharide als enzymsubstrate und - inhibitoren: verfahren und zusammensetzungen
EP0642526B1 (en) * 1991-10-15 1998-12-23 The Scripps Research Institute Production of fucosylated carbohydrates by enzymatic fucosylation synthesis of sugar nucleotides; and in situ regeneration of gdp-fucose
IT1260154B (it) * 1992-07-03 1996-03-28 Lanfranco Callegaro Acido ialuronico e suoi derivati in polimeri interpenetranti (ipn)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7462606B2 (en) 2002-03-12 2008-12-09 Fidia Farmaceutici S.P.A. Ester derivatives of hyaluronic acid for the preparation of hydrogel materials by photocuring
US8178499B2 (en) 2002-03-12 2012-05-15 Fidia Farmaceutici S.P.A. Ester derivatives of hyaluronic acid for the preparation of hydrogel materials by photocuring
US8178663B2 (en) 2002-03-12 2012-05-15 Fidia Farmaceutici S.P.A. Ester derivatives of hyaluronic acid for the preparation of hydrogel materials by photocuring

Also Published As

Publication number Publication date
WO1995024497A2 (en) 1995-09-14
ITPD940042A1 (it) 1995-09-11
ITPD940042A0 (it) 1994-03-11
AU2069995A (en) 1995-09-25
WO1995024497A3 (en) 1995-11-16

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Legal Events

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0001 Granted
TA Fee payment date (situation as of event date), data collected since 19931001

Effective date: 19970221